ATE458746T1 - Melphalan-derivate und ihre verwendung als chemotherapeutika gegen krebs - Google Patents

Melphalan-derivate und ihre verwendung als chemotherapeutika gegen krebs

Info

Publication number
ATE458746T1
ATE458746T1 AT01938945T AT01938945T ATE458746T1 AT E458746 T1 ATE458746 T1 AT E458746T1 AT 01938945 T AT01938945 T AT 01938945T AT 01938945 T AT01938945 T AT 01938945T AT E458746 T1 ATE458746 T1 AT E458746T1
Authority
AT
Austria
Prior art keywords
cancer chemotherapeutics
melphalan
melphalan derivatives
derivatives
alkylating
Prior art date
Application number
AT01938945T
Other languages
German (de)
English (en)
Inventor
Rolf Lewensohn
Joakim Gullbo
Rolf Larsson
Hans Ehrsson
Kristina Luthman
Original Assignee
Oncopeptides Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Oncopeptides Ab filed Critical Oncopeptides Ab
Application granted granted Critical
Publication of ATE458746T1 publication Critical patent/ATE458746T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06191—Dipeptides containing heteroatoms different from O, S, or N
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08—Tripeptides
    • C07K5/0827—Tripeptides containing heteroatoms different from O, S, or N
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biochemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Genetics & Genomics (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
AT01938945T 2000-06-13 2001-06-11 Melphalan-derivate und ihre verwendung als chemotherapeutika gegen krebs ATE458746T1 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US21122700P 2000-06-13 2000-06-13
SE0002202A SE0002202D0 (sv) 2000-06-13 2000-06-13 New peptides
PCT/SE2001/001318 WO2001096367A1 (en) 2000-06-13 2001-06-11 Melphalan derivatives and their use as cancer chemotherapeutic drugs

Publications (1)

Publication Number Publication Date
ATE458746T1 true ATE458746T1 (de) 2010-03-15

Family

ID=20280067

Family Applications (1)

Application Number Title Priority Date Filing Date
AT01938945T ATE458746T1 (de) 2000-06-13 2001-06-11 Melphalan-derivate und ihre verwendung als chemotherapeutika gegen krebs

Country Status (10)

Country Link
EP (1) EP1290011B1 (es)
JP (1) JP4798930B2 (es)
AT (1) ATE458746T1 (es)
AU (1) AU2001264515A1 (es)
CA (1) CA2408501C (es)
DK (1) DK1290011T3 (es)
ES (1) ES2341702T3 (es)
PT (1) PT1290011E (es)
SE (1) SE0002202D0 (es)
WO (1) WO2001096367A1 (es)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1374907A3 (en) * 2002-06-24 2004-01-07 Ghanem Elias c/o Institut Jules Bordet Ghanem Drug transport and delivery system
DE10239832A1 (de) * 2002-08-29 2004-03-18 Lipal Biochemicals AG c/o University of Zurich Sarcolysyl-Derivate und Verfahren zu deren Herstellung
WO2011011865A1 (en) * 2009-07-29 2011-02-03 3R Valo, S.E.C. Anticancer agents based on amino acid derivatives
WO2011078782A1 (en) * 2009-12-22 2011-06-30 Oncopeptides Ab A composition comprising of melphalan derivatives and gemcitabine or etoposide useful in the treatment of cancer
EP2701720B1 (en) 2011-04-28 2017-07-12 Oncopeptides AB Lyophilized preparation of cytotoxic dipeptides
LT3228319T (lt) * 2011-04-28 2020-09-25 Oncopeptides Ab Liofilizuotas citotoksinių dipeptidų preparatas
LT2928463T (lt) * 2012-10-26 2020-02-10 Oncopeptides Ab Liofilizuoti melfalano flufenamido preparatai
JP6284945B2 (ja) 2012-10-26 2018-02-28 オンコペプティデス エービーＯｎｃｏｐｅｐｔｉｄｅｓ ＡＢ メルファランフルフェナミドの凍結乾燥製剤
GB201507903D0 (en) 2015-05-08 2015-06-24 Oncopeptides Ab Process for preparation of nitrogen mustard derivatives
GB201521217D0 (en) * 2015-12-01 2016-01-13 Oncopeptides Ab Dosage regimens
CN108864251B (zh) * 2018-06-30 2022-06-14 大连理工大学 一类氨肽酶n激活的药物前体化合物及其制备方法和应用
ES2942468T3 (es) * 2018-10-18 2023-06-01 Oncopeptides Ab Compuestos que contienen deuterio
EP3946309A1 (en) 2019-04-03 2022-02-09 Oncopeptides AB Treatment of al amyloidosis with melflufen
GB201905477D0 (en) * 2019-04-17 2019-05-29 Oncopeptides Ab Novel formulations
WO2021053185A1 (en) 2019-09-20 2021-03-25 Oncopeptides Ab Melflufen formulations and their use in the treatment or prophylaxis of osteosarcoma
WO2022167087A1 (en) * 2021-02-05 2022-08-11 Oncopeptides Ab Peptidase enhanced cytotoxic dipeptides
EP4083052A1 (en) 2021-04-29 2022-11-02 BKmdcl AB Peptide conjugates of melphalan for the treatment of cancer
WO2022253894A1 (en) 2021-06-01 2022-12-08 Synthon B.V. Process for making melflufen or a salt thereof
EP4366721A1 (en) 2021-07-08 2024-05-15 Oncopeptides Innovation AB Melflufen for use in the treatment of multiple myeloma
GB202109896D0 (en) 2021-07-08 2021-08-25 Oncopeptides Ab Novel treatments
GB202109895D0 (en) 2021-07-08 2021-08-25 Oncopeptides Ab Novel treatments
GB202109894D0 (en) 2021-07-08 2021-08-25 Oncopeptides Ab Novel treatments
GB202204171D0 (en) 2022-03-24 2022-05-11 Oncopeptides Ab Novel formulations

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB750155A (en) 1953-03-17 1956-06-13 Nat Res Dev Substituted alanines

Also Published As

Publication number Publication date
WO2001096367A1 (en) 2001-12-20
DK1290011T3 (da) 2010-06-07
EP1290011A1 (en) 2003-03-12
CA2408501C (en) 2011-01-18
SE0002202D0 (sv) 2000-06-13
JP4798930B2 (ja) 2011-10-19
JP2004503564A (ja) 2004-02-05
ES2341702T3 (es) 2010-06-25
CA2408501A1 (en) 2001-12-20
PT1290011E (pt) 2010-05-11
AU2001264515A1 (en) 2001-12-24
EP1290011B1 (en) 2010-02-24

Similar Documents

Publication Publication Date Title
ATE458746T1 (de) Melphalan-derivate und ihre verwendung als chemotherapeutika gegen krebs
BR0316350A (pt) Diaminotriazóis úteis como inibidores de proteìna cinases
DK1594833T3 (da) 1-phenylalkancarboxylsyrederivater til behandling af neurodegenerative sygdomme
WO2007038459A3 (en) Carboxyamine compounds and their use in the treatment of hdac dependent diseases
UY27755A1 (es) Nuevas composiciones farmacéuticas basadas en anticolinérgicos e inhibidores.
EP3533461A3 (en) Prame derived peptides and immunogenic compositions comprising these
DE602005008996D1 (de) Radiofluorierte peptide
DE602006011196D1 (de) Ophthalmische pharmazeutische zusammensetzungen auf basis von aminosäuren und natriumhyaluronat
CU23932B1 (es) Sales farmacéuticamente aceptables de (3-{[[3-(6-amino-2-butoxi-8-oxo-7,8-dihidro-9h-purin-9-il)propil](3-morfolin-4-ilpropil)amino]metil}fenil)acetato de metilo y sus usos en terapia
CO5660287A2 (es) Derivados de tetrahidrocarbazol y su uso farmaceutico
CY1110906T1 (el) Φαρμακευτικη συνθεση για ρινικη χορηγηση φεντανυλης
ATE457736T1 (de) Zusammensetzung aus einem pulmonalen surfactant und einem von tnf stammenden peptid
BR0318278A (pt) compostos de éter aminocicloexìlico e usos dos mesmo
TR200401793T4 (tr) Perindopril tuzu ve bunu içeren farmasötik bileşimler.
BR0014378A (pt) Derivados de ácido indolil-3-glioxìlico tendo propriedades terapeuticamente valiosas
CY1109537T1 (el) Πεπτιδια και παραγωγα πεπτιδιου, παρασκευη αυτων καθως επισης χρηση αυτων για την παρασκευη θεραπευτικως η/και προληπτικως δραστικης φαρμακευτικης συνθεσης
CL2007002619A1 (es) Compuestos derivados de 3-aza-biciclo[4.1.0]heptano; composicion farmaceutica; y uso en el tratamiento de la depresion.
BR0009472A (pt) Antagonistas de lhrh com propriedades desolubilidade aperfeiçoadas
NO20054662D0 (no) Farmasoytisk sammensetning omfattende 5-metyl-2-2'-(klor-6'-fluoranilin)fenyleddiksyre
CY1110401T1 (el) Παραγωγα των 1-φαινυλαλκανοκαρβοξυλικων οξεων για την αντιμετωπιση των νευροεκφυλιστικων νοσων
CY1108711T1 (el) Συνθεσεις βενζοθειαζολιου και η χρηση αυτων
DE602006020155D1 (de) Pharmazeutische wundheilungs-zusammensetzungen in ren und natriumhyaluronat
EP1774966A4 (en) MEANS TO INHIBIT THE USE AND PROGRESS OF LIVER CANCER IN PATIENTS WITH HEPATITIS C-VIRUS POSITIVE LIVER CIRR
WO2002030964A3 (en) Comparative ligand mapping from mhc positive cells
ATE439443T1 (de) NEUES Aß-BINDUNGSPROTEIN UND DESSEN PEPTIDDERIVATE SOWIE VERWENDUNGEN DAVON

Legal Events

Date Code Title Description
RER Ceased as to paragraph 5 lit. 3 law introducing patent treaties