ATE468331T1 - NEW CYANOPYRIDINE DERIVATIVES FOR THE TREATMENT OF CANCER AND OTHER DISEASES - Google Patents

NEW CYANOPYRIDINE DERIVATIVES FOR THE TREATMENT OF CANCER AND OTHER DISEASES

Info

Publication number
ATE468331T1
ATE468331T1 AT04716144T AT04716144T ATE468331T1 AT E468331 T1 ATE468331 T1 AT E468331T1 AT 04716144 T AT04716144 T AT 04716144T AT 04716144 T AT04716144 T AT 04716144T AT E468331 T1 ATE468331 T1 AT E468331T1
Authority
AT
Austria
Prior art keywords
cancer
diseases
treatment
new
cyanopyridine derivatives
Prior art date
Application number
AT04716144T
Other languages
German (de)
Inventor
William Scott
Jacques Dumas
Stephen Boyer
Wendy Lee
Yuanwei Chen
Barton Phillips
Sharad Verma
Jianqing Chen
Zhi Chen
Jianmei Fan
Brian Raudenbush
Aniko Redman
Lin Yi
Qingming Zhu
Original Assignee
Bayer Healthcare Llc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bayer Healthcare Llc filed Critical Bayer Healthcare Llc
Application granted granted Critical
Publication of ATE468331T1 publication Critical patent/ATE468331T1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/84—Nitriles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/14—Vasoprotectives; Antihaemorrhoidals; Drugs for varicose therapy; Capillary stabilisers
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/62—Oxygen or sulfur atoms
    • C07D213/63—One oxygen atom
    • C07D213/68—One oxygen atom attached in position 4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Oncology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hematology (AREA)
  • Vascular Medicine (AREA)
  • Immunology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Rheumatology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
AT04716144T 2003-02-28 2004-03-01 NEW CYANOPYRIDINE DERIVATIVES FOR THE TREATMENT OF CANCER AND OTHER DISEASES ATE468331T1 (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US45032403P 2003-02-28 2003-02-28
US45034803P 2003-02-28 2003-02-28
US45032303P 2003-02-28 2003-02-28
PCT/US2004/006286 WO2004078747A1 (en) 2003-02-28 2004-03-01 Novel cyanopyridine derivatives useful in the treatment of cancer and other disorders

Publications (1)

Publication Number Publication Date
ATE468331T1 true ATE468331T1 (en) 2010-06-15

Family

ID=32966445

Family Applications (1)

Application Number Title Priority Date Filing Date
AT04716144T ATE468331T1 (en) 2003-02-28 2004-03-01 NEW CYANOPYRIDINE DERIVATIVES FOR THE TREATMENT OF CANCER AND OTHER DISEASES

Country Status (21)

Country Link
US (5) US7557129B2 (en)
EP (1) EP1599467B1 (en)
JP (1) JP4658037B2 (en)
KR (1) KR101109262B1 (en)
AR (1) AR043437A1 (en)
AT (1) ATE468331T1 (en)
AU (1) AU2004217977B2 (en)
BR (1) BRPI0407897A (en)
CA (1) CA2517361C (en)
CY (1) CY1111143T1 (en)
DE (1) DE602004027218D1 (en)
DK (1) DK1599467T3 (en)
ES (1) ES2344347T3 (en)
IL (1) IL170503A (en)
MX (1) MXPA05009067A (en)
PL (1) PL1599467T3 (en)
PT (1) PT1599467E (en)
SI (1) SI1599467T1 (en)
TW (1) TW200504053A (en)
UY (1) UY28213A1 (en)
WO (1) WO2004078747A1 (en)

Families Citing this family (90)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8124630B2 (en) 1999-01-13 2012-02-28 Bayer Healthcare Llc ω-carboxyaryl substituted diphenyl ureas as raf kinase inhibitors
ATE538794T1 (en) 1999-01-13 2012-01-15 Bayer Healthcare Llc GAMMA CARBOXYARYL SUBSTITUTED DIPHENYL UREA COMPOUNDS AS P38 KINASE INHIBITORS
US7371763B2 (en) * 2001-04-20 2008-05-13 Bayer Pharmaceuticals Corporation Inhibition of raf kinase using quinolyl, isoquinolyl or pyridyl ureas
US20080108672A1 (en) * 2002-01-11 2008-05-08 Bernd Riedl Omega-Carboxyaryl Substituted Diphenyl Ureas As Raf Kinase Inhibitors
PT1580188E (en) 2002-02-11 2012-01-25 Bayer Healthcare Llc Aryl ureas as kinase inhibitors
US7838541B2 (en) 2002-02-11 2010-11-23 Bayer Healthcare, Llc Aryl ureas with angiogenesis inhibiting activity
US7399866B2 (en) * 2003-01-14 2008-07-15 Cytokinetics, Inc. Compounds, compositions, and methods
NZ589793A (en) * 2003-02-21 2011-12-22 Resmed Ltd Nozzle configuration of nasal cushion for respiratory assistance mask
UY28213A1 (en) 2003-02-28 2004-09-30 Bayer Pharmaceuticals Corp NEW CYANOPIRIDINE DERIVATIVES USEFUL IN THE TREATMENT OF CANCER AND OTHER DISORDERS.
WO2004113274A2 (en) * 2003-05-20 2004-12-29 Bayer Pharmaceuticals Corporation Diaryl ureas with kinase inhibiting activity
RS52625B (en) 2003-07-23 2013-06-28 Bayer Healthcare Llc FLUORO SUBSTITUTED OMEGA-CARBOXYARYL DIPHENYL UREA FOR TREATMENT AND PREVENTION OF DISEASES AND DISEASES
EP1720567A2 (en) * 2004-02-10 2006-11-15 Innate Pharma Composition and method for the treatment of carcinoma
ATE517885T1 (en) 2004-04-30 2011-08-15 Bayer Healthcare Llc SUBSTITUTED PYRAZOLYL UREA DERIVATIVES FOR THE TREATMENT OF CANCER
MXPA06014495A (en) 2004-06-17 2007-03-01 Cytokinetics Inc COMPOUNDS, COMPOSITIONS AND METHODS.
KR101381454B1 (en) * 2004-09-29 2014-04-04 바이엘 인텔렉쳐 프로퍼티 게엠베하 Thermodynamically stable form of bay 43-9006 tosylate
DE502005002697D1 (en) 2004-10-13 2008-03-13 Merck Patent Gmbh DERIVATIVES OF N, N'-DIPHENYL HARDENE SUITABLE AS KINASEINHIBITORS
DE102004054216A1 (en) * 2004-11-10 2006-05-11 Merck Patent Gmbh Substituted 4-amino-pyridopyrimidinones
JP5197016B2 (en) 2004-12-23 2013-05-15 デシファラ ファーマスーティカルズ， エルエルシー Enzyme modulators and therapy
US7968574B2 (en) 2004-12-28 2011-06-28 Kinex Pharmaceuticals, Llc Biaryl compositions and methods for modulating a kinase cascade
WO2006071960A2 (en) 2004-12-28 2006-07-06 Kinex Pharmaceuticals, Llc Compositions and methods of treating cell proliferation disorders
KR101335932B1 (en) * 2005-03-07 2013-12-04 바이엘 헬스케어 엘엘씨 Pharmaceutical composition comprising an omega-carboxyaryl substituted diphenyl urea for the treatment of cancer
ES2580108T3 (en) 2005-07-11 2016-08-19 Aerie Pharmaceuticals, Inc Isoquinoline compounds
US7538223B2 (en) * 2005-08-04 2009-05-26 Cytokinetics, Inc. Compounds, compositions and methods
CA2880727C (en) 2005-08-31 2019-05-07 Neil P. Desai Compositions comprising poorly water soluble pharmaceutical agents and antimicrobial agents
KR101643416B1 (en) 2005-08-31 2016-07-27 아브락시스 바이오사이언스, 엘엘씨 Compositions and methods for preparation of poorly water soluble drugs with increased stability
US20070208000A1 (en) * 2005-12-15 2007-09-06 Morgan Bradley P Certain chemical entities, compositions and methods
US20070197505A1 (en) * 2005-12-15 2007-08-23 Morgan Bradley P Certain chemical entities, compositions and methods
US7825120B2 (en) * 2005-12-15 2010-11-02 Cytokinetics, Inc. Certain substituted ((piperazin-1-ylmethyl)benzyl)ureas
TW200808321A (en) * 2005-12-15 2008-02-16 Cytokinetics Inc Certain chemical entities, compositions and methods
EP1959962A2 (en) * 2005-12-16 2008-08-27 Cytokinetics, Inc. Certain chemical entities, compositions, and methods
US7989455B2 (en) * 2005-12-19 2011-08-02 Cytokinetics, Inc. Compounds, compositions and methods
ES2480440T3 (en) * 2005-12-21 2014-07-28 Bayer Intellectual Property Gmbh Substituted pyrimidine derivatives useful in the treatment of cancer and other disorders
TW200804349A (en) * 2005-12-23 2008-01-16 Kalypsys Inc Novel substituted pyrimidinyloxy ureas as inhibitors of protein kinases
MX2008009125A (en) 2006-01-18 2008-10-23 Qps Llc Pharmaceutical compositions with enhanced stability.
US20080045589A1 (en) 2006-05-26 2008-02-21 Susan Kelley Drug Combinations with Substituted Diaryl Ureas for the Treatment of Cancer
US8017129B2 (en) * 2006-06-15 2011-09-13 SciClone Pharmaceuticals International Ltd Use of thymosin alpha 1 for preparing a medicament for the treatment of stage IV malignant melanoma
DE102006029795A1 (en) * 2006-06-27 2008-01-03 Schebo Biotech Ag New urea derivatives and their uses
CN101478989A (en) * 2006-06-28 2009-07-08 Aska制药株式会社 Treatment agent for inflammatory bowel disease
AU2007265373B2 (en) 2006-06-29 2013-02-21 Atnx Spv, Llc Biaryl compositions and methods for modulating a kinase cascade
US8188113B2 (en) 2006-09-14 2012-05-29 Deciphera Pharmaceuticals, Inc. Dihydropyridopyrimidinyl, dihydronaphthyidinyl and related compounds useful as kinase inhibitors for the treatment of proliferative diseases
CA2664335C (en) 2006-09-20 2014-12-02 Boehringer Ingelheim International Gmbh Rho kinase inhibitors
AR062927A1 (en) * 2006-10-11 2008-12-17 Bayer Healthcare Ag 4- [4- ([[4- CHLORINE-3- (TRIFLUOROMETILE) PHENYL) CARBAMOIL] AMINO] -3- FLUOROPHENOXY) -N- METHYLPIRIDIN-2-MONOHIDRATED CARBOXAMIDE
US7939529B2 (en) 2007-05-17 2011-05-10 Kinex Pharmaceuticals, Llc Process for the preparation of compositions for modulating a kinase cascade and methods of use thereof
US7935697B2 (en) 2006-12-28 2011-05-03 Kinex Pharmaceuticals, Llc Compositions for modulating a kinase cascade and methods of use thereof
US8455513B2 (en) * 2007-01-10 2013-06-04 Aerie Pharmaceuticals, Inc. 6-aminoisoquinoline compounds
EP2129376B1 (en) 2007-01-19 2013-07-24 Bayer HealthCare LLC Treatment of cancers with acquired resistance to KIT inhibitors
CN101657203B (en) * 2007-03-02 2012-09-05 卧龙岗大学 Compositions and delivery methods of anticancer drugs
CN101674833A (en) * 2007-03-20 2010-03-17 柯瑞斯公司 Raf kinase inhibitors containing a zinc binding moiety
AU2008242720A1 (en) * 2007-04-20 2008-10-30 Deciphera Pharmaceuticals, Llc Kinase inhibitors useful for the treatment of myleoproliferative diseases and other proliferative diseases
US20110189167A1 (en) * 2007-04-20 2011-08-04 Flynn Daniel L Methods and Compositions for the Treatment of Myeloproliferative Diseases and other Proliferative Diseases
US20080300166A1 (en) * 2007-06-01 2008-12-04 Sciclone Pharmaceuticals, Inc. Treatment of Melanoma with Alpha Thymosin Peptides
MX2010000393A (en) * 2007-11-09 2010-05-19 Rnl Bio Co Ltd Method for isolating and culturing adult stem cells derived from human amniotic epithelium.
US8455514B2 (en) 2008-01-17 2013-06-04 Aerie Pharmaceuticals, Inc. 6-and 7-amino isoquinoline compounds and methods for making and using the same
US8450344B2 (en) 2008-07-25 2013-05-28 Aerie Pharmaceuticals, Inc. Beta- and gamma-amino-isoquinoline amide compounds and substituted benzamide compounds
MY156789A (en) * 2008-09-05 2016-03-31 Celgene Avilomics Res Inc Algorithm for designing irreversible inhibitors
EP2365752B1 (en) * 2008-10-29 2014-09-24 Deciphera Pharmaceuticals, Llc Cyclopropane amides and analogs exhibiting anti-cancer and anti-proliferative activities
ES2834451T3 (en) 2009-05-01 2021-06-17 Aerie Pharmaceuticals Inc Dual Mechanism Inhibitors for Treating Diseases
AU2010253820A1 (en) * 2009-05-28 2011-12-22 President And Fellows Of Harvard College N,N-diarylurea compounds and N,N'-diarylthiourea compounds as inhibitors of translation initiation
IN2012DN02534A (en) 2009-09-16 2015-08-28 Avila Therapeutics Inc
US20110269244A1 (en) 2009-12-30 2011-11-03 Petter Russell C Ligand-directed covalent modification of protein
KR20130012072A (en) 2010-03-31 2013-01-31 액테리온 파마슈티칼 리미티드 Antibacterial isoquinolin-3-ylurea derivatives
AR081060A1 (en) 2010-04-15 2012-06-06 Bayer Schering Pharma Ag PROCEDURE TO PREPARE 4- {4 - [({[4-CHLORINE-3- (TRIFLUOROMETIL) PHENYL] AMINO} CARBONYL) AMINO] -3-FLUOROPHENOXY} -N-METHYLPIRIDIN-2-CARBOXAMIDE
EP2558085B1 (en) 2010-04-16 2017-08-30 Athenex, Inc. Compositions and methods for the prevention and treatment of cancer
US20130183268A1 (en) 2010-07-19 2013-07-18 Bayer Healthcare Llc Drug combinations with fluoro-substituted omega-carboxyaryl diphenyl urea for the treatment and prevention of diseases and conditions
WO2012031118A2 (en) * 2010-09-01 2012-03-08 President And Fellows Of Harvard College Cell permeable inhibitors of anaphase promoting complex
AR088729A1 (en) 2011-03-29 2014-07-02 Actelion Pharmaceuticals Ltd DERIVATIVES OF 3-UREIDOISOQUINOLIN-8-ILO AND A PHARMACEUTICAL COMPOSITION
US8461179B1 (en) 2012-06-07 2013-06-11 Deciphera Pharmaceuticals, Llc Dihydronaphthyridines and related compounds useful as kinase inhibitors for the treatment of proliferative diseases
LT2890680T (en) 2012-08-30 2018-05-10 Athenex, Inc. N-(3-fluorobenzyl)-2-(5-(4-morpholinophenyl)pyridin-2-yl) acetamide as protein tyrosine kinase modulators
EP2976080B1 (en) 2013-03-15 2019-12-25 Aerie Pharmaceuticals, Inc. Conjugates of isoquinoline compounds and prostaglandins
WO2014145386A2 (en) 2013-03-15 2014-09-18 University Of Florida Research Foundation Incorporated Novel allosteric inhibitors of thymidylate synthase
EP3105222B1 (en) 2014-02-14 2018-04-11 Respivert Limited Aromatic heterocyclic compounds as antiinflammatory compounds
US9572788B2 (en) 2014-05-13 2017-02-21 President And Fellows Of Harvard College Cell permeable inhibitors of anaphase promoting complex
WO2016209688A1 (en) 2015-06-24 2016-12-29 University Of Florida Research Foundation, Incorporated Compositions for the treatment of cancer and uses thereof
CN108026035B (en) * 2015-09-02 2021-03-30 陈昆锋 Compounds with protein tyrosine phosphatase SHP-1 agonist activity
US9643927B1 (en) 2015-11-17 2017-05-09 Aerie Pharmaceuticals, Inc. Process for the preparation of kinase inhibitors and intermediates thereof
EP3376870B1 (en) 2015-11-17 2021-08-11 Aerie Pharmaceuticals, Inc. Process for the preparation of kinase inhibitors and intermediates thereof
MX2019002396A (en) 2016-08-31 2019-07-08 Aerie Pharmaceuticals Inc OPHTHALMIC COMPOSITIONS.
JP2020515583A (en) 2017-03-31 2020-05-28 アエリエ ファーマシューティカルズ インコーポレイテッド Aryl cyclopropyl-amino-isoquinolinyl amide compound
SG11202007198WA (en) 2018-01-31 2020-08-28 Deciphera Pharmaceuticals Llc Combination therapy for the treatment of gastrointestinal stromal tumors
EA202091763A1 (en) 2018-01-31 2020-12-14 ДЕСИФЕРА ФАРМАСЬЮТИКАЛЗ, ЭлЭлСи COMBINATION THERAPY FOR TREATMENT OF MASTOCYTOSIS
CN108918713B (en) * 2018-07-18 2021-03-16 香港浸会大学深圳研究院 Ammonium triclosan sulfonate and preparation method and application thereof
AU2019337703B2 (en) 2018-09-14 2023-02-02 Aerie Pharmaceuticals, Inc. Aryl cyclopropyl-amino-isoquinolinyl amide compounds
EP3938363A1 (en) 2019-03-11 2022-01-19 Teva Pharmaceuticals International GmbH Solid state forms of ripretinib
US20230092163A1 (en) * 2019-06-14 2023-03-23 Ifm Due, Inc. Compounds and compositions for treating conditions associated with sting activity
WO2021030405A1 (en) 2019-08-12 2021-02-18 Deciphera Pharmaceuticals, Llc Ripretinib for treating gastrointestinal stromal tumors
JP7818502B2 (en) 2019-08-12 2026-02-20 デシフェラ・ファーマシューティカルズ，エルエルシー Ripretinib for treating gastrointestinal stromal tumors
AU2020417282B2 (en) 2019-12-30 2023-08-31 Deciphera Pharmaceuticals, Llc Compositions of 1-(4-bromo-5-(1-ethyl-7-(methylamino)-2-oxo-1,2-dihydro-1,6-naphthyridin-3-yl)-2-fluorophenyl)-3-phenylurea
SI4084778T1 (en) 2019-12-30 2024-01-31 Deciphera Pharmaceuticals, Llc Amorphous kinase inhibitor formulations and methods of use thereof
EP4274824A1 (en) 2021-01-08 2023-11-15 IFM Due, Inc. Heterobicyclic compounds having an urea or analogue and their compositions for treating conditions associated with sting activity
US11779572B1 (en) 2022-09-02 2023-10-10 Deciphera Pharmaceuticals, Llc Methods of treating gastrointestinal stromal tumors

Family Cites Families (379)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US502504A (en) 1893-08-01 Hermann thoms
GB111554A (en) 1916-12-11 1917-12-06 Centrale D Entpr S Armand D Ri Electro-magnet for Lifting Materials.
DE487014C (en) 1927-10-23 1929-12-09 I G Farbenindustrie Akt Ges Process for the preparation of urea derivatives
US1792156A (en) 1928-01-17 1931-02-10 Gen Aniline Works Inc 5-halogen-2-amino-1-alkyloxy and 1-aralkyloxy-benzenes and intermediate products thereof and process of preparing them
DE511468C (en) 1928-01-18 1930-10-30 I G Farbenindustrie Akt Ges Process for the preparation of 5-chloro-2-amino-1-methoxybenzene
DE523437C (en) 1928-12-25 1931-05-05 I G Farbenindustrie Akt Ges Process for the preparation of 5-chloro- and 5-bromo-2-amino-1-alkyloxy- and 1-aralkyloxybenzenes
US2093265A (en) 1931-03-31 1937-09-14 Ici Ltd Process for the manufacture of diaryl ureas
US2046375A (en) 1931-06-04 1936-07-07 Ici Ltd p-halogen-omicron-alkoxy-aniline derivatives and process of preparing the same
US2288422A (en) 1938-11-11 1942-06-30 Gen Aniline & Film Corp Mixed ureas
US2973386A (en) 1943-01-05 1961-02-28 Harry A Weldon Purification of sym dichloro-bis (2, 4, 6-trichlorophenyl)urea
DE925476C (en) 1950-04-29 1955-03-21 Variapat Ag Process for the preparation of colorless, water-soluble, trifluoromethyl and sulfonic acid groups, aliphatic or aromatic carboxylic acid or sulfonic acid arylides
US2683082A (en) 1950-12-09 1954-07-06 Ethyl Corp Nu-aryl-nu'-(p-hydroxyphenyl) ureas as antioxidants for petroleum hydrocarbon fuels
US2722544A (en) 1950-12-26 1955-11-01 Variapat Ag Trifluoromethyl halogenated diphenylcarbamide sulfonic acids and their preparation
US2781330A (en) 1953-02-09 1957-02-12 Monsanto Chemicals Rubber containing urea compound as an anti-exposure cracking agent
NL185660B (en) 1953-03-06 Great Lakes Chemical Corp PROCESS FOR PREPARING ALKALI OR ALKALINE METAL BROMIDES.
US2745874A (en) 1953-06-18 1956-05-15 Geigy Ag J R Insecticidal derivatives of diphenyl urea
NL193403A (en) 1953-12-22 1924-02-17
GB771333A (en) 1953-12-22 1957-03-27 Geigy Ag J R Improvements relating to halogen substituted diphenyl urea and thiourea compounds and their use
GB828231A (en) 1955-10-20 1960-02-17 Geigy Ag J R Improvements relating to insecticidal compounds and their use
US2877268A (en) 1956-12-24 1959-03-10 Monsanto Chemicals Substituted ureas
US2960488A (en) 1958-04-25 1960-11-15 Eastman Kodak Co Poly-alpha-olefins containing substituted ureas
NL254871A (en) 1959-08-14
NL277504A (en) 1961-04-21
CH479557A (en) 1961-09-11 1969-10-15 Wander Ag Dr A Process for the preparation of new polybasic compounds
US3505057A (en) * 1962-03-22 1970-04-07 Du Pont Method for the control of plants
US3200035A (en) 1962-06-01 1965-08-10 Ciba Ltd Treatment of synthetic products, especially synthetic fibers
US3242761A (en) * 1963-05-27 1966-03-29 Outboard Marine Corp Cable actuating device
US3284433A (en) 1963-07-17 1966-11-08 Merck & Co Inc 4-phenoxy-carbanilides
US3505323A (en) * 1963-12-06 1970-04-07 Du Pont Tetrahydro-s-triazin-2-(1h)-ones and thiones
FR1457172A (en) 1964-12-12 1966-10-28 Ferrania Spa Process for the production of color photographic images and corresponding photographic material
FR90420E (en) 1965-06-09 1968-02-21
US3424761A (en) 1966-03-07 1969-01-28 Robins Co Inc A H 3-ureidopyrrolidines
US3424762A (en) 1966-03-07 1969-01-28 Robins Co Inc A H Certain 3-ureidopyrrolidines
US3424760A (en) 1966-03-07 1969-01-28 Robins Co Inc A H 3-ureidopyrrolidines
US3743498A (en) 1967-10-31 1973-07-03 Du Pont Method of selectively controlling undesirable vegetation
US3547940A (en) 1967-10-31 1970-12-15 Du Pont Substituted ureido isoxazoles
SE370866B (en) 1968-03-21 1974-11-04 Ciba Geigy Ag
DE1768244A1 (en) 1968-04-19 1971-10-14 Bayer Ag N- (2,2,4,4-tetrafluoro-1,3-benz-dioxanyl) ureas and process for their preparation
US3698886A (en) * 1968-06-04 1972-10-17 Monsanto Co 1-(3 - trifluoromethylphenyl) - 4,6-diisopropyl - 3,5 - dimethylhexahydro-1,3,5-triazin-2-one as a herbicide
US3754887A (en) 1969-05-05 1973-08-28 Du Pont Ureidopyrazoles defoliants
US3646059A (en) 1969-05-05 1972-02-29 Du Pont Plant growth regulatory ureidopyrazoles
BE754782A (en) 1969-08-14 1971-02-12 May & Baker Ltd THIOPHENE DERIVATIVES WITH HERBICIDAL ACTION
US3823161A (en) 1970-05-07 1974-07-09 Exxon Research Engineering Co Aminothiophene derivatives
US3666222A (en) 1970-10-28 1972-05-30 Arthur U Griggers Supporting frame for receptacle with anchor therefor
US3860593A (en) * 1972-10-10 1975-01-14 Velsicol Chemical Corp Thiadiazole substituted triazines
DE2221787A1 (en) * 1972-05-04 1973-11-22 Hoechst Ag HEXAHYDROTRIAZINONE DERIVATIVES AND THEIR USE AS A SELECTIVE AGENT FOR WEED CONTROL
US3860645A (en) 1973-05-23 1975-01-14 Givaudan Corp Bacteriostatic substituted carbanilides
US4062861A (en) 1973-07-27 1977-12-13 Shionogi & Co., Ltd. 3-Isoxazolylurea derivatives
US4116671A (en) 1973-07-27 1978-09-26 Shionogi & Co., Ltd. 3-Isoxazolylcarbamate derivatives
US4212981A (en) 1973-07-27 1980-07-15 Shionogi & Co., Ltd. Process for preparing 3-isoxazolylurea derivatives
JPS5031039A (en) 1973-07-27 1975-03-27
US3914224A (en) * 1973-11-12 1975-10-21 Du Pont 1,3,5-S-Triazines
US4001256A (en) 1973-12-26 1977-01-04 The Upjohn Company Pyridylalkyl phenyl ureas and their n-oxides
US3931201A (en) 1974-01-22 1976-01-06 The Dow Chemical Company Substituted pyridinyloxy(thio)phenyl -acetamides, -ureas and urea derivatives
US4009847A (en) 1974-04-17 1977-03-01 E. I. Du Pont De Nemours And Company 1-Tertiary-alkyl-3-(substituted thienyl)ureas and 1-tertiary-alkyl-3-(substituted thietyl)ureas as antihypertensive agents
US3990879A (en) 1974-12-26 1976-11-09 Eli Lilly And Company Method of controlling aquatic weeds
US4111683A (en) 1975-06-27 1978-09-05 Chevron Research Company N-alkyl or alkoxy-N'-substituted hydrocarbyl urea
DE2637947C2 (en) 1976-08-24 1985-09-19 Bayer Ag, 5090 Leverkusen Tetrafluoro-1,3-benzodioxanyl-benzoylureas, process for their preparation and their use as insecticides
US4173637A (en) 1976-10-29 1979-11-06 Ishihara Sangyo Kaisha Ltd. N-Benzoyl-N'-pyridyloxy phenyl urea and insecticidal compositions thereof
JPS5840946B2 (en) 1976-10-29 1983-09-08 石原産業株式会社 N-benzoyl-N'-pyridyloxyphenylurea compounds, methods for producing them, and insecticides containing them
US4071524A (en) 1976-11-08 1978-01-31 Riker Laboratories, Inc. Derivatives of urea
US4183854A (en) 1976-11-10 1980-01-15 John Wyeth & Brother Limited Thiazole compound
US4042372A (en) 1976-11-19 1977-08-16 Eli Lilly And Company Substituted thiadiazolotriazinediones and method of preparation
US4152516A (en) * 1978-02-09 1979-05-01 Ppg Industries, Inc. 1-(3-Alkyl- or -alkaryl-4-H-alkyl- or -aryl-5-isothiazolyl)-2-oxo-3,5-dimethylhexahydro-1,3,5-triazines
DE2817449A1 (en) 1978-04-21 1979-10-31 Bayer Ag MEANS OF REGULATING PLANT GROWTH
GB1590870A (en) 1978-05-31 1981-06-10 Shionogi & Co N-(5-t-butyl-3-isoxazolyl) alkanamide derivatives having herbicidal activity
JPS5562066A (en) 1978-11-03 1980-05-10 Toshihiko Okamoto N-(2-substituted-4-pyridyl)-urea and thio urea, their preparation and plant growth regulator
DE2848330A1 (en) 1978-11-03 1980-05-14 Schering Ag METHOD FOR PRODUCING 1,2,3-THIADIAZOL-5-YL UREA
FI800559A7 (en) 1979-03-14 1981-01-01 F Hoffmann La Roche & Co Urea derivatives.
JPS55124763A (en) 1979-03-19 1980-09-26 Ishihara Sangyo Kaisha Ltd 5-trifluoromethyl-2-pyridone derivative
DE2928485A1 (en) 1979-07-14 1981-01-29 Bayer Ag USE OF UREA DERIVATIVES AS A MEDICINAL PRODUCT IN THE TREATMENT OF FATTY METABOLISM DISORDERS
US4468380A (en) 1979-12-26 1984-08-28 Eli Lilly And Company Anticoccidial combinations comprising polyether antibiotics and carbanilides
CH649078A5 (en) 1980-01-25 1985-04-30 Reanal Finomvegyszergyar METHOD FOR PRODUCING N-MONO- OR DISUBSTITUTED N-ARYL-UREA DERIVATIVES.
EP0057797B1 (en) 1981-02-03 1986-06-25 Imperial Chemical Industries Plc Process for the extraction of metal values and novel metal extractants
US4526997A (en) 1981-05-06 1985-07-02 Doherty George O P O Anticoccidial combinations comprising polyether antibiotics and carbanilides
US4511571A (en) 1981-10-20 1985-04-16 Ciba Geigy Corporation N-(2-Pyridyloxyphenyl)-N'-benzoyl ureas, pesticidal compositions containing same and pesticidal methods of use
US4623662A (en) 1985-05-23 1986-11-18 American Cyanamid Company Antiatherosclerotic ureas and thioureas
US4473579A (en) 1982-01-26 1984-09-25 American Cyanamid Company Antiatherosclerotic tetrasubstituted ureas and thioureas
DE3211851A1 (en) 1982-03-31 1983-10-06 Basf Ag DIHYDROTHIOPHENE-CARBONESTER, METHOD FOR THE PRODUCTION THEREOF AND THEIR USE FOR CONTROLLING UNWANTED PLANT GROWTH
JPS58203957A (en) 1982-05-25 1983-11-28 Ube Ind Ltd Preparation of urea derivative
IL69621A0 (en) 1982-09-02 1983-12-30 Duphar Int Res Pharmaceutical compositions having antitumor activity,comprising certain phenylurea derivatives
CA1254212A (en) 1982-11-12 1989-05-16 Shiro Hirai Amine derivatives, salts thereof, process for preparing the same and an anti-ulcer agent containing the same
DE3305866A1 (en) 1983-02-19 1984-08-23 Basf Ag, 6700 Ludwigshafen THIOPHEN-CARBONESTER, METHOD FOR THE PRODUCTION THEREOF AND THEIR USE FOR CONTROLLING UNWANTED PLANT GROWTH
US4499097A (en) 1983-03-10 1985-02-12 American Cyanamid Company 2-(Pyridyl)imidazolyl ketones
GB8325496D0 (en) 1983-09-23 1983-10-26 Hider R C Pharmaceutical compositions
JPS6183A (en) * 1984-02-03 1986-01-06 Kureha Chem Ind Co Ltd Tetrahydrobenzothiazolyl-1,3,5-triazinone derivative and herbicide containing said derivative
US4540566A (en) 1984-04-02 1985-09-10 Forest Laboratories, Inc. Prolonged release drug dosage forms based on modified low viscosity grade hydroxypropylmethylcellulose
US4727077A (en) 1985-02-20 1988-02-23 Ishihara Sangyo Kaisha Ltd. Benzoyl urea compounds, process for their production, and antitumorous compositions containing them
DE3529247A1 (en) 1985-05-17 1986-11-20 Bayer Ag, 5090 Leverkusen USE OF THIENYL UREAS AND ISOHARNS AS AN PERFORMANCE DRIVER IN ANIMALS, NEW THIENYL URINS AND ISOHARNS AND THEIR PRODUCTION
US4767858A (en) * 1985-06-06 1988-08-30 Biomeasure, Incorporated Anti-arthritic pyrazolo-triazine derivatives
US4734414A (en) * 1985-06-06 1988-03-29 Biomeasure, Inc. Anti-inflammatory and anti-arthritic pyrazolo-[1,5-a]-1,3,5-triazine derivatives, compositions, and method of use therefor
EP0222566A3 (en) 1985-11-08 1988-07-13 Sumitomo Chemical Company, Limited Stabilised polyolefin composition
DE3540377A1 (en) 1985-11-14 1987-05-21 Bayer Ag THIENOOXAZINONE, METHOD FOR THE PRODUCTION THEREOF AND THEIR USE AS A PERFORMANCE PROVIDER
DE3541631A1 (en) 1985-11-26 1987-05-27 Bayer Ag SELECTIVE-FUNGICIDAL USE OF THIENYL URINE DERIVATIVES
AU594098B2 (en) 1985-12-11 1990-03-01 Ishihara Sangyo Kaisha Ltd. N-benzoyl urea compounds, antitumorous compositions containing them, and process for their preparation
EP0230400A3 (en) 1986-01-21 1990-02-14 Ciba-Geigy Ag N-3-(5-trifluoromethyl-pyridyl-2-oxy)phenyl-n'-benzoylureas for combating helminths in livestock
JPS62185013A (en) 1986-02-08 1987-08-13 Green Cross Corp:The Easily absorbable pharmaceutical composition
DE3612830A1 (en) 1986-04-16 1987-10-22 Basf Ag THIADIAZOLYL URINE CONTAINING AGENT FOR DEBELING PLANTS
EP0255297B1 (en) 1986-07-31 1993-04-21 Beecham Group Plc Azabicyclic compounds, process for their preparation, and their pharmaceutical use
NZ221964A (en) 1986-10-03 1990-03-27 Ishihara Sangyo Kaisha Benzoylurea compounds and insecticidal compositions
EP0264904A3 (en) 1986-10-23 1988-08-17 Ishihara Sangyo Kaisha, Ltd. Pharmaceutical compositions containing benzoyl urea derivatives
DE3636190A1 (en) 1986-10-24 1988-04-28 Bayer Ag METHOD FOR PRODUCING N, N-DIARYL UREAS
DD253997A1 (en) 1986-11-26 1988-02-10 Karl Marx Uni Buero Fuer Neuer PROCESS FOR PREPARING SUBSTITUTED 2-ARYLUREIDOPHENOLES
EP0278610A3 (en) * 1987-02-13 1990-03-14 Sumitomo Chemical Company, Limited Novel pyridinyl-s-triazine derivatives, method for production thereof and a fungicide containing them as the active ingredient
JPH06100808B2 (en) 1987-05-28 1994-12-12 富士写真フイルム株式会社 Processing method of silver halide color photographic light-sensitive material
ES2070861T3 (en) 1987-10-16 1995-06-16 Ciba Geigy Ag ANTIPARASITIC COMPOUNDS.
DE3810382A1 (en) 1988-03-26 1989-10-12 Bayer Ag 5-AMINO-1-PHENYLPYRAZOLE, METHOD AND 5-HALOGEN-1-PHENYLPYRAZOLE AS INTERMEDIATE PRODUCTS FOR THE PRODUCTION THEREOF AND THEIR USE AS HERBICIDES
JPH0278699A (en) 1988-09-12 1990-03-19 Green Cross Corp:The Benzoylurea compound-albumin complex
FR2639636B1 (en) 1988-11-30 1994-03-04 Novapharme NOVEL HETEROCYCLIC COMPOUNDS WITH ANTICONVULSIVE ACTIVITY, PREPARATION METHOD AND THERAPEUTIC COMPOSITIONS CONTAINING THEM
FR2662692B1 (en) 1990-05-30 1995-04-28 Novapharme HETEROCYCLIC DERIVATIVES WITH ANTICONVULSIVE ACTIVITY, PREPARATION METHOD AND PHARMACEUTICAL COMPOSITION.
JPH02196719A (en) 1989-01-24 1990-08-03 Green Cross Corp:The Powdery drug composition
JPH02237922A (en) 1989-01-24 1990-09-20 Green Cross Corp:The Antiviral agent
EP0379915A1 (en) 1989-01-26 1990-08-01 Bayer Ag Substituted phenoxybenzonitrile derivatives, processes for their preparation and their use as herbicides and plant growth regulators
JP3002204B2 (en) 1989-03-13 2000-01-24 株式会社東芝 Time-series signal recognition device
US4973675A (en) 1989-04-13 1990-11-27 University Of Tennessee Research Center Hybrid nitrosoureidoanthracyclines having antitumor activity
JPH0395153A (en) 1989-06-15 1991-04-19 Mitsubishi Kasei Corp Diphenyl urea derivative
US5096907A (en) 1989-06-29 1992-03-17 American Cyanamid Company Antibiotic LL-E19085
US5665543A (en) 1989-07-18 1997-09-09 Oncogene Science, Inc. Method of discovering chemicals capable of functioning as gene expression modulators
IL95860A0 (en) 1989-10-13 1991-07-18 Ciba Geigy Ag Thienylthioureas,-isothioureas and-carbodiimides
EP0425443A1 (en) 1989-10-27 1991-05-02 Ciba-Geigy Ag Injectable antiparasitic agent
US5177110A (en) 1989-10-27 1993-01-05 Ciba-Geigy Corporation Injectable parasiticidal composition
CN1034934C (en) 1990-06-19 1997-05-21 明治制果株式会社 Pyridine derivatives having angiotensin II antagonism
EP0525197B1 (en) 1991-01-21 1997-08-27 Shionogi Seiyaku Kabushiki Kaisha 3-benzylidene-1-carbamoyl-2-pyrrolidone analogs
JP2671693B2 (en) 1991-03-04 1997-10-29 松下電器産業株式会社 Biosensor and manufacturing method thereof
US5120842A (en) 1991-04-01 1992-06-09 American Home Products Corporation Silyl ethers of rapamycin
US5185438A (en) 1991-04-02 1993-02-09 The Trustees Of Princeton University Nucleic acids encoding hencatoporetic stem cell receptor flk-2
US5270458A (en) 1991-04-02 1993-12-14 The Trustees Of Princeton University Nucleic acids encoding fragments of hematopoietic stem cell receptor flk-2
US5100883A (en) 1991-04-08 1992-03-31 American Home Products Corporation Fluorinated esters of rapamycin
NO921449L (en) 1991-04-17 1992-10-19 American Home Prod CARBAMATES OF RAPAMYCIN
US5118678A (en) 1991-04-17 1992-06-02 American Home Products Corporation Carbamates of rapamycin
US5721237A (en) 1991-05-10 1998-02-24 Rhone-Poulenc Rorer Pharmaceuticals Inc. Protein tyrosine kinase aryl and heteroaryl quinazoline compounds having selective inhibition of HER-2 autophosphorylation properties
US5118677A (en) 1991-05-20 1992-06-02 American Home Products Corporation Amide esters of rapamycin
US5162360A (en) 1991-06-24 1992-11-10 Warner-Lambert Company 2-heteroatom containing urea and thiourea ACAT inhibitors
US5185358A (en) 1991-06-24 1993-02-09 Warner-Lambert Co. 3-heteroatom containing urea and thiourea ACAT inhibitors
WO1993004170A1 (en) 1991-08-23 1993-03-04 The United States Of America Represented By The Secretary, Department Of Health And Human Services Raf protein kinase therapeutics
DE4128789A1 (en) * 1991-08-30 1993-03-04 Bayer Ag SUBSTITUTED PYRIDYLTRIAZINE, METHOD FOR THE PRODUCTION THEREOF, THEIR USE AND NEW INTERMEDIATE PRODUCTS
US5151413A (en) 1991-11-06 1992-09-29 American Home Products Corporation Rapamycin acetals as immunosuppressant and antifungal agents
US5508288A (en) 1992-03-12 1996-04-16 Smithkline Beecham, P.L.C. Indole derivatives as 5HT1C antagonists
US5312820A (en) 1992-07-17 1994-05-17 Merck & Co., Inc. Substituted carbamoyl and oxycarbonyl derivatives of biphenylmethylamines
US5256790A (en) 1992-08-13 1993-10-26 American Home Products Corporation 27-hydroxyrapamycin and derivatives thereof
JP2717481B2 (en) 1992-08-25 1998-02-18 富士写真フイルム株式会社 Silver halide color photographic materials
US5258389A (en) 1992-11-09 1993-11-02 Merck & Co., Inc. O-aryl, O-alkyl, O-alkenyl and O-alkynylrapamycin derivatives
US6177401B1 (en) 1992-11-13 2001-01-23 Max-Planck-Gesellschaft Zur Forderung Der Wissenschaften Use of organic compounds for the inhibition of Flk-1 mediated vasculogenesis and angiogenesis
US5512473A (en) 1993-01-29 1996-04-30 Brent; Roger Max-interacting proteins and related molecules and methods
TW272942B (en) 1993-02-10 1996-03-21 Takeda Pharm Industry Co Ltd
DK41193D0 (en) 1993-04-07 1993-04-07 Neurosearch As ion channel openers
DE4322806A1 (en) 1993-07-08 1995-01-12 Janich Gmbh & Co Device for sealing between two parts of the system
US5378725A (en) 1993-07-19 1995-01-03 The Arizona Board Of Regents Inhibition of phosphatidylinositol 3-kinase with wortmannin and analogs thereof
US6514745B1 (en) 1993-07-19 2003-02-04 The Regents Of The University Of California Oncoprotein protein kinase
NZ264063A (en) 1993-08-13 1995-11-27 Nihon Nohyaku Co Ltd N-(2-phenylpyrid-3-yl)- and n-(4-phenylpyrimidin-5-yl)-n'-phenylurea derivatives and pharmaceutical compositions
US5468773A (en) 1993-08-25 1995-11-21 Eli Lilly And Company Methods for inhibiting bone loss and cartilage degradation using wortmannin and its analogs
US5441947A (en) 1993-08-25 1995-08-15 Eli Lilly And Company Methods of inhibiting vascular restenosis
US6361773B1 (en) 1993-09-17 2002-03-26 Smithkline Beecham Corporation Antibodies produced against cytokine suppressive anti-inflammatory drug binding proteins
US5783664A (en) 1993-09-17 1998-07-21 Smithkline Beecham Corporation Cytokine suppressive anit-inflammatory drug binding proteins
ATE186551T1 (en) 1993-09-17 1999-11-15 Smithkline Beecham Corp DRUG BINDING PROTEIN
US5869043A (en) 1993-09-17 1999-02-09 Smithkline Beecham Corporation Drug binding protein
US5547966A (en) 1993-10-07 1996-08-20 Bristol-Myers Squibb Company Aryl urea and related compounds
CA2133815A1 (en) 1993-10-12 1995-04-13 Jeffrey Alan Dodge Inhibition of phosphatidylinositol 3-kinase with viridin, demethoxyviridin, viridiol, demethoxyviridiol, virone, wortmannolone, and analogs thereof
US5596001A (en) 1993-10-25 1997-01-21 Pfizer Inc. 4-aryl-3-(heteroarylureido)quinoline derivatves
JPH07141053A (en) 1993-11-17 1995-06-02 Nec Niigata Ltd Clock generating circuit
CH686211A5 (en) 1994-01-27 1996-02-15 Ciba Geigy Ag Moth and Koferschutzmittel.
US6524832B1 (en) 1994-02-04 2003-02-25 Arch Development Corporation DNA damaging agents in combination with tyrosine kinase inhibitors
DE4412334A1 (en) 1994-04-11 1995-10-19 Hoechst Ag Substituted N-heteroaroylguanidines, process for their preparation, their use as a medicament or diagnostic agent, and medicament containing them
US5559137A (en) 1994-05-16 1996-09-24 Smithkline Beecham Corp. Compounds
US5744362A (en) 1994-05-31 1998-04-28 Isis Pharmaceuticals, Inc. Antisense oligonucleotide modulation of raf gene expression
US5656612A (en) 1994-05-31 1997-08-12 Isis Pharmaceuticals, Inc. Antisense oligonucleotide modulation of raf gene expression
US5470882A (en) 1994-06-02 1995-11-28 Smithkline Beecham Corp. Anti-inflammatory compounds
US5447957A (en) 1994-06-02 1995-09-05 Smithkline Beecham Corp. Anti-inflammatory compounds
US5786362A (en) 1994-06-16 1998-07-28 University Of Miami Method of treating Hormone independent cancer
EP0690344A1 (en) 1994-06-29 1996-01-03 Konica Corporation Silver halide color photographic light-sensitive material
US5480906A (en) 1994-07-01 1996-01-02 Eli Lilly And Company Stereochemical Wortmannin derivatives
FR2722319B1 (en) 1994-07-08 1996-08-14 Thomson Csf COLOR DISPLAY DEVICE
US5597719A (en) 1994-07-14 1997-01-28 Onyx Pharmaceuticals, Inc. Interaction of RAF-1 and 14-3-3 proteins
DK0708085T3 (en) 1994-10-19 2002-11-11 Novartis Ag Antiviral ethers of aspartate protease substrate isosters
CA2161376C (en) 1994-10-27 2005-01-11 Toshiaki Minami Reversible multi-color thermal recording medium
JP3591938B2 (en) 1994-10-27 2004-11-24 キヤノン株式会社 Ink jet recording medium and image forming method using the same
TW313568B (en) 1994-12-20 1997-08-21 Hoffmann La Roche
US5780483A (en) 1995-02-17 1998-07-14 Smithkline Beecham Corporation IL-8 receptor antagonists
EP0809492A4 (en) 1995-02-17 2007-01-24 Smithkline Beecham Corp Il-8 receptor antagonists
US5814646A (en) 1995-03-02 1998-09-29 Eli Lilly And Company Inhibitors of amyloid beta-protein production
US5624937A (en) 1995-03-02 1997-04-29 Eli Lilly And Company Chemical compounds as inhibitors of amyloid beta protein production
DE19512639A1 (en) 1995-04-05 1996-10-10 Merck Patent Gmbh Benzonitriles and fluorides
JP3198049B2 (en) 1995-05-31 2001-08-13 平田 政弘 Rectification type constant flow water saving valve device
US5747498A (en) 1996-05-28 1998-05-05 Pfizer Inc. Alkynyl and azido-substituted 4-anilinoquinazolines
US5658903A (en) 1995-06-07 1997-08-19 Smithkline Beecham Corporation Imidazole compounds, compositions and use
US5773459A (en) 1995-06-07 1998-06-30 Sugen, Inc. Urea- and thiourea-type compounds
HUP9602538A3 (en) 1995-09-18 1997-08-28 Sankyo Co New urea and amide derivatives having acat inhibitory activity, their preparation and their use
WO1997017329A1 (en) 1995-11-07 1997-05-15 Kirin Beer Kabushiki Kaisha Quinoline derivatives and quinazoline derivatives inhibiting autophosphorylation of growth factor receptor originating in platelet and pharmaceutical compositions containing the same
EP0882715B1 (en) 1995-12-28 2003-04-23 Kureha Kagaku Kogyo Kabushiki Kaisha Novel n-(unsubstituted or substituted)-4-substituted-6-(unsubstituted or substituted)phenoxy-2-pyridinecarboxamides or thiocarboxamides, processes for producing the same, and herbicides
US5807876A (en) 1996-04-23 1998-09-15 Vertex Pharmaceuticals Incorporated Inhibitors of IMPDH enzyme
US6005008A (en) 1996-02-16 1999-12-21 Smithkline Beecham Corporation IL-8 receptor antagonists
US6103692A (en) 1996-03-12 2000-08-15 The General Hospital Corporation Inhibiting protein interactions
US6262113B1 (en) 1996-03-20 2001-07-17 Smithkline Beecham Corporation IL-8 receptor antagonists
US6211373B1 (en) 1996-03-20 2001-04-03 Smithkline Beecham Corporation Phenyl urea antagonists of the IL-8 receptor
CA2202578A1 (en) 1996-04-15 1997-10-15 Mitsuru Shiraishi Hydroxypyridine derivatives, their production and use
JPH09301858A (en) 1996-05-13 1997-11-25 Senju Pharmaceut Co Ltd Chlorhexidine gluconate stabilized aqueous drug
US5910417A (en) 1996-05-31 1999-06-08 National Jewish Center For Immunology And Respiratory Medicine Regulation of cytokine production in a hematopoietic cell
JP2000513360A (en) 1996-06-27 2000-10-10 スミスクライン・ビーチャム・コーポレイション IL-8 receptor antagonist
CZ425598A3 (en) 1996-06-27 1999-08-11 Smithkline Beecham Corporation IL-8 receptor antagonist
KR20000022273A (en) 1996-06-27 2000-04-25 스튜어트 알. 수터, 스티븐 베네티아너, 피터 존 기딩스 Il-8 receptor antagonists
US5861419A (en) * 1996-07-18 1999-01-19 Merck Frosst Canad, Inc. Substituted pyridines as selective cyclooxygenase-2 inhibitors
US6150415A (en) 1996-08-13 2000-11-21 The Regents Of The University Of California Epoxide hydrolase complexes and methods therewith
US5808080A (en) 1996-09-05 1998-09-15 Eli Lilly And Company Selective β3 adrenergic agonists
US5965573A (en) 1996-10-23 1999-10-12 Zymogenetics, Inc. Compositions and methods for treating bone deficit conditions
JP2001503775A (en) 1996-11-15 2001-03-21 ザ ピコワー インスティテュート フォー メディカル リサーチ Guanylhydrazone useful for treating diseases associated with T cell activation
FR2755967B1 (en) 1996-11-21 1999-01-29 Pf Medicament PYRIDIN-2-YL-METHYLAMINE DERIVATIVES, THEIR PREPARATION PROCESS AND THEIR APPLICATION AS MEDICAMENTS
US5929250A (en) 1997-01-23 1999-07-27 Smithkline Beecham Corporation IL-8 receptor antagonists
TR199902432T2 (en) 1997-04-04 2000-01-21 Prizer Products Inc. Nicotinamide is highly valued.
US20020111495A1 (en) 1997-04-04 2002-08-15 Pfizer Inc. Nicotinamide acids, amides, and their mimetics active as inhibitors of PDE4 isozymes
DK0973735T3 (en) 1997-04-10 2003-06-23 Upjohn Co Polyaromatic antiviral preparations
AU7080298A (en) * 1997-04-25 1998-11-24 Takeda Chemical Industries Ltd. Triazine derivatives, their production and agrochemical composition
US6210710B1 (en) 1997-04-28 2001-04-03 Hercules Incorporated Sustained release polymer blend for pharmaceutical applications
AR012634A1 (en) 1997-05-02 2000-11-08 Sugen Inc QUINAZOLINE BASED COMPOUND, FAMACEUTICAL COMPOSITION THAT UNDERSTANDS IT, METHOD TO SYNTHESIZE IT, ITS USE, METHODS OF MODULATION OF THE DESERINE / TREONIN PROTEIN-KINASE FUNCTION AND IN VITRO METHOD TO IDENTIFY COMPOUNDS THAT MODULATE
US6316479B1 (en) 1997-05-19 2001-11-13 Sugen, Inc. Isoxazole-4-carboxamide compounds active against protein tryosine kinase related disorders
US6514977B1 (en) 1997-05-22 2003-02-04 G.D. Searle & Company Substituted pyrazoles as p38 kinase inhibitors
US6344476B1 (en) 1997-05-23 2002-02-05 Bayer Corporation Inhibition of p38 kinase activity by aryl ureas
US6187799B1 (en) 1997-05-23 2001-02-13 Onyx Pharmaceuticals Inhibition of raf kinase activity using aryl ureas
US6150395A (en) 1997-05-30 2000-11-21 The Regents Of The University Of California Indole-3-carbinol (I3C) derivatives and methods
US5985592A (en) 1997-06-05 1999-11-16 Dalhousie University Uses for pentoxifylline or functional derivatives/metabolites thereof
US6294350B1 (en) 1997-06-05 2001-09-25 Dalhousie University Methods for treating fibroproliferative diseases
US6093742A (en) 1997-06-27 2000-07-25 Vertex Pharmaceuticals, Inc. Inhibitors of p38
CA2294076A1 (en) 1997-06-27 1999-01-07 Kureha Kagaku Kogyo Kabushiki Kaisha 6-phenoxypicolinic acid, alkylidenehydrazide derivatives, process for producing the same, and herbicide
US6525065B1 (en) 1997-06-30 2003-02-25 Targacept, Inc. Pharmaceutical compositions and methods for effecting dopamine release
UA71555C2 (en) 1997-10-06 2004-12-15 Zentaris Gmbh Methods for modulating function of serine/threonine protein kinases by 5-azaquinoline derivatives
DE69835688T2 (en) 1997-10-31 2007-10-04 Aventis Pharma Ltd., West Malling SUBSTITUTED ANILIDES
EP1028953A1 (en) 1997-11-03 2000-08-23 Boehringer Ingelheim Pharmaceuticals Inc. Aromatic heterocyclic compounds as anti-inflammatory agents
US6022884A (en) 1997-11-07 2000-02-08 Amgen Inc. Substituted pyridine compounds and methods of use
WO1999026657A1 (en) 1997-11-25 1999-06-03 Musc Foundation For Research Development Inhibitors of nitric oxide synthase
US6635421B1 (en) 1997-12-09 2003-10-21 Children's Medical Center Corporation Neuropilins and use thereof in methods for diagnosis and prognosis of cancer
SK282727B6 (en) 1997-12-19 2002-11-06 Slovakofarma, A. S. 1,3-Disubstituted ureas - ACAT inhibitors and method of preparing
US6174901B1 (en) 1998-12-18 2001-01-16 Amgen Inc. Substituted pyridine and pyridazine compounds and methods of use
US7517880B2 (en) 1997-12-22 2009-04-14 Bayer Pharmaceuticals Corporation Inhibition of p38 kinase using symmetrical and unsymmetrical diphenyl ureas
US20070244120A1 (en) 2000-08-18 2007-10-18 Jacques Dumas Inhibition of raf kinase using substituted heterocyclic ureas
US20080300281A1 (en) 1997-12-22 2008-12-04 Jacques Dumas Inhibition of p38 Kinase Activity Using Aryl and Heteroaryl Substituted Heterocyclic Ureas
EP1047418B1 (en) 1997-12-22 2005-07-27 Bayer Pharmaceuticals Corp. Inhibition of raf kinase using substituted heterocyclic ureas
DE69834842T2 (en) 1997-12-22 2007-05-10 Bayer Pharmaceuticals Corp., West Haven INHIBITION OF RAF-KINASE USING ARYL AND HETEROARYL SUBSTITUTED HETEROCYCLIC UREA
US7329670B1 (en) 1997-12-22 2008-02-12 Bayer Pharmaceuticals Corporation Inhibition of RAF kinase using aryl and heteroaryl substituted heterocyclic ureas
US6221913B1 (en) 1998-01-21 2001-04-24 Zymogenetics, Inc. Dialkyl ureas as calcitonin mimetics
FR2774824B1 (en) 1998-02-09 2000-04-28 Moving Magnet Tech IMPROVED LINEAR ACTUATOR
WO1999042821A2 (en) 1998-02-18 1999-08-26 Theryte Limited Treating cancer
US6413773B1 (en) 1998-06-01 2002-07-02 The Regents Of The University Of California Phosphatidylinositol 3-kinase inhibitors as stimulators of endocrine differentiation
UA60365C2 (en) 1998-06-04 2003-10-15 Пфайзер Продактс Інк. Isothiazole derivatives, a method for preparing thereof, a pharmaceutical composition and a method for treatment of hyperproliferative disease of mammal
US6667340B1 (en) 1998-06-26 2003-12-23 Arizona Board Of Regents On Behalf Of The University Of Arizona Inhibitors of phosphatidyl myo-inositol cycle
US6352977B1 (en) 1998-07-13 2002-03-05 Aventis Pharma Limited Substituted β-alanines
US6383734B1 (en) 1998-09-30 2002-05-07 Advanced Research And Technology Institute, Inc. Method to determine inhibition of PAK3 activation of Raf-1
DE19846687C2 (en) * 1998-10-09 2001-07-26 Auer Dorothee Auxiliary surgical device for use in performing medical procedures and methods for generating an image in the context of medical procedures
JP3144634B2 (en) 1998-10-09 2001-03-12 日本電気株式会社 Light emitting and receiving device for infrared communication and method of manufacturing the same
US6130053A (en) 1999-08-03 2000-10-10 Cell Pathways, Inc. Method for selecting compounds for inhibition of neoplastic lesions
US6114517A (en) 1998-12-10 2000-09-05 Isis Pharmaceuticals Inc. Methods of modulating tumor necrosis factor α-induced expression of cell adhesion molecules
UY25842A1 (en) 1998-12-16 2001-04-30 Smithkline Beecham Corp IL-8 RECEPTOR ANTAGONISTS
US6331541B1 (en) 1998-12-18 2001-12-18 Soo S. Ko N-ureidoalkyl-piperidines as modulators of chemokine receptor activity
US6147107A (en) 1998-12-20 2000-11-14 Virginia Commonwealth University Specific inhibition of the P42/44 mitogen activated protein (map) kinase cascade sensitizes tumor cells
US20080269265A1 (en) 1998-12-22 2008-10-30 Scott Miller Inhibition Of Raf Kinase Using Symmetrical And Unsymmetrical Substituted Diphenyl Ureas
WO2000039116A1 (en) 1998-12-25 2000-07-06 Teikoku Hormone Mfg. Co., Ltd. Aminopyrazole derivatives
US20020065296A1 (en) 1999-01-13 2002-05-30 Bayer Corporation Heteroaryl ureas containing nitrogen hetero-atoms as p38 kinase inhibitors
US8124630B2 (en) 1999-01-13 2012-02-28 Bayer Healthcare Llc ω-carboxyaryl substituted diphenyl ureas as raf kinase inhibitors
EP1140840B1 (en) 1999-01-13 2006-03-22 Bayer Pharmaceuticals Corp. -g(v)-carboxyaryl substituted diphenyl ureas as raf kinase inhibitors
US7928239B2 (en) 1999-01-13 2011-04-19 Bayer Healthcare Llc Inhibition of RAF kinase using quinolyl, isoquinolyl or pyridyl ureas
ATE538794T1 (en) 1999-01-13 2012-01-15 Bayer Healthcare Llc GAMMA CARBOXYARYL SUBSTITUTED DIPHENYL UREA COMPOUNDS AS P38 KINASE INHIBITORS
RU2319693C9 (en) 1999-01-13 2008-08-20 Байер Копэрейшн Derivatives of urea (variants), pharmaceutical composition (variants) and method for treatment of diseases associated with cancer cells growth (variants)
TWI284642B (en) * 1999-01-18 2007-08-01 Hoffmann La Roche Novel heterocyclic sulfonamides
UA73492C2 (en) 1999-01-19 2005-08-15 Aromatic heterocyclic compounds as antiinflammatory agents
JP3519368B2 (en) 1999-01-22 2004-04-12 麒麟麦酒株式会社 Quinoline derivatives and quinazoline derivatives
DE60023853T2 (en) 1999-03-12 2006-05-24 Boehringer Ingelheim Pharmaceuticals, Inc., Ridgefield AROMATIC HETEROCYCLIC COMPOUNDS OF ANTI-INFLAMMATORY ACTIVE SUBSTANCES
PL350357A1 (en) 1999-03-12 2002-12-02 Boehringer Ingelheim Pharma Heterocyclic urea and related compounds useful as anti−inflammatory agents
UA72244C2 (en) 1999-03-26 2005-02-15 Aryl-substituted pyrazols, imidazols, oxazols, thiazols, pyrrols and their use
US6140124A (en) 1999-04-06 2000-10-31 Isis Pharmaceuticals Inc. Antisense modulation of P38 mitogen activated protein kinase expression
US6316462B1 (en) 1999-04-09 2001-11-13 Schering Corporation Methods of inducing cancer cell death and tumor regression
DE60009480T2 (en) 1999-05-05 2005-09-01 Aventis Pharma Ltd., West Malling UREAES AS MODULATORS OF CELL ADHESION
HK1047236A1 (en) 1999-05-14 2003-02-14 Imclone Llc Treatment of refractory human tumors with epidermal growth factor receptor antagonists
DE19927835A1 (en) 1999-06-18 2000-12-21 Clariant Gmbh Use of improved cyan pigments in electrophotographic toners and developers, powder coatings and ink jet inks
EP1200411B1 (en) 1999-07-09 2005-12-14 Boehringer Ingelheim Pharmaceuticals Inc. Process for synthesis of heteroaryl-substituted urea compounds
US6958333B1 (en) 1999-07-26 2005-10-25 Banyu Pharmaceutical Co., Ltd. Biarylurea derivatives
US6387900B1 (en) 1999-08-12 2002-05-14 Pharmacia & Upjohn S.P.A. 3(5)-ureido-pyrazole derivatives process for their preparation and their use as antitumor agents
US6372933B1 (en) 1999-08-26 2002-04-16 Smithkline Beecham Corporation Process for preparing certain phenyl urea compounds
US6794393B1 (en) 1999-10-19 2004-09-21 Merck & Co., Inc. Tyrosine kinase inhibitors
JP4955171B2 (en) * 1999-11-16 2012-06-20 ベーリンガー インゲルハイム ファーマシューティカルズ インコーポレイテッド Urea derivatives as anti-inflammatory agents
PL356848A1 (en) * 1999-12-24 2004-07-12 Bayer Aktiengesellschaft Novel imidazo[1,3,5]triazinones and the use thereof
US6525046B1 (en) 2000-01-18 2003-02-25 Boehringer Ingelheim Pharmaceuticals, Inc. Aromatic heterocyclic compounds as antiinflammatory agents
JP2003521543A (en) 2000-02-07 2003-07-15 アボット ゲーエムベーハー ウント カンパニー カーゲー 2-benzothiazolyl urea derivatives and their use as protein kinase inhibitors
US6608052B2 (en) 2000-02-16 2003-08-19 Boehringer Ingelheim Pharmaceuticals, Inc. Compounds useful as anti-inflammatory agents
JP2003525248A (en) 2000-03-02 2003-08-26 ルードヴィッヒ インスティテュート フォー キャンサー リサーチ Method for treating, screening and detecting cancer expressing vascular endothelial growth factor D
US6667300B2 (en) 2000-04-25 2003-12-23 Icos Corporation Inhibitors of human phosphatidylinositol 3-kinase delta
US6403588B1 (en) 2000-04-27 2002-06-11 Yamanouchi Pharmaceutical Co., Ltd. Imidazopyridine derivatives
EP1355933A2 (en) 2000-08-04 2003-10-29 Loma Linda University Medical Center Iron regulating protein-2 (irp-2) as a diagnostic for neurodegenerative diseases
US20020173507A1 (en) 2000-08-15 2002-11-21 Vincent Santora Urea compounds and methods of uses
WO2002014338A1 (en) 2000-08-17 2002-02-21 The Kitasato Institute Novel pseudoerythromycin derivatives
ATE419239T1 (en) 2000-10-20 2009-01-15 Eisai R&D Man Co Ltd METHOD FOR PRODUCING 4-PHENOXYQUINOLINE DERIVATIVES
JP3768800B2 (en) 2000-10-31 2006-04-19 キヤノン株式会社 Image forming apparatus
DE60133781T2 (en) 2000-12-08 2009-06-25 Kyowa Hakko Kogyo Co., Ltd. ORAL PREPARATIONS WITH JEWELRY LIGHTER OR ANTIPRURITIC EFFECT
KR100362390B1 (en) 2000-12-29 2002-11-23 삼성전자 주식회사 Developing device-toner cartridge assembly for image forming apparatus
US7235576B1 (en) 2001-01-12 2007-06-26 Bayer Pharmaceuticals Corporation Omega-carboxyaryl substituted diphenyl ureas as raf kinase inhibitors
EP1360173A2 (en) 2001-01-25 2003-11-12 Guilford Pharmaceuticals Inc. Trisubstituted carbocyclic cyclophilin binding compounds and their use
FR2820136A1 (en) 2001-01-26 2002-08-02 Aventis Pharma Sa NOVEL UREA DERIVATIVES, PROCESS FOR THEIR PREPARATION, USE THEREOF AS MEDICAMENTS, PHARMACEUTICAL COMPOSITIONS AND USE THEREOF
EP3342411B1 (en) 2001-02-19 2019-08-21 Novartis Pharma AG Rapamycin derivative for treating pancreas cancer
UA76977C2 (en) 2001-03-02 2006-10-16 Icos Corp Aryl- and heteroaryl substituted chk1 inhibitors and their use as radiosensitizers and chemosensitizers
US6525091B2 (en) 2001-03-07 2003-02-25 Telik, Inc. Substituted diarylureas as stimulators for Fas-mediated apoptosis
EP1383532B1 (en) 2001-04-02 2011-05-04 Genentech, Inc. Combination therapy
MXPA03009000A (en) 2001-04-13 2004-02-12 Boehringer Ingelheim Pharma 1,4-disubstituted benzo-fused compounds.
US20030207914A1 (en) 2001-04-20 2003-11-06 Bayer Corporation Inhibition of raf kinase using quinolyl, isoquinolyl or pyridyl ureas
US7371763B2 (en) 2001-04-20 2008-05-13 Bayer Pharmaceuticals Corporation Inhibition of raf kinase using quinolyl, isoquinolyl or pyridyl ureas
ES2284887T3 (en) 2001-07-11 2007-11-16 Boehringer Ingelheim Pharmaceuticals Inc. METHODS TO TREAT DISEASES TRANSMITTED BY CITOCINES.
US7173032B2 (en) * 2001-09-21 2007-02-06 Reddy Us Therapeutics, Inc. Methods and compositions of novel triazine compounds
ATE345130T1 (en) 2001-12-03 2006-12-15 Bayer Pharmaceuticals Corp ARYLUREA COMPOUNDS IN COMBINATION WITH OTHER CYTOSTATIC OR CYTOTOXIC SUBSTANCES FOR THE TREATMENT OF HUMAN CANCER DISEASES
AU2002365899B2 (en) 2001-12-04 2007-09-13 Onyx Pharmaceuticals, Inc. RAF-MEK-ERK pathway inhibitors to treat cancer
US20040096855A1 (en) 2001-12-24 2004-05-20 Michael Stratton Genes
US20080108672A1 (en) 2002-01-11 2008-05-08 Bernd Riedl Omega-Carboxyaryl Substituted Diphenyl Ureas As Raf Kinase Inhibitors
US20030207872A1 (en) 2002-01-11 2003-11-06 Bayer Corporation Omega-carboxyaryl substituted diphenyl ureas as raf kinase inhibitors
PT1580188E (en) 2002-02-11 2012-01-25 Bayer Healthcare Llc Aryl ureas as kinase inhibitors
US20040023961A1 (en) 2002-02-11 2004-02-05 Bayer Corporation Aryl ureas with raf kinase and angiogenisis inhibiting activity
US7838541B2 (en) 2002-02-11 2010-11-23 Bayer Healthcare, Llc Aryl ureas with angiogenesis inhibiting activity
US20030216396A1 (en) 2002-02-11 2003-11-20 Bayer Corporation Pyridine, quinoline, and isoquinoline N-oxides as kinase inhibitors
US8299108B2 (en) 2002-03-29 2012-10-30 Novartis Ag Substituted benzazoles and methods of their use as inhibitors of raf kinase
DE10221524A1 (en) 2002-05-14 2003-12-04 Kmb Produktions Ag Felben Method and device for producing consumer goods
US7202244B2 (en) * 2002-05-29 2007-04-10 Millennium Pharmaceuticals, Inc. Chk-1 inhibitors
AR037647A1 (en) * 2002-05-29 2004-12-01 Novartis Ag USED DIARILUREA DERIVATIVES FOR THE TREATMENT OF DEPENDENT DISEASES OF THE PROTEIN KINase
DE10224462A1 (en) * 2002-06-03 2003-12-11 Bayer Ag Use of cGMP stimulating compounds
JP2005538975A (en) 2002-07-03 2005-12-22 アステックス テクノロジー リミテッド 3- (Hetero) arylmethoxypyridines and their analogs as p38 MAP kinase inhibitors
FR2842809A1 (en) * 2002-07-26 2004-01-30 Greenpharma Sas NOVEL SUBSTITUTED PYRAZOLO [1,5-a] -1,3,5-TRIAZINES AND THEIR ANALOGUES, PHARMACEUTICAL COMPOSITIONS CONTAINING THE SAME, USE AS A MEDICAMENT AND METHODS FOR THEIR PREPARATION
WO2004013124A1 (en) * 2002-07-31 2004-02-12 Ciba Specialty Chemicals Holding Inc. Pyridyl-triazine derivatives as microbicidal active substances
US7476683B2 (en) 2002-08-27 2009-01-13 Merck Patent Gmbh Glycinamide derivatives as raf-kinase inhibitors
EP1537075B1 (en) 2002-09-05 2009-07-01 Neurosearch A/S Diarylurea derivatives and their use as chloride channel blockers
US7772197B2 (en) * 2002-09-24 2010-08-10 1,3,5-Triazines for Treatment of Viral Diseases 1,3,5-triazines for treatment of viral diseases
SE0203654D0 (en) 2002-12-09 2002-12-09 Astrazeneca Ab New compounds
US20030232400A1 (en) 2002-12-20 2003-12-18 Susan Radka Methods of screening subjects for expression of soluble receptors of vascular endothelial growth factor (VEGF) for use in managing treatment and determining prognostic outcome
US7202257B2 (en) 2003-12-24 2007-04-10 Deciphera Pharmaceuticals, Llc Anti-inflammatory medicaments
UY28213A1 (en) 2003-02-28 2004-09-30 Bayer Pharmaceuticals Corp NEW CYANOPIRIDINE DERIVATIVES USEFUL IN THE TREATMENT OF CANCER AND OTHER DISORDERS.
US7531553B2 (en) 2003-03-21 2009-05-12 Amgen Inc. Heterocyclic compounds and methods of use
MXPA05010020A (en) 2003-03-24 2005-11-17 Merck Patent Gmbh Oxamide derivatives useful as raf-kinase inhibitors.
WO2004084889A1 (en) 2003-03-28 2004-10-07 Pfizer Inc. Use of protein kinase c inhibitor for suppressing sustained slow postsynaptic excitation (sspe) of enteric neurons
US6896863B2 (en) 2003-04-01 2005-05-24 E. I. Du Pont De Nemours And Company Sodium cyanide process
WO2004113274A2 (en) 2003-05-20 2004-12-29 Bayer Pharmaceuticals Corporation Diaryl ureas with kinase inhibiting activity
US20040259926A1 (en) 2003-06-05 2004-12-23 Bruendl Michelle M. 3-Aryloxy and 3-heteroaryloxy substituted benzo[b]thiophenes as therapeutic agents
CA2527573A1 (en) 2003-06-05 2004-12-16 Warner-Lambert Company Llc Cycloalkyl and heterocycloalkyl substituted benzothiophenes as therapeutic agents
JP2006219374A (en) * 2003-06-13 2006-08-24 Daiichi Asubio Pharma Co Ltd Imidazotriazinone derivatives having PDE7 inhibitory action
WO2005002673A1 (en) 2003-07-03 2005-01-13 Astex Therapeutics Limited Raf kinase inhibitors
CA2531454C (en) 2003-07-08 2011-10-25 Novartis Ag Use of rapamycin and rapamycin derivatives for the treatment of bone loss
EP1643991B1 (en) 2003-07-11 2014-03-12 Merck Patent GmbH Benzimidazole carboxamides as raf kinase inhibitors
CA2531859C (en) 2003-07-11 2013-08-06 Merck Patent Gesellschaft Mit Beschraenkter Haftung Benzimidazole derivatives as raf kinase inhibitors
WO2005009367A2 (en) 2003-07-17 2005-02-03 Ambit Biosciences Corporation Treatment of diseases with kinase inhibitors
RS52625B (en) 2003-07-23 2013-06-28 Bayer Healthcare Llc FLUORO SUBSTITUTED OMEGA-CARBOXYARYL DIPHENYL UREA FOR TREATMENT AND PREVENTION OF DISEASES AND DISEASES
TW200523262A (en) 2003-07-29 2005-07-16 Smithkline Beecham Corp Inhibitors of AKT activity
DE10334663A1 (en) 2003-07-30 2005-03-10 Merck Patent Gmbh urea derivatives
AU2004264948A1 (en) 2003-08-15 2005-02-24 University Of Pittsburgh-Of The Commonwealth System Of Higher Education Multifactorial assay for cancer detection
DE10344223A1 (en) 2003-09-24 2005-04-21 Merck Patent Gmbh New 2-anilino-1,3-benzoxazole derivatives, are inhibitors of kinases, especially tyrosine- or Raf-kinases, useful e.g. for treating solid tumors, angiogenesis, diabetic retinopathy, inflammation or psoriasis
US20080045546A1 (en) * 2003-10-15 2008-02-21 Axel Bouchon Tetradydro-Naphthalene And Urea Derivatives
DE602004021838D1 (en) 2003-10-16 2009-08-13 Novartis Vaccines & Diagnostic SUBSTITUTED BENZAZOLE AND THEIR USE AS RAF KINASE HEMMER
MXPA06003607A (en) 2003-10-16 2006-06-05 Chiron Corp 2,6-disubstituted quinazolines, quinoxalines, quinolines and isoquinolines as inhibitors of raf kinase for treatment of cancer.
DE10349587A1 (en) 2003-10-24 2005-05-25 Merck Patent Gmbh Benzimidazolylderivate
DE10352979A1 (en) 2003-11-13 2005-06-09 Merck Patent Gmbh Pyridopyrimidinone
DE10354060A1 (en) 2003-11-19 2005-06-02 Merck Patent Gmbh pyrrole
AU2004299174A1 (en) 2003-12-10 2005-06-30 Merck Patent Gmbh Diacylhydrazine derivatives
US20070134670A1 (en) 2003-12-12 2007-06-14 Bayer Pharmaceuticals Corporation Methods for prediction and prognosis of cancer, and monitoring cancer therapy
TW200536536A (en) * 2004-02-25 2005-11-16 Schering Corp Pyrazolotriazines as kinase inhibitors
ATE517885T1 (en) 2004-04-30 2011-08-15 Bayer Healthcare Llc SUBSTITUTED PYRAZOLYL UREA DERIVATIVES FOR THE TREATMENT OF CANCER
JP5128948B2 (en) 2004-08-27 2013-01-23 ニッポネックス インコーポレイテッド Novel pharmaceutical composition for the treatment of cancer
MY191349A (en) 2004-08-27 2022-06-17 Bayer Pharmaceuticals Corp New pharmaceutical compositions for the treatment of hyper-proliferative disorders
KR101381454B1 (en) 2004-09-29 2014-04-04 바이엘 인텔렉쳐 프로퍼티 게엠베하 Thermodynamically stable form of bay 43-9006 tosylate
WO2006076592A1 (en) 2005-01-14 2006-07-20 Cgi Pharmaceuticals, Inc. 1,3 substituted diaryl ureas as modulators of kinase activity
JP2008529394A (en) 2005-01-31 2008-07-31 エヌエックスピー ビー ヴィ Improved communication between communication stations and data carriers
KR101335932B1 (en) 2005-03-07 2013-12-04 바이엘 헬스케어 엘엘씨 Pharmaceutical composition comprising an omega-carboxyaryl substituted diphenyl urea for the treatment of cancer
DE102005015253A1 (en) 2005-04-04 2006-10-05 Merck Patent Gmbh New pyrazole derivatives are tyrosine kinase inhibitors useful to treat e.g. solid tumors, diabetic retinopathy, age-related macular degeneration or inflammatory disease, osteoarthritis and rickets
WO2006125539A2 (en) 2005-05-27 2006-11-30 Bayer Healthcare Ag Combination therapy comprising diaryl ureas for treating diseases
RU2007148266A (en) 2005-05-27 2009-07-10 Байер ХельсКер АГ (DE) COMBINED THERAPY USING THE COMPOUND OF DIARYL UREA AND PI3, AKT KINASE OR MTOR (RAMAMICIN) INHIBITORS FOR THE TREATMENT OF CANCER
WO2007021860A2 (en) * 2005-08-11 2007-02-22 Bayer Healthcare Llc QUANTITATIVE ASSAYS FOR PDGFR-β IN BODY FLUIDS
AU2006298881A1 (en) 2005-09-21 2007-04-12 4Sc Ag Sulphonylpyrrole hydrochloride salts as histone deacetylases inhibitors
CN101506351A (en) 2005-10-21 2009-08-12 拜尔健康护理有限责任公司 Methods for cancer prediction and prognosis and monitoring cancer treatment
US8329408B2 (en) 2005-10-31 2012-12-11 Bayer Healthcare Llc Methods for prognosis and monitoring cancer therapy
WO2007053573A2 (en) 2005-10-31 2007-05-10 Bayer Pharmaceuticals Corporation Treatment of cancer with sorafenib
WO2007053574A2 (en) 2005-10-31 2007-05-10 Bayer Pharmaceuticals Corporation Combinations comprising sorafenib and interferon for the treatment of cancer
WO2007056012A2 (en) 2005-11-02 2007-05-18 Bayer Healthcare Llc Methods for prediction and prognosis of cancer, and monitoring cancer therapy
US20080311601A1 (en) 2005-11-02 2008-12-18 Elting James J Methods for Prediction and Prognosis of Cancer, and Monitoring Cancer Therapy
KR20080067000A (en) * 2005-11-10 2008-07-17 바이엘 헬스케어 아게 Diaryl Urea to Treat Pulmonary Hypertension
EP1948176B1 (en) 2005-11-10 2011-01-05 Bayer Schering Pharma Aktiengesellschaft Diaryl ureas for treating pulmonary hypertension
WO2007059155A1 (en) 2005-11-14 2007-05-24 Bayer Pharmaceuticals Corporation Treatment of cancers having resistance to chemotherapeutic agents
KR20080073745A (en) 2005-11-14 2008-08-11 바이엘 헬스케어 엘엘씨 How to predict and predict cancer, and how to monitor cancer therapy
US20090227637A1 (en) 2005-12-15 2009-09-10 Olaf Weber Diaryl ureas for treating virus infections
US20080045589A1 (en) 2006-05-26 2008-02-21 Susan Kelley Drug Combinations with Substituted Diaryl Ureas for the Treatment of Cancer
EP2111401B1 (en) 2006-12-20 2011-02-16 Bayer HealthCare, LLC 4-{4-[({3-tert-butyl-1-[3-(hydroxymethyl) phenyl]-1h-pyrazol-5-yl } carbamoyl)-amino]-3-fluorophenoxy} -n-methylpyridine-2-carboxamide as well as prodrugs and salts thereof for the treatment of cancer

Also Published As

Publication number Publication date
US7557129B2 (en) 2009-07-07
ES2344347T3 (en) 2010-08-25
US20040235829A1 (en) 2004-11-25
JP4658037B2 (en) 2011-03-23
IL170503A (en) 2012-02-29
PL1599467T3 (en) 2010-10-29
US20050038031A1 (en) 2005-02-17
US20040229937A1 (en) 2004-11-18
BRPI0407897A (en) 2006-03-01
AR043437A1 (en) 2005-07-27
US20050032798A1 (en) 2005-02-10
UY28213A1 (en) 2004-09-30
WO2004078747A1 (en) 2004-09-16
PT1599467E (en) 2010-07-15
DE602004027218D1 (en) 2010-07-01
CA2517361A1 (en) 2004-09-16
JP2006519264A (en) 2006-08-24
KR101109262B1 (en) 2012-01-30
WO2004078747A8 (en) 2004-11-04
CA2517361C (en) 2012-05-15
US8076488B2 (en) 2011-12-13
MXPA05009067A (en) 2005-11-17
HK1089155A1 (en) 2006-11-24
AU2004217977A1 (en) 2004-09-16
SI1599467T1 (en) 2010-09-30
KR20050106050A (en) 2005-11-08
US20100075971A1 (en) 2010-03-25
EP1599467A1 (en) 2005-11-30
DK1599467T3 (en) 2010-09-06
US7928227B2 (en) 2011-04-19
EP1599467B1 (en) 2010-05-19
AU2004217977B2 (en) 2010-04-01
TW200504053A (en) 2005-02-01
CY1111143T1 (en) 2015-06-11

Similar Documents

Publication Publication Date Title
ATE468331T1 (en) NEW CYANOPYRIDINE DERIVATIVES FOR THE TREATMENT OF CANCER AND OTHER DISEASES
DE602005020293D1 (en) FOR THE TREATMENT OF HYPERPROLIFERATION DISEASES AND PYRROLOTRIAZINE DERIVATIVES SUITABLE FOR ANGIOGENESIS OF ASSOCIATED DISEASES
ATE390925T1 (en) USE OF SUBSTITUTED QUINOLINE DERIVATIVES FOR THE TREATMENT OF DRUG RESISTANT MYCOBACTERIAL DISEASES
EP1896083A4 (en) METHOD FOR THE TREATMENT OF POMPE DISEASE WITH 1-DESOXYNO-JIMIMYCIN AND DERIVATIVES
ATE551100T1 (en) PHARMACEUTICAL COMPOSITION FOR THE TREATMENT OF CARDIOVASCULAR AND CEREBROVASCULAR DISEASES
DE602006018583D1 (en) METHOD AND COMPOSITION FOR THE TREATMENT OF PERIPHERAL VASCULAR DISEASES
DE60335293D1 (en) PYRROLOPYRIDAZINE COMPOUNDS AND USE METHOD FOR THE TREATMENT OF PROLIFERATIVE DISEASES
DE602004022036D1 (en) METHOD FOR THE TREATMENT OF ATHEROSCLEROSIS, DYSLIPIDEMIA AND RELATED DISEASES AND PHARMACEUTICAL COMPOSITIONS
DE602004028763D1 (en) TE FOR THE TREATMENT OF VIRUS DISEASES
DE602004026891D1 (en) TLR7 LIGANDS FOR THE TREATMENT OF HEPATITIS C
ATE389649T1 (en) SUBSTITUTED AMINE DERIVATIVES AND THEIR USE IN THE TREATMENT OF ANGIONESIS-RELATED DISEASES
ATE448206T1 (en) BENZOQUINAZOLINE DERIVATIVES AND THEIR USE IN THE TREATMENT OF BONE DISEASES
ATE494279T1 (en) PYRIMIDE DERIVATIVES SUITABLE FOR THE TREATMENT OF CRTH2-MEDIATED DISEASES
EP1651164A4 (en) COMPOSITION AND METHOD FOR THE TREATMENT OF NEUROLOGICAL ILLNESSES
EP1951892A4 (en) ANTIBODY TREATMENT OF MORBUS ALZHEIMER AND RELATED DISEASES
ATE501721T1 (en) QUINOLINE DERIVATIVES FOR THE TREATMENT OF LATENT TUBERCULOSIS
DE602005023172D1 (en) HYDANTINE DERIVATIVES FOR THE TREATMENT OF INFLAMMATORY DISEASES
DE602005017636D1 (en) NEW HYDANTINE DERIVATIVES FOR THE TREATMENT OF OBSTRUCTIVE RESPIRATORY DISEASES
ATE414512T1 (en) COMBINATION THERAPY FOR THE TREATMENT OF CANCER
ATE443704T1 (en) PYRIDOPYRIMIDINONE FOR THE TREATMENT OF CANCER DISEASES
DE60027290D1 (en) SCLER APROTHESIS FOR THE TREATMENT OF WEIGHTNESS AND OTHER EYE DISEASES
EP1487480A4 (en) FUSION MOLECULES AND METHOD FOR THE TREATMENT OF IMMUNE DISEASES
DE602004001134D1 (en) TETRAZOL DERIVATIVES AND METHOD FOR THE TREATMENT OF METABOLISM-RELATED DISEASES THEREWITH
ATE482709T1 (en) NEW DRUG COMBINATIONS FOR THE TREATMENT OF RESPIRATORY DISEASES
EP1694364A4 (en) SYSTEM FOR THE TREATMENT AND PREVENTION OF BREAST CANCER

Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification

Ref document number: 1599467

Country of ref document: EP