ATE492558T1 - Makrocyclische peptide als hepatitis-c-virus- hemmer - Google Patents

Makrocyclische peptide als hepatitis-c-virus- hemmer

Info

Publication number
ATE492558T1
ATE492558T1 AT07864438T AT07864438T ATE492558T1 AT E492558 T1 ATE492558 T1 AT E492558T1 AT 07864438 T AT07864438 T AT 07864438T AT 07864438 T AT07864438 T AT 07864438T AT E492558 T1 ATE492558 T1 AT E492558T1
Authority
AT
Austria
Prior art keywords
hepatitis
macrocyclic peptides
virus inhibitors
compounds
disclosed
Prior art date
Application number
AT07864438T
Other languages
German (de)
English (en)
Inventor
Alan Xiangdong Wang
Barbara Zhizhen Zheng
Andrea Stanley D
Nicholas A Meanwell
Paul Michael Scola
Original Assignee
Bristol Myers Squibb Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bristol Myers Squibb Co filed Critical Bristol Myers Squibb Co
Application granted granted Critical
Publication of ATE492558T1 publication Critical patent/ATE492558T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08—Tripeptides
    • C07K5/0802—Tripeptides with the first amino acid being neutral
    • C07K5/0812—Tripeptides with the first amino acid being neutral and aromatic or cycloaliphatic

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Virology (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
AT07864438T 2006-11-16 2007-11-15 Makrocyclische peptide als hepatitis-c-virus- hemmer ATE492558T1 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US86612506P 2006-11-16 2006-11-16
US11/939,768 US7763584B2 (en) 2006-11-16 2007-11-14 Hepatitis C virus inhibitors
PCT/US2007/084788 WO2008064061A1 (en) 2006-11-16 2007-11-15 Macrocyclic peptides as hepatitis c virus inhibitors

Publications (1)

Publication Number Publication Date
ATE492558T1 true ATE492558T1 (de) 2011-01-15

Family

ID=39245073

Family Applications (1)

Application Number Title Priority Date Filing Date
AT07864438T ATE492558T1 (de) 2006-11-16 2007-11-15 Makrocyclische peptide als hepatitis-c-virus- hemmer

Country Status (7)

Country Link
US (1) US7763584B2 (enExample)
EP (1) EP2086980B1 (enExample)
JP (1) JP5221552B2 (enExample)
AT (1) ATE492558T1 (enExample)
DE (1) DE602007011488D1 (enExample)
NO (1) NO20091845L (enExample)
WO (1) WO2008064061A1 (enExample)

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Also Published As

Publication number Publication date
US7763584B2 (en) 2010-07-27
NO20091845L (no) 2009-06-15
WO2008064061A1 (en) 2008-05-29
JP2010510233A (ja) 2010-04-02
DE602007011488D1 (de) 2011-02-03
US20080145334A1 (en) 2008-06-19
EP2086980A1 (en) 2009-08-12
EP2086980B1 (en) 2010-12-22
JP5221552B2 (ja) 2013-06-26

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