ATE48603T1 - 5-(6-imidazo(1,2-a>pyridyl)pyridinderivat. - Google Patents

5-(6-imidazo(1,2-a>pyridyl)pyridinderivat.

Info

Publication number
ATE48603T1
ATE48603T1 AT86104064T AT86104064T ATE48603T1 AT E48603 T1 ATE48603 T1 AT E48603T1 AT 86104064 T AT86104064 T AT 86104064T AT 86104064 T AT86104064 T AT 86104064T AT E48603 T1 ATE48603 T1 AT E48603T1
Authority
AT
Austria
Prior art keywords
sup
group
hydrogen atom
represents hydrogen
lower alkyl
Prior art date
Application number
AT86104064T
Other languages
German (de)
English (en)
Inventor
Motosuke Yamanaka
Kazutoshi Miyake
Shinji Suda
Hideto Ohhara
Ogawa Toshiaki
Original Assignee
Eisai Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Eisai Co Ltd filed Critical Eisai Co Ltd
Application granted granted Critical
Publication of ATE48603T1 publication Critical patent/ATE48603T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Cardiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Vascular Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Hospice & Palliative Care (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
AT86104064T 1985-03-26 1986-03-25 5-(6-imidazo(1,2-a>pyridyl)pyridinderivat. ATE48603T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP60059450A JPS61218589A (ja) 1985-03-26 1985-03-26 ５―（６―イミダゾ〔１，２―ａ〕ピリジニル）ピリジン誘導体
EP86104064A EP0199127B1 (en) 1985-03-26 1986-03-25 5-(6-imidazo[1,2-a]pyridyl) pyridine derivative

Publications (1)

Publication Number Publication Date
ATE48603T1 true ATE48603T1 (de) 1989-12-15

Family

ID=13113637

Family Applications (1)

Application Number Title Priority Date Filing Date
AT86104064T ATE48603T1 (de) 1985-03-26 1986-03-25 5-(6-imidazo(1,2-a>pyridyl)pyridinderivat.

Country Status (23)

Country Link
US (4) US4751227A (forum.php)
EP (1) EP0199127B1 (forum.php)
JP (1) JPS61218589A (forum.php)
KR (1) KR930005005B1 (forum.php)
CN (1) CN1020608C (forum.php)
AT (1) ATE48603T1 (forum.php)
AU (1) AU589410B2 (forum.php)
CA (1) CA1309718C (forum.php)
DD (2) DD263057A5 (forum.php)
DE (1) DE3667466D1 (forum.php)
DK (1) DK164788C (forum.php)
ES (5) ES8706146A1 (forum.php)
FI (1) FI86722C (forum.php)
GR (1) GR860720B (forum.php)
HU (1) HU198045B (forum.php)
IE (1) IE59294B1 (forum.php)
IL (1) IL78248A (forum.php)
MX (1) MX163696B (forum.php)
NO (1) NO163490C (forum.php)
PH (1) PH22999A (forum.php)
PT (1) PT82270B (forum.php)
SU (1) SU1468420A3 (forum.php)
ZA (1) ZA862259B (forum.php)

Families Citing this family (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5002941A (en) * 1985-12-12 1991-03-26 Smithkline Beecham Corporation Pyrrolo(1,2-a)imidazole and imidazo(1,2-a)pyridine derivatives and their use as 5-lipoxygenase pathway inhibitors
WO1991000092A1 (en) * 1989-06-13 1991-01-10 Smithkline Beecham Corporation Inhibition of interleukin-1 and tumor necrosis factor production by monocytes and/or macrophages
GB9008818D0 (en) * 1990-04-19 1990-06-13 Ici Plc Amine derivatives
US5958926A (en) * 1996-11-01 1999-09-28 Nitromed, Inc. Nitrosated and nitrosylated phosphodiesterase inhibitor compounds, compositions and their uses
SE9903611D0 (sv) * 1999-10-06 1999-10-06 Astra Ab Novel compounds III
JP2005104838A (ja) * 2003-01-09 2005-04-21 Tanabe Seiyaku Co Ltd 縮合フラン化合物
US7772188B2 (en) 2003-01-28 2010-08-10 Ironwood Pharmaceuticals, Inc. Methods and compositions for the treatment of gastrointestinal disorders
DE102005019181A1 (de) * 2005-04-25 2006-10-26 Novartis Ag Peptid-Deformylase (PDF) Inhibitoren 1
ES2559319T3 (es) 2007-06-04 2016-02-11 Synergy Pharmaceuticals Inc. Agonistas de guanilato cliclasa útiles para el tratamiento de trastornos gastrointestinales, inflamación, cáncer y otros trastornos
US8969514B2 (en) 2007-06-04 2015-03-03 Synergy Pharmaceuticals, Inc. Agonists of guanylate cyclase useful for the treatment of hypercholesterolemia, atherosclerosis, coronary heart disease, gallstone, obesity and other cardiovascular diseases
JP2011522828A (ja) 2008-06-04 2011-08-04 シナジー ファーマシューティカルズ インコーポレイテッド 胃腸障害、炎症、癌、およびその他の障害の治療のために有用なグアニル酸シクラーゼのアゴニスト
EP3241839B1 (en) 2008-07-16 2019-09-04 Bausch Health Ireland Limited Agonists of guanylate cyclase useful for the treatment of gastrointestinal, inflammation, cancer and other disorders
TWI504600B (zh) * 2009-12-18 2015-10-21 Mitsubishi Tanabe Pharma Corp 新穎抗血小板藥
CN101830900B (zh) * 2010-05-27 2012-06-06 齐鲁制药(海南)有限公司 盐酸奥普力农晶型及其制备方法
US9616097B2 (en) 2010-09-15 2017-04-11 Synergy Pharmaceuticals, Inc. Formulations of guanylate cyclase C agonists and methods of use
CN107090016A (zh) 2011-03-01 2017-08-25 辛纳吉制药公司 制备鸟苷酸环化酶c激动剂的方法
CN102702197B (zh) * 2012-06-27 2014-12-03 武汉武药科技有限公司 盐酸奥普力农衍生物及其制备方法
CN102718747B (zh) * 2012-06-27 2014-06-11 武汉武药科技有限公司 盐酸奥普力农衍生物及其合成方法
JP6499591B2 (ja) 2013-02-25 2019-04-10 シナジー ファーマシューティカルズ インコーポレイテッド 結腸洗浄において用いるためのグアニル酸シクラーゼ受容体アゴニスト
JP2016514670A (ja) 2013-03-15 2016-05-23 シナジー ファーマシューティカルズ インコーポレイテッド 他の薬物と組み合わせたグアニル酸シクラーゼ受容体アゴニスト
WO2014151206A1 (en) 2013-03-15 2014-09-25 Synergy Pharmaceuticals Inc. Agonists of guanylate cyclase and their uses
WO2014197720A2 (en) 2013-06-05 2014-12-11 Synergy Pharmaceuticals, Inc. Ultra-pure agonists of guanylate cyclase c, method of making and using same
US20160184387A1 (en) 2013-08-09 2016-06-30 Dominique Charmot Compounds and methods for inhibiting phosphate transport
CN106349246B (zh) * 2016-08-29 2018-10-26 山东百诺医药股份有限公司 奥普力农及9-氮杂吲哚-5-硼酸的制备方法
CN108840866A (zh) * 2018-05-24 2018-11-20 河北宇辰医药科技有限公司 一种奥普力农类似物ⅰ的制备方法与用途
CN109575017A (zh) * 2018-11-01 2019-04-05 山东蒲济医药科技有限公司 一种盐酸奥普力农化合物的制备方法
CN114340631A (zh) 2019-05-21 2022-04-12 阿德利克斯股份有限公司 用于降低患者的血清磷酸盐的组合
CN111499631B (zh) * 2020-06-02 2021-07-30 济南康桥医药科技有限公司 一种盐酸奥普力农关键中间体1-咪唑并[1,2-a]吡啶-6-基-2-丙酮的制备方法

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4105767A (en) * 1977-03-28 1978-08-08 Merck & Co., Inc. Imidazo [1,2-a] pyridines substituted with a thienyl, thiazolyl, or thiadiazolyl group
ZA81219B (en) * 1980-01-23 1982-01-27 Schering Corp Imidazo (1,2-a) pyridines ,process for their preparation and pharmaceutical compositions containing them
DE3269604D1 (en) * 1981-06-26 1986-04-10 Schering Corp Novel imidazo(1,2-a)pyridines and pyrazines, processes for their preparation and pharmaceutical compositions containing them
DE3406329A1 (de) * 1984-02-22 1985-08-22 Merck Patent Gmbh, 6100 Darmstadt Pyridone

Also Published As

Publication number Publication date
FI861262A7 (fi) 1986-09-27
FI86722C (fi) 1992-10-12
AU5507286A (en) 1986-10-02
US4791202A (en) 1988-12-13
PT82270B (pt) 1988-02-17
CA1309718C (en) 1992-11-03
DD283390A5 (de) 1990-10-10
MX163696B (es) 1992-06-15
CN86102812A (zh) 1986-11-26
NO861190L (no) 1986-09-29
DK137786A (da) 1986-09-27
DK164788C (da) 1992-12-28
ES557587A0 (es) 1988-02-16
ES8706146A1 (es) 1987-05-16
GR860720B (en) 1986-03-25
FI861262A0 (fi) 1986-03-25
JPS61218589A (ja) 1986-09-29
US4791203A (en) 1988-12-13
ES557235A0 (es) 1987-10-01
IE860775L (en) 1986-09-26
US4751227A (en) 1988-06-14
AU589410B2 (en) 1989-10-12
KR930005005B1 (ko) 1993-06-11
EP0199127B1 (en) 1989-12-13
ES8708231A1 (es) 1987-10-01
IL78248A (en) 1989-09-10
ES553370A0 (es) 1987-05-16
JPH0558437B2 (forum.php) 1993-08-26
HUT41026A (en) 1987-03-30
IL78248A0 (en) 1986-07-31
IE59294B1 (en) 1994-02-09
EP0199127A1 (en) 1986-10-29
ES557236A0 (es) 1987-10-01
DD263057A5 (de) 1988-12-21
DK137786D0 (da) 1986-03-25
PT82270A (en) 1986-04-01
KR860007257A (ko) 1986-10-10
FI86722B (fi) 1992-06-30
DE3667466D1 (de) 1990-01-18
ES8801655A1 (es) 1988-02-16
NO163490C (no) 1990-06-06
NO163490B (no) 1990-02-26
ES8801654A1 (es) 1988-02-16
CN1020608C (zh) 1993-05-12
SU1468420A3 (ru) 1989-03-23
HU198045B (en) 1989-07-28
US4803276A (en) 1989-02-07
PH22999A (en) 1989-02-24
DK164788B (da) 1992-08-17
ZA862259B (en) 1986-11-26
ES557588A0 (es) 1988-02-16
ES8708230A1 (es) 1987-10-01

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Legal Events

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UEP Publication of translation of european patent specification
REN Ceased due to non-payment of the annual fee