WO2014149161A3 - Microfluidic systems for electrochemical transdermal glucose sensing using a paper-based or other wicking substrate - Google Patents

Microfluidic systems for electrochemical transdermal glucose sensing using a paper-based or other wicking substrate Download PDF

Info

Publication number
WO2014149161A3
WO2014149161A3 PCT/US2014/011296 US2014011296W WO2014149161A3 WO 2014149161 A3 WO2014149161 A3 WO 2014149161A3 US 2014011296 W US2014011296 W US 2014011296W WO 2014149161 A3 WO2014149161 A3 WO 2014149161A3
Authority
WO
WIPO (PCT)
Prior art keywords
paper
user
wicking substrate
microfluidic systems
glucose sensing
Prior art date
Application number
PCT/US2014/011296
Other languages
French (fr)
Other versions
WO2014149161A2 (en
Inventor
Paranjape MAKARAND
Original Assignee
Georgetown University
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Georgetown University filed Critical Georgetown University
Publication of WO2014149161A2 publication Critical patent/WO2014149161A2/en
Publication of WO2014149161A3 publication Critical patent/WO2014149161A3/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue
    • A61B5/1468—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue using chemical or electrochemical methods, e.g. by polarographic means
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue
    • A61B5/14507—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue specially adapted for measuring characteristics of body fluids other than blood
    • A61B5/1451—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue specially adapted for measuring characteristics of body fluids other than blood for interstitial fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue
    • A61B5/14532—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue for measuring glucose, e.g. by tissue impedance measurement
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/68—Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient
    • A61B5/6887—Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient mounted on external non-worn devices, e.g. non-medical devices

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Biomedical Technology (AREA)
  • Medical Informatics (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Biophysics (AREA)
  • Pathology (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Optics & Photonics (AREA)
  • Molecular Biology (AREA)
  • Surgery (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Emergency Medicine (AREA)
  • Measurement Of The Respiration, Hearing Ability, Form, And Blood Characteristics Of Living Organisms (AREA)
  • Measuring And Recording Apparatus For Diagnosis (AREA)

Abstract

A sensing device comprising a paper-based or other wicking substrate contains detection sites for electrochemically monitoring an analyte in interstitial fluid of a user. Each site includes a heating element, for receiving a first predetermined voltage applied thereto, in order to thermally ablate a stratum corneum of a user's skin to access the interstitial fluid of the user, which is imbibed into a hydrophilic region at the detection site. In one embodiment, the heating element is a serpentine conductive pattern attached at first and second ends thereof to electrode material. In this embodiment, the first voltage preferably creates an open-circuit configuration, including first and second portions of the electrode material that are electrically isolated from each other. The sensing device further comprises a sensing area incorporated into one such electrode that is in contact with the hydrophilic region at the detection site.
PCT/US2014/011296 2013-03-15 2014-01-13 Microfluidic systems for electrochemical transdermal glucose sensing using a paper-based or other wicking substrate WO2014149161A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201313835696A 2013-03-15 2013-03-15
US13/835,696 2013-03-15

Publications (2)

Publication Number Publication Date
WO2014149161A2 WO2014149161A2 (en) 2014-09-25
WO2014149161A3 true WO2014149161A3 (en) 2015-04-23

Family

ID=51581591

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2014/011296 WO2014149161A2 (en) 2013-03-15 2014-01-13 Microfluidic systems for electrochemical transdermal glucose sensing using a paper-based or other wicking substrate

Country Status (1)

Country Link
WO (1) WO2014149161A2 (en)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US11219390B2 (en) 2015-08-03 2022-01-11 Georgetown University Apparatus and method for delivery of antimicrobial during a transdermal sampling and delivery process
WO2020062143A1 (en) * 2018-09-29 2020-04-02 京东方科技集团股份有限公司 Electrochemical sensor and detection device for body fluid detection
CN113376240A (en) * 2021-06-11 2021-09-10 南京师范大学 Fabric-based microfluidic chip for detecting Pb based on CeMOF labeled DNA aptamer2+Method (2)

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20030225362A1 (en) * 2000-06-01 2003-12-04 Currie John F. Systems and methods for monitoring health and delivering drugs transdermally
US20070027383A1 (en) * 2004-07-01 2007-02-01 Peyser Thomas A Patches, systems, and methods for non-invasive glucose measurement
WO2009025698A1 (en) * 2007-08-17 2009-02-26 Vivomedical, Inc. Devices, systems, and methods for the measurement of analytes

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20030225362A1 (en) * 2000-06-01 2003-12-04 Currie John F. Systems and methods for monitoring health and delivering drugs transdermally
US20070027383A1 (en) * 2004-07-01 2007-02-01 Peyser Thomas A Patches, systems, and methods for non-invasive glucose measurement
WO2009025698A1 (en) * 2007-08-17 2009-02-26 Vivomedical, Inc. Devices, systems, and methods for the measurement of analytes

Also Published As

Publication number Publication date
WO2014149161A2 (en) 2014-09-25

Similar Documents

Publication Publication Date Title
Parrilla et al. Wearable potentiometric ion patch for on-body electrolyte monitoring in sweat: toward a validation strategy to ensure physiological relevance
Choi et al. Soft, skin-integrated multifunctional microfluidic systems for accurate colorimetric analysis of sweat biomarkers and temperature
EP4048152B1 (en) Continuous analyte monitoring system with microneedle array
Lipani et al. Non-invasive, transdermal, path-selective and specific glucose monitoring via a graphene-based platform
CN107249471B (en) Device integrating indirect sweat stimulation and sensing
Sonner et al. Integrated sudomotor axon reflex sweat stimulation for continuous sweat analyte analysis with individuals at rest
US10932761B2 (en) Advanced sweat sensor adhesion, sealing, and fluidic strategies
JP2016067936A5 (en)
US20200061379A1 (en) Devices, systems, and methods for remotely monitoring and treating wounds or wound infections
US9877673B2 (en) Transdermal sampling and analysis device
US20160058342A1 (en) Apparatus and methods for transdermal and cell interstitial body fluid examination, sensing of analytes, biomarkers and drug concentrations and associated data transmission systems
US10646142B2 (en) Smart sweat stimulation and sensing devices
EP3324835A1 (en) Reduced sample volume for sensing of analytes generated by reverse iontophoresis
JP2013543405A5 (en)
WO2014152717A3 (en) On-body microsensor for biomonitoring
MX2015007690A (en) Soil chemistry sensor.
WO2013177573A3 (en) Foldover sensors and methods for making and using them
Dam et al. Flexible chloride sensor for sweat analysis
WO2010014964A3 (en) Analyte sensor apparatuses comprising multiple implantable sensor elements and methods for making and using them
US20180235522A1 (en) Mechanically co-located sweat stimulation and sensing
EP3484360B1 (en) Device for assessing psychophysiological responsiveness
WO2014149161A3 (en) Microfluidic systems for electrochemical transdermal glucose sensing using a paper-based or other wicking substrate
MX2017000584A (en) Sensor array.
US20180289299A1 (en) Microfluidic Systems For Electrochemical Transdermal Analyte Sensing Using a Capillary-Located Electrode
KR20180097370A (en) Apparatus for measuring blood sugar level

Legal Events

Date Code Title Description
121 Ep: the epo has been informed by wipo that ep was designated in this application

Ref document number: 14767347

Country of ref document: EP

Kind code of ref document: A2

122 Ep: pct application non-entry in european phase

Ref document number: 14767347

Country of ref document: EP

Kind code of ref document: A2