ATE466852T1 - Verfahren zur herstellung von n-(2-acetyl-4,6- dimethylphenyl)-3-ää(3,4 dimethyl-5- - Google Patents
Verfahren zur herstellung von n-(2-acetyl-4,6- dimethylphenyl)-3-ää(3,4 dimethyl-5-Info
- Publication number
- ATE466852T1 ATE466852T1 AT07836498T AT07836498T ATE466852T1 AT E466852 T1 ATE466852 T1 AT E466852T1 AT 07836498 T AT07836498 T AT 07836498T AT 07836498 T AT07836498 T AT 07836498T AT E466852 T1 ATE466852 T1 AT E466852T1
- Authority
- AT
- Austria
- Prior art keywords
- dimethylphenyl
- acetyl
- dimethyl
- producing
- thiophenecarboxamide
- Prior art date
Links
- 238000004519 manufacturing process Methods 0.000 title 1
- 102000002045 Endothelin Human genes 0.000 abstract 1
- 108050009340 Endothelin Proteins 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- ZUBDGKVDJUIMQQ-UBFCDGJISA-N endothelin-1 Chemical compound C([C@@H](C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(O)=O)NC(=O)[C@H]1NC(=O)[C@H](CC=2C=CC=CC=2)NC(=O)[C@@H](CC=2C=CC(O)=CC=2)NC(=O)[C@H](C(C)C)NC(=O)[C@H]2CSSC[C@@H](C(N[C@H](CO)C(=O)N[C@@H](CO)C(=O)N[C@H](CC(C)C)C(=O)N[C@@H](CCSC)C(=O)N[C@H](CC(O)=O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(O)=O)C(=O)N2)=O)NC(=O)[C@@H](CO)NC(=O)[C@H](N)CSSC1)C1=CNC=N1 ZUBDGKVDJUIMQQ-UBFCDGJISA-N 0.000 abstract 1
- 230000001404 mediated effect Effects 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- IAYNHDZSSDUYHY-UHFFFAOYSA-N n-(2-acetyl-4,6-dimethylphenyl)-3-[(3,4-dimethyl-1,2-oxazol-5-yl)sulfamoyl]thiophene-2-carboxamide Chemical compound CC(=O)C1=CC(C)=CC(C)=C1NC(=O)C1=C(S(=O)(=O)NC2=C(C(C)=NO2)C)C=CS1 IAYNHDZSSDUYHY-UHFFFAOYSA-N 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
- C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
- C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D333/30—Hetero atoms other than halogen
- C07D333/34—Sulfur atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/08—Bronchodilators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
- C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
- C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D333/38—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
- C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
- C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D333/38—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D333/40—Thiophene-2-carboxylic acid
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
- C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
- C07D513/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Pulmonology (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Plural Heterocyclic Compounds (AREA)
- Heterocyclic Compounds Containing Sulfur Atoms (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US83563606P | 2006-08-04 | 2006-08-04 | |
| PCT/US2007/017391 WO2008019096A1 (en) | 2006-08-04 | 2007-08-03 | Processes for the preparation of n-(2-acetyl-4,6-dimethylphenyl)-3-{[(3,4 dimethyl-5-isoxazolyl)amino}sulfonyl}-2-thiophenecarboxamide |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE466852T1 true ATE466852T1 (de) | 2010-05-15 |
Family
ID=38819265
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT07836498T ATE466852T1 (de) | 2006-08-04 | 2007-08-03 | Verfahren zur herstellung von n-(2-acetyl-4,6- dimethylphenyl)-3-ää(3,4 dimethyl-5- |
Country Status (16)
| Country | Link |
|---|---|
| US (3) | US7754892B2 (de) |
| JP (1) | JP2009545631A (de) |
| KR (1) | KR20090036126A (de) |
| CN (1) | CN101501017A (de) |
| AT (1) | ATE466852T1 (de) |
| AU (1) | AU2007281965B8 (de) |
| CA (1) | CA2659884A1 (de) |
| DE (1) | DE602007006327D1 (de) |
| DK (1) | DK2069323T3 (de) |
| ES (1) | ES2344438T3 (de) |
| IL (1) | IL196605A0 (de) |
| MX (1) | MX2009001046A (de) |
| NO (1) | NO20090347L (de) |
| PT (1) | PT2069323E (de) |
| WO (1) | WO2008019096A1 (de) |
| ZA (1) | ZA200900369B (de) |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IL150311A0 (en) * | 1999-12-31 | 2002-12-01 | Texas Biotechnology Corp | Sulfonamides and derivatives thereof that modulate the activity of endothelin |
-
2007
- 2007-08-03 US US11/890,201 patent/US7754892B2/en not_active Expired - Fee Related
- 2007-08-03 MX MX2009001046A patent/MX2009001046A/es active IP Right Grant
- 2007-08-03 ES ES07836498T patent/ES2344438T3/es active Active
- 2007-08-03 AU AU2007281965A patent/AU2007281965B8/en not_active Ceased
- 2007-08-03 JP JP2009523795A patent/JP2009545631A/ja not_active Withdrawn
- 2007-08-03 PT PT07836498T patent/PT2069323E/pt unknown
- 2007-08-03 KR KR1020097002298A patent/KR20090036126A/ko not_active Ceased
- 2007-08-03 CN CNA2007800290318A patent/CN101501017A/zh active Pending
- 2007-08-03 CA CA002659884A patent/CA2659884A1/en not_active Abandoned
- 2007-08-03 US US12/376,083 patent/US20090318704A1/en not_active Abandoned
- 2007-08-03 DE DE602007006327T patent/DE602007006327D1/de active Active
- 2007-08-03 DK DK07836498.1T patent/DK2069323T3/da active
- 2007-08-03 AT AT07836498T patent/ATE466852T1/de active
- 2007-08-03 WO PCT/US2007/017391 patent/WO2008019096A1/en not_active Ceased
-
2009
- 2009-01-16 ZA ZA200900369A patent/ZA200900369B/xx unknown
- 2009-01-20 IL IL196605A patent/IL196605A0/en unknown
- 2009-01-22 NO NO20090347A patent/NO20090347L/no not_active Application Discontinuation
-
2010
- 2010-06-03 US US12/793,098 patent/US20100240904A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| US20090318704A1 (en) | 2009-12-24 |
| CN101501017A (zh) | 2009-08-05 |
| PT2069323E (pt) | 2010-07-05 |
| DE602007006327D1 (de) | 2010-06-17 |
| AU2007281965B2 (en) | 2010-08-12 |
| AU2007281965A1 (en) | 2008-02-14 |
| JP2009545631A (ja) | 2009-12-24 |
| IL196605A0 (en) | 2009-11-18 |
| NO20090347L (no) | 2009-02-19 |
| AU2007281965B8 (en) | 2010-09-02 |
| MX2009001046A (es) | 2009-03-10 |
| ES2344438T3 (es) | 2010-08-26 |
| DK2069323T3 (da) | 2010-08-02 |
| ZA200900369B (en) | 2010-04-28 |
| US20100240904A1 (en) | 2010-09-23 |
| WO2008019096A1 (en) | 2008-02-14 |
| US20080086011A1 (en) | 2008-04-10 |
| CA2659884A1 (en) | 2008-02-14 |
| US7754892B2 (en) | 2010-07-13 |
| KR20090036126A (ko) | 2009-04-13 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| UEP | Publication of translation of european patent specification |
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