ATE490257T1 - Kristalline formen von pemetrexed-disäure und herstellungsverfahren dafür - Google Patents

Kristalline formen von pemetrexed-disäure und herstellungsverfahren dafür

Info

Publication number
ATE490257T1
ATE490257T1 AT07836867T AT07836867T ATE490257T1 AT E490257 T1 ATE490257 T1 AT E490257T1 AT 07836867 T AT07836867 T AT 07836867T AT 07836867 T AT07836867 T AT 07836867T AT E490257 T1 ATE490257 T1 AT E490257T1
Authority
AT
Austria
Prior art keywords
pemetrexed
disacid
production
crystalline forms
pyrrolo
Prior art date
Application number
AT07836867T
Other languages
English (en)
Inventor
Jonathan Busolli
Nicola Diulgheroff
Racz Nemethne
Moran Pirkes
Alessandro Pontiroli
Marco Villa
Judith Aronhime
Original Assignee
Sicor Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sicor Inc filed Critical Sicor Inc
Application granted granted Critical
Publication of ATE490257T1 publication Critical patent/ATE490257T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Transition And Organic Metals Composition Catalysts For Addition Polymerization (AREA)
  • Control And Other Processes For Unpacking Of Materials (AREA)
  • Crystals, And After-Treatments Of Crystals (AREA)
AT07836867T 2006-08-14 2007-08-14 Kristalline formen von pemetrexed-disäure und herstellungsverfahren dafür ATE490257T1 (de)

Applications Claiming Priority (16)

Application Number Priority Date Filing Date Title
US83730306P 2006-08-14 2006-08-14
US83763706P 2006-08-15 2006-08-15
US83955106P 2006-08-22 2006-08-22
US84503106P 2006-09-14 2006-09-14
US84729106P 2006-09-25 2006-09-25
US85513906P 2006-10-30 2006-10-30
US86055406P 2006-11-21 2006-11-21
US86055706P 2006-11-21 2006-11-21
US88017807P 2007-01-11 2007-01-11
US88017907P 2007-01-11 2007-01-11
US89992807P 2007-02-06 2007-02-06
US93655307P 2007-06-20 2007-06-20
US95832607P 2007-07-02 2007-07-02
US95821307P 2007-07-03 2007-07-03
US95841307P 2007-07-05 2007-07-05
PCT/US2007/018085 WO2008021405A1 (en) 2006-08-14 2007-08-14 Crystalline forms of pemetrexed diacid and processes for the preparation thereof

Publications (1)

Publication Number Publication Date
ATE490257T1 true ATE490257T1 (de) 2010-12-15

Family

ID=49584972

Family Applications (1)

Application Number Title Priority Date Filing Date
AT07836867T ATE490257T1 (de) 2006-08-14 2007-08-14 Kristalline formen von pemetrexed-disäure und herstellungsverfahren dafür

Country Status (9)

Country Link
US (2) US8088919B2 (de)
EP (6) EP2322526A1 (de)
JP (1) JP2008543974A (de)
KR (2) KR101045616B1 (de)
AT (1) ATE490257T1 (de)
DE (1) DE602007010894D1 (de)
ES (1) ES2354843T3 (de)
TW (1) TWI377063B (de)
WO (1) WO2008021405A1 (de)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2322526A1 (de) * 2006-08-14 2011-05-18 Sicor, Inc. Kristalline Form von Pemetrexed-Disäure und Verfahren zu deren Herstellung
JP2010523589A (ja) * 2007-04-03 2010-07-15 ドクター レディズ ラボラトリーズ リミテッド ペメトレキセドの固体形
CN101417998B (zh) * 2007-10-24 2012-10-24 重庆医药工业研究院有限责任公司 一种培美曲塞盐的纯化方法
EP2072518A1 (de) * 2007-12-23 2009-06-24 Sun Pharma Advanced Research Company Limited Stabile amorphe Form aus Pemextred Disodium
EP2334685A4 (de) * 2008-09-08 2011-10-26 Reddys Lab Ltd Dr Amorphes pemetrexed-dinatrium
WO2010030598A2 (en) * 2008-09-11 2010-03-18 Dr. Reddy's Laboratories Limited Pharmaceutical formulations comprising pemetrexed
CN101684121B (zh) * 2008-09-22 2013-04-03 重庆医药工业研究院有限责任公司 培美曲塞二酸的新晶型及其制备方法
IT1401677B1 (it) * 2010-07-22 2013-08-02 Chemi Spa Nuovo processo per la sintesi di pemetrexed sale disodico
KR101308767B1 (ko) 2011-01-20 2013-12-31 에스티팜 주식회사 고 순도 페메트렉세드 디에틸 에스테르의 제조방법 및 이 방법을 포함하는 페메트렉세드 이나트륨염의 제조방법
KR101069128B1 (ko) * 2011-03-10 2011-09-30 건일제약 주식회사 페메트렉시드 또는 그의 염을 포함하는 항산화제-비함유 주사용 용액 형태의 약학적 제제의 제조방법
TR201113223A2 (tr) * 2011-12-29 2012-06-21 Koçak Farma İlaç Ve Ki̇mya Sanayi̇ A. Ş. Pemetrekset disodyum hazırlanmasına yönelik tek basamaklı işlem.
CN103030640B (zh) * 2012-06-11 2015-04-22 江苏豪森医药集团连云港宏创医药有限公司 一种培美曲塞或其盐的制备方法
CN102977107B (zh) * 2012-12-25 2015-04-22 山西普德药业股份有限公司 一种培美曲塞二钠化合物及其组合物
WO2014185797A1 (en) 2013-05-17 2014-11-20 Instytut Farmaceutyczny Process for the preparation of high purity amorphous pemetrexed disodium and crystalline forms of n-[4-[2-(2-amino-4,7-dihydro-4-oxo-3h-pyrrolo[2,3- d] pyrimidin-5-yl)ethyl] benzoyl]-l-glutamic acid
CN103254196B (zh) * 2013-05-28 2015-02-18 苏州明锐医药科技有限公司 培美曲塞二酸的制备方法
EP3008064B1 (de) 2013-06-14 2017-11-22 Synthon B.V. Stabile argininsalze von pemetrexed und zusammensetzungen davon
JP2016527227A (ja) * 2013-07-16 2016-09-08 ドクター レディズ ラボラトリーズ リミテッド ペメトレキセドトロメタミン塩の新規な結晶形
NZ630299A (en) 2014-06-30 2014-11-28 Shilpa Medicare Ltd Pemetrexed dipotassium formulations
CA2962383C (en) 2014-10-30 2019-10-08 Scinopharm Taiwan, Ltd. Crystalline forms of pemetrexed diacid and manufacturing processes therefor
CN105566328B (zh) * 2014-11-06 2018-04-24 博瑞生物医药（苏州）股份有限公司 培美曲塞二酸多晶型的制备方法
KR102484846B1 (ko) * 2015-11-27 2023-01-05 한림제약(주) 벤조피란 유도체의 정제방법, 이의 결정형 및 상기 결정형의 제조방법
CN107641124A (zh) * 2016-07-22 2018-01-30 上海创诺制药有限公司 一种培美曲塞二酸新晶型及其制备方法
CN114262332A (zh) * 2020-09-16 2022-04-01 齐鲁制药有限公司 培美曲塞二酸新晶型及其制备方法

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL96531A (en) 1989-12-11 1995-08-31 Univ Princeton History of Acid N- (Diomeric-H1-Pyrolo] D-2,3 [Pyrimidine-3-Ilacyl (-glutamic, preparation and pharmaceutical preparations containing them)
US5248775A (en) * 1989-12-11 1993-09-28 The Trustees Of Princeton University Pyrrolo(2,3-d)pyrimidines
KR0162654B1 (ko) * 1989-12-11 1998-11-16 알렌 제이. 시니스갤리 N-(피롤로[2,3-d]피리미딘-3-일아크릴)-글루타민산 유도체
CA2032695A1 (en) 1989-12-20 1991-06-21 Hiroshi Akimoto Condensed heterocyclic compounds, their production and use
US5416211A (en) * 1992-09-25 1995-05-16 Eli Lilly And Company Process for preparing 5-substituted pyrrolo-[2,3-d]pyrimidines
US6262262B1 (en) * 1997-09-26 2001-07-17 Eli Lilly And Company Processes and intermediates useful to make antifolates
CA2304656A1 (en) * 1997-09-26 1999-04-08 Eli Lilly And Company Processes and intermediates useful to make antifolates
AU6890800A (en) * 1999-08-23 2001-03-19 Eli Lilly And Company A novel crystalline form of disodium n-[4-[2-(2-amino-4,7-dihydro-4-oxo-3h-pyrrolo[2,3-D]- pyrimidin-5-yl)ethyl]benzoyl]-l-glutamic acid salt and processes therefor
CZ303772B6 (cs) * 2000-02-25 2013-05-02 Eli Lilly And Company Heptahydrátová krystalická forma disodné soli N-[4-[2-(2-amino-4,7-dihydro-4-oxo-3H-pyrrolo[2,3-d]pyrimidin-5-yl)ethyl]-benzoyl]L-glutamové kyseliny a zpusob její prípravy
EP2322526A1 (de) * 2006-08-14 2011-05-18 Sicor, Inc. Kristalline Form von Pemetrexed-Disäure und Verfahren zu deren Herstellung
JP2010523589A (ja) 2007-04-03 2010-07-15 ドクター レディズ ラボラトリーズ リミテッド ペメトレキセドの固体形
CN101684121B (zh) 2008-09-22 2013-04-03 重庆医药工业研究院有限责任公司 培美曲塞二酸的新晶型及其制备方法

Also Published As

Publication number Publication date
EP2322526A1 (de) 2011-05-18
US9156841B2 (en) 2015-10-13
KR20110028520A (ko) 2011-03-18
EP2270012A1 (de) 2011-01-05
US8088919B2 (en) 2012-01-03
TW200831103A (en) 2008-08-01
US20080045711A1 (en) 2008-02-21
US20110196155A1 (en) 2011-08-11
EP2305681A1 (de) 2011-04-06
EP1945645A1 (de) 2008-07-23
KR101045616B1 (ko) 2011-07-01
JP2008543974A (ja) 2008-12-04
KR101359838B1 (ko) 2014-02-07
EP1945645B1 (de) 2010-12-01
ES2354843T3 (es) 2011-03-18
KR20080050594A (ko) 2008-06-09
TWI377063B (en) 2012-11-21
DE602007010894D1 (de) 2011-01-13
EP2270013A1 (de) 2011-01-05
EP2311838A1 (de) 2011-04-20
WO2008021405A1 (en) 2008-02-21

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