ATE508115T1 - Kristalline formen von 4-ä2-(4- methylphenylsulfanyl)phenylüpiperidin mit kombinierter serotonin- und norepinephrinwiederaufnahmehemmung zur behandlung neuropathischer schmerzen - Google Patents

Kristalline formen von 4-ä2-(4- methylphenylsulfanyl)phenylüpiperidin mit kombinierter serotonin- und norepinephrinwiederaufnahmehemmung zur behandlung neuropathischer schmerzen

Info

Publication number
ATE508115T1
ATE508115T1 AT07764496T AT07764496T ATE508115T1 AT E508115 T1 ATE508115 T1 AT E508115T1 AT 07764496 T AT07764496 T AT 07764496T AT 07764496 T AT07764496 T AT 07764496T AT E508115 T1 ATE508115 T1 AT E508115T1
Authority
AT
Austria
Prior art keywords
reuppost
phenylupiperidine
methylphenylsulfanyl
norepinephrine
inhibition
Prior art date
Application number
AT07764496T
Other languages
German (de)
English (en)
Inventor
Benny Bang-Andersen
Andre Faldt
Tine Stensbyl
Silke Miller
De Diego Heidi Lopez
Original Assignee
Lundbeck & Co As H
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lundbeck & Co As H filed Critical Lundbeck & Co As H
Priority claimed from PCT/DK2007/050076 external-priority patent/WO2007144006A1/en
Application granted granted Critical
Publication of ATE508115T1 publication Critical patent/ATE508115T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
    • C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D211/20—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by singly bound oxygen or sulphur atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4465—Non condensed piperidines, e.g. piperocaine only substituted in position 4
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/451—Non condensed piperidines, e.g. piperocaine having a carbocyclic group directly attached to the heterocyclic ring, e.g. glutethimide, meperidine, loperamide, phencyclidine, piminodine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C229/04—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated
    • C07C229/24—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having more than one carboxyl group bound to the carbon skeleton, e.g. aspartic acid
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C55/00—Saturated compounds having more than one carboxyl group bound to acyclic carbon atoms
    • C07C55/02—Dicarboxylic acids
    • C07C55/08—Malonic acid
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C55/00—Saturated compounds having more than one carboxyl group bound to acyclic carbon atoms
    • C07C55/02—Dicarboxylic acids
    • C07C55/12—Glutaric acid
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C59/01—Saturated compounds having only one carboxyl group and containing hydroxy or O-metal groups
    • C07C59/08—Lactic acid
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
AT07764496T 2006-06-16 2007-06-15 Kristalline formen von 4-ä2-(4- methylphenylsulfanyl)phenylüpiperidin mit kombinierter serotonin- und norepinephrinwiederaufnahmehemmung zur behandlung neuropathischer schmerzen ATE508115T1 (de)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US80500906P 2006-06-16 2006-06-16
DKPA200600816 2006-06-16
DKPA200700423 2007-03-20
PCT/DK2007/050076 WO2007144006A1 (en) 2006-06-16 2007-06-15 Crystalline forms of 4- [2- (4-methylphenylsulfanyl) -phenyl] piperidine with combined serotonin and norepinephrine reuptake inhibition for the treatment of neuropathic pain

Publications (1)

Publication Number Publication Date
ATE508115T1 true ATE508115T1 (de) 2011-05-15

Family

ID=39722478

Family Applications (1)

Application Number Title Priority Date Filing Date
AT07764496T ATE508115T1 (de) 2006-06-16 2007-06-15 Kristalline formen von 4-ä2-(4- methylphenylsulfanyl)phenylüpiperidin mit kombinierter serotonin- und norepinephrinwiederaufnahmehemmung zur behandlung neuropathischer schmerzen

Country Status (15)

Country Link
JP (1) JP2014098017A (ja)
KR (1) KR101472595B1 (ja)
AR (1) AR061480A1 (ja)
AT (1) ATE508115T1 (ja)
BR (1) BRPI0712758A2 (ja)
CA (1) CA2784304A1 (ja)
DE (1) DE602007014372D1 (ja)
DK (1) DK2044020T3 (ja)
MY (1) MY150698A (ja)
NZ (1) NZ572856A (ja)
PT (1) PT2044020E (ja)
RS (1) RS51687B (ja)
SI (1) SI2044020T1 (ja)
TN (1) TNSN08461A1 (ja)
TW (1) TWI444365B (ja)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR101972931B1 (ko) 2017-10-19 2019-04-26 재단법인대구경북과학기술원 풍선 타입 피질전도 측정장치 및 이의 제조방법
CN116930385B (zh) * 2023-08-08 2024-02-20 北京爱思益普生物科技股份有限公司 一种高盐浓度制剂中化合物浓度的测定方法

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
UA81749C2 (uk) * 2001-10-04 2008-02-11 Х. Луннбек А/С Фенілпіперазинові похідні як інгібітори зворотного захоплення серотоніну
EP2044020B1 (en) * 2006-06-16 2011-05-04 H. Lundbeck A/S Crystalline forms of 4- [2- (4-methylphenylsulfanyl) -phenyl]piperidine with combined serotonin and norepinephrine reuptake inhibition for the treatment of neuropathic pain

Also Published As

Publication number Publication date
MY150698A (en) 2014-02-28
JP2014098017A (ja) 2014-05-29
RS51687B (en) 2011-10-31
DE602007014372D1 (de) 2011-06-16
PT2044020E (pt) 2011-05-12
NZ572856A (en) 2012-02-24
TW200817329A (en) 2008-04-16
TNSN08461A1 (en) 2010-04-14
DK2044020T3 (da) 2011-08-15
TWI444365B (zh) 2014-07-11
KR101472595B1 (ko) 2014-12-15
AR061480A1 (es) 2008-08-27
KR20090018630A (ko) 2009-02-20
SI2044020T1 (sl) 2011-06-30
CA2784304A1 (en) 2007-12-21
BRPI0712758A2 (pt) 2012-09-25

Similar Documents

Publication Publication Date Title
ATE429218T1 (de) Pinolensäure zur behandlung von übergewicht
ATE434620T1 (de) Dihydrothienopyrimidine zur behandlung von entzündlichen erkrankungen
DE502005010499D1 (de) Implantat zur Behandlung von Fettsucht
ATE534633T1 (de) Indazolderivate zur behandlung von hsp90- induzierten krankheiten
ATE438623T1 (de) Aroyl-o-piperidinderivate zur behandlung von problemen im zusammenhang mit diabetes
ATE490825T1 (de) Behandlung von mineralschlämmen mit verbesserter pflanzenwachstumsrehabilitation
ATE550338T1 (de) Spiropiperidininhibitoren von beta-secretase zur behandlung von alzheimer-krankheit
ATE550329T1 (de) Heterobicyclische sulfonamidderivate zur behandlung von diabetes
ATE527241T1 (de) Pyridiazinonderivate zur behandlung von tumoren
ATE512948T1 (de) Biphenyl-sulfonyl- und phenyl-heteroaryl-sulfonyl-modulatoren des histamin-h3-rezeptors zur behandlung von damit verbundenen erkrankungen
ATE545418T1 (de) Zusammensetzungen und kits zur behandlung von influenza
EA201370208A1 (ru) Формы рифаксимина и их применение
IL201309A0 (en) Novel n - (8 - heteroaryltetrahydronaphtalene - 2yl) or n - (5 - heteroarylchromane - 3 - yl) carboxamide derivatives for the treatment of pain
DE602006019838D1 (de) Piperazinsubstituierte benzothiophene zur behandlung von geisteskrankheiten
ATE493986T1 (de) Diarylharnstoffe zur behandlung von pulmonaler hypertonie
ATE447551T1 (de) Biphenyloxyessigsäure - derivate zur behandlung von atemwegserkränkungen
ATE532507T1 (de) Neramexane zur behandlung von subakuten tinnitus
DE602006009899D1 (de) Verwendung von oxycodon zur behandlung von viszeralem schmerz
DE602006013945D1 (de) Substituierte cyclopentane oder cyclopentanone zur behandlung von augenhochdruck
DE502006007982D1 (de) Neue arzneimittelkombinationen zur behandlung von atemwegserkrankungen
ATE509621T1 (de) Verwendung von 2,5-dihydroxybenzolderivaten zur behandlung von arthritis und schmerzen
DE602005016141D1 (de) S-mirtazapin zur behandlung von hitzewallungen
ATE504297T1 (de) Visnadin zur behandlung von kopfhautjucken
DE112007001255A5 (de) Tergurid/Protergurid zur Behandlung von chronischen Schmerzen
IL213703A0 (en) Compounds and methods for the treatment of pain and other diseases

Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification

Ref document number: 2044020

Country of ref document: EP