ATE46189T1 - Mikrobiologisches verfahren zur stereoselektiven synthese von (l-)-carnitin. - Google Patents

Mikrobiologisches verfahren zur stereoselektiven synthese von (l-)-carnitin.

Info

Publication number
ATE46189T1
ATE46189T1 AT84830296T AT84830296T ATE46189T1 AT E46189 T1 ATE46189 T1 AT E46189T1 AT 84830296 T AT84830296 T AT 84830296T AT 84830296 T AT84830296 T AT 84830296T AT E46189 T1 ATE46189 T1 AT E46189T1
Authority
AT
Austria
Prior art keywords
carnitine
crotonoylbetaine
microbiological process
stereoselective synthesis
unsaturated compound
Prior art date
Application number
AT84830296T
Other languages
English (en)
Inventor
Hermann Seim
Heinz Loester
Reiner Claus
Hans-Peter Kleber
Erich Strack
Original Assignee
Sigma Tau Ind Farmaceuti
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sigma Tau Ind Farmaceuti filed Critical Sigma Tau Ind Farmaceuti
Application granted granted Critical
Publication of ATE46189T1 publication Critical patent/ATE46189T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P13/00—Preparation of nitrogen-containing organic compounds
    • C12P13/02—Amides, e.g. chloramphenicol or polyamides; Imides or polyimides; Urethanes, i.e. compounds comprising N-C=O structural element or polyurethanes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P13/00—Preparation of nitrogen-containing organic compounds
    • C12P13/007—Carnitine; Butyrobetaine; Crotonobetaine

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Microbiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biotechnology (AREA)
  • Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
AT84830296T 1983-11-03 1984-10-31 Mikrobiologisches verfahren zur stereoselektiven synthese von (l-)-carnitin. ATE46189T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DD83256281A DD221905B1 (de) 1983-11-03 1983-11-03 Verfahren zur herstellung von l(-)-carnitin und seinen derivaten
EP84830296A EP0148132B1 (de) 1983-11-03 1984-10-31 Mikrobiologisches Verfahren zur stereoselektiven Synthese von (L-)-Carnitin

Publications (1)

Publication Number Publication Date
ATE46189T1 true ATE46189T1 (de) 1989-09-15

Family

ID=5551596

Family Applications (1)

Application Number Title Priority Date Filing Date
AT84830296T ATE46189T1 (de) 1983-11-03 1984-10-31 Mikrobiologisches verfahren zur stereoselektiven synthese von (l-)-carnitin.

Country Status (8)

Country Link
US (1) US5028538A (de)
EP (1) EP0148132B1 (de)
JP (1) JPS60137295A (de)
KR (1) KR870002073B1 (de)
AT (1) ATE46189T1 (de)
CA (1) CA1244788A (de)
DD (1) DD221905B1 (de)
DE (1) DE3479670D1 (de)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS59183694A (ja) * 1983-04-05 1984-10-18 Hamari Yakuhin Kogyo Kk 光学活性なカルニチンの生化学的製造法
JPS59192095A (ja) * 1983-04-13 1984-10-31 Ajinomoto Co Inc Ｌ−カルニチンの製造法
FI86889C (fi) * 1984-03-29 1992-10-26 Lonza Ag Foerfarande foer framstaellning av av l-karnitin pao mikrobiologiskt saett
JPS6167494A (ja) * 1984-09-06 1986-04-07 Seitetsu Kagaku Co Ltd Ｌ−カルニチンの製造方法
CH664374A5 (de) * 1985-02-27 1988-02-29 Lonza Ag Verfahren zur herstellung von l-carnitin auf mikrobiologischem weg.
ES2051890T3 (es) * 1987-10-26 1994-07-01 Sigma Tau Ind Farmaceuti Procedimiento para aislar la enzima carnitinhidroliasa de cepas pertenecientes a la familia enterobacteriaceae y empleo de la enzima inmobilizada para producir l(-)-carnitina.
IT1240833B (it) * 1990-05-14 1993-12-17 Sigma Tau Ind Farmaceuti Procedimento biocatalitico per la produzione di l-(-)- carnitina da crotonilbetaina e ceppi di proteeae per l'uso in tale procedimento
US5316917A (en) * 1992-11-04 1994-05-31 Duke University Automated analysis of free l-carnitine and total short-chain acylcarnitine
IT1261230B (it) * 1993-04-08 1996-05-09 Sigma Tau Ind Farmaceuti Procedimento migliorato per la preparazione di l-(-)-carnitina a partire da suoi precursori aventi opposta configurazione.
DE19749480A1 (de) * 1997-11-08 1999-05-20 Univ Leipzig Verfahren zur Herstellung von L-Carnitin aus Crotonobetain
US6337197B2 (en) * 1998-10-27 2002-01-08 Sigma-Tau Industrie Farmaceutiche Riunite S.P.A. Coenzymes useful for the synthesis of L-carnitine
EP1452604A3 (de) 1998-10-27 2005-03-30 Sigma-Tau Industrie Farmaceutiche Riunite S.p.A. Coenzyme zur Herstellung von L-Carnitin
US7407778B2 (en) * 2002-02-07 2008-08-05 Pettegrew Jay W Compounds, compositions and methods for treating neuropsychiatric disorders
US7700074B2 (en) * 2002-02-07 2010-04-20 Pettegrew Jay W Method and system for diagnosis of neuropsychiatric disorders including chronic alcoholism
ES2220219B1 (es) * 2003-05-23 2005-10-01 Universidad De Murcia Procedimiento para la produccion de l-carnitina a partir de crotonobetaina, d-carnitina, sus sales y derivados, mediante celulas permeabilizadas de proteus sp. o escherichia coli.
US20060257842A1 (en) * 2003-05-29 2006-11-16 Pettegrew Jay W Cryopreservation media and molecules
EP1641806B1 (de) * 2003-05-29 2009-07-29 Jay W. Pettegrew Glycerophosphocholin und derivate davon zur medizinischen abbildung von neuropsychiatrischen erkrankungen
US20050232911A1 (en) * 2004-04-19 2005-10-20 Schreiber Brian D Prevention and treatment of metabolic abnormalities associated with excess intramyocellular lipid
KR100713103B1 (ko) * 2005-07-07 2007-05-02 씨제이 주식회사 뉴로스포라 크라사 유래 ｌ-카르니틴 생합성 관련 유전자를포함하는 엔테로박테리아세 속 미생물 및 이를 이용한ｌ-카르니틴의 제조방법
KR100713104B1 (ko) * 2005-07-07 2007-05-02 씨제이 주식회사 뉴로스포라 크라사 유래의ｓ-아데노실메티오닌-6-ｎ-라이신-메틸트란스퍼라제, 그를코딩하는 폴리뉴클레오티드, 상기 폴리뉴클레오티드를포함하는 벡터 및 숙주세포 및 상기 숙주세포를 이용하여트리메틸라이신을 생산하는 방법
DE602005022120D1 (de) 2005-07-19 2010-08-12 Cj Cheiljedang Corp Mikroorganismus der gattung enterobacteriacae mit genen in zusammenhang mit der biosynthese von l-carnitin sowie verfahren zur produktion von l-carnitin mit dem mikroorganismus

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1446979A (en) * 1973-11-14 1976-08-18 Kanegafuchi Chemical Ind Process for cultivating yeasts
IT1142201B (it) * 1980-06-24 1986-10-08 Sigma Tau Ind Farmaceuti Procedimento per la produzione enzimatica di l-carnitina
JPS59183694A (ja) * 1983-04-05 1984-10-18 Hamari Yakuhin Kogyo Kk 光学活性なカルニチンの生化学的製造法
JPS59192095A (ja) * 1983-04-13 1984-10-31 Ajinomoto Co Inc Ｌ−カルニチンの製造法
FI86889C (fi) * 1984-03-29 1992-10-26 Lonza Ag Foerfarande foer framstaellning av av l-karnitin pao mikrobiologiskt saett
CH664374A5 (de) * 1985-02-27 1988-02-29 Lonza Ag Verfahren zur herstellung von l-carnitin auf mikrobiologischem weg.

Also Published As

Publication number Publication date
DD221905B1 (de) 1987-03-18
KR870002073B1 (ko) 1987-12-03
DE3479670D1 (en) 1989-10-12
EP0148132B1 (de) 1989-09-06
EP0148132A3 (en) 1986-07-16
DD221905A1 (de) 1985-05-08
JPS60137295A (ja) 1985-07-20
US5028538A (en) 1991-07-02
EP0148132A2 (de) 1985-07-10
KR850004502A (ko) 1985-07-15
CA1244788A (en) 1988-11-15

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UEP Publication of translation of european patent specification
REN Ceased due to non-payment of the annual fee