ATE478893T1 - Genetisch hergestellte zellen für therapeutische anwendungen - Google Patents
Genetisch hergestellte zellen für therapeutische anwendungenInfo
- Publication number
- ATE478893T1 ATE478893T1 AT05763600T AT05763600T ATE478893T1 AT E478893 T1 ATE478893 T1 AT E478893T1 AT 05763600 T AT05763600 T AT 05763600T AT 05763600 T AT05763600 T AT 05763600T AT E478893 T1 ATE478893 T1 AT E478893T1
- Authority
- AT
- Austria
- Prior art keywords
- therapeutic applications
- genetically designed
- designed cells
- cells
- genetically
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/177—Receptors; Cell surface antigens; Cell surface determinants
- A61K38/1793—Receptors; Cell surface antigens; Cell surface determinants for cytokines; for lymphokines; for interferons
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/28—Bone marrow; Haematopoietic stem cells; Mesenchymal stem cells of any origin, e.g. adipose-derived stem cells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/48—Reproductive organs
- A61K35/54—Ovaries; Ova; Ovules; Embryos; Foetal cells; Germ cells
- A61K35/545—Embryonic stem cells; Pluripotent stem cells; Induced pluripotent stem cells; Uncharacterised stem cells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/19—Cytokines; Lymphokines; Interferons
- A61K38/193—Colony stimulating factors [CSF]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/19—Cytokines; Lymphokines; Interferons
- A61K38/195—Chemokines, e.g. RANTES
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0652—Cells of skeletal and connective tissues; Mesenchyme
- C12N5/0662—Stem cells
- C12N5/0663—Bone marrow mesenchymal stem cells (BM-MSC)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/20—Cytokines; Chemokines
- C12N2501/21—Chemokines, e.g. MIP-1, MIP-2, RANTES, MCP, PF-4
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2510/00—Genetically modified cells
- C12N2510/02—Cells for production
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US57234904P | 2004-05-19 | 2004-05-19 | |
PCT/US2005/017050 WO2005116192A2 (en) | 2004-05-19 | 2005-05-17 | Genetically engineered cells for therapeutic applications |
Publications (1)
Publication Number | Publication Date |
---|---|
ATE478893T1 true ATE478893T1 (de) | 2010-09-15 |
Family
ID=35451463
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AT05763600T ATE478893T1 (de) | 2004-05-19 | 2005-05-17 | Genetisch hergestellte zellen für therapeutische anwendungen |
Country Status (9)
Country | Link |
---|---|
US (3) | US20050271639A1 (de) |
EP (1) | EP1763538B1 (de) |
JP (1) | JP5095403B2 (de) |
CN (1) | CN101065400A (de) |
AT (1) | ATE478893T1 (de) |
AU (1) | AU2005248352B2 (de) |
CA (1) | CA2567177C (de) |
DE (1) | DE602005023158D1 (de) |
WO (1) | WO2005116192A2 (de) |
Families Citing this family (34)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AU2003901668A0 (en) * | 2003-03-28 | 2003-05-01 | Medvet Science Pty. Ltd. | Non-haemopoietic precursor cells |
US20050271639A1 (en) * | 2002-08-22 | 2005-12-08 | Penn Marc S | Genetically engineered cells for therapeutic applications |
JP2008514188A (ja) * | 2004-09-24 | 2008-05-08 | アンジオブラスト システムズ,インコーポレーテッド | 間葉系前駆細胞(mpc)の増殖および/または生存を増強させる方法 |
GB0514300D0 (en) * | 2005-07-12 | 2005-08-17 | Fond Ct San Raffaele | Imflammation |
US8168169B2 (en) * | 2006-08-09 | 2012-05-01 | Mclean Hospital Corporation | Methods and compositions for the treatment of medical disorders |
US7696309B2 (en) * | 2006-10-23 | 2010-04-13 | The Brigham And Women's Hospital, Inc. | Protease resistant mutants of stromal cell derived factor-1 in the repair of tissue damage |
CA2682469A1 (en) * | 2007-03-30 | 2008-10-09 | The Cleveland Clinic Foundation | Method of treating ischemic disorders |
US8440199B2 (en) * | 2007-12-12 | 2013-05-14 | Imperial Innovations Limited | Methods for mobilizing mesenchymal stem cells in a patient |
CA2709398C (en) * | 2007-12-14 | 2017-11-07 | The Cleveland Clinic Foundation | Use of stromal cell-derived factor 1 for promoting wound healing |
WO2009134532A2 (en) * | 2008-03-07 | 2009-11-05 | The Trustees Of Columbia University In The City Of New York | Homing in mesenchymal stem cells |
WO2010111522A2 (en) | 2009-03-26 | 2010-09-30 | The Regents Of The University Of California | Mesenchymal stem cells producing inhibitory rna for disease modification |
US20100247495A1 (en) * | 2009-03-30 | 2010-09-30 | Tom Ichim | Treatment of Muscular Dystrophy |
AU2010286511B2 (en) | 2009-08-28 | 2016-05-26 | Juventas Therapeutics, Inc. | SDF-1 delivery for treating ischemic tissue |
WO2011047058A2 (en) * | 2009-10-13 | 2011-04-21 | Allocure Inc. | Assay for the prediction of therapeutic effectiveness of mesenchymal stromal cells, and methods of using same |
US9308277B2 (en) | 2010-02-25 | 2016-04-12 | Mesoblast International Sàrl | Protease-resistant mutants of stromal cell derived factor-1 in the repair of tissue damage |
EP2625264B1 (de) | 2010-10-08 | 2022-12-07 | Terumo BCT, Inc. | Verfahren und systeme für züchtung und ernte von zellen in einem hohlfaser-bioreaktorsystem mit steuerungsbedingungen |
US10662234B2 (en) | 2011-06-07 | 2020-05-26 | Mesoblast International Sàrl | Methods for repairing tissue damage using protease-resistant mutants of stromal cell derived factor-1 |
EP2626369A1 (de) * | 2011-11-24 | 2013-08-14 | Fundació Institut d'Investigació Biomèdica de Bellvitge (IDIBELL) | Gentechnisch veränderte mesenchymale Stammzellen und ihre therapeutische Verwendung |
HUE041853T2 (hu) * | 2012-05-21 | 2019-05-28 | Univ California | Humán IPS sejtek elõállítása szintetikus önreplikációra képes RNS segítségével |
US20140065110A1 (en) | 2012-08-31 | 2014-03-06 | The Regents Of The University Of California | Genetically modified msc and therapeutic methods |
WO2014145199A2 (en) * | 2013-03-15 | 2014-09-18 | The Cleveland Clinic Foundation | Retrograde delivery of sdf-1 for treatment of myocardial infarction |
JP6612227B2 (ja) | 2013-11-16 | 2019-11-27 | テルモ ビーシーティー、インコーポレーテッド | バイオリアクターにおける細胞増殖 |
CN106029086A (zh) * | 2013-12-13 | 2016-10-12 | 美索布拉斯特国际有限公司 | 使用基质细胞来源的因子-1的抗蛋白酶突变体修复组织损伤的方法 |
EP3613841B1 (de) | 2014-03-25 | 2022-04-20 | Terumo BCT, Inc. | Passives ersetzen von medien |
WO2016049421A1 (en) | 2014-09-26 | 2016-03-31 | Terumo Bct, Inc. | Scheduled feed |
WO2017004592A1 (en) | 2015-07-02 | 2017-01-05 | Terumo Bct, Inc. | Cell growth with mechanical stimuli |
US11965175B2 (en) | 2016-05-25 | 2024-04-23 | Terumo Bct, Inc. | Cell expansion |
US11685883B2 (en) | 2016-06-07 | 2023-06-27 | Terumo Bct, Inc. | Methods and systems for coating a cell growth surface |
US11104874B2 (en) | 2016-06-07 | 2021-08-31 | Terumo Bct, Inc. | Coating a bioreactor |
JP7393945B2 (ja) | 2017-03-31 | 2023-12-07 | テルモ ビーシーティー、インコーポレーテッド | 細胞増殖 |
US11624046B2 (en) | 2017-03-31 | 2023-04-11 | Terumo Bct, Inc. | Cell expansion |
CN111742044A (zh) | 2017-10-03 | 2020-10-02 | 沃尔基尔生物制药公司 | 用遗传修饰的β细胞治疗糖尿病 |
WO2019204509A2 (en) * | 2018-04-18 | 2019-10-24 | Summa Health | Compositions and methods for the treatment of ischemia and cardiomyopathy |
WO2020023806A1 (en) * | 2018-07-25 | 2020-01-30 | The Johns Hopkins University | Compositions and methods for generation of heart field-specific progenitor cells |
Family Cites Families (52)
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US3773919A (en) * | 1969-10-23 | 1973-11-20 | Du Pont | Polylactide-drug mixtures |
US5061620A (en) | 1990-03-30 | 1991-10-29 | Systemix, Inc. | Human hematopoietic stem cell |
EP0557459B1 (de) | 1990-11-13 | 1997-10-22 | Immunex Corporation | Bifunktionelle wählbare fusionsgene |
US5197985A (en) | 1990-11-16 | 1993-03-30 | Caplan Arnold I | Method for enhancing the implantation and differentiation of marrow-derived mesenchymal cells |
EP0804590A1 (de) | 1993-05-21 | 1997-11-05 | Targeted Genetics Corporation | Bifunktionelle selektierbare fusionsgene auf dem cytosin-deaminase (cd) gen beruhend |
US5602301A (en) * | 1993-11-16 | 1997-02-11 | Indiana University Foundation | Non-human mammal having a graft and methods of delivering protein to myocardial tissue |
US5591625A (en) | 1993-11-24 | 1997-01-07 | Case Western Reserve University | Transduced mesenchymal stem cells |
CA2188575A1 (en) * | 1995-02-28 | 1996-09-06 | H. Kirk Hammond | Gene transfer-mediated angiogenesis therapy |
US6121246A (en) * | 1995-10-20 | 2000-09-19 | St. Elizabeth's Medical Center Of Boston, Inc. | Method for treating ischemic tissue |
US5980887A (en) * | 1996-11-08 | 1999-11-09 | St. Elizabeth's Medical Center Of Boston | Methods for enhancing angiogenesis with endothelial progenitor cells |
US7393528B2 (en) * | 1997-01-09 | 2008-07-01 | Tvedten Stephen L | Biological pesticide |
US6121428A (en) * | 1997-06-13 | 2000-09-19 | Genentech, Inc. | Protein recovery |
AU8401498A (en) * | 1997-07-14 | 1999-02-10 | Osiris Therapeutics, Inc. | Cardiac muscle regeneration using mesenchymal stem cells |
MXPA00003885A (es) * | 1997-10-22 | 2004-04-23 | Inst Genetics Llc | Quimiocinas con modificiaciones de la terminacion amino. |
EP1053326A2 (de) * | 1998-02-06 | 2000-11-22 | Collateral Therapeutics | Varianten des angiogenen faktors vaskularer endothelialzell-wachstumsfaktor: vegf |
US6676937B1 (en) * | 1998-03-09 | 2004-01-13 | Caritas St. Elizabeth's Medical Center Of Boston Inc. | Compositions and methods for modulating vascularization |
US20020107196A1 (en) * | 1998-07-21 | 2002-08-08 | Smithkline Beecham Corporation | Method for inducing chemotaxis in endothelial cells by administering stromal cell derived factor-1alpha |
IL125532A0 (en) * | 1998-07-27 | 1999-03-12 | Yeda Res & Dev | Hematopoietic cell composition for use in transplantation |
AU5241099A (en) * | 1998-07-31 | 2000-02-21 | Trustees Of Columbia University In The City Of New York, The | Use of inhibitors of the activation of cxcr4 receptor by sdf-1 in treating rheumatoid arthritis |
US7399751B2 (en) * | 1999-11-04 | 2008-07-15 | Sertoli Technologies, Inc. | Production of a biological factor and creation of an immunologically privileged environment using genetically altered Sertoli cells |
CA2367173A1 (en) * | 1999-04-08 | 2000-10-12 | The General Hospital Corporation | Purposeful movement of human migratory cells away from an agent source |
US7125856B1 (en) * | 1999-04-15 | 2006-10-24 | St. Elizabeth's Medical Center Of Boston, Inc. | Angiogenic growth factors for treatment of peripheral neuropathy |
US6358697B2 (en) * | 1999-04-21 | 2002-03-19 | Children's Hospital Medical Center | Intracellular pharmaceutical targeting |
MXPA02012067A (es) * | 2000-06-05 | 2004-08-19 | Univ Columbia | Identificacion y uso de celulas endoteliales precursoras derivadas de medula osea par mejorar la funcion del miocardio despues de dano isquemico. |
AU2001284695A1 (en) * | 2000-07-31 | 2002-02-13 | New York Medical College | Methods and compositions for the repair and/or regeneration of damaged myocardium |
US7402567B2 (en) * | 2000-10-27 | 2008-07-22 | The Regents Of The University Of California | Treatment of disease by inducing cell apoptosis |
WO2002036078A2 (en) * | 2000-11-05 | 2002-05-10 | University Of Florida | Targeting pluripotent stem cells to tissues |
AU2002224851A1 (en) * | 2000-11-14 | 2002-05-27 | Universite Libre De Bruxelles | Generation and use of dendritic cells |
US20020111290A1 (en) * | 2000-12-01 | 2002-08-15 | Bernhard Homey | Uses of mammalian genes and related reagents |
US7399740B2 (en) * | 2001-06-28 | 2008-07-15 | Yeda Research And Development Co. Ltd. | Poly-Glu,Tyr for neuroprotective therapy |
EP1424389A4 (de) * | 2001-08-07 | 2004-08-25 | Kirin Brewery | Verfahren zur herstellung hämatopoetischer stammzellen |
JP4906231B2 (ja) * | 2001-09-14 | 2012-03-28 | ステム セル セラピューティクス インコーポレイテッド | プロラクチン誘導性の神経幹細胞数の増加ならびにその治療用途 |
US7402724B2 (en) * | 2002-01-04 | 2008-07-22 | Mayo Foundation For Medical Education And Research | Longevity and PAPP-A |
JPWO2003059375A1 (ja) * | 2002-01-17 | 2005-05-19 | 株式会社カルディオ | 組織再生複合療法 |
US7396537B1 (en) * | 2002-02-28 | 2008-07-08 | The Trustees Of The University Of Pennsylvania | Cell delivery patch for myocardial tissue engineering |
KR20050013531A (ko) * | 2002-03-15 | 2005-02-04 | 디파트먼트 오브 베테랑스 어페어스 오피스 오브 더 제네럴 카운셀 (024) | 세포의 아시알로결정자 및 당접합체를 이용하여 세포를조직 및 기관으로 표적화하는 방법 및 이를 위한 조성물 |
US20030199464A1 (en) * | 2002-04-23 | 2003-10-23 | Silviu Itescu | Regeneration of endogenous myocardial tissue by induction of neovascularization |
US20040037811A1 (en) * | 2002-08-22 | 2004-02-26 | The Cleveland Clinic Foundation | Stromal cell-derived factor-1 mediates stem cell homing and tissue regeneration in ischemic cardiomyopathy |
US20050271639A1 (en) * | 2002-08-22 | 2005-12-08 | Penn Marc S | Genetically engineered cells for therapeutic applications |
JP2004099471A (ja) * | 2002-09-05 | 2004-04-02 | Cardio Corp | 心筋梗塞および心不全の治療薬 |
WO2004044142A2 (en) * | 2002-11-05 | 2004-05-27 | The Brigham And Women's Hospital, Inc. | Mesenchymal stem cells and methods of use thereof |
JP4672370B2 (ja) * | 2002-12-05 | 2011-04-20 | ケース ウエスタン リザーブ ユニバーシティ | 虚血の細胞ベースの治療 |
AU2003902037A0 (en) * | 2003-04-24 | 2003-05-15 | Mclachlan, Craig | Method for tissue growth |
US7396680B2 (en) * | 2003-10-31 | 2008-07-08 | Cornell Research Foundation, Inc. | Stem cell-specific promoters and their use |
IL158868A0 (en) * | 2003-11-13 | 2004-05-12 | Yeda Res & Dev | Methods of generating and using stem cells enriched with immature primitive progenitor |
US20060105950A1 (en) * | 2004-10-25 | 2006-05-18 | Caritas St. Elizabeth's Medical Center Of Boston, Inc. | Morphogen compositions and use thereof to treat wounds |
WO2006083394A2 (en) * | 2004-12-21 | 2006-08-10 | Ethicon, Inc. | Postpartum cells derived from placental tissue, and methods of making, culturing, and using the same |
US20070173471A1 (en) * | 2006-01-24 | 2007-07-26 | Losordo Douglas W | Morphogen compositions and methods of use thereof to treat heart disorders |
US7405195B2 (en) * | 2006-03-27 | 2008-07-29 | Natural Beauty Bio-Technology Limited | Cosmetic compositions |
CA2682469A1 (en) * | 2007-03-30 | 2008-10-09 | The Cleveland Clinic Foundation | Method of treating ischemic disorders |
CA2709398C (en) * | 2007-12-14 | 2017-11-07 | The Cleveland Clinic Foundation | Use of stromal cell-derived factor 1 for promoting wound healing |
AU2010286511B2 (en) * | 2009-08-28 | 2016-05-26 | Juventas Therapeutics, Inc. | SDF-1 delivery for treating ischemic tissue |
-
2005
- 2005-01-04 US US11/028,922 patent/US20050271639A1/en not_active Abandoned
- 2005-05-17 DE DE602005023158T patent/DE602005023158D1/de active Active
- 2005-05-17 WO PCT/US2005/017050 patent/WO2005116192A2/en active Application Filing
- 2005-05-17 CN CNA2005800241647A patent/CN101065400A/zh active Pending
- 2005-05-17 JP JP2007527338A patent/JP5095403B2/ja not_active Expired - Fee Related
- 2005-05-17 EP EP05763600A patent/EP1763538B1/de not_active Not-in-force
- 2005-05-17 AU AU2005248352A patent/AU2005248352B2/en not_active Ceased
- 2005-05-17 CA CA2567177A patent/CA2567177C/en not_active Expired - Fee Related
- 2005-05-17 AT AT05763600T patent/ATE478893T1/de not_active IP Right Cessation
-
2007
- 2007-05-25 US US11/807,282 patent/US20070224171A1/en not_active Abandoned
- 2007-06-29 US US11/824,528 patent/US20070258943A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
CN101065400A (zh) | 2007-10-31 |
AU2005248352A1 (en) | 2005-12-08 |
WO2005116192A2 (en) | 2005-12-08 |
US20070224171A1 (en) | 2007-09-27 |
US20050271639A1 (en) | 2005-12-08 |
US20070258943A1 (en) | 2007-11-08 |
DE602005023158D1 (de) | 2010-10-07 |
CA2567177A1 (en) | 2005-12-08 |
EP1763538B1 (de) | 2010-08-25 |
AU2005248352B2 (en) | 2009-07-30 |
CA2567177C (en) | 2011-08-09 |
WO2005116192A3 (en) | 2006-04-13 |
JP2007537752A (ja) | 2007-12-27 |
EP1763538A2 (de) | 2007-03-21 |
JP5095403B2 (ja) | 2012-12-12 |
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