WO2014149161A3 - Microfluidic systems for electrochemical transdermal glucose sensing using a paper-based or other wicking substrate - Google Patents

Microfluidic systems for electrochemical transdermal glucose sensing using a paper-based or other wicking substrate Download PDF

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Publication number
WO2014149161A3
WO2014149161A3 PCT/US2014/011296 US2014011296W WO2014149161A3 WO 2014149161 A3 WO2014149161 A3 WO 2014149161A3 US 2014011296 W US2014011296 W US 2014011296W WO 2014149161 A3 WO2014149161 A3 WO 2014149161A3
Authority
WO
WIPO (PCT)
Prior art keywords
paper
user
wicking substrate
microfluidic systems
glucose sensing
Prior art date
Application number
PCT/US2014/011296
Other languages
French (fr)
Other versions
WO2014149161A2 (en
Inventor
Paranjape MAKARAND
Original Assignee
Georgetown University
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Publication date
Application filed by Georgetown University filed Critical Georgetown University
Publication of WO2014149161A2 publication Critical patent/WO2014149161A2/en
Publication of WO2014149161A3 publication Critical patent/WO2014149161A3/en

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue
    • A61B5/1468—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue using chemical or electrochemical methods, e.g. by polarographic means
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue
    • A61B5/14507—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue specially adapted for measuring characteristics of body fluids other than blood
    • A61B5/1451—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue specially adapted for measuring characteristics of body fluids other than blood for interstitial fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue
    • A61B5/14532—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue for measuring glucose, e.g. by tissue impedance measurement
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/68—Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient
    • A61B5/6887—Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient mounted on external non-worn devices, e.g. non-medical devices

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Biomedical Technology (AREA)
  • Medical Informatics (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Biophysics (AREA)
  • Pathology (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Optics & Photonics (AREA)
  • Molecular Biology (AREA)
  • Surgery (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Emergency Medicine (AREA)
  • Measurement Of The Respiration, Hearing Ability, Form, And Blood Characteristics Of Living Organisms (AREA)
  • Measuring And Recording Apparatus For Diagnosis (AREA)

Abstract

A sensing device comprising a paper-based or other wicking substrate contains detection sites for electrochemically monitoring an analyte in interstitial fluid of a user. Each site includes a heating element, for receiving a first predetermined voltage applied thereto, in order to thermally ablate a stratum corneum of a user's skin to access the interstitial fluid of the user, which is imbibed into a hydrophilic region at the detection site. In one embodiment, the heating element is a serpentine conductive pattern attached at first and second ends thereof to electrode material. In this embodiment, the first voltage preferably creates an open-circuit configuration, including first and second portions of the electrode material that are electrically isolated from each other. The sensing device further comprises a sensing area incorporated into one such electrode that is in contact with the hydrophilic region at the detection site.
PCT/US2014/011296 2013-03-15 2014-01-13 Microfluidic systems for electrochemical transdermal glucose sensing using a paper-based or other wicking substrate WO2014149161A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201313835696A 2013-03-15 2013-03-15
US13/835,696 2013-03-15

Publications (2)

Publication Number Publication Date
WO2014149161A2 WO2014149161A2 (en) 2014-09-25
WO2014149161A3 true WO2014149161A3 (en) 2015-04-23

Family

ID=51581591

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2014/011296 WO2014149161A2 (en) 2013-03-15 2014-01-13 Microfluidic systems for electrochemical transdermal glucose sensing using a paper-based or other wicking substrate

Country Status (1)

Country Link
WO (1) WO2014149161A2 (en)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US11219390B2 (en) 2015-08-03 2022-01-11 Georgetown University Apparatus and method for delivery of antimicrobial during a transdermal sampling and delivery process
EP3862750A4 (en) * 2018-09-29 2022-07-27 Boe Technology Group Co., Ltd. Electrochemical sensor and detection device for body fluid detection
CN113376240A (en) * 2021-06-11 2021-09-10 南京师范大学 Fabric-based microfluidic chip for detecting Pb based on CeMOF labeled DNA aptamer2+Method (2)

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20030225362A1 (en) * 2000-06-01 2003-12-04 Currie John F. Systems and methods for monitoring health and delivering drugs transdermally
US20070027383A1 (en) * 2004-07-01 2007-02-01 Peyser Thomas A Patches, systems, and methods for non-invasive glucose measurement
WO2009025698A1 (en) * 2007-08-17 2009-02-26 Vivomedical, Inc. Devices, systems, and methods for the measurement of analytes

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20030225362A1 (en) * 2000-06-01 2003-12-04 Currie John F. Systems and methods for monitoring health and delivering drugs transdermally
US20070027383A1 (en) * 2004-07-01 2007-02-01 Peyser Thomas A Patches, systems, and methods for non-invasive glucose measurement
WO2009025698A1 (en) * 2007-08-17 2009-02-26 Vivomedical, Inc. Devices, systems, and methods for the measurement of analytes

Also Published As

Publication number Publication date
WO2014149161A2 (en) 2014-09-25

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