ATE487129T1 - Eine auf zellen gegründete rezeptor-effektor- elektrode - Google Patents

Eine auf zellen gegründete rezeptor-effektor- elektrode

Info

Publication number
ATE487129T1
ATE487129T1 AT01936116T AT01936116T ATE487129T1 AT E487129 T1 ATE487129 T1 AT E487129T1 AT 01936116 T AT01936116 T AT 01936116T AT 01936116 T AT01936116 T AT 01936116T AT E487129 T1 ATE487129 T1 AT E487129T1
Authority
AT
Austria
Prior art keywords
cell
electrode
ion channel
based receptor
receptor system
Prior art date
Application number
AT01936116T
Other languages
English (en)
Inventor
Peter Fromherz
Elisabeth Meyer
Bernhard Straub
Original Assignee
Max Planck Gesellschaft
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Max Planck Gesellschaft filed Critical Max Planck Gesellschaft
Application granted granted Critical
Publication of ATE487129T1 publication Critical patent/ATE487129T1/de

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54366—Apparatus specially adapted for solid-phase testing
    • G01N33/54373—Apparatus specially adapted for solid-phase testing involving physiochemical end-point determination, e.g. wave-guides, FETS, gratings
    • G01N33/5438—Electrodes
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6872—Intracellular protein regulatory factors and their receptors, e.g. including ion channels

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Urology & Nephrology (AREA)
  • Biomedical Technology (AREA)
  • Hematology (AREA)
  • Chemical & Material Sciences (AREA)
  • Cell Biology (AREA)
  • Food Science & Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biotechnology (AREA)
  • Medicinal Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Secondary Cells (AREA)
  • Immobilizing And Processing Of Enzymes And Microorganisms (AREA)
AT01936116T 2000-03-22 2001-03-21 Eine auf zellen gegründete rezeptor-effektor- elektrode ATE487129T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US09/532,871 US6602399B1 (en) 2000-03-22 2000-03-22 Signal recording of a receptor-effector-system by an extracellular planar potential-sensitive electrode
PCT/EP2001/003209 WO2001070002A2 (en) 2000-03-22 2001-03-21 Signal recording of a receptor-effector-system by an extracellular planar potential-sensitive electrode

Publications (1)

Publication Number Publication Date
ATE487129T1 true ATE487129T1 (de) 2010-11-15

Family

ID=24123512

Family Applications (1)

Application Number Title Priority Date Filing Date
AT01936116T ATE487129T1 (de) 2000-03-22 2001-03-21 Eine auf zellen gegründete rezeptor-effektor- elektrode

Country Status (5)

Country Link
US (1) US6602399B1 (de)
EP (1) EP1305613B1 (de)
AT (1) ATE487129T1 (de)
DE (1) DE60143400D1 (de)
WO (1) WO2001070002A2 (de)

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DE10151020A1 (de) * 2001-10-16 2003-04-30 Infineon Technologies Ag Schaltkreis-Anordnung, Sensor-Array und Biosensor-Array
DE10209075A1 (de) 2002-03-01 2003-09-18 Infineon Technologies Ag CMOS-Prozeß-kompatible Hoch-DK Oberflächenbeschichtung zur kapazitiven Detektion und Stimulation biologischer Gewebe
US7427489B1 (en) * 2002-06-17 2008-09-23 The Scripps Research Institute Screening assay to identify modulators of the sleep/wake cycle
DE10243599A1 (de) * 2002-09-19 2004-04-01 MAX-PLANCK-Gesellschaft zur Förderung der Wissenschaften e.V. Messvorrichtung und -verfahren für ein Screening bei auf Elektroden immobilisierten Zellen
DE10254158A1 (de) * 2002-11-20 2004-06-09 Infineon Technologies Ag Sensorvorrichtung zur Detektion elektrischer Signale einer biologischen Zelle und Detektionsverfahren
US7015011B2 (en) * 2003-04-18 2006-03-21 Electronic Biosciences, Llc Circuit and method to non-invasively detect the electrical potential of a cell or neuron
DE10323096A1 (de) * 2003-05-16 2004-12-09 Siemens Ag Verfahren zur Untersuchung eines Wirkstoffeinflusses auf biologische Zellen
DE102004010635B4 (de) * 2004-03-02 2006-10-05 Micronas Gmbh Vorrichtung zur Durchführung von Messungen an Biokomponenten
KR100682918B1 (ko) * 2005-01-20 2007-02-15 삼성전자주식회사 표면 개질을 갖는 ｆｅｔ형 바이오 센서
US20060217771A1 (en) * 2005-02-07 2006-09-28 Medtronic, Inc. Potassium monitoring
AU2006335689A1 (en) * 2006-01-20 2007-07-26 Agency For Science, Technology And Research Biosensor
US20090032411A1 (en) * 2006-02-10 2009-02-05 Max-Planck-Gesellschaft Zur Foerderung Der Wissenschaften E.V. Method and system for detecting pharmacologically active substances by measuring membrane currents with extracellular sensors
US9399091B2 (en) 2009-09-30 2016-07-26 Medtronic, Inc. System and method to regulate ultrafiltration
US9456755B2 (en) 2011-04-29 2016-10-04 Medtronic, Inc. Method and device to monitor patients with kidney disease
US9848778B2 (en) 2011-04-29 2017-12-26 Medtronic, Inc. Method and device to monitor patients with kidney disease
US9061099B2 (en) 2011-04-29 2015-06-23 Medtronic, Inc. Cardiovascular monitoring for fluid removal processes
EP3165245B1 (de) 2011-08-02 2019-02-20 Medtronic, Inc. Hämodialysesystem mit einem durchflussweg mit gesteuertem nachgiebigem volumen
WO2013025844A2 (en) 2011-08-16 2013-02-21 Medtronic, Inc. Modular hemodialysis system
WO2013103906A1 (en) 2012-01-04 2013-07-11 Medtronic, Inc. Multi-staged filtration system for blood fluid removal
US10905816B2 (en) 2012-12-10 2021-02-02 Medtronic, Inc. Sodium management system for hemodialysis
US11565029B2 (en) 2013-01-09 2023-01-31 Medtronic, Inc. Sorbent cartridge with electrodes
US9713666B2 (en) 2013-01-09 2017-07-25 Medtronic, Inc. Recirculating dialysate fluid circuit for blood measurement
US11154648B2 (en) 2013-01-09 2021-10-26 Medtronic, Inc. Fluid circuits for sorbent cartridge with sensors
US9707328B2 (en) 2013-01-09 2017-07-18 Medtronic, Inc. Sorbent cartridge to measure solute concentrations
US9526822B2 (en) 2013-02-01 2016-12-27 Medtronic, Inc. Sodium and buffer source cartridges for use in a modular controlled compliant flow path
US10850016B2 (en) 2013-02-01 2020-12-01 Medtronic, Inc. Modular fluid therapy system having jumpered flow paths and systems and methods for cleaning and disinfection
US10543052B2 (en) 2013-02-01 2020-01-28 Medtronic, Inc. Portable dialysis cabinet
US9623164B2 (en) 2013-02-01 2017-04-18 Medtronic, Inc. Systems and methods for multifunctional volumetric fluid control
US10010663B2 (en) 2013-02-01 2018-07-03 Medtronic, Inc. Fluid circuit for delivery of renal replacement therapies
US9144640B2 (en) 2013-02-02 2015-09-29 Medtronic, Inc. Sorbent cartridge configurations for improved dialysate regeneration
US9827361B2 (en) 2013-02-02 2017-11-28 Medtronic, Inc. pH buffer measurement system for hemodialysis systems
WO2015066731A2 (en) 2013-11-04 2015-05-07 Medtronic, Inc. Method and device to manage fluid volumes in the body
US9884145B2 (en) 2013-11-26 2018-02-06 Medtronic, Inc. Parallel modules for in-line recharging of sorbents using alternate duty cycles
US10537875B2 (en) 2013-11-26 2020-01-21 Medtronic, Inc. Precision recharging of sorbent materials using patient and session data
US10617349B2 (en) 2013-11-27 2020-04-14 Medtronic, Inc. Precision dialysis monitoring and synchronization system
US10172991B2 (en) 2014-06-24 2019-01-08 Medtronic, Inc. Modular dialysate regeneration assembly
US10357757B2 (en) 2014-06-24 2019-07-23 Medtronic, Inc. Stacked sorbent assembly
US10874787B2 (en) 2014-12-10 2020-12-29 Medtronic, Inc. Degassing system for dialysis
US9895479B2 (en) 2014-12-10 2018-02-20 Medtronic, Inc. Water management system for use in dialysis
US9713665B2 (en) 2014-12-10 2017-07-25 Medtronic, Inc. Degassing system for dialysis
US10098993B2 (en) 2014-12-10 2018-10-16 Medtronic, Inc. Sensing and storage system for fluid balance
US10335534B2 (en) 2015-11-06 2019-07-02 Medtronic, Inc. Dialysis prescription optimization for decreased arrhythmias
US12329892B2 (en) 2016-04-04 2025-06-17 Mozarc Medical Us Llc Dextrose concentration sensor for a peritoneal dialysis system
US10994064B2 (en) 2016-08-10 2021-05-04 Medtronic, Inc. Peritoneal dialysate flow path sensing
US10874790B2 (en) 2016-08-10 2020-12-29 Medtronic, Inc. Peritoneal dialysis intracycle osmotic agent adjustment
EP3439711A1 (de) 2016-04-04 2019-02-13 Medtronic Inc. Erzeugungssystem für peritonealdialysatflüssigkeit
US11013843B2 (en) 2016-09-09 2021-05-25 Medtronic, Inc. Peritoneal dialysis fluid testing system
US10981148B2 (en) 2016-11-29 2021-04-20 Medtronic, Inc. Zirconium oxide module conditioning
US10960381B2 (en) 2017-06-15 2021-03-30 Medtronic, Inc. Zirconium phosphate disinfection recharging and conditioning
US11278654B2 (en) 2017-12-07 2022-03-22 Medtronic, Inc. Pneumatic manifold for a dialysis system
US11033667B2 (en) 2018-02-02 2021-06-15 Medtronic, Inc. Sorbent manifold for a dialysis system
US11110215B2 (en) 2018-02-23 2021-09-07 Medtronic, Inc. Degasser and vent manifolds for dialysis
US12285552B2 (en) 2018-08-14 2025-04-29 Mozarc Medical Us Llc Precision dialysis therapy based on sorbent effluent analysis
US11213616B2 (en) 2018-08-24 2022-01-04 Medtronic, Inc. Recharge solution for zirconium phosphate
US11806457B2 (en) 2018-11-16 2023-11-07 Mozarc Medical Us Llc Peritoneal dialysis adequacy meaurements
US11806456B2 (en) 2018-12-10 2023-11-07 Mozarc Medical Us Llc Precision peritoneal dialysis therapy based on dialysis adequacy measurements
US12433976B2 (en) 2019-01-08 2025-10-07 Mozarc Medical Us Llc Bicarbonate sensor for dialysis
US12128165B2 (en) 2020-04-27 2024-10-29 Mozarc Medical Us Llc Dual stage degasser
US12569601B2 (en) 2021-04-07 2026-03-10 Mozarc Medical Us Llc Increased operational capabilities of a dialysis system
US12397093B2 (en) 2021-05-18 2025-08-26 Mozarc Medical Us Llc Sorbent cartridge designs
CN115616058A (zh) * 2021-07-16 2023-01-17 德州奥格锐生生物科技有限公司 石墨烯传感器及制作方法、肝细胞分化实时原位检测方法
US12154673B2 (en) 2021-08-02 2024-11-26 Mozarc Medical Us Llc Artificial intelligence assisted home therapy settings for dialysis
US11850344B2 (en) 2021-08-11 2023-12-26 Mozarc Medical Us Llc Gas bubble sensor
US11965763B2 (en) 2021-11-12 2024-04-23 Mozarc Medical Us Llc Determining fluid flow across rotary pump
US11944733B2 (en) 2021-11-18 2024-04-02 Mozarc Medical Us Llc Sodium and bicarbonate control

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DE19512117A1 (de) * 1995-04-04 1996-10-10 Itt Ind Gmbh Deutsche Meßeinrichtung
EP0773292A1 (de) 1995-11-07 1997-05-14 Bayer Ag Unsterbliche embryonale Hippocampus-Zellen und deren Verwendung
US5981268A (en) * 1997-05-30 1999-11-09 Board Of Trustees, Leland Stanford, Jr. University Hybrid biosensors

Also Published As

Publication number Publication date
DE60143400D1 (de) 2010-12-16
EP1305613B1 (de) 2010-11-03
WO2001070002A3 (en) 2003-01-03
WO2001070002A2 (en) 2001-09-27
US6602399B1 (en) 2003-08-05
EP1305613A2 (de) 2003-05-02

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