ATE477000T1 - Verfahren und immunmodulierende nukleinsäurezusammensetzungen zur vorbeugung und behandlungvon erkrankungen - Google Patents
Verfahren und immunmodulierende nukleinsäurezusammensetzungen zur vorbeugung und behandlungvon erkrankungenInfo
- Publication number
- ATE477000T1 ATE477000T1 AT03789883T AT03789883T ATE477000T1 AT E477000 T1 ATE477000 T1 AT E477000T1 AT 03789883 T AT03789883 T AT 03789883T AT 03789883 T AT03789883 T AT 03789883T AT E477000 T1 ATE477000 T1 AT E477000T1
- Authority
- AT
- Austria
- Prior art keywords
- preventing
- relates
- treating diseases
- nucleic acid
- methods
- Prior art date
Links
- 201000010099 disease Diseases 0.000 title abstract 4
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 title abstract 4
- 230000002519 immonomodulatory effect Effects 0.000 title abstract 4
- 238000000034 method Methods 0.000 title abstract 4
- 239000000203 mixture Substances 0.000 title abstract 3
- 102000039446 nucleic acids Human genes 0.000 title abstract 3
- 108020004707 nucleic acids Proteins 0.000 title abstract 3
- 150000007523 nucleic acids Chemical class 0.000 title abstract 3
- 229920001184 polypeptide Polymers 0.000 abstract 2
- 208000023275 Autoimmune disease Diseases 0.000 abstract 1
- 230000001363 autoimmune Effects 0.000 abstract 1
- 230000006806 disease prevention Effects 0.000 abstract 1
- 208000027866 inflammatory disease Diseases 0.000 abstract 1
- 230000035790 physiological processes and functions Effects 0.000 abstract 1
- 102000040430 polynucleotide Human genes 0.000 abstract 1
- 108091033319 polynucleotide Proteins 0.000 abstract 1
- 239000002157 polynucleotide Substances 0.000 abstract 1
- 230000002265 prevention Effects 0.000 abstract 1
- 102000004196 processed proteins & peptides Human genes 0.000 abstract 1
- 108090000765 processed proteins & peptides Proteins 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/04—Drugs for skeletal disorders for non-specific disorders of the connective tissue
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Immunology (AREA)
- Epidemiology (AREA)
- Molecular Biology (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Diabetes (AREA)
- Neurology (AREA)
- Biotechnology (AREA)
- Physical Education & Sports Medicine (AREA)
- Rheumatology (AREA)
- Genetics & Genomics (AREA)
- Hematology (AREA)
- Emergency Medicine (AREA)
- Psychiatry (AREA)
- Pain & Pain Management (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Obesity (AREA)
- Endocrinology (AREA)
- Hospice & Palliative Care (AREA)
- Transplantation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Saccharide Compounds (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US42864302P | 2002-11-21 | 2002-11-21 | |
| PCT/US2003/037157 WO2004047734A2 (en) | 2002-11-21 | 2003-11-21 | Methods and immune modulatory nucleic acid compositions for preventing and treating disease |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE477000T1 true ATE477000T1 (de) | 2010-08-15 |
Family
ID=32393438
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT03789883T ATE477000T1 (de) | 2002-11-21 | 2003-11-21 | Verfahren und immunmodulierende nukleinsäurezusammensetzungen zur vorbeugung und behandlungvon erkrankungen |
Country Status (15)
| Country | Link |
|---|---|
| US (1) | US7811813B2 (de) |
| EP (5) | EP1569696B1 (de) |
| JP (2) | JP4750419B2 (de) |
| CN (2) | CN100546657C (de) |
| AT (1) | ATE477000T1 (de) |
| AU (2) | AU2003294400B2 (de) |
| CA (1) | CA2507249A1 (de) |
| DE (1) | DE60333786D1 (de) |
| DK (1) | DK1569696T3 (de) |
| ES (1) | ES2350576T3 (de) |
| IL (1) | IL168715A (de) |
| NZ (1) | NZ540276A (de) |
| PT (1) | PT1569696E (de) |
| SI (1) | SI1569696T1 (de) |
| WO (1) | WO2004047734A2 (de) |
Families Citing this family (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7935675B1 (en) | 1994-07-15 | 2011-05-03 | University Of Iowa Research Foundation | Immunostimulatory nucleic acid molecules |
| JP4101888B2 (ja) * | 1997-06-06 | 2008-06-18 | ダイナバックス テクノロジーズ コーポレイション | 免疫刺激オリゴヌクレオチド、その組成物およびその使用方法 |
| AU2005282889B2 (en) * | 2004-09-01 | 2012-03-15 | Dynavax Technologies Corporation | Methods and conpositions for inhibition of innate immune responses and autoimmunity |
| WO2006136821A1 (en) * | 2005-06-22 | 2006-12-28 | Astex Therapeutics Limited | Pharmaceutical compounds |
| AU2007260775A1 (en) * | 2006-06-13 | 2007-12-21 | Bayhill Therapeutics, Inc. | Methods and immune modulatory nucleic acid compositions for preventing and treating disease |
| EP2712930A3 (de) * | 2006-12-06 | 2014-04-23 | MedImmune, LLC | Interferon-alpha-induzierte pharmakodynamische Marker |
| AU2008247398B2 (en) | 2007-05-03 | 2013-10-10 | Medimmune, Llc | Interferon alpha-induced pharmacodynamic markers |
| US20100261172A1 (en) * | 2007-05-03 | 2010-10-14 | Medimmune, Llc | Interferon alpha-induced pharmacodynamic markers |
| CA2703931C (en) | 2007-10-26 | 2016-08-16 | Dynavax Technologies Corporation | Methods and compositions for inhibition of immune responses and autoimmunity |
| ES2534947T3 (es) | 2009-03-25 | 2015-04-30 | The Board Of Regents Of The University Of Texas System | Composiciones para la estimulación de resistencia inmunitaria innata de mamíferos a patógenos |
| US8940310B2 (en) | 2010-06-16 | 2015-01-27 | Dynavax Technologies Corporation | Methods of treatment using TLR7 and/or TLR9 inhibitors |
| SE535625C2 (sv) | 2010-10-28 | 2012-10-16 | Toleranzia Ab | Nya kompositioner och förfaranden för behandling av autoimmuna och allergiska sjukdomar |
| US20130236453A1 (en) * | 2012-03-12 | 2013-09-12 | The Ohio State University | Methods and Compositions for Modulating Acute Graft-versus-Host Disease using miR-155 Specific Inhibitors |
| WO2013160865A1 (en) | 2012-04-26 | 2013-10-31 | Toleranzia Ab | Immunotolerizing fusion proteins for treatment of multiple sclerosis |
| US9228184B2 (en) * | 2012-09-29 | 2016-01-05 | Dynavax Technologies Corporation | Human toll-like receptor inhibitors and methods of use thereof |
| US9868955B2 (en) | 2012-09-29 | 2018-01-16 | Dynavax Technologies Corporation | Human toll-like receptor inhibitors and methods of use thereof |
| WO2016044839A2 (en) | 2014-09-19 | 2016-03-24 | The Board Of Regents Of The University Of Texas System | Compositions and methods for treating viral infections through stimulated innate immunity in combination with antiviral compounds |
| AU2017353323B2 (en) | 2016-11-01 | 2024-02-29 | Novo Nordisk A/S | Tolerogenic DNA vaccine |
| US11279745B2 (en) | 2019-04-26 | 2022-03-22 | Novo Nordisk A/S | Tolerogenic DNA vaccine |
Family Cites Families (32)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4458066A (en) | 1980-02-29 | 1984-07-03 | University Patents, Inc. | Process for preparing polynucleotides |
| US4425732A (en) | 1981-06-17 | 1984-01-17 | Kania Tadeusz E | Animal trap |
| US4650675A (en) | 1983-08-18 | 1987-03-17 | The Children's Medical Center Corporation | Oligonucleotide conjugates |
| US5139941A (en) | 1985-10-31 | 1992-08-18 | University Of Florida Research Foundation, Inc. | AAV transduction vectors |
| US5219740A (en) | 1987-02-13 | 1993-06-15 | Fred Hutchinson Cancer Research Center | Retroviral gene transfer into diploid fibroblasts for gene therapy |
| US5218103A (en) | 1988-05-26 | 1993-06-08 | University Patents, Inc. | Nucleoside thiophosphoramidites |
| US5278302A (en) | 1988-05-26 | 1994-01-11 | University Patents, Inc. | Polynucleotide phosphorodithioates |
| US5703055A (en) | 1989-03-21 | 1997-12-30 | Wisconsin Alumni Research Foundation | Generation of antibodies through lipid mediated DNA delivery |
| US5399346A (en) | 1989-06-14 | 1995-03-21 | The United States Of America As Represented By The Department Of Health And Human Services | Gene therapy |
| WO1992001070A1 (en) | 1990-07-09 | 1992-01-23 | The United States Of America, As Represented By The Secretary, U.S. Department Of Commerce | High efficiency packaging of mutant adeno-associated virus using amber suppressions |
| US5173414A (en) | 1990-10-30 | 1992-12-22 | Applied Immune Sciences, Inc. | Production of recombinant adeno-associated virus vectors |
| AU663725B2 (en) | 1991-08-20 | 1995-10-19 | United States Of America, Represented By The Secretary, Department Of Health And Human Services, The | Adenovirus mediated transfer of genes to the gastrointestinal tract |
| DE69535905D1 (de) * | 1994-07-15 | 2009-02-26 | Coley Pharm Group Inc | Immunomodulatorische Oligonukleotide |
| US6207646B1 (en) * | 1994-07-15 | 2001-03-27 | University Of Iowa Research Foundation | Immunostimulatory nucleic acid molecules |
| US5712258A (en) | 1995-03-23 | 1998-01-27 | The Trustees Of The University Of Pennsylvania | Inotropic ADP and ATP analogues and their pharmaceutical compositions |
| US5939400A (en) | 1996-02-26 | 1999-08-17 | The Board Of Trustees Of The Leland Stanford Junior University | DNA vaccination for induction of suppressive T cell response |
| WO1997046253A2 (en) | 1996-06-03 | 1997-12-11 | Powderject Vaccines, Inc. | Immunotherapy for autoimmune disease |
| EP0930893B1 (de) * | 1996-10-11 | 2005-04-13 | The Regents of The University of California | Immunostimulierende oligonucleotidekonjugate |
| US6406705B1 (en) * | 1997-03-10 | 2002-06-18 | University Of Iowa Research Foundation | Use of nucleic acids containing unmethylated CpG dinucleotide as an adjuvant |
| WO1998052581A1 (en) | 1997-05-20 | 1998-11-26 | Ottawa Civic Hospital Loeb Research Institute | Vectors and methods for immunization or therapeutic protocols |
| JP4101888B2 (ja) * | 1997-06-06 | 2008-06-18 | ダイナバックス テクノロジーズ コーポレイション | 免疫刺激オリゴヌクレオチド、その組成物およびその使用方法 |
| US6087341A (en) | 1998-02-12 | 2000-07-11 | The Board Of Trustees Of The Leland Standford Junior University | Introduction of nucleic acid into skin cells by topical application |
| US7030098B2 (en) * | 1999-03-12 | 2006-04-18 | The Board Of Trustees Of The Leland Stanford Junior University | DNA vaccination for treatment of autoimmune disease |
| US6949520B1 (en) * | 1999-09-27 | 2005-09-27 | Coley Pharmaceutical Group, Inc. | Methods related to immunostimulatory nucleic acid-induced interferon |
| WO2001051626A2 (en) * | 2000-01-10 | 2001-07-19 | Elim Biopharmaceuticals, Inc. | Novel plasmid expression vectors |
| AU2001297693A1 (en) * | 2000-12-08 | 2002-09-12 | Coley Pharmaceutical Gmbh | Cpg-like nucleic acids and methods of use thereof |
| CN100534436C (zh) * | 2001-11-21 | 2009-09-02 | 利兰·斯坦福青年大学托管委员会 | 多核苷酸 |
| US20050002953A1 (en) * | 2003-05-06 | 2005-01-06 | Jens Herold | SARS-coronavirus virus-like particles and methods of use |
| US7585843B2 (en) * | 2003-10-03 | 2009-09-08 | Bayhill Therapeutics, Inc. | Treatment of demyelinating autoimmune disease with modified ordered peptides |
| JP2009540017A (ja) * | 2006-06-13 | 2009-11-19 | ベイヒル セラピューティクス インコーポレーティッド | ポリヌクレオチド療法 |
| EP2068866A4 (de) * | 2006-07-24 | 2010-04-07 | Biogen Idec Inc | Verfahren zur förderung von myelinisierung, neuronalem überleben und oligodendrozytendifferenzierung mittels verabreichung von sp35- bzw. trka-antagonisten |
| US8257700B2 (en) * | 2008-02-05 | 2012-09-04 | The Board Of Trustees Of The Leland Stanford Junior University | Proteomic analysis of active multiple sclerosis lesions |
-
2003
- 2003-11-21 NZ NZ540276A patent/NZ540276A/en not_active IP Right Cessation
- 2003-11-21 EP EP03789883A patent/EP1569696B1/de not_active Expired - Lifetime
- 2003-11-21 EP EP10008309A patent/EP2298360A3/de not_active Withdrawn
- 2003-11-21 DK DK03789883.0T patent/DK1569696T3/da active
- 2003-11-21 EP EP10008312A patent/EP2322186A3/de not_active Withdrawn
- 2003-11-21 DE DE60333786T patent/DE60333786D1/de not_active Expired - Lifetime
- 2003-11-21 ES ES03789883T patent/ES2350576T3/es not_active Expired - Lifetime
- 2003-11-21 AU AU2003294400A patent/AU2003294400B2/en not_active Ceased
- 2003-11-21 EP EP10008310A patent/EP2329827A3/de not_active Withdrawn
- 2003-11-21 SI SI200331894T patent/SI1569696T1/sl unknown
- 2003-11-21 EP EP10008311A patent/EP2353614A1/de not_active Withdrawn
- 2003-11-21 US US10/524,643 patent/US7811813B2/en not_active Expired - Fee Related
- 2003-11-21 PT PT03789883T patent/PT1569696E/pt unknown
- 2003-11-21 CN CNB2003801077301A patent/CN100546657C/zh not_active Expired - Fee Related
- 2003-11-21 CN CN2009101704078A patent/CN101955976A/zh active Pending
- 2003-11-21 JP JP2004555515A patent/JP4750419B2/ja not_active Expired - Fee Related
- 2003-11-21 WO PCT/US2003/037157 patent/WO2004047734A2/en not_active Ceased
- 2003-11-21 CA CA002507249A patent/CA2507249A1/en not_active Abandoned
- 2003-11-21 AT AT03789883T patent/ATE477000T1/de active
-
2005
- 2005-05-19 IL IL168715A patent/IL168715A/en active IP Right Revival
-
2009
- 2009-03-18 AU AU2009201102A patent/AU2009201102A1/en not_active Abandoned
-
2011
- 2011-02-15 JP JP2011029297A patent/JP2011148801A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| US7811813B2 (en) | 2010-10-12 |
| JP2006514933A (ja) | 2006-05-18 |
| AU2003294400B2 (en) | 2008-12-18 |
| CN1777447A (zh) | 2006-05-24 |
| EP2298360A2 (de) | 2011-03-23 |
| JP2011148801A (ja) | 2011-08-04 |
| AU2009201102A1 (en) | 2009-04-09 |
| SI1569696T1 (sl) | 2010-12-31 |
| EP2353614A1 (de) | 2011-08-10 |
| AU2003294400A1 (en) | 2004-06-18 |
| EP2329827A3 (de) | 2011-07-13 |
| US20050261215A1 (en) | 2005-11-24 |
| CN100546657C (zh) | 2009-10-07 |
| IL168715A (en) | 2011-09-27 |
| EP2322186A3 (de) | 2011-07-13 |
| WO2004047734A2 (en) | 2004-06-10 |
| EP1569696A4 (de) | 2006-01-11 |
| EP2298360A3 (de) | 2011-07-13 |
| CA2507249A1 (en) | 2004-06-10 |
| PT1569696E (pt) | 2010-11-11 |
| JP4750419B2 (ja) | 2011-08-17 |
| ES2350576T3 (es) | 2011-01-25 |
| EP1569696B1 (de) | 2010-08-11 |
| CN101955976A (zh) | 2011-01-26 |
| DE60333786D1 (de) | 2010-09-23 |
| EP2322186A2 (de) | 2011-05-18 |
| EP2329827A2 (de) | 2011-06-08 |
| DK1569696T3 (da) | 2010-11-15 |
| NZ540276A (en) | 2007-12-21 |
| EP1569696A2 (de) | 2005-09-07 |
| WO2004047734A3 (en) | 2004-08-12 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| UEP | Publication of translation of european patent specification |
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