ATE485520T1 - Mittel und methoden für die diagnose, behandlung und vorbeugung von auf steroid hormone reagierende krebskrankheiten - Google Patents

Mittel und methoden für die diagnose, behandlung und vorbeugung von auf steroid hormone reagierende krebskrankheiten

Info

Publication number
ATE485520T1
ATE485520T1 AT01952116T AT01952116T ATE485520T1 AT E485520 T1 ATE485520 T1 AT E485520T1 AT 01952116 T AT01952116 T AT 01952116T AT 01952116 T AT01952116 T AT 01952116T AT E485520 T1 ATE485520 T1 AT E485520T1
Authority
AT
Austria
Prior art keywords
methods
steroid hormone
diagnosis
prevention
treatment
Prior art date
Application number
AT01952116T
Other languages
English (en)
Inventor
David A Sirbasku
Original Assignee
Signe Biopharma Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Signe Biopharma Inc filed Critical Signe Biopharma Inc
Application granted granted Critical
Publication of ATE485520T1 publication Critical patent/ATE485520T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0625—Epidermal cells, skin cells; Cells of the oral mucosa
    • C12N5/0629—Keratinocytes; Whole skin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
    • A61K31/138—Aryloxyalkylamines, e.g. propranolol, tamoxifen, phenoxybenzamine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/14—Blood; Artificial blood
    • A61K35/16—Blood plasma; Blood serum
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/0005—Vertebrate antigens
    • A61K39/0008—Antigens related to auto-immune diseases; Preparations to induce self-tolerance
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70567—Nuclear receptors, e.g. retinoic acid receptor [RAR], RXR, nuclear orphan receptors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/06—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies from serum
    • C07K16/065—Purification, fragmentation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/12—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/26—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against hormones ; against hormone releasing or inhibiting factors
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0625—Epidermal cells, skin cells; Cells of the oral mucosa
    • C12N5/0631—Mammary cells
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0693—Tumour cells; Cancer cells
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • G01N33/5011—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics for testing antineoplastic activity
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6854—Immunoglobulins
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/74—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving hormones or other non-cytokine intercellular protein regulatory factors such as growth factors, including receptors to hormones and growth factors
    • G01N33/743—Steroid hormones
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/96—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving blood or serum control standard
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/54—Medicinal preparations containing antigens or antibodies characterised by the route of administration
    • A61K2039/541—Mucosal route
    • A61K2039/542—Mucosal route oral/gastrointestinal
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/545—Medicinal preparations containing antigens or antibodies characterised by the dose, timing or administration schedule
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/52—Constant or Fc region; Isotype
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2500/00—Specific components of cell culture medium
    • C12N2500/05—Inorganic components
    • C12N2500/10—Metals; Metal chelators
    • C12N2500/12—Light metals, i.e. alkali, alkaline earth, Be, Al, Mg
    • C12N2500/14—Calcium; Ca chelators; Calcitonin
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2500/00—Specific components of cell culture medium
    • C12N2500/05—Inorganic components
    • C12N2500/10—Metals; Metal chelators
    • C12N2500/20—Transition metals
    • C12N2500/24—Iron; Fe chelators; Transferrin
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2500/00—Specific components of cell culture medium
    • C12N2500/05—Inorganic components
    • C12N2500/10—Metals; Metal chelators
    • C12N2500/20—Transition metals
    • C12N2500/24—Iron; Fe chelators; Transferrin
    • C12N2500/25—Insulin-transferrin; Insulin-transferrin-selenium
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2500/00—Specific components of cell culture medium
    • C12N2500/90—Serum-free medium, which may still contain naturally-sourced components
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/30—Hormones
    • C12N2501/38—Hormones with nuclear receptors
    • C12N2501/39—Steroid hormones
    • C12N2501/392—Sexual steroids
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/30—Hormones
    • C12N2501/38—Hormones with nuclear receptors
    • C12N2501/395—Thyroid hormones
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2503/00—Use of cells in diagnostics
    • C12N2503/02—Drug screening
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2510/00—Genetically modified cells
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2510/00—Genetically modified cells
    • C12N2510/02—Cells for production
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2510/00—Genetically modified cells
    • C12N2510/04—Immortalised cells
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/705—Assays involving receptors, cell surface antigens or cell surface determinants
    • G01N2333/71—Assays involving receptors, cell surface antigens or cell surface determinants for growth factors; for growth regulators
AT01952116T 2000-05-10 2001-05-10 Mittel und methoden für die diagnose, behandlung und vorbeugung von auf steroid hormone reagierende krebskrankheiten ATE485520T1 (de)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
US20331400P 2000-05-10 2000-05-10
US20834800P 2000-05-31 2000-05-31
US20811100P 2000-05-31 2000-05-31
US22907100P 2000-08-30 2000-08-30
US23127300P 2000-09-08 2000-09-08
PCT/US2001/015171 WO2001086307A2 (en) 2000-05-10 2001-05-10 Compositions and methods for the diagnosis, treatment and prevention of steroid hormone responsive cancers

Publications (1)

Publication Number Publication Date
ATE485520T1 true ATE485520T1 (de) 2010-11-15

Family

ID=27539481

Family Applications (2)

Application Number Title Priority Date Filing Date
AT01952116T ATE485520T1 (de) 2000-05-10 2001-05-10 Mittel und methoden für die diagnose, behandlung und vorbeugung von auf steroid hormone reagierende krebskrankheiten
AT01948216T ATE545433T1 (de) 2000-05-10 2001-05-10 Mittel und methoden zur demonstration der sekretorischen immunsystem-regulierung von auf steroid hormon reagierende krebszellen

Family Applications After (1)

Application Number Title Priority Date Filing Date
AT01948216T ATE545433T1 (de) 2000-05-10 2001-05-10 Mittel und methoden zur demonstration der sekretorischen immunsystem-regulierung von auf steroid hormon reagierende krebszellen

Country Status (8)

Country Link
US (4) US7947275B2 (de)
EP (5) EP2394660A1 (de)
AT (2) ATE485520T1 (de)
AU (2) AU2001269690A1 (de)
CA (2) CA2409765A1 (de)
DE (1) DE60143320D1 (de)
MX (2) MXPA02011093A (de)
WO (2) WO2001086307A2 (de)

Families Citing this family (41)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7863011B2 (en) * 2000-05-10 2011-01-04 Signe Biopharma, Inc. Screening method for predicting susceptibility to breast cancer
US20030072812A1 (en) * 2001-05-10 2003-04-17 Sirbasku David A Breast cancer eradication program
US8119138B2 (en) * 2000-05-10 2012-02-21 Signe Biopharma Inc. Anti-estrogen and immune modulator combinations for treating breast cancer
MXPA02011093A (es) 2000-05-10 2004-08-19 David A Sirbasku Composiciones y metodos para el diagnostico, tratamiento y prevencion de canceres que responden a la hormona esteroidea.
CA2451770A1 (en) * 2001-06-28 2003-01-09 Entelos, Inc. Method and apparatus for computer modeling of an adaptive immune response
AU2002343714A1 (en) 2001-11-13 2003-05-26 David A. Sirbasku Breast cancer eradication program
EP1515748A4 (de) * 2001-11-14 2006-04-12 David A Sirbasku Antiöstrogen und immunmodulator-kombinationen zur behandlung von brustkrebs
EP1490502B1 (de) * 2001-11-14 2013-01-09 Signe BioPharma Inc. Screening-verfahren zur vorhersage der anfälligkeit für brustkrebs
US7364846B2 (en) * 2002-10-11 2008-04-29 Molecular Devices Corporation Gene expression profiling from FFPE samples
EP2471924A1 (de) * 2004-05-28 2012-07-04 Asuragen, INC. Verfahren und Zusammensetzungen mit microRNA
EP2302055B1 (de) 2004-11-12 2014-08-27 Asuragen, Inc. Verfahren und Zusammensetzungen, die miRNAs und miRNAa-inhibitorischen Molekülen verbunden sind
WO2008073922A2 (en) * 2006-12-08 2008-06-19 Asuragen, Inc. Functions and targets of let-7 micro rnas
ATE552334T1 (de) * 2005-09-13 2012-04-15 Takara Bio Inc Serumfreies medium zur herstellung von retroviralen vektoren
AU2007299748A1 (en) * 2006-09-19 2008-03-27 Asuragen, Inc. miR-15, miR-26, miR -31,miR -145, miR-147, miR-188, miR-215, miR-216 miR-331, mmu-miR-292-3p regulated genes and pathways as targets for therapeutic intervention
EP2487240B1 (de) * 2006-09-19 2016-11-16 Interpace Diagnostics, LLC Mikro-RNA, die differentiell in Pankreaserkrankungen exprimiert sind, und ihre Verwendung
WO2008073915A2 (en) * 2006-12-08 2008-06-19 Asuragen, Inc. Micrornas differentially expressed in leukemia and uses thereof
EP2104735A2 (de) * 2006-12-08 2009-09-30 Asuragen, INC. Mir-21-regulierte gene und pfade als ziele für therapeutische interventionen
US8709413B2 (en) * 2006-12-13 2014-04-29 Michael R. Simon Treatment of celiac disease with IgA
CA2671270A1 (en) * 2006-12-29 2008-07-17 Asuragen, Inc. Mir-16 regulated genes and pathways as targets for therapeutic intervention
US20090131354A1 (en) * 2007-05-22 2009-05-21 Bader Andreas G miR-126 REGULATED GENES AND PATHWAYS AS TARGETS FOR THERAPEUTIC INTERVENTION
US20090232893A1 (en) * 2007-05-22 2009-09-17 Bader Andreas G miR-143 REGULATED GENES AND PATHWAYS AS TARGETS FOR THERAPEUTIC INTERVENTION
US8015145B2 (en) * 2007-06-05 2011-09-06 Siemens Medical Solutions Usa, Inc. System for providing healthcare operation specific user interface display images
WO2008154333A2 (en) * 2007-06-08 2008-12-18 Asuragen, Inc. Mir-34 regulated genes and pathways as targets for therapeutic intervention
EP2198050A1 (de) 2007-09-14 2010-06-23 Asuragen, INC. Mikrornas mit unterschiedlicher expression bei zervikalkarzinom und verwendungen davon
WO2009052386A1 (en) * 2007-10-18 2009-04-23 Asuragen, Inc. Micrornas differentially expressed in lung diseases and uses thereof
WO2009070805A2 (en) * 2007-12-01 2009-06-04 Asuragen, Inc. Mir-124 regulated genes and pathways as targets for therapeutic intervention
US20090192114A1 (en) * 2007-12-21 2009-07-30 Dmitriy Ovcharenko miR-10 Regulated Genes and Pathways as Targets for Therapeutic Intervention
US20090193338A1 (en) * 2008-01-28 2009-07-30 Trevor Fiatal Reducing network and battery consumption during content delivery and playback
EP2260110B1 (de) * 2008-02-08 2014-11-12 Asuragen, INC. In lymphknoten von krebspatienten differentiell exprimierte mirnas
EP2268832A2 (de) * 2008-03-06 2011-01-05 Asuragen, INC. Microrna-marker für das wiederauftreten eines kolorektalkarzinoms
WO2009154835A2 (en) * 2008-03-26 2009-12-23 Asuragen, Inc. Compositions and methods related to mir-16 and therapy of prostate cancer
US8258111B2 (en) 2008-05-08 2012-09-04 The Johns Hopkins University Compositions and methods related to miRNA modulation of neovascularization or angiogenesis
US20100179213A1 (en) * 2008-11-11 2010-07-15 Mirna Therapeutics, Inc. Methods and Compositions Involving miRNAs In Cancer Stem Cells
JP2012530133A (ja) * 2009-06-16 2012-11-29 ザ トラスティーズ オブ コロンビア ユニバーシティ イン ザ シティ オブ ニューヨーク 時間の経った赤血球の輸血に伴う副作用を改善するための方法
US8993347B2 (en) 2009-12-17 2015-03-31 Cornell University Methods for detecting antibodies in mucosal samples and device for sampling mucosal material
WO2013040251A2 (en) 2011-09-13 2013-03-21 Asurgen, Inc. Methods and compositions involving mir-135b for distinguishing pancreatic cancer from benign pancreatic disease
EP3049514B1 (de) * 2013-09-24 2019-11-20 University Of Miami Zellkulturmedien
DK3126383T3 (en) 2014-04-03 2019-04-01 Igm Biosciences Inc MODIFIED J-CHAIN
DK3265575T3 (da) 2015-03-04 2021-05-31 Igm Biosciences Inc Cd20-bindende molekyler og anvendelser deraf
DK3356401T3 (da) * 2015-09-30 2020-09-07 Igm Biosciences Inc Bindingsmolekyler med modificeret j-kæde
AU2016329197B2 (en) 2015-09-30 2021-01-21 Igm Biosciences, Inc. Binding molecules with modified J-chain

Family Cites Families (38)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4393071A (en) 1975-03-17 1983-07-12 Naoharu Fujii Method of treating gastric, mammary, lung and uterus tumors
FR2558373B1 (fr) 1984-01-20 1987-07-03 Mauvais Jarvis Pierre Medicament antioestrogene a base de 4-hydroxytamoxifene pour administration percutanee
US4683200A (en) 1984-05-17 1987-07-28 Setsuo Hirohashi Monoclonal antibody to human cancer antigen and method for producing same
GB8607137D0 (en) 1986-03-21 1986-04-30 Efamol Ltd Compositions
US5135849A (en) 1986-04-17 1992-08-04 Trustees Of Tufts College In-vitro methods for identifying compositions which are agonists and antagonists of androgens
US4859585A (en) * 1986-04-17 1989-08-22 Trustees Of Tufts College In-vitro methods for identifying compositions which are agonists and antagonists of estrogens
GB8628104D0 (en) 1986-11-25 1986-12-31 Connaught Lab Pasteurization of immunoglobin solutions
US5980896A (en) 1989-06-30 1999-11-09 Bristol-Myers Squibb Company Antibodies reactive with human carcinomas
DE3927112C1 (de) * 1989-08-17 1990-10-25 Biotest Pharma Gmbh, 6072 Dreieich, De
CN1057785A (zh) * 1990-04-16 1992-01-15 哈佛大学校长及研究员协会 合成多聚免疫球蛋白受体，受体-抗体复合物，生产及应用
RU1837891C (ru) 1991-01-31 1993-08-30 Keshelava Viktor V Способ получени противоопухолевого средства
WO1992013500A1 (en) 1991-02-08 1992-08-20 Surgical Innovations, Inc. Method and apparatus for repair of inguinal hernias
US6200547B1 (en) 1994-01-26 2001-03-13 Ferx Incorporated Magnetically responsive compositions for carrying biologically active substances and methods of production and use
US5405772A (en) * 1993-06-18 1995-04-11 Amgen Inc. Medium for long-term proliferation and development of cells
US5641863A (en) 1993-09-30 1997-06-24 University Of Pennsylvania Chimeric IgG Fc receptors
GB9320820D0 (en) * 1993-10-08 1993-12-01 Biokine Tech Ltd Compounds for medicinal use
JPH07238036A (ja) * 1994-02-28 1995-09-12 Green Cross Corp:The 静注用グロブリン液状組成物のグロブリン二量体増加抑制方法
US5772995A (en) 1994-07-18 1998-06-30 Sidney Kimmel Cancer Center Compositions and methods for enhanced tumor cell immunity in vivo
US5866323A (en) * 1995-04-07 1999-02-02 Case Western Reserve University Cancer diagnosis prognosis and therapy based on mutation of receptors for transforming growth factor β and homologous growth controlling factors
US6902743B1 (en) 1995-05-22 2005-06-07 The United States Of America As Represented By The Secretary Of The Army Therapeutic treatment and prevention of infections with a bioactive material(s) encapuslated within a biodegradable-bio-compatable polymeric matrix
CA2224115A1 (en) 1995-06-07 1996-12-19 Washington University Multidentate metal complexes and methods of making and using thereof
WO1997046715A1 (en) * 1996-06-03 1997-12-11 New York Society For The Ruptured And Crippled Maintaining The Hospital For Special Surgery Fc receptor polymorphism
EP0920490A2 (de) 1996-07-25 1999-06-09 Genzyme Corporation Chondrozyten-medien formeln und kulturverfahren
EP2221361A3 (de) * 1996-08-30 2011-02-09 Life Technologies Corporation Methode zur Herstellung eines Polypeptids in vitro in einer Säugerzelle in einem Kulturmedium ohne Serum und ohne Proteine
JP2001510690A (ja) * 1997-07-28 2001-08-07 エール ユニヴァーシティ ヒトエストロゲン受容体β
US6020161A (en) 1997-08-19 2000-02-01 Smithkline Beecham Corporation PIGR-1, a member of immunoglobulin gene superfamily
JP2002507387A (ja) 1997-12-24 2002-03-12 コリクサ コーポレイション 乳癌の免疫療法および診断のための化合物ならびにそれらの使用のための方法
WO2000005403A1 (en) * 1998-07-24 2000-02-03 Uab Research Foundation GENETIC POLYMORPHISM IN THE RECEPTOR FOR IgA
IL125608A0 (en) * 1998-07-30 1999-03-12 Yeda Res & Dev Tumor associated antigen peptides and use of same as anti-tumor vaccines
US6844189B1 (en) 1998-11-06 2005-01-18 Myriad Genetics, Inc. Chromosome 17P-linked prostate cancer susceptibility gene
JP2003532378A (ja) 1999-11-29 2003-11-05 ザ・トラスティーズ・オブ・コランビア・ユニバーシティー・イン・ザ・シティー・オブ・ニューヨーク リンパ腫／黒色腫の発症に関与する新規Ｆｃ受容体型黒色腫をコードする５つの新規遺伝子の単離
EP1261371A4 (de) 2000-02-25 2005-04-13 Univ California Auf den membranöstrogenrezeptor ausgerichtete therapie für brustkrebs
US6763307B2 (en) 2000-03-06 2004-07-13 Bioseek, Inc. Patient classification
EP1268555A2 (de) 2000-03-27 2003-01-02 The Regents of The University of California Gerichtete liganden gegen die nicht-sekrethorische komponente, und nicht-stengelregion von pigr und methoden zu deren verwendung
MXPA02011093A (es) 2000-05-10 2004-08-19 David A Sirbasku Composiciones y metodos para el diagnostico, tratamiento y prevencion de canceres que responden a la hormona esteroidea.
US8119138B2 (en) 2000-05-10 2012-02-21 Signe Biopharma Inc. Anti-estrogen and immune modulator combinations for treating breast cancer
AU2002343714A1 (en) 2001-11-13 2003-05-26 David A. Sirbasku Breast cancer eradication program
EP1490502B1 (de) 2001-11-14 2013-01-09 Signe BioPharma Inc. Screening-verfahren zur vorhersage der anfälligkeit für brustkrebs

Also Published As

Publication number Publication date
US20120028258A1 (en) 2012-02-02
DE60143320D1 (de) 2010-12-02
EP1366366A2 (de) 2003-12-03
ATE545433T1 (de) 2012-03-15
US20020012954A1 (en) 2002-01-31
EP2359857A2 (de) 2011-08-24
EP1328293A2 (de) 2003-07-23
CA2409150A1 (en) 2001-11-15
US7947463B2 (en) 2011-05-24
MXPA02011092A (es) 2004-08-19
EP1328293B1 (de) 2012-02-15
EP2394659B1 (de) 2014-01-22
MXPA02011093A (es) 2004-08-19
CA2409765A1 (en) 2001-11-15
WO2001086307A2 (en) 2001-11-15
EP1366366B1 (de) 2010-10-20
AU2001272908A1 (en) 2001-11-20
EP2394660A1 (de) 2011-12-14
WO2001085210A3 (en) 2003-04-17
US20120115161A1 (en) 2012-05-10
US8563249B2 (en) 2013-10-22
EP2359857A3 (de) 2012-02-22
AU2001269690A1 (en) 2001-11-20
WO2001086307A3 (en) 2003-10-02
US7947275B2 (en) 2011-05-24
US20020006630A1 (en) 2002-01-17
EP2394659A1 (de) 2011-12-14
WO2001085210A2 (en) 2001-11-15

Similar Documents

Publication Publication Date Title
ATE485520T1 (de) Mittel und methoden für die diagnose, behandlung und vorbeugung von auf steroid hormone reagierende krebskrankheiten
NZ330887A (en) Monoclonals and polyclonals antibodies for the diagnosis of breast cancer
HK1038498A1 (en) Cancer treatment methods using therapeutic conjugates that bind to aminophospholipids
ATE174796T1 (de) Neue verfahren zur progesteronabgabe
TR199903154T2 (xx) Meme kanserinin tedavisi ve te�hisi i�in bile�imler ve y�ntemler
Becker et al. Gamma-globulin in the trabecular meshwork of glaucomatous eyes
PL338449A1 (en) Ligands, including antibodies, exhibiting reactivity in respect to endocrine secretion cells
BR0311146A (pt) Uso de tibolona e de modulador de receptor de estrogênio seletivo, e, método e kit para o tratamento de um sintoma relacionado com a deficiência de estrogênio em um paciente do sexo feminino
Zanon et al. Palliative treatment of malignant refractory ascites by positioning of Denver peritoneovenous shunt
MXPA02000680A (es) Polipeptidos vgf y metodos para tratar desordenes relacionados con vgf.
WO2003023060A3 (de) Verfahren und kit zur diagnostik oder behandlungskontrolle von brustkrebs
Krco et al. Priapism due to solid malignancy
ATE348183T1 (de) Zusammensetzungen und verfahren zur intraductalen gentherapie
ATE373711T1 (de) Gewebe-spezifische protein 103p2d6, hochexprimiert in verschiedene krebsarten
HK1094768A1 (en) Use of 4-hydroxytamoxifen for the preparation of amedicament for the treatment of gynecomastia
Aktuğ et al. Outpatient catheterless Mathieu repair: how to cover ventral penile skin defect
RU2408399C1 (ru) Способ лечения доброкачественной гиперплазии предстательной железы
Chan et al. Duct ectasia in the male breast
Kim et al. Metastatic carcinoma of oral cavity
Yuan et al. Case Report A case of suprapubic cutaneous metastasis from prostatic adenocarcinoma
RU2243771C1 (ru) Способ лечения местно-распространённого рака тела матки
NO20064609L (no) Behandling og forhindring av godartet brystsykdom med 4-hydroksytamoksifen
Winblad et al. for Recurrent Malignant Melanoma of Ex-tremity: A Progress Report. Ann. Surg., 169: 969, 1969.
Shelat This case illustrates the fact that scar endometriosis is not uncom-mon, pain may not be cyclical and often disturbs the quality of life, and it could be confused with incisional hernia. Wide excision should be the treatment of choice.
Castallo Experimental studies on the immunizing properties of colostrum| Repetti, M.: Experimental studies on the immunizing properties of colostrum, Folia gynaec.-demograph. 31: 505, 1934

Legal Events

Date Code Title Description
RER Ceased as to paragraph 5 lit. 3 law introducing patent treaties