ATE487489T1 - Rekombinante intrazellulärepathogen-immunogene zusammensetzungen und anwendungsverfahren - Google Patents
Rekombinante intrazellulärepathogen-immunogene zusammensetzungen und anwendungsverfahrenInfo
- Publication number
- ATE487489T1 ATE487489T1 AT03755009T AT03755009T ATE487489T1 AT E487489 T1 ATE487489 T1 AT E487489T1 AT 03755009 T AT03755009 T AT 03755009T AT 03755009 T AT03755009 T AT 03755009T AT E487489 T1 ATE487489 T1 AT E487489T1
- Authority
- AT
- Austria
- Prior art keywords
- immunogenic compositions
- recombinant
- methods
- intracellular pathogen
- recombinant intracellular
- Prior art date
Links
- 230000003834 intracellular effect Effects 0.000 title abstract 5
- 244000052769 pathogen Species 0.000 title abstract 5
- 230000002163 immunogen Effects 0.000 title abstract 4
- 239000000203 mixture Substances 0.000 title abstract 3
- 230000001717 pathogenic effect Effects 0.000 title abstract 2
- 230000002238 attenuated effect Effects 0.000 abstract 3
- 239000000427 antigen Substances 0.000 abstract 1
- 102000036639 antigens Human genes 0.000 abstract 1
- 108091007433 antigens Proteins 0.000 abstract 1
- 102000037865 fusion proteins Human genes 0.000 abstract 1
- 108020001507 fusion proteins Proteins 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/02—Bacterial antigens
- A61K39/04—Mycobacterium, e.g. Mycobacterium tuberculosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/02—Bacterial antigens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
- A61P31/06—Antibacterial agents for tuberculosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
- C07K14/35—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Mycobacteriaceae (F)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
- A61K2039/52—Bacterial cells; Fungal cells; Protozoal cells
- A61K2039/522—Bacterial cells; Fungal cells; Protozoal cells avirulent or attenuated
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
- A61K2039/52—Bacterial cells; Fungal cells; Protozoal cells
- A61K2039/523—Bacterial cells; Fungal cells; Protozoal cells expressing foreign proteins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Genetics & Genomics (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- Pharmacology & Pharmacy (AREA)
- Microbiology (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- Mycology (AREA)
- Biophysics (AREA)
- Zoology (AREA)
- Molecular Biology (AREA)
- Wood Science & Technology (AREA)
- Biochemistry (AREA)
- Epidemiology (AREA)
- Biotechnology (AREA)
- Biomedical Technology (AREA)
- Pulmonology (AREA)
- Communicable Diseases (AREA)
- Plant Pathology (AREA)
- Physics & Mathematics (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Gastroenterology & Hepatology (AREA)
- Oncology (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Peptides Or Proteins (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US10/261,981 US20030124135A1 (en) | 2000-04-17 | 2002-09-30 | Recombinant intracellular pathogen vaccines and methods for use |
| US10/439,611 US6924118B2 (en) | 2000-04-17 | 2003-05-15 | Recombinant intracellular pathogen immunogenic compositions and methods for use |
| PCT/US2003/030994 WO2004031356A2 (en) | 2002-09-30 | 2003-09-30 | Recombinant intracellular pathogen immunogenic compositions and methods for use |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE487489T1 true ATE487489T1 (de) | 2010-11-15 |
Family
ID=32072849
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT03755009T ATE487489T1 (de) | 2002-09-30 | 2003-09-30 | Rekombinante intrazellulärepathogen-immunogene zusammensetzungen und anwendungsverfahren |
Country Status (13)
| Country | Link |
|---|---|
| US (1) | US6924118B2 (https=) |
| EP (1) | EP1556081B1 (https=) |
| JP (1) | JP2006501304A (https=) |
| KR (1) | KR101066951B1 (https=) |
| CN (1) | CN1703238B (https=) |
| AT (1) | ATE487489T1 (https=) |
| AU (1) | AU2003272808B2 (https=) |
| BR (1) | BR0314937A (https=) |
| CA (1) | CA2500433A1 (https=) |
| MX (1) | MXPA05003407A (https=) |
| RU (1) | RU2337707C2 (https=) |
| WO (1) | WO2004031356A2 (https=) |
| ZA (1) | ZA200502596B (https=) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6924118B2 (en) | 2000-04-17 | 2005-08-02 | The Regents Of The University Of California | Recombinant intracellular pathogen immunogenic compositions and methods for use |
| WO2007121194A1 (en) * | 2006-04-10 | 2007-10-25 | The Regents Of The University Of California | Immunostimulatory recombinant intracellular pathogen immunogenic compositions and methods of use |
| US8383132B2 (en) * | 2003-10-16 | 2013-02-26 | The Regents Of The University Of California | Immunostimulatory recombinant intracellular pathogen immunogenic compositions and methods of use |
| US8163294B2 (en) * | 2003-10-16 | 2012-04-24 | The Regents Of The University Of California | Growth regulatable recombinant BCG compositions |
| US7622107B2 (en) | 2003-10-16 | 2009-11-24 | The Regents Of The University Of California | Recombinant intracellular pathogen immunogenic compositions and methods for use |
| CN101198358B (zh) * | 2004-12-01 | 2013-06-26 | Aeras全球Tb疫苗基金会 | 具有增强的逃出内体能力的重组bcg菌株 |
| CN107092614B (zh) | 2010-08-09 | 2021-04-20 | Sk 普兰尼特有限公司 | 集成图像搜索终端、设备及其服务方法 |
| RU2517218C1 (ru) * | 2012-10-25 | 2014-05-27 | Федеральное государственное бюджетное образовательное учреждение высшего профессионального образования Курская государственная сельскохозяйственная академия имени профессора И.И. Иванова Министерства сельского хозяйства Российской Федерации | Способ моделирования гиперчувствительности замедленного типа у морских свинок на микобактерии m.bovis |
| CN113999865B (zh) * | 2021-10-09 | 2023-06-16 | 安徽理工大学 | 结核分枝杆菌融合蛋白ar2及其构建与表达纯化方法和应用 |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5591632A (en) | 1987-03-02 | 1997-01-07 | Beth Israel Hospital | Recombinant BCG |
| ATE132195T1 (de) | 1987-03-02 | 1996-01-15 | Whitehead Biomedical Inst | Rekombinant-mykobakterielle impfstoffe |
| US5807723A (en) | 1987-03-02 | 1998-09-15 | Whitehead Institute For Biomedical Research | Homologously recombinant slow growing mycobacteria and uses therefor |
| US5504005A (en) | 1987-03-02 | 1996-04-02 | Albert Einstein College Of Medicine Of Yeshiva University | Recombinant mycobacterial vaccine |
| JP2903414B2 (ja) | 1989-05-31 | 1999-06-07 | 味の素株式会社 | 抗酸菌分泌発現ベクター及び抗酸菌 |
| WO1993007897A1 (en) | 1991-10-21 | 1993-04-29 | Medimmune, Inc. | Bacterial expression vectors containing dna encoding secretion signals of lipoproteins |
| US5736367A (en) | 1992-03-31 | 1998-04-07 | Medimmune, Inc. | Vectors and prokaryotes which autocatalytically delete antibiotic resistance |
| US5679515A (en) | 1994-10-03 | 1997-10-21 | Pathogenesis Corporation | Mycobacterial reporter strains and uses thereof |
| US5700683A (en) | 1995-02-17 | 1997-12-23 | Pathogenesis Corporation | Virulence-attenuating genetic deletions deleted from mycobacterium BCG |
| US5869057A (en) | 1995-06-07 | 1999-02-09 | Rock; Edwin P. | Recombinant vaccines to break self-tolerance |
| RU2112543C1 (ru) * | 1996-09-26 | 1998-06-10 | Александр Григорьевич Хоменко | Иммуномодулирующее лекарственное средство |
| US6924118B2 (en) | 2000-04-17 | 2005-08-02 | The Regents Of The University Of California | Recombinant intracellular pathogen immunogenic compositions and methods for use |
| US6471967B1 (en) * | 2000-04-17 | 2002-10-29 | The Regents Of The University Of California | Recombinant intracellular pathogen vaccines and methods for use |
-
2003
- 2003-05-15 US US10/439,611 patent/US6924118B2/en not_active Expired - Lifetime
- 2003-09-30 EP EP03755009A patent/EP1556081B1/en not_active Expired - Lifetime
- 2003-09-30 KR KR1020057005499A patent/KR101066951B1/ko not_active Expired - Lifetime
- 2003-09-30 RU RU2005113266/13A patent/RU2337707C2/ru active
- 2003-09-30 BR BR0314937-4A patent/BR0314937A/pt not_active Application Discontinuation
- 2003-09-30 AT AT03755009T patent/ATE487489T1/de not_active IP Right Cessation
- 2003-09-30 CN CN038254441A patent/CN1703238B/zh not_active Expired - Lifetime
- 2003-09-30 CA CA002500433A patent/CA2500433A1/en not_active Abandoned
- 2003-09-30 MX MXPA05003407A patent/MXPA05003407A/es active IP Right Grant
- 2003-09-30 WO PCT/US2003/030994 patent/WO2004031356A2/en not_active Ceased
- 2003-09-30 JP JP2004541966A patent/JP2006501304A/ja active Pending
- 2003-09-30 AU AU2003272808A patent/AU2003272808B2/en not_active Ceased
-
2005
- 2005-03-31 ZA ZA2005/02596A patent/ZA200502596B/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| US6924118B2 (en) | 2005-08-02 |
| CA2500433A1 (en) | 2004-04-15 |
| EP1556081A2 (en) | 2005-07-27 |
| BR0314937A (pt) | 2005-08-02 |
| US20040009184A1 (en) | 2004-01-15 |
| WO2004031356A3 (en) | 2004-08-26 |
| AU2003272808B2 (en) | 2010-01-21 |
| JP2006501304A (ja) | 2006-01-12 |
| CN1703238B (zh) | 2012-05-30 |
| KR101066951B1 (ko) | 2011-09-23 |
| AU2003272808A1 (en) | 2004-04-23 |
| ZA200502596B (en) | 2005-12-28 |
| RU2005113266A (ru) | 2006-01-20 |
| RU2337707C2 (ru) | 2008-11-10 |
| KR20050075343A (ko) | 2005-07-20 |
| WO2004031356A2 (en) | 2004-04-15 |
| CN1703238A (zh) | 2005-11-30 |
| EP1556081A4 (en) | 2006-10-25 |
| EP1556081B1 (en) | 2010-11-10 |
| MXPA05003407A (es) | 2005-08-02 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |