ATE478154T1 - Verfahren zur herstellung einer optisch aktiven biphenylalanin-verbindung oder eines salzes oder esters davon - Google Patents

Verfahren zur herstellung einer optisch aktiven biphenylalanin-verbindung oder eines salzes oder esters davon

Info

Publication number
ATE478154T1
ATE478154T1 AT07713656T AT07713656T ATE478154T1 AT E478154 T1 ATE478154 T1 AT E478154T1 AT 07713656 T AT07713656 T AT 07713656T AT 07713656 T AT07713656 T AT 07713656T AT E478154 T1 ATE478154 T1 AT E478154T1
Authority
AT
Austria
Prior art keywords
optically active
salt
formula
estere
producing
Prior art date
Application number
AT07713656T
Other languages
English (en)
Inventor
Kiyoshi Sugi
Masahide Tanaka
Yoshihiro Kawada
Daisuke Sasayama
Original Assignee
Sumitomo Chemical Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sumitomo Chemical Co filed Critical Sumitomo Chemical Co
Application granted granted Critical
Publication of ATE478154T1 publication Critical patent/ATE478154T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P13/00—Preparation of nitrogen-containing organic compounds
    • C12P13/04—Alpha- or beta- amino acids
    • C12P13/06—Alanine; Leucine; Isoleucine; Serine; Homoserine
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P13/00—Preparation of nitrogen-containing organic compounds
    • C12P13/04—Alpha- or beta- amino acids
    • C12P13/22—Tryptophan; Tyrosine; Phenylalanine; 3,4-Dihydroxyphenylalanine
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P41/00—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture
    • C12P41/003—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture by ester formation, lactone formation or the inverse reactions
    • C12P41/005—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture by ester formation, lactone formation or the inverse reactions by esterification of carboxylic acid groups in the enantiomers or the inverse reaction
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00—Preparation of oxygen-containing organic compounds
    • C12P7/62—Carboxylic acid esters

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Health & Medical Sciences (AREA)
  • General Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Microbiology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Analytical Chemistry (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Peptides Or Proteins (AREA)
AT07713656T 2006-01-17 2007-01-15 Verfahren zur herstellung einer optisch aktiven biphenylalanin-verbindung oder eines salzes oder esters davon ATE478154T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2006009002 2006-01-17
PCT/JP2007/050851 WO2007083776A1 (ja) 2006-01-17 2007-01-15 光学活性ビフェニルアラニン化合物またはその塩およびそのエステルの製造方法

Publications (1)

Publication Number Publication Date
ATE478154T1 true ATE478154T1 (de) 2010-09-15

Family

ID=38287725

Family Applications (1)

Application Number Title Priority Date Filing Date
AT07713656T ATE478154T1 (de) 2006-01-17 2007-01-15 Verfahren zur herstellung einer optisch aktiven biphenylalanin-verbindung oder eines salzes oder esters davon

Country Status (6)

Country Link
US (1) US8017378B2 (de)
EP (1) EP1980622B1 (de)
CN (1) CN101370943B (de)
AT (1) ATE478154T1 (de)
DE (1) DE602007008526D1 (de)
WO (1) WO2007083776A1 (de)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2008120567A1 (ja) * 2007-03-20 2008-10-09 Sumitomo Chemical Company, Limited Ｌ－ビフェニルアラニン化合物の塩の回収方法、およびそれを用いたビフェニルアラニンエステル化合物の回収方法
KR101034709B1 (ko) 2009-12-14 2011-05-17 삼성에스디아이 주식회사 이차전지
US9139515B2 (en) 2011-08-19 2015-09-22 Dpx Holdings B.V. Synthesis of R-biphenylalaninol
AU2012326361B2 (en) 2011-10-17 2017-08-03 Biotheryx, Inc. Substituted biaryl alkyl amides
CN104725256B (zh) * 2015-02-11 2018-03-16 威海迪素制药有限公司 一种联苯丙氨酸衍生物的制备方法
CN104725279B (zh) * 2015-02-12 2018-03-02 威海迪素制药有限公司 一种N‑Boc‑联苯丙氨酸衍生物的制备方法
CN106467471B (zh) * 2015-08-18 2021-02-02 上海翰森生物医药科技有限公司 一种高光学纯度联苯基丙氨酸及其衍生物的制备方法和应用
CN105585511B (zh) * 2016-01-08 2017-05-31 浙江大学 (r)‑n‑叔丁氧羰基联苯丙氨醇的制备方法
KR20170119447A (ko) 2016-04-19 2017-10-27 주식회사 아미노로직스 Dl-4,4'-바이페닐알라닌 알킬에스터로부터 d-4,4'-바이페닐알라닌 알킬에스터 또는 l-4,4'-바이페닐알라닌 알킬에스터를 제조하는 방법
CN106399412B (zh) * 2016-06-03 2019-12-10 南京红杉生物科技有限公司 合成d-联苯基丙氨酸的方法
CN109415308B (zh) 2016-07-05 2022-09-06 诺华股份有限公司 用于早期沙卡布曲中间体的新方法
JP6945619B2 (ja) 2016-08-17 2021-10-06 ノバルティス アーゲー Ｎｅｐ阻害剤合成のための新規な方法および中間体
ES2883363T3 (es) 2016-12-23 2021-12-07 Novartis Ag Proceso nuevo para intermedios iniciales de sacubitrilo
CN108675943A (zh) * 2018-06-13 2018-10-19 常州亚邦制药有限公司 一种沙库巴曲关键中间体的制备方法

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4262092A (en) 1979-05-08 1981-04-14 Ethyl Corporation Process for producing N-acyl-D-phenylalanine ester
US5294632A (en) 1991-05-01 1994-03-15 Ciba-Geigy Corporation Phosphono/biaryl substituted dipetide derivatives
JP3160879B2 (ja) 1996-01-30 2001-04-25 田辺製薬株式会社 光学活性アミノ酸誘導体の製法
JP4270484B2 (ja) 2002-03-08 2009-06-03 第一ファインケミカル株式会社 光学活性フェニルアラニン誘導体の製造方法
KR100654587B1 (ko) * 2002-12-18 2006-12-07 주식회사 엘지생명과학 효소를 이용한 (ｒ)- 또는(ｓ)-ｎ-(2,6-디메틸페닐)알라닌과 그것의 대응 에스테르화합물의 입체이성질체의 제조방법

Also Published As

Publication number Publication date
WO2007083776A1 (ja) 2007-07-26
EP1980622A4 (de) 2009-10-21
EP1980622B1 (de) 2010-08-18
CN101370943B (zh) 2012-02-15
CN101370943A (zh) 2009-02-18
US20090011475A1 (en) 2009-01-08
EP1980622A1 (de) 2008-10-15
US8017378B2 (en) 2011-09-13
DE602007008526D1 (de) 2010-09-30

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