ATE46189T1 - Mikrobiologisches verfahren zur stereoselektiven synthese von (l-)-carnitin. - Google Patents
Mikrobiologisches verfahren zur stereoselektiven synthese von (l-)-carnitin.Info
- Publication number
- ATE46189T1 ATE46189T1 AT84830296T AT84830296T ATE46189T1 AT E46189 T1 ATE46189 T1 AT E46189T1 AT 84830296 T AT84830296 T AT 84830296T AT 84830296 T AT84830296 T AT 84830296T AT E46189 T1 ATE46189 T1 AT E46189T1
- Authority
- AT
- Austria
- Prior art keywords
- carnitine
- crotonoylbetaine
- microbiological process
- stereoselective synthesis
- unsaturated compound
- Prior art date
Links
- 238000000034 method Methods 0.000 title abstract 2
- 230000002906 microbiologic effect Effects 0.000 title abstract 2
- 230000015572 biosynthetic process Effects 0.000 title 1
- 229960004203 carnitine Drugs 0.000 title 1
- 230000000707 stereoselective effect Effects 0.000 title 1
- 238000003786 synthesis reaction Methods 0.000 title 1
- GUYHPGUANSLONG-SNAWJCMRSA-N (E)-4-(trimethylammonio)but-2-enoate Chemical compound C[N+](C)(C)C\C=C\C([O-])=O GUYHPGUANSLONG-SNAWJCMRSA-N 0.000 abstract 2
- PHIQHXFUZVPYII-UHFFFAOYSA-N carnitine Chemical compound C[N+](C)(C)CC(O)CC([O-])=O PHIQHXFUZVPYII-UHFFFAOYSA-N 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- 244000005700 microbiome Species 0.000 abstract 2
- 241000588923 Citrobacter Species 0.000 abstract 1
- 241000193403 Clostridium Species 0.000 abstract 1
- 241000588722 Escherichia Species 0.000 abstract 1
- 241000588731 Hafnia Species 0.000 abstract 1
- 241000588769 Proteus <enterobacteria> Species 0.000 abstract 1
- 241000607142 Salmonella Species 0.000 abstract 1
- 241000607768 Shigella Species 0.000 abstract 1
- 150000001408 amides Chemical class 0.000 abstract 1
- -1 crotonoylbetaine nitrile Chemical class 0.000 abstract 1
- 150000002148 esters Chemical class 0.000 abstract 1
- CJNBYAVZURUTKZ-UHFFFAOYSA-N hafnium(IV) oxide Inorganic materials O=[Hf]=O CJNBYAVZURUTKZ-UHFFFAOYSA-N 0.000 abstract 1
- 230000000640 hydroxylating effect Effects 0.000 abstract 1
- 239000002243 precursor Substances 0.000 abstract 1
- 239000012429 reaction media Substances 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 230000002194 synthesizing effect Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P13/00—Preparation of nitrogen-containing organic compounds
- C12P13/02—Amides, e.g. chloramphenicol or polyamides; Imides or polyimides; Urethanes, i.e. compounds comprising N-C=O structural element or polyurethanes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P13/00—Preparation of nitrogen-containing organic compounds
- C12P13/007—Carnitine; Butyrobetaine; Crotonobetaine
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Zoology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Wood Science & Technology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Microbiology (AREA)
- General Chemical & Material Sciences (AREA)
- Biotechnology (AREA)
- Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DD83256281A DD221905B1 (de) | 1983-11-03 | 1983-11-03 | Verfahren zur herstellung von l(-)-carnitin und seinen derivaten |
| EP84830296A EP0148132B1 (de) | 1983-11-03 | 1984-10-31 | Mikrobiologisches Verfahren zur stereoselektiven Synthese von (L-)-Carnitin |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE46189T1 true ATE46189T1 (de) | 1989-09-15 |
Family
ID=5551596
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT84830296T ATE46189T1 (de) | 1983-11-03 | 1984-10-31 | Mikrobiologisches verfahren zur stereoselektiven synthese von (l-)-carnitin. |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US5028538A (de) |
| EP (1) | EP0148132B1 (de) |
| JP (1) | JPS60137295A (de) |
| KR (1) | KR870002073B1 (de) |
| AT (1) | ATE46189T1 (de) |
| CA (1) | CA1244788A (de) |
| DD (1) | DD221905B1 (de) |
| DE (1) | DE3479670D1 (de) |
Families Citing this family (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS59183694A (ja) * | 1983-04-05 | 1984-10-18 | Hamari Yakuhin Kogyo Kk | 光学活性なカルニチンの生化学的製造法 |
| JPS59192095A (ja) * | 1983-04-13 | 1984-10-31 | Ajinomoto Co Inc | Ｌ−カルニチンの製造法 |
| FI86889C (fi) * | 1984-03-29 | 1992-10-26 | Lonza Ag | Foerfarande foer framstaellning av av l-karnitin pao mikrobiologiskt saett |
| JPS6167494A (ja) * | 1984-09-06 | 1986-04-07 | Seitetsu Kagaku Co Ltd | Ｌ−カルニチンの製造方法 |
| CH664374A5 (de) * | 1985-02-27 | 1988-02-29 | Lonza Ag | Verfahren zur herstellung von l-carnitin auf mikrobiologischem weg. |
| EP0320460B1 (de) * | 1987-10-26 | 1994-04-27 | Sigma-Tau Industrie Farmaceutiche Riunite S.p.A. | Verfahren zur Isolierung des Enzyms Karnitin-Hydrolyase von zur Familie der Enterobakteriaceae gehörenden Stämmen und Verwendung des immobilisierten Enzyms zur Herstellung von L(-)Karnitin |
| IT1240833B (it) * | 1990-05-14 | 1993-12-17 | Sigma Tau Ind Farmaceuti | Procedimento biocatalitico per la produzione di l-(-)- carnitina da crotonilbetaina e ceppi di proteeae per l'uso in tale procedimento |
| US5316917A (en) * | 1992-11-04 | 1994-05-31 | Duke University | Automated analysis of free l-carnitine and total short-chain acylcarnitine |
| IT1261230B (it) * | 1993-04-08 | 1996-05-09 | Sigma Tau Ind Farmaceuti | Procedimento migliorato per la preparazione di l-(-)-carnitina a partire da suoi precursori aventi opposta configurazione. |
| DE19749480A1 (de) * | 1997-11-08 | 1999-05-20 | Univ Leipzig | Verfahren zur Herstellung von L-Carnitin aus Crotonobetain |
| US6337197B2 (en) * | 1998-10-27 | 2002-01-08 | Sigma-Tau Industrie Farmaceutiche Riunite S.P.A. | Coenzymes useful for the synthesis of L-carnitine |
| ATE290096T1 (de) | 1998-10-27 | 2005-03-15 | Sigma Tau Ind Farmaceuti | Coenzym zur herstellung von l-carnitin |
| US7407778B2 (en) * | 2002-02-07 | 2008-08-05 | Pettegrew Jay W | Compounds, compositions and methods for treating neuropsychiatric disorders |
| US7700074B2 (en) * | 2002-02-07 | 2010-04-20 | Pettegrew Jay W | Method and system for diagnosis of neuropsychiatric disorders including chronic alcoholism |
| ES2220219B1 (es) * | 2003-05-23 | 2005-10-01 | Universidad De Murcia | Procedimiento para la produccion de l-carnitina a partir de crotonobetaina, d-carnitina, sus sales y derivados, mediante celulas permeabilizadas de proteus sp. o escherichia coli. |
| US20060257842A1 (en) * | 2003-05-29 | 2006-11-16 | Pettegrew Jay W | Cryopreservation media and molecules |
| DE602004022301D1 (de) * | 2003-05-29 | 2009-09-10 | Jay W Pettegrew | Glycerophosphocholin und derivate davon zur medizinischen abbildung von neuropsychiatrischen erkrankungen |
| US20050232911A1 (en) * | 2004-04-19 | 2005-10-20 | Schreiber Brian D | Prevention and treatment of metabolic abnormalities associated with excess intramyocellular lipid |
| KR100713104B1 (ko) * | 2005-07-07 | 2007-05-02 | 씨제이 주식회사 | 뉴로스포라 크라사 유래의ｓ-아데노실메티오닌-6-ｎ-라이신-메틸트란스퍼라제, 그를코딩하는 폴리뉴클레오티드, 상기 폴리뉴클레오티드를포함하는 벡터 및 숙주세포 및 상기 숙주세포를 이용하여트리메틸라이신을 생산하는 방법 |
| KR100713103B1 (ko) * | 2005-07-07 | 2007-05-02 | 씨제이 주식회사 | 뉴로스포라 크라사 유래 ｌ-카르니틴 생합성 관련 유전자를포함하는 엔테로박테리아세 속 미생물 및 이를 이용한ｌ-카르니틴의 제조방법 |
| DE602005022120D1 (de) * | 2005-07-19 | 2010-08-12 | Cj Cheiljedang Corp | Mikroorganismus der gattung enterobacteriacae mit genen in zusammenhang mit der biosynthese von l-carnitin sowie verfahren zur produktion von l-carnitin mit dem mikroorganismus |
| US20240217920A1 (en) * | 2022-12-28 | 2024-07-04 | Hubei Xujie Pharmaceutical Co., Ltd. | Process for producing l-carnitine |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1446979A (en) * | 1973-11-14 | 1976-08-18 | Kanegafuchi Chemical Ind | Process for cultivating yeasts |
| IT1142201B (it) * | 1980-06-24 | 1986-10-08 | Sigma Tau Ind Farmaceuti | Procedimento per la produzione enzimatica di l-carnitina |
| JPS59183694A (ja) * | 1983-04-05 | 1984-10-18 | Hamari Yakuhin Kogyo Kk | 光学活性なカルニチンの生化学的製造法 |
| JPS59192095A (ja) * | 1983-04-13 | 1984-10-31 | Ajinomoto Co Inc | Ｌ−カルニチンの製造法 |
| FI86889C (fi) * | 1984-03-29 | 1992-10-26 | Lonza Ag | Foerfarande foer framstaellning av av l-karnitin pao mikrobiologiskt saett |
| CH664374A5 (de) * | 1985-02-27 | 1988-02-29 | Lonza Ag | Verfahren zur herstellung von l-carnitin auf mikrobiologischem weg. |
-
1983
- 1983-11-03 DD DD83256281A patent/DD221905B1/de not_active IP Right Cessation
-
1984
- 1984-10-31 DE DE8484830296T patent/DE3479670D1/de not_active Expired
- 1984-10-31 AT AT84830296T patent/ATE46189T1/de not_active IP Right Cessation
- 1984-10-31 EP EP84830296A patent/EP0148132B1/de not_active Expired
- 1984-11-02 CA CA000466940A patent/CA1244788A/en not_active Expired
- 1984-11-02 JP JP59232275A patent/JPS60137295A/ja active Pending
- 1984-11-03 KR KR1019840006883A patent/KR870002073B1/ko not_active Expired
-
1989
- 1989-05-09 US US07/349,929 patent/US5028538A/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| EP0148132B1 (de) | 1989-09-06 |
| DD221905A1 (de) | 1985-05-08 |
| KR850004502A (ko) | 1985-07-15 |
| JPS60137295A (ja) | 1985-07-20 |
| CA1244788A (en) | 1988-11-15 |
| US5028538A (en) | 1991-07-02 |
| DE3479670D1 (en) | 1989-10-12 |
| KR870002073B1 (ko) | 1987-12-03 |
| EP0148132A2 (de) | 1985-07-10 |
| DD221905B1 (de) | 1987-03-18 |
| EP0148132A3 (en) | 1986-07-16 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| UEP | Publication of translation of european patent specification | ||
| REN | Ceased due to non-payment of the annual fee |