ATE50779T1 - N6-acenaphthyl-adenosine und analoga davon. - Google Patents

N6-acenaphthyl-adenosine und analoga davon.

Info

Publication number
ATE50779T1
ATE50779T1 AT85307544T AT85307544T ATE50779T1 AT E50779 T1 ATE50779 T1 AT E50779T1 AT 85307544 T AT85307544 T AT 85307544T AT 85307544 T AT85307544 T AT 85307544T AT E50779 T1 ATE50779 T1 AT E50779T1
Authority
AT
Austria
Prior art keywords
hydrogen
lower alkyl
alkyl
halogen
independently
Prior art date
Application number
AT85307544T
Other languages
English (en)
Inventor
James A Bristol
Bharat Trivedi
Walter Moos
Original Assignee
Warner Lambert Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Warner Lambert Co filed Critical Warner Lambert Co
Application granted granted Critical
Publication of ATE50779T1 publication Critical patent/ATE50779T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16—Purine radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Biochemistry (AREA)
  • Cardiology (AREA)
  • Anesthesiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pain & Pain Management (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
AT85307544T 1984-10-26 1985-10-18 N6-acenaphthyl-adenosine und analoga davon. ATE50779T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US06/665,219 US4593019A (en) 1984-10-26 1984-10-26 N6 -tricyclic adenosines
EP85307544A EP0179630B1 (de) 1984-10-26 1985-10-18 N6-Acenaphthyl-Adenosine und Analoga davon

Publications (1)

Publication Number Publication Date
ATE50779T1 true ATE50779T1 (de) 1990-03-15

Family

ID=24669222

Family Applications (1)

Application Number Title Priority Date Filing Date
AT85307544T ATE50779T1 (de) 1984-10-26 1985-10-18 N6-acenaphthyl-adenosine und analoga davon.

Country Status (5)

Country Link
US (1) US4593019A (de)
EP (1) EP0179630B1 (de)
JP (1) JPS61103893A (de)
AT (1) ATE50779T1 (de)
DE (1) DE3576346D1 (de)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4683223A (en) * 1985-09-09 1987-07-28 Warner-Lambert Company N6 -Benzopyrano-and benzothiopyrano adenosines and methods of use
US4755594A (en) * 1986-01-31 1988-07-05 Warner-Lambert Company N6 -substituted adenosines
JP2930589B2 (ja) * 1986-10-06 1999-08-03 ザ ユニバーシィティ オブ バージニア アルミニ パテンツ ファンデーション 外科手術中における改善された心臓保護のためのアデノシン，ヒポキサンチン及びリボース含有溶液の使用
US4954504A (en) * 1986-11-14 1990-09-04 Ciba-Geigy Corporation N9 -cyclopentyl-substituted adenine derivatives having adenosine-2 receptor stimulating activity
US5063233A (en) * 1986-11-14 1991-11-05 Ciba-Geigy Corporation N9 -cyclopentyl-substituted adenine derivatives useful as adenosine receptor agonists
US4968697A (en) * 1987-02-04 1990-11-06 Ciba-Geigy Corporation 2-substituted adenosine 5'-carboxamides as antihypertensive agents
US5034381A (en) * 1988-01-07 1991-07-23 Ciba-Geigy Corporation 2-(substituted amino) adenosines as antihypertensives
JPH0725785B2 (ja) * 1989-01-11 1995-03-22 日本臓器製薬株式会社 アデノシン誘導体及び該化合物を有効成分として含有する医薬組成物
US5055569A (en) * 1989-10-19 1991-10-08 G. D. Searle & Co. N-(6)-substituted adenosine compounds
US5561134A (en) * 1990-09-25 1996-10-01 Rhone-Poulenc Rorer Pharmaceuticals Inc. Compounds having antihypertensive, cardioprotective, anti-ischemic and antilipolytic properties
ATE147074T1 (de) * 1990-09-25 1997-01-15 Rhone Poulenc Rorer Int Verbindungen welche antihypertensive und antiischemische eigenschaften besitzen
US6576619B2 (en) 1999-05-24 2003-06-10 Cv Therapeutics, Inc. Orally active A1 adenosine receptor agonists
CN102812033B (zh) * 2009-12-10 2015-11-25 中国医学科学院药物研究所 N6-取代腺苷衍生物和n6-取代腺嘌呤衍生物及其用途
US9295423B2 (en) * 2013-04-03 2016-03-29 Toshiba America Electronic Components, Inc. System and method for audio kymographic diagnostics

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL6717061A (de) * 1966-12-21 1968-06-24
DE1670265A1 (de) * 1967-08-25 1971-01-28 Boehringer Mannheim Gmbh 2-Amino-Adenosinderivate und Verfahren zu deren Herstellung
DE2139107A1 (de) * 1971-08-04 1973-02-15 Merck Patent Gmbh Heterocyclisch substituierte adenosinverbindungen
BE788958A (fr) * 1971-09-18 1973-03-19 Schering Ag Derives d'adenosine et leur procede de preparation
DE2230160A1 (de) * 1972-06-21 1974-01-31 Merck Patent Gmbh Adenosinderivat
DE2406587A1 (de) * 1974-02-12 1975-08-21 Klinge Co Chem Pharm Fab Hypolipaemisch wirksame adenosinderivate

Also Published As

Publication number Publication date
US4593019A (en) 1986-06-03
JPS61103893A (ja) 1986-05-22
EP0179630A3 (en) 1987-05-20
DE3576346D1 (de) 1990-04-12
EP0179630A2 (de) 1986-04-30
EP0179630B1 (de) 1990-03-07

Similar Documents

Publication Publication Date Title
ATE50779T1 (de) N6-acenaphthyl-adenosine und analoga davon.
ES8403858A1 (es) Procedimiento para la preparacion de dipeptidos carboxialquilicos.
UA37178C2 (uk) Терапевтичні гетероциклічні сполуки, спосіб їх одержання, спосіб профілактики та лікування, лікарський засіб та спосіб його одержання
IL85988A (en) 1-phenyl-3-naphthalenyloxy-propanamines,process for their preparation and pharmaceutical compositions containing them
ES8105298A1 (es) Un procedimiento para la preparacion de imidazol-cianoguani-dinas.
ES547826A0 (es) Un procedimiento para preparar nuevos derivados de 6-(4-fenilo sustituido -3(2h) piradazinona.
ES542125A0 (es) Un procedimiento para preparar un derivado de 1,5-benzotiazepina.
HUT39166A (en) Process for producing 2-/phenyl-alkyl/-3-/amino-alkyl/-4/3h/-quinazolinone derivatives and pharmaceutical compositions containing them
ES539123A0 (es) Un compuesto de 3-indolcarboxamida
ES548898A0 (es) Un procedimiento para la preparacion de derivados de 1,5-benzotiazepina'
ES8604185A1 (es) Un procedimiento para la preparacion de nuevos derivados de 1,5-benzotiazepina.
IL75165A0 (en) Dihydropyridines and pharmaceutical compositions containing them
ES8607338A1 (es) Procedimiento para preparar n6-bicicloadenosinas
DK216186A (da) Hexensyrer
IL79928A (en) Spiro(benzofuran-2(3h),1'-cycloheptane)s,process for their preparation and pharmaceutical compositions containing them
EP0238211A3 (en) Dihydropyridines, process for their preparation and their use as medicaments

Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification
REN Ceased due to non-payment of the annual fee