ATE476751T1 - Piezoelektrisch geladene tröpfchenquelle - Google Patents

Piezoelektrisch geladene tröpfchenquelle

Info

Publication number
ATE476751T1
ATE476751T1 AT02725459T AT02725459T ATE476751T1 AT E476751 T1 ATE476751 T1 AT E476751T1 AT 02725459 T AT02725459 T AT 02725459T AT 02725459 T AT02725459 T AT 02725459T AT E476751 T1 ATE476751 T1 AT E476751T1
Authority
AT
Austria
Prior art keywords
ion sources
relates
mass
charged droplet
sources
Prior art date
Application number
AT02725459T
Other languages
English (en)
Inventor
William Berggren
Michael Westphall
Mark Scalf
Lloyd Michael Smith
Original Assignee
Wisconsin Alumni Res Found
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Wisconsin Alumni Res Found filed Critical Wisconsin Alumni Res Found
Application granted granted Critical
Publication of ATE476751T1 publication Critical patent/ATE476751T1/de

Links

Classifications

    • H—ELECTRICITY
    • H01—ELECTRIC ELEMENTS
    • H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
    • H01J49/00—Particle spectrometers or separator tubes
    • H01J49/02—Details
    • H01J49/04—Arrangements for introducing or extracting samples to be analysed, e.g. vacuum locks; Arrangements for external adjustment of electron- or ion-optical components
    • H01J49/0431—Arrangements for introducing or extracting samples to be analysed, e.g. vacuum locks; Arrangements for external adjustment of electron- or ion-optical components for liquid samples
    • H01J49/0454—Arrangements for introducing or extracting samples to be analysed, e.g. vacuum locks; Arrangements for external adjustment of electron- or ion-optical components for liquid samples with means for vaporising using mechanical energy, e.g. by ultrasonic vibrations
    • H—ELECTRICITY
    • H01—ELECTRIC ELEMENTS
    • H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
    • H01J49/00—Particle spectrometers or separator tubes
    • H01J49/02—Details
    • H01J49/10—Ion sources; Ion guns
    • H01J49/16—Ion sources; Ion guns using surface ionisation, e.g. field-, thermionic- or photo-emission
    • H01J49/165—Electrospray ionisation
    • H01J49/167—Capillaries and nozzles specially adapted therefor

Landscapes

  • Chemical & Material Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Engineering & Computer Science (AREA)
  • Plasma & Fusion (AREA)
  • Other Investigation Or Analysis Of Materials By Electrical Means (AREA)
  • Pyrane Compounds (AREA)
  • Chair Legs, Seat Parts, And Backrests (AREA)
  • Sampling And Sample Adjustment (AREA)
  • Electron Tubes For Measurement (AREA)
AT02725459T 2001-03-29 2002-03-29 Piezoelektrisch geladene tröpfchenquelle ATE476751T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US28063201P 2001-03-29 2001-03-29
PCT/US2002/010182 WO2002080223A1 (en) 2001-03-29 2002-03-29 Piezoelectric charged droplet source

Publications (1)

Publication Number Publication Date
ATE476751T1 true ATE476751T1 (de) 2010-08-15

Family

ID=23073932

Family Applications (1)

Application Number Title Priority Date Filing Date
AT02725459T ATE476751T1 (de) 2001-03-29 2002-03-29 Piezoelektrisch geladene tröpfchenquelle

Country Status (6)

Country Link
US (2) US6797945B2 (de)
EP (1) EP1380045B1 (de)
AT (1) ATE476751T1 (de)
CA (1) CA2440833C (de)
DE (1) DE60237196D1 (de)
WO (1) WO2002080223A1 (de)

Families Citing this family (104)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7470547B2 (en) * 2003-07-31 2008-12-30 Biodot, Inc. Methods and systems for dispensing sub-microfluidic drops
US7754439B2 (en) 2003-06-12 2010-07-13 Accupath Diagnostic Laboratories, Inc. Method and system for the analysis of high density cells samples
WO2001080283A1 (en) * 2000-04-18 2001-10-25 Waters Investments Limited Improved electrospray and other lc/ms interfaces
NL1016030C1 (nl) * 2000-08-28 2002-03-01 Aquamarijn Holding B V Sproei inrichting met een nozzleplaat, een nozzleplaat, alsmede werkwijzen ter vervaardiging en voor toepassing van een dergelijke nozzleplaat.
US20020106308A1 (en) * 2001-02-02 2002-08-08 Zweifel Ronald A. Microdrop dispensing apparatus
DE60237196D1 (de) * 2001-03-29 2010-09-16 Wisconsin Alumni Res Found Piezoelektrisch geladene tröpfchenquelle
US6777671B2 (en) * 2001-04-10 2004-08-17 Science & Engineering Services, Inc. Time-of-flight/ion trap mass spectrometer, a method, and a computer program product to use the same
US20030209005A1 (en) * 2002-05-13 2003-11-13 Fenn John Bennett Wick injection of liquids for colloidal propulsion
US6906319B2 (en) * 2002-05-17 2005-06-14 Micromass Uk Limited Mass spectrometer
US7368728B2 (en) * 2002-10-10 2008-05-06 Universita' Degli Studi Di Milano Ionization source for mass spectrometry analysis
US7078679B2 (en) 2002-11-27 2006-07-18 Wisconsin Alumni Research Foundation Inductive detection for mass spectrometry
US6827287B2 (en) * 2002-12-24 2004-12-07 Palo Alto Research Center, Incorporated High throughput method and apparatus for introducing biological samples into analytical instruments
US7208727B2 (en) * 2003-01-14 2007-04-24 Georgia Tech Research Corporation Electrospray systems and methods
GB0308021D0 (en) * 2003-04-07 2003-05-14 Aerstream Technology Ltd Spray electrode
US7091477B2 (en) * 2003-06-09 2006-08-15 Ionica Mass Spectrometry Group, Inc. Mass spectrometer interface
FR2857451B1 (fr) * 2003-07-11 2005-09-30 Commissariat Energie Atomique Procede et dispositif pour l'analyse de milieux reactionnels vivants
US6943346B2 (en) * 2003-08-13 2005-09-13 Science & Engineering Services, Inc. Method and apparatus for mass spectrometry analysis of aerosol particles at atmospheric pressure
WO2005024381A2 (en) * 2003-09-05 2005-03-17 Griffin Analytical Technologies, Inc. Analysis methods, analysis device waveform generation methods, analysis devices, and articles of manufacture
DE10350614B4 (de) * 2003-10-30 2007-11-29 Bruker Daltonik Gmbh Dispenser
KR100543176B1 (ko) * 2003-11-06 2006-01-20 한국기계연구원 나노 패터닝용 프린팅헤드 장치
DE10361903A1 (de) * 2003-12-22 2005-07-28 Carl Zeiss Jena Gmbh Verfahren zur spektroskopischen Analyse einer biologischen oder chemischen Substanz
US7170052B2 (en) * 2003-12-31 2007-01-30 Ionwerks, Inc. MALDI-IM-ortho-TOF mass spectrometry with simultaneous positive and negative mode detection
US8003934B2 (en) * 2004-02-23 2011-08-23 Andreas Hieke Methods and apparatus for ion sources, ion control and ion measurement for macromolecules
DE102004014618B3 (de) * 2004-03-23 2005-11-10 Eads Space Transportation Gmbh Elektrothermisches Impuls-Triebwerk
RU2342894C2 (ru) * 2004-04-23 2009-01-10 Мацушита Электрик Уорк, Лтд. Тепловентилятор с электростатическим водораспылительным устройством
DE102004022950A1 (de) * 2004-05-10 2005-12-08 MAX-PLANCK-Gesellschaft zur Förderung der Wissenschaften e.V. Verfahren und Vorrichtung zur Manipulation und Analyse tropfenförmiger Proben im Vakuum
DE112005001385T5 (de) 2004-06-15 2007-05-10 Griffin analytical Technologies Inc., West Lafayette Analyseinstrumente, -baugruppen und -verfahren
CA2518706A1 (en) * 2004-09-09 2006-03-09 Simon Fraser University Method and apparatus for coupling an analyte supply to an electrodynamic droplet processor
US6972408B1 (en) * 2004-09-30 2005-12-06 Ut-Battelle, Llc Ultra high mass range mass spectrometer systems
US7642511B2 (en) * 2004-09-30 2010-01-05 Ut-Battelle, Llc Ultra high mass range mass spectrometer systems
US7388195B2 (en) * 2004-09-30 2008-06-17 Charles Stark Draper Laboratory, Inc. Apparatus and systems for processing samples for analysis via ion mobility spectrometry
GB0424426D0 (en) 2004-11-04 2004-12-08 Micromass Ltd Mass spectrometer
US7476851B2 (en) * 2004-11-12 2009-01-13 Regents Of The University Of Minnesota Aerodynamic focusing of nanoparticle or cluster beams
US20060210443A1 (en) 2005-03-14 2006-09-21 Stearns Richard G Avoidance of bouncing and splashing in droplet-based fluid transport
WO2006116564A2 (en) 2005-04-25 2006-11-02 Griffin Analytical Technologies, L.L.C. Analytical instrumentation, appartuses, and methods
JP2008544258A (ja) * 2005-06-17 2008-12-04 ローレンス リヴァーモア ナショナル セキュリティ，エルエルシー エアロゾル焦点化装置用の圧流レジューサ
US20070001114A1 (en) * 2005-06-29 2007-01-04 Goodley Paul C Apparatus and method for ion capture and production
US7645987B2 (en) * 2005-09-22 2010-01-12 Academia Sinica Acoustic desorption mass spectrometry
US7518108B2 (en) * 2005-11-10 2009-04-14 Wisconsin Alumni Research Foundation Electrospray ionization ion source with tunable charge reduction
EP1984934A4 (de) * 2006-02-08 2015-01-14 Dh Technologies Dev Pte Ltd Hochfrequenzionenführung
WO2007109292A2 (en) * 2006-03-21 2007-09-27 Wisconsin Alumni Research Foundation Ionizable isotopic labeling reagents for relative quantification by mass spectrometry
KR100802139B1 (ko) * 2006-08-08 2008-02-11 한국생명공학연구원 자성 나노입자를 함유하는 골드 나노케이지
US7992424B1 (en) 2006-09-14 2011-08-09 Griffin Analytical Technologies, L.L.C. Analytical instrumentation and sample analysis methods
JP2010504504A (ja) * 2006-09-25 2010-02-12 エムディーエス アナリティカル テクノロジーズ， ア ビジネス ユニット オブ エムディーエス インコーポレイテッド， ドゥーイング ビジネス スルー イッツ サイエックス ディビジョン 質量分析計とともに使用するための複数の試料供給源、ならびにそのための装置、デバイスおよび方法
US20090283674A1 (en) * 2006-11-07 2009-11-19 Reinhold Pesch Efficient Atmospheric Pressure Interface for Mass Spectrometers and Method
US7982183B2 (en) * 2006-11-07 2011-07-19 Thermo Fisher Scientific (Bremen) Gmbh Ion transfer tube with spatially alternating DC fields
CN101606220B (zh) * 2006-11-07 2012-08-29 塞莫费雪科学（不来梅）有限公司 离子迁移装置
US7909897B2 (en) * 2006-11-28 2011-03-22 Georgia Tech Research Corporation Droplet impingement chemical reactors and methods of processing fuel
US20080227663A1 (en) 2007-01-19 2008-09-18 Biodot, Inc. Systems and methods for high speed array printing and hybridization
US20090078064A1 (en) * 2007-08-06 2009-03-26 Abraham Oommen Instrument for simultaneous analysis of multiple samples using multiple differential mobility analyzers
US8217345B2 (en) * 2007-10-18 2012-07-10 Dh Technologies Development Pte. Ltd. Interface between differential mobility analyzer and mass spectrometer
DE102007052500A1 (de) * 2007-11-02 2009-06-04 Helmholtz Zentrum München Deutsches Forschungszentrum Für Gesundheit Und Umwelt (Gmbh) Verfahren und Vorrichtung für den Nachweis von mindestens einer Zielsubstanz
US8502507B1 (en) 2012-03-29 2013-08-06 Accio Energy, Inc. Electro-hydrodynamic system
DE102009007265B4 (de) * 2009-02-03 2011-07-28 Bruker Daltonik GmbH, 28359 Tröpfchen- und Ionenführung in einer Elektrosprüh-Ionenquelle
US8592216B2 (en) * 2009-04-15 2013-11-26 Wisconsin Alumni Research Foundation Labeling peptides with tertiary amines and other basic functional groups for improved mass spectrometric analysis
US20160368006A9 (en) * 2009-04-29 2016-12-22 Accio Energy, Inc. Wave electro-hydrodynamic device
US8561486B2 (en) * 2009-07-13 2013-10-22 Enertechnix, Inc Particle interrogation devices and methods
US8307723B2 (en) * 2009-07-13 2012-11-13 Enertechnix, Inc. Particle interrogation devices and methods
US20110203931A1 (en) * 2009-07-13 2011-08-25 Enertechnix, Inc Particle Interrogation Devices and Methods
DE102009037715B4 (de) * 2009-08-17 2012-04-26 Bruker Daltonik Gmbh Führung von Sprühtröpfchen zur Einlasskapillare eines Massenspektrometers
US8399828B2 (en) * 2009-12-31 2013-03-19 Virgin Instruments Corporation Merged ion beam tandem TOF-TOF mass spectrometer
US20110196657A1 (en) * 2010-02-11 2011-08-11 Jie Zhang Solving a Solute Lubrication Equation for 3D Droplet Evaporation on a Complicated OLED Bank Structure
EP2561333B1 (de) 2010-04-19 2015-11-25 Battelle Memorial Institute Elektrohydrodynamisches sprühen
EP2405463A1 (de) * 2010-07-06 2012-01-11 ETH Zurich Ionenquelle für Laserablation mit Ionentrichter
US10154923B2 (en) 2010-07-15 2018-12-18 Eyenovia, Inc. Drop generating device
EP2612344A2 (de) * 2010-09-01 2013-07-10 DH Technologies Development Pte. Ltd. Ionenquelle für massenspektrometrie
EP2665557B1 (de) 2011-01-21 2020-01-01 Biodot, Inc. Piezoelektrischer spender mit einem länglichen wandler und einem auswechselbaren kapillarrohr
DE102012102875B4 (de) * 2011-04-04 2024-04-18 Wisconsin Alumni Research Foundation Vorläuferauswahl mit einem Artificial-Intelligence-Algorithmus erhöht Abdeckung und Reproduzierbarkeit von proteomischen Proben
JP5537487B2 (ja) * 2011-04-12 2014-07-02 日本特殊陶業株式会社 微粒子検知システム
EP2776822B1 (de) * 2011-10-26 2016-09-21 DH Technologies Development Pte. Ltd. Quantifizierung eines analyten im serum und anderen biologischen matrizen
GB201120143D0 (en) * 2011-11-22 2012-01-04 Micromass Ltd Droplet manipulation using gas-phase standing-wave ultrasound fields in MS sources
AU2013267976B2 (en) 2012-05-29 2016-06-02 Biodesix, Inc. Deep-MALDI TOF mass spectrometry of complex biological samples, e.g., serum, and uses thereof
WO2014074456A1 (en) 2012-11-06 2014-05-15 Biodot, Inc. Controlled printing of a cell sample for karyotyping
FR3003083B1 (fr) * 2013-03-11 2015-04-10 Commissariat Energie Atomique Dispositif de determination de la masse d'une particule en suspension ou en solution dans un fluide
US9653276B2 (en) * 2013-08-07 2017-05-16 DH Technologies Development Pte Ltd. Enhanced spray formation for liquid samples
US20170045427A1 (en) * 2014-02-20 2017-02-16 The Arizona Board Of Regents On Behalf Of The University Of Arizona Method for guiding cell spreading in automated cytogenetic assays
US11148164B2 (en) 2014-07-25 2021-10-19 Biodot, Inc. Piezoelectric dispenser with a longitudinal transducer and replaceable capillary tube
CN107106325B (zh) * 2015-01-12 2021-05-25 科达莱昂治疗公司 微滴递送设备和方法
AU2016246060B2 (en) * 2015-04-10 2020-10-22 Bausch + Lomb Ireland Limited Piezoelectric dispenser with replaceable ampoule
JP6335861B2 (ja) * 2015-10-27 2018-05-30 日本特殊陶業株式会社 微粒子測定システム
US20180076014A1 (en) * 2016-09-09 2018-03-15 Science And Engineering Services, Llc Sub-atmospheric pressure laser ionization source using an ion funnel
CA3039106A1 (en) * 2017-01-20 2018-07-26 Kedalion Therapeutics, Inc. Piezoelectric fluid dispenser
US20210343515A1 (en) * 2017-06-08 2021-11-04 Board Of Regents, The University Of Texas System Systems and methods for microarray droplet ionization analysis
CN115300226A (zh) 2017-06-10 2022-11-08 艾诺维亚股份有限公司 用于将一体积的流体输送到眼睛的设备
JP6841340B2 (ja) * 2017-10-27 2021-03-10 株式会社島津製作所 Ｅｓｉスプレイヤー用管及びｅｓｉスプレイヤー
AU2018380433B2 (en) 2017-12-08 2024-10-10 Bausch + Lomb Ireland Limited Fluid delivery alignment system
US12350194B1 (en) 2018-04-12 2025-07-08 Bausch + Lomb Ireland Limited Topical ocular delivery of fluids with controlled mass dosing and wireless communication
US20190314197A1 (en) 2018-04-12 2019-10-17 Kedalion Therapeutics, Inc. Topical Ocular Delivery Methods and Devices for Use in the Same
US11798796B2 (en) * 2018-06-15 2023-10-24 University Of New Hampshire Preconcentrating of environmental contaminant analytes for ambient ionization mass spectrometry
WO2020010116A1 (en) 2018-07-03 2020-01-09 Kedalion Therapeutics, Inc. Topical ocular delivery devices and methods for using the same
EP3921085B1 (de) * 2019-02-07 2023-10-04 University of Washington Vorrichtungen und systeme zur tröpfchenerzeugung und verfahren zur erzeugung von tröpfchen
US12097145B2 (en) 2019-03-06 2024-09-24 Bausch + Lomb Ireland Limited Vented multi-dose ocular fluid delivery system
US11679028B2 (en) 2019-03-06 2023-06-20 Novartis Ag Multi-dose ocular fluid delivery system
US10763072B1 (en) * 2019-03-15 2020-09-01 Applied Materials, Inc. Apparatus, system and techniques for mass analyzed ion beam
CN111403259A (zh) * 2019-10-24 2020-07-10 宁波华仪宁创智能科技有限公司 液滴喷射方法
US12496218B1 (en) 2019-11-12 2025-12-16 Bausch + Lomb Ireland Limited Fractionated topical ocular drug delivery methods and devices for use in the same
AU2020399803A1 (en) 2019-12-11 2022-06-23 Eyenovia, Inc. Systems and devices for delivering fluids to the eye and methods of use
US12290472B2 (en) 2020-04-17 2025-05-06 Bausch + Lomb Ireland Limited Hydrodynamically actuated preservative free dispensing system
IL297215A (en) 2020-04-17 2022-12-01 Kedallon Therapeutics Inc A hydrodynamically activated preservative free distribution system
WO2021212038A1 (en) 2020-04-17 2021-10-21 Kedalion Therapeutics, Inc. Hydrodynamically actuated preservative free dispensing system having a collapsible liquid reservoir
US11938057B2 (en) 2020-04-17 2024-03-26 Bausch + Lomb Ireland Limited Hydrodynamically actuated preservative free dispensing system
US11651945B2 (en) 2020-09-25 2023-05-16 Ut-Battelle, Llc Rapid droplet introduction interface (RDII) for mass spectrometry
CN113996354B (zh) * 2021-10-25 2023-03-24 苏州缔因安生物科技有限公司 一种控制微液滴生成装置、生成方法及用途
CN113996353A (zh) * 2021-10-25 2022-02-01 苏州缔因安生物科技有限公司 一种微滴生成装置、生成方法及用途

Family Cites Families (66)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US35494A (en) * 1862-06-03 Improvement in stoves
US158196A (en) * 1874-12-29 Improvement in derricks for hoisting cans containing fluids
US125423A (en) * 1872-04-09 Improvement in machines for making horseshoe-nails
US3298030A (en) * 1965-07-12 1967-01-10 Clevite Corp Electrically operated character printer
US3683212A (en) 1970-09-09 1972-08-08 Clevite Corp Pulsed droplet ejecting system
US3857049A (en) 1972-06-05 1974-12-24 Gould Inc Pulsed droplet ejecting system
US4461155A (en) 1979-09-10 1984-07-24 Bertil Werjefelt Aircraft cabin ventilation system
US4352570A (en) 1980-05-27 1982-10-05 Applied Plastics Co., Inc. Vibratory treatment apparatus and method
US4383171A (en) * 1980-11-17 1983-05-10 The United States Of America As Represented By The Administrator Of The National Aeronautics And Space Administration Particle analyzing method and apparatus
US4492322A (en) 1982-04-30 1985-01-08 Indiana University Foundation Device for the accurate dispensing of small volumes of liquid samples
JPS5935347A (ja) 1982-08-20 1984-02-27 Masahiko Tsuchiya イオン生成装置
EP0121288B1 (de) * 1983-01-06 1989-05-17 National Research Development Corporation Elektrostatischer Spritzkopf
GB8305865D0 (en) * 1983-03-03 1983-04-07 British Res Agricult Eng Electrostatic sprayers
US4924097A (en) * 1984-06-22 1990-05-08 Georgia Tech Rss. Corp Monodisperse aerosol generator for use with infrared spectrometry
US4762995A (en) * 1984-06-22 1988-08-09 Georgia Tech Research Corporation Monodisperse aerosol generator
US5175433A (en) * 1984-06-22 1992-12-29 Georgia Tech Research Corporation Monodisperse aerosol generator for use with infrared spectrometry
US4580148A (en) 1985-02-19 1986-04-01 Xerox Corporation Thermal ink jet printer with droplet ejection by bubble collapse
US4667100A (en) * 1985-04-17 1987-05-19 Lagna William M Methods and apparatus for mass spectrometric analysis of fluids
US4761545A (en) * 1986-05-23 1988-08-02 The Ohio State University Research Foundation Tailored excitation for trapped ion mass spectrometry
US4935624A (en) * 1987-09-30 1990-06-19 Cornell Research Foundation, Inc. Thermal-assisted electrospray interface (TAESI) for LC/MS
USRE34757E (en) * 1988-04-05 1994-10-18 Battelle Memorial Institute Combined electrophoresis-electrospray interface and method
US4845512A (en) * 1988-10-12 1989-07-04 Videojet Systems International, Inc. Drop deflection device and method for drop marking systems
US4883958A (en) * 1988-12-16 1989-11-28 Vestec Corporation Interface for coupling liquid chromatography to solid or gas phase detectors
US5073713A (en) 1990-05-29 1991-12-17 Battelle Memorial Institute Detection method for dissociation of multiple-charged ions
US5076097A (en) 1990-06-28 1991-12-31 Tsi Incorporated Method and apparatus for determining concentration of macromolecules and colloids in a liquid sample
WO1992021138A1 (en) * 1991-05-21 1992-11-26 Analytica Of Brandford, Inc. Method and apparatus for improving electrospray ionization of solute species
US5247842A (en) * 1991-09-30 1993-09-28 Tsi Incorporated Electrospray apparatus for producing uniform submicrometer droplets
US5192865A (en) 1992-01-14 1993-03-09 Cetac Technologies Inc. Atmospheric pressure afterglow ionization system and method of use, for mass spectrometer sample analysis systems
US5270542A (en) * 1992-12-31 1993-12-14 Regents Of The University Of Minnesota Apparatus and method for shaping and detecting a particle beam
US5359196A (en) * 1993-05-24 1994-10-25 Hewlett-Packard Company Mass spectrometry with gas counterflow for particle beam
DK0706352T3 (da) 1993-06-29 2002-07-15 Ponwell Entpr Ltd Dispenser
US5448062A (en) * 1993-08-30 1995-09-05 Mims Technology Development Co. Analyte separation process and apparatus
US5403617A (en) 1993-09-15 1995-04-04 Mobium Enterprises Corporation Hybrid pulsed valve for thin film coating and method
US5504327A (en) 1993-11-04 1996-04-02 Hv Ops, Inc. (H-Nu) Electrospray ionization source and method for mass spectrometric analysis
US5611846A (en) 1994-01-14 1997-03-18 Board Of Supervisors Of Louisiana State University And Agricultural And Mechanical College Portable gas chromatograph
US5608217A (en) * 1994-03-10 1997-03-04 Bruker-Franzen Analytik Gmbh Electrospraying method for mass spectrometric analysis
US5750988A (en) 1994-07-11 1998-05-12 Hewlett-Packard Company Orthogonal ion sampling for APCI mass spectrometry
US5560543A (en) 1994-09-19 1996-10-01 Board Of Regents, The University Of Texas System Heat-resistant broad-bandwidth liquid droplet generators
US6558633B1 (en) 1994-09-21 2003-05-06 Isis Pharmaceuticals, Inc. Chemical reaction apparatus and methods
US5614711A (en) 1995-05-04 1997-03-25 Indiana University Foundation Time-of-flight mass spectrometer
US5565677A (en) * 1995-08-04 1996-10-15 The University Of Delaware Aerodynamic nozzle for aerosol particle beam formation into a vacuum
US6278111B1 (en) 1995-08-21 2001-08-21 Waters Investments Limited Electrospray for chemical analysis
US5838002A (en) 1996-08-21 1998-11-17 Chem-Space Associates, Inc Method and apparatus for improved electrospray analysis
US5922976A (en) 1995-10-12 1999-07-13 California Institute Of Technology Method of measuring aerosol particles using automated mobility-classified aerosol detector
US5767512A (en) 1996-01-05 1998-06-16 Battelle Memorial Institute Method for reduction of selected ion intensities in confined ion beams
US5873523A (en) 1996-02-29 1999-02-23 Yale University Electrospray employing corona-assisted cone-jet mode
US5958342A (en) * 1996-05-17 1999-09-28 Incyte Pharmaceuticals, Inc. Jet droplet device
US5945678A (en) 1996-05-21 1999-08-31 Hamamatsu Photonics K.K. Ionizing analysis apparatus
US6469295B1 (en) * 1997-05-30 2002-10-22 Bruker Daltonics Inc. Multiple reflection time-of-flight mass spectrometer
US6433154B1 (en) 1997-06-12 2002-08-13 Bristol-Myers Squibb Company Functional receptor/kinase chimera in yeast cells
US6027699A (en) 1997-07-28 2000-02-22 Lockheed Martin Energy Research Corp. Material forming apparatus using a directed droplet stream
US5965883A (en) 1997-08-25 1999-10-12 California Institute Of Technology Capillary for electrospray ion source
EP1021819B1 (de) * 1997-09-12 2005-03-16 Analytica Of Branford, Inc. Mehrprobeneinführungs-massenspektrometrie
US6051189A (en) 1997-10-01 2000-04-18 The United States Of America As Represented By The Secretary Of The Army System and method for detection, identification and monitoring of submicron-sized particles
US5973904A (en) 1997-10-10 1999-10-26 Regents Of The University Of Minnesota Particle charging apparatus and method of charging particles
US6331702B1 (en) 1999-01-25 2001-12-18 University Of Manitoba Spectrometer provided with pulsed ion source and transmission device to damp ion motion and method of use
US5992244A (en) 1998-03-04 1999-11-30 Regents Of The University Of Minnesota Charged particle neutralizing apparatus and method of neutralizing charged particles
US6107628A (en) * 1998-06-03 2000-08-22 Battelle Memorial Institute Method and apparatus for directing ions and other charged particles generated at near atmospheric pressures into a region under vacuum
WO2000017908A2 (en) 1998-09-23 2000-03-30 Wisconsin Alumni Research Foundation Charge reduction in electrospray mass spectrometry
US6359275B1 (en) * 1999-07-14 2002-03-19 Agilent Technologies, Inc. Dielectric conduit with end electrodes
US6815668B2 (en) 1999-07-21 2004-11-09 The Charles Stark Draper Laboratory, Inc. Method and apparatus for chromatography-high field asymmetric waveform ion mobility spectrometry
US6787764B2 (en) 2000-02-18 2004-09-07 Bruker Daltonics, Inc. Method and apparatus for automating a matrix-assisted laser desorption/ionization (MALDI) mass spectrometer
US6396057B1 (en) * 2000-04-18 2002-05-28 Waters Investments Limited Electrospray and other LC/MS interfaces
US6593570B2 (en) * 2000-05-24 2003-07-15 Agilent Technologies, Inc. Ion optic components for mass spectrometers
US6649907B2 (en) 2001-03-08 2003-11-18 Wisconsin Alumni Research Foundation Charge reduction electrospray ionization ion source
DE60237196D1 (de) * 2001-03-29 2010-09-16 Wisconsin Alumni Res Found Piezoelektrisch geladene tröpfchenquelle

Also Published As

Publication number Publication date
CA2440833C (en) 2009-07-14
EP1380045A1 (de) 2004-01-14
US20020166961A1 (en) 2002-11-14
DE60237196D1 (de) 2010-09-16
CA2440833A1 (en) 2002-10-10
US20020158196A1 (en) 2002-10-31
WO2002080223A1 (en) 2002-10-10
EP1380045A4 (de) 2005-11-23
US6797945B2 (en) 2004-09-28
US6906322B2 (en) 2005-06-14
EP1380045B1 (de) 2010-08-04

Similar Documents

Publication Publication Date Title
ATE476751T1 (de) Piezoelektrisch geladene tröpfchenquelle
Fuchs et al. An update of MALDI-TOF mass spectrometry in lipid research
Cody et al. Direct analysis in real time (DART) mass spectrometry
EP2176640B1 (de) Verfahren und vorrichtung zur echtzeitanalyse chemischer, biologischer und explosiver stoffe in der luft
ES2922330T3 (es) Dispositivo de determinación de la masa de una partícula en suspensión o en solución en un fluido
Forbes et al. Chemical imaging of artificial fingerprints by desorption electro-flow focusing ionization mass spectrometry
Steele et al. Laser power dependence of mass spectral signatures from individual bacterial spores in bioaerosol mass spectrometry
MX2021001203A (es) Técnicas para la detección y cuantificación rápidas de compuestos orgánicos volátiles (cov) utilizando muestras de aliento.
US20090014646A1 (en) Method and apparatus for incorporating electrostatic concentrators and/or ion mobility separators with Raman, IR, UV, XRF, LIF and LIBS spectroscopy and /or other spectroscopic techniques
WO2004088271A3 (en) Method for increasing ionization efficiency in mass spectroscopy
US7855360B2 (en) Method and apparatus to accurately discriminate gas phase ions with several filtering devices in tandem
US20130264475A1 (en) Selective ionization using high frequency filtering of reactive ions
Huffman et al. Online techniques for quantification and characterization of biological aerosols
Bruns et al. Atmospheric solids analysis probe mass spectrometry: a new approach for airborne particle analysis
JP2007046966A5 (de)
WO2005047848A3 (en) Method and apparatus for mass spectrometric analysis
Koeniger et al. Development of field modulation in a split-field drift tube for high-throughput multidimensional separations
WO2008070570A3 (en) Positive selection of serum proteins for proteomic analysis
Nielsen et al. Physicochemical properties determining the detection probability of tryptic peptides in Fourier transform mass spectrometry. A correlation study
Rathore et al. Collision-induced release, ion mobility separation, and amino acid sequence analysis of subunits from mass-selected noncovalent protein complexes
Onggo et al. General Principles in Electrospray Mass Spectrometry: A New Technique in Mass Spectral Analysis
SE0402966D0 (sv) A device, methods and interfaces for single and multidimensional separations for characterization and/or identification of molecules by mass spectrometry
Olumee et al. Protonation of Gly n Homologues in Matrix-Assisted Laser Desorption Ionization
Heptner et al. A gated atmospheric pressure drift tube ion mobility spectrometer–time-of-flight mass spectrometer
US5532140A (en) Method and apparatus for suspending microparticles

Legal Events

Date Code Title Description
RER Ceased as to paragraph 5 lit. 3 law introducing patent treaties