ES8105298A1 - Un procedimiento para la preparacion de imidazol-cianoguani-dinas. - Google Patents

Un procedimiento para la preparacion de imidazol-cianoguani-dinas.

Info

Publication number
ES8105298A1
ES8105298A1 ES492116A ES492116A ES8105298A1 ES 8105298 A1 ES8105298 A1 ES 8105298A1 ES 492116 A ES492116 A ES 492116A ES 492116 A ES492116 A ES 492116A ES 8105298 A1 ES8105298 A1 ES 8105298A1
Authority
ES
Spain
Prior art keywords
imidazole
guanidines
preparation
chem
compositions containing
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES492116A
Other languages
English (en)
Other versions
ES492116A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck and Co Inc
Original Assignee
Merck and Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck and Co Inc filed Critical Merck and Co Inc
Publication of ES492116A0 publication Critical patent/ES492116A0/es
Publication of ES8105298A1 publication Critical patent/ES8105298A1/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/64—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms, e.g. histidine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/415—1,2-Diazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C205/00—Compounds containing nitro groups bound to a carbon skeleton
    • C07C205/45—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by at least one doubly—bound oxygen atom, not being part of a —CHO group
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/61—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
    • C07C45/63—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by introduction of halogen; by substitution of halogen atoms by other halogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D233/90—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D333/42—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms with nitro or nitroso radicals directly attached to ring carbon atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Lubricants (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Compositions Of Macromolecular Compounds (AREA)

Abstract

PROCEDIMIENTO DE OBTENCION DE IMIDAZOL-CIANOGUANIDINAS. CONSISTE EN HACER REACCIONAR UN COMPUESTO DE FORMULA GENERAL (I) CON OTRO II, OBTENIENDOSE EL COMPUESTO III, EN QUE R1 ES HIDROGENO O METILO, R2 ES ALQUILO INFERIOR, <<M>> Y <<N>> SON UN NUMERO DE 0 A 3; A ES UN RADICAL BIVALENTE CICLICO SELECCIONADO ENTRE FENILENO, CICLOHEXILENO, TIENILIENO, TETRAHIDROTIENILENO Y 1,3-DITIANILENO; Y ES OXIGENO, AZUFRE=NR3 O =CHR4; R3 ES HIDROGENO CIANO, ALQUILO INFERIOR, FENILO, ALQUILSULFONILO O FENILSULFONILO; R4 ES NITRO, FENIL SULFONILO O ALQUILSULFONILO INFERIOR. *FORMULA* SUPRESION DE SECRECION DE ACIDO GASTRICO EN MAMIFEROS. O
ES492116A 1979-06-04 1980-06-03 Un procedimiento para la preparacion de imidazol-cianoguani-dinas. Expired ES8105298A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US06/045,545 US4220654A (en) 1979-06-04 1979-06-04 Cyclic imidazole cyanoguanidines

Publications (2)

Publication Number Publication Date
ES492116A0 ES492116A0 (es) 1981-05-16
ES8105298A1 true ES8105298A1 (es) 1981-05-16

Family

ID=21938523

Family Applications (1)

Application Number Title Priority Date Filing Date
ES492116A Expired ES8105298A1 (es) 1979-06-04 1980-06-03 Un procedimiento para la preparacion de imidazol-cianoguani-dinas.

Country Status (9)

Country Link
US (1) US4220654A (es)
EP (1) EP0020173B1 (es)
JP (1) JPS55164678A (es)
AT (1) ATE2428T1 (es)
DE (1) DE3061883D1 (es)
DK (1) DK238380A (es)
ES (1) ES8105298A1 (es)
GR (1) GR68522B (es)
PT (1) PT71306B (es)

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4374843A (en) * 1980-10-14 1983-02-22 Pfizer Inc. 2-Guanidino-4-heteroarylthiazoles
GB2092569B (en) * 1981-02-05 1984-09-19 Farmos Oy Substituted imidazole derivatives and their preparation and use
EP0058286A1 (fr) * 1981-02-12 1982-08-25 Société de Recherches et de Synthèses Organiques SA Isomères géométriques de cyano-guanidines et leurs procédés de préparation
US4590299A (en) * 1981-08-20 1986-05-20 Pfizer Inc. 2-guanidino-4-heteroarylthiazoles
US4510313A (en) * 1981-08-20 1985-04-09 Pfizer Inc. 2-Guanidino-4-heteroarylthiazoles
US4452987A (en) * 1981-08-20 1984-06-05 Pfizer Inc. Haloacetyl imidazoles
US4435396A (en) 1982-05-10 1984-03-06 Pfizer Inc. Antiulcer 2-guanidino-4-(2-substituted-amino-4-imidazolyl)thiazoles and process therefor
US4590192A (en) * 1982-10-01 1986-05-20 Beecham Group P.L.C. Benzisothiazoles, their pharmaceutical compositions, and method of use
US4558044A (en) * 1983-02-19 1985-12-10 Beecham Group P.L.C. 1,2,4-Benzothiadiazines
JPH01238574A (ja) * 1988-03-17 1989-09-22 Mitsui Toatsu Chem Inc グアニジン誘導体の製造法
US4960938A (en) * 1988-11-02 1990-10-02 Occidental Chemical Corporation Preparing 2-chlorobenzylamine from 2-chlorobenzylchloride via 2-chlorobenzylphthalimide
IE960442L (en) * 1988-12-27 1990-06-27 Takeda Chemical Industries Ltd Guanidine derivatives, their production and insecticides
US4963689A (en) * 1989-05-19 1990-10-16 Pfizer Inc. Heterocyclicguanidines as 5HT3 antagonists
DE4033612A1 (de) * 1990-10-23 1992-04-30 Merck Patent Gmbh Verfahren zur herstellung von racemischen pilosinin-derivaten
US6291514B1 (en) 1998-02-09 2001-09-18 3-Dimensional Pharmaceuticals, Inc. Heteroaryl amidines, methylamidines and guanidines, preparation thereof, and use thereof as protease inhibitors
JP2002502852A (ja) * 1998-02-09 2002-01-29 ３−ディメンショナル ファーマシューティカルズ， インコーポレイテッド プロテアーゼ阻害剤、特にウロキナーゼ阻害剤としてのヘテロアリールアミジン、メチルアミジンおよびグアニジン
CA2362390A1 (en) * 1999-02-09 2000-08-17 3-Dimensional Pharmaceuticals, Inc. Heteroaryl amidines, methylamidines and guanidines as protease inhibitors
US6858615B2 (en) 2002-02-19 2005-02-22 Parion Sciences, Inc. Phenyl guanidine sodium channel blockers
US6818711B2 (en) 2003-01-01 2004-11-16 Fina Technology, Inc. Polymerization of olefins using a ziegler-natta catalyst system having an external electron donor
US6903105B2 (en) 2003-02-19 2005-06-07 Parion Sciences, Inc. Sodium channel blockers
US7745442B2 (en) 2003-08-20 2010-06-29 Parion Sciences, Inc. Methods of reducing risk of infection from pathogens
AR086745A1 (es) 2011-06-27 2014-01-22 Parion Sciences Inc 3,5-diamino-6-cloro-n-(n-(4-(4-(2-(hexil(2,3,4,5,6-pentahidroxihexil)amino)etoxi)fenil)butil)carbamimidoil)pirazina-2-carboxamida
BR112015014178A2 (pt) 2012-12-17 2017-07-11 Parion Sciences Inc compostos de 3,5-diamino-6-cloro-n-(n-(4-fenilbutil)carbamimidoil) pirazina-2- carboxamida
RS55618B1 (sr) 2012-12-17 2017-06-30 Parion Sciences Inc Derivati hloropirazin karboksamida korisni za lečenje bolesti kojima pogoduje nedovoljna hidracija sluznica
US9102633B2 (en) 2013-12-13 2015-08-11 Parion Sciences, Inc. Arylalkyl- and aryloxyalkyl-substituted epithelial sodium channel blocking compounds

Family Cites Families (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1305549A (es) * 1969-10-29 1973-02-07
GB1307539A (en) * 1970-06-25 1973-02-21 Smith Kline French Lab Thiourea derivatives
GB1338169A (en) * 1971-03-09 1973-11-21 Smith Kline French Lab Ureas thioureas and guanidines
US4000296A (en) * 1972-09-05 1976-12-28 Smith Kline & French Laboratories Limited Imidazole alkylguanidine compounds
GB1397436A (en) * 1972-09-05 1975-06-11 Smith Kline French Lab Heterocyclic n-cyanoguinidines
US4072748A (en) * 1972-09-05 1978-02-07 Smith Kline & French Laboratories Limited Certain guanidine compounds, and their use as inhibitors of histamine activity
GB1421999A (en) * 1973-02-08 1976-01-21 Smith Kline French Lab Heterocyclic containing sulphoxides
US3979398A (en) * 1973-02-08 1976-09-07 Smith Kline & French Laboratories Limited Sulphoxides
GB1421792A (en) * 1973-05-17 1976-01-21 Smith Kline French Lab Heterocyclic substituted-1, 1-diamino-ethylene derivatives methods for their preparation and compositions containing them
GB1565205A (en) * 1975-07-31 1980-04-16 Smith Kline French Lab Heterocyclic sulphoxides
US4118496A (en) * 1974-03-12 1978-10-03 Smith Kline & French Laboratories Limited Heterocyclic-methylthioalkyl-amidines
GB1531221A (en) * 1974-09-02 1978-11-08 Smith Kline French Lab Process for preparing guanidine derivatives
GB1531231A (en) * 1974-09-02 1978-11-08 Smith Kline French Lab Process for the production of cyanoguanidine derivatives
US4093621A (en) * 1974-09-02 1978-06-06 Smith Kline & French Laboratories Limited Process for preparing heterocyclicalkylthioalkyl-N-cyanoguanidines and thioureas
IL49528A (en) * 1975-05-21 1980-11-30 Smith Kline French Lab Imidazolyl(or thiazolyl)methylthio(or butyl)guanidine or thiourea derivatives,their preparation and pharmaceutical compositions comprising them
GB1565966A (en) * 1976-08-04 1980-04-23 Allen & Hanburys Ltd Aminoalkyl furan derivatives
US4112234A (en) * 1977-08-22 1978-09-05 Bristol-Myers Company Imidazolylmethylthioethyl alkynyl guanidines

Also Published As

Publication number Publication date
ES492116A0 (es) 1981-05-16
JPS55164678A (en) 1980-12-22
DE3061883D1 (en) 1983-03-17
PT71306B (en) 1981-09-21
US4220654A (en) 1980-09-02
EP0020173A1 (en) 1980-12-10
DK238380A (da) 1980-12-05
GR68522B (es) 1982-01-11
PT71306A (en) 1980-06-01
ATE2428T1 (de) 1983-03-15
EP0020173B1 (en) 1983-02-09

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