ATE504570T1 - Tartratsalz aus isofagomin und verwendungsverfahren dafür - Google Patents

Tartratsalz aus isofagomin und verwendungsverfahren dafür

Info

Publication number
ATE504570T1
ATE504570T1 AT07252109T AT07252109T ATE504570T1 AT E504570 T1 ATE504570 T1 AT E504570T1 AT 07252109 T AT07252109 T AT 07252109T AT 07252109 T AT07252109 T AT 07252109T AT E504570 T1 ATE504570 T1 AT E504570T1
Authority
AT
Austria
Prior art keywords
isofagomin
salt
tartrate salt
gaucher disease
isofagomine tartrate
Prior art date
Application number
AT07252109T
Other languages
English (en)
Inventor
Benjamin Mugrage
David Palling
Kamlesh A Sheth
Philip J Rybczynski
Original Assignee
Amicus Therapeutics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Amicus Therapeutics Inc filed Critical Amicus Therapeutics Inc
Application granted granted Critical
Publication of ATE504570T1 publication Critical patent/ATE504570T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D211/40—Oxygen atoms
    • C07D211/44—Oxygen atoms attached in position 4
    • C07D211/46—Oxygen atoms attached in position 4 having a hydrogen atom as the second substituent in position 4
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Diabetes (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Endocrinology (AREA)
  • Emergency Medicine (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Cephalosporin Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
AT07252109T 2006-05-24 2007-05-23 Tartratsalz aus isofagomin und verwendungsverfahren dafür ATE504570T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US80802006P 2006-05-24 2006-05-24
US89071907P 2007-02-20 2007-02-20

Publications (1)

Publication Number Publication Date
ATE504570T1 true ATE504570T1 (de) 2011-04-15

Family

ID=38462442

Family Applications (1)

Application Number Title Priority Date Filing Date
AT07252109T ATE504570T1 (de) 2006-05-24 2007-05-23 Tartratsalz aus isofagomin und verwendungsverfahren dafür

Country Status (14)

Country Link
US (2) US7501439B2 (de)
EP (1) EP1860101B1 (de)
JP (1) JP5292605B2 (de)
AT (1) ATE504570T1 (de)
AU (1) AU2007202359B2 (de)
BR (1) BRPI0706114A2 (de)
CA (1) CA2590122C (de)
DE (1) DE602007013648D1 (de)
DK (1) DK1860101T3 (de)
IL (1) IL183415A (de)
MX (1) MX2007006175A (de)
PL (1) PL1860101T3 (de)
PT (1) PT1860101E (de)
WO (1) WO2007140212A2 (de)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1888068B1 (de) 2005-06-08 2014-05-21 Amicus Therapeutics, Inc. Behandlung von zns-erkrankungen in zusammenhang mit mutationen bei für lysosomale enzyme kodierenden genen
WO2007150064A2 (en) * 2006-06-23 2007-12-27 Amicus Therapeutics, Inc. METHOD FOR THE TREATMENT OF NEUROLOGICAL DISORDERS BY ENHANCING THE ACTIVITY OF β-GLUCOCEREBROSIDASE
KR101597499B1 (ko) 2007-05-22 2016-02-24 아미쿠스 세라퓨틱스, 인코포레이티드 이소파고민과 이의 유도체를 제조하는 새로운 방법
HUE051377T2 (hu) 2008-02-12 2021-03-01 Amicus Therapeutics Inc Eljárás betegségek gyógyászati chaperonnal történõ kezelésére adott válasz elõrejelzésére
US20120052053A1 (en) * 2008-11-14 2012-03-01 Manning-Bog Amy B Compositions and methods for the treatment of altered alpha-synuclein function
EP3354277B1 (de) 2009-07-28 2021-06-30 Takeda Pharmaceutical Company Limited Zusammensetzungen und verfahren zur behandlung der gaucher-krankheit
HUE028129T2 (en) * 2009-10-19 2016-11-28 Amicus Therapeutics Inc New preparations for the prevention and / or treatment of lysosomal storage disorders
WO2011049736A1 (en) 2009-10-19 2011-04-28 Amicus Therapeutics, Inc. Novel compositions for preventing and/or treating degenerative disorders of the central nervous system
DK2707101T3 (da) 2011-05-12 2019-05-13 Proteostasis Therapeutics Inc Proteostaseregulatorer
JP6061922B2 (ja) 2011-06-22 2017-01-18 ザ ジェネラル ホスピタル コーポレイション プロテイノパチーの処置方法
JP2015504919A (ja) 2012-01-25 2015-02-16 プロテオステイシス セラピューティクス，インコーポレイテッド プロテアソーム活性を調節する化合物
WO2013130963A1 (en) 2012-03-02 2013-09-06 Shire Human Genetic Therapies, Inc. Compositions and methods for treating type iii gaucher disease
NZ630612A (en) 2012-03-27 2016-11-25 Amicus Therapeutics Inc Novel compounds for preventing and/or treating lysosomal storage disorders and/or degenerative disorders of the central nervous system
US9464035B2 (en) 2012-03-28 2016-10-11 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Salicylic acid derivatives useful as glucocerebrosidase activators
EP3318277A1 (de) 2016-11-04 2018-05-09 Institut du Cerveau et de la Moelle Epiniere-ICM Inhibitoren der glucosylceramidsynthase zur behandlung von motoneuronerkrankungen
DE102017103346A1 (de) * 2017-02-17 2018-08-23 Lts Lohmann Therapie-Systeme Ag Strukturierte orodispergierbare Filme
EP3700526A4 (de) * 2017-10-26 2021-09-08 Takeda Pharmaceutical Company Limited Formulierungen mit glucocerebrosidase und isofagomin
MA53014A (fr) 2018-06-27 2021-05-05 Proteostasis Therapeutics Inc Composés améliorant l'activité du protéasome
WO2020006269A1 (en) 2018-06-27 2020-01-02 Proteostasis Therapeutics, Inc. Proteasome activity enhancing compounds
US20220184185A1 (en) 2018-07-25 2022-06-16 Modernatx, Inc. Mrna based enzyme replacement therapy combined with a pharmacological chaperone for the treatment of lysosomal storage disorders
WO2020219874A1 (en) * 2019-04-25 2020-10-29 Shire Human Genetic Therapies, Inc. Isofagomine salts, methods of use and formulations

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5844102A (en) 1994-07-07 1998-12-01 University Of Maryland Baltimore County Glycohydrolase inhibitors, their preparation and use thereof
US6274597B1 (en) 1998-06-01 2001-08-14 Mount Sinai School Of Medicine Of New York University Method of enhancing lysosomal α-Galactosidase A

Also Published As

Publication number Publication date
AU2007202359A1 (en) 2007-12-13
IL183415A (en) 2012-03-29
US7501439B2 (en) 2009-03-10
WO2007140212A2 (en) 2007-12-06
DK1860101T3 (da) 2011-07-25
IL183415A0 (en) 2007-09-20
DE602007013648D1 (de) 2011-05-19
EP1860101A1 (de) 2007-11-28
PL1860101T3 (pl) 2011-10-31
WO2007140212A3 (en) 2008-12-24
BRPI0706114A2 (pt) 2008-11-18
MX2007006175A (es) 2009-02-16
US7863453B2 (en) 2011-01-04
CA2590122A1 (en) 2007-11-24
US20070281975A1 (en) 2007-12-06
AU2007202359B2 (en) 2012-02-16
JP2007314540A (ja) 2007-12-06
JP5292605B2 (ja) 2013-09-18
EP1860101B1 (de) 2011-04-06
PT1860101E (pt) 2011-07-12
US20090176830A1 (en) 2009-07-09
CA2590122C (en) 2015-03-31

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