ATE454455T1 - Leitsequenzen zur anleitung von polypeptidsekretion und verfahren zur herstellung - Google Patents
Leitsequenzen zur anleitung von polypeptidsekretion und verfahren zur herstellungInfo
- Publication number
- ATE454455T1 ATE454455T1 AT06719694T AT06719694T ATE454455T1 AT E454455 T1 ATE454455 T1 AT E454455T1 AT 06719694 T AT06719694 T AT 06719694T AT 06719694 T AT06719694 T AT 06719694T AT E454455 T1 ATE454455 T1 AT E454455T1
- Authority
- AT
- Austria
- Prior art keywords
- guiding
- production
- heterologous
- polypeptides
- sequences
- Prior art date
Links
- 229920001184 polypeptide Polymers 0.000 title abstract 5
- 102000004196 processed proteins & peptides Human genes 0.000 title abstract 5
- 108090000765 processed proteins & peptides Proteins 0.000 title abstract 5
- 238000004519 manufacturing process Methods 0.000 title abstract 2
- 230000028327 secretion Effects 0.000 title 1
- 102000039446 nucleic acids Human genes 0.000 abstract 3
- 108020004707 nucleic acids Proteins 0.000 abstract 3
- 150000007523 nucleic acids Chemical class 0.000 abstract 3
- 239000013598 vector Substances 0.000 abstract 2
- 102000040430 polynucleotide Human genes 0.000 abstract 1
- 108091033319 polynucleotide Proteins 0.000 abstract 1
- 239000002157 polynucleotide Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Gastroenterology & Hepatology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Zoology (AREA)
- Genetics & Genomics (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Toxicology (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Peptides Or Proteins (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US64701305P | 2005-01-27 | 2005-01-27 | |
| PCT/US2006/002951 WO2006081430A2 (en) | 2005-01-27 | 2006-01-27 | Leader sequences for directing secretion of polypeptides and methods for production thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE454455T1 true ATE454455T1 (de) | 2010-01-15 |
Family
ID=36741080
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT06719694T ATE454455T1 (de) | 2005-01-27 | 2006-01-27 | Leitsequenzen zur anleitung von polypeptidsekretion und verfahren zur herstellung |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US20080286834A1 (https=) |
| EP (1) | EP1841874B1 (https=) |
| JP (2) | JP2008528033A (https=) |
| AT (1) | ATE454455T1 (https=) |
| AU (1) | AU2006207999A1 (https=) |
| CA (1) | CA2589895A1 (https=) |
| DE (1) | DE602006011574D1 (https=) |
| DK (1) | DK1841874T3 (https=) |
| WO (1) | WO2006081430A2 (https=) |
Families Citing this family (49)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2083081A1 (en) | 2005-07-22 | 2009-07-29 | Five Prime Therapeutics, Inc. | Compositions and methods of treating disease with FGFR fusion proteins |
| ES2543341T3 (es) | 2005-09-13 | 2015-08-18 | National Research Council Of Canada | Métodos y composiciones para modular la actividad de células tumorales |
| US9060961B2 (en) * | 2006-11-09 | 2015-06-23 | University Of Washington | Molecules and methods for treatment and detection of cancer |
| WO2009056330A1 (en) * | 2007-10-31 | 2009-05-07 | Eth Zurich | Soluble truncated apom proteins and medical uses thereof |
| EP2271358B1 (en) * | 2008-03-25 | 2018-11-21 | Amarantus Therapeutics, Inc. | use of mesencephalic astrocyte-derived neurotrophic factor for treating Parkinson's disease |
| FR2933773B1 (fr) * | 2008-07-10 | 2013-02-15 | Biomerieux Sa | Procede de dosage de la proteine disulfide isomerase pour le diagnostic in vitro du cancer colorectal |
| EP2318529B1 (en) | 2008-08-04 | 2017-10-18 | Five Prime Therapeutics, Inc. | Fgfr extracellular domain acidic region muteins |
| WO2010075194A1 (en) * | 2008-12-22 | 2010-07-01 | St. Jude Children's Research Hospital | Prokaryotic expression of soluble, active dkk |
| JP2010183885A (ja) * | 2009-02-13 | 2010-08-26 | Kobe Univ | タンパク質の製造方法およびそれに用いる発現ベクター |
| US8445445B2 (en) | 2009-09-15 | 2013-05-21 | Five Prime Therapeutics, Inc. | Method of promoting hair growth using FGFR4 extracellular domains |
| LT2498799T (lt) | 2009-11-13 | 2016-11-10 | Five Prime Therapeutics, Inc. | Fgfr1 ekstraląstelinio domeno baltymų panaudojimas gydymui vėžio su nuo ligando priklausančiomis, aktyvuojančiomis fgfr2 mutacijomis |
| EA034462B1 (ru) | 2009-11-24 | 2020-02-11 | Алетиа Байотерапьютикс Инк. | Антикластериновые антитела и антигенсвязывающие фрагменты и их использование для уменьшения объема новообразований |
| WO2011084711A2 (en) | 2009-12-17 | 2011-07-14 | Five Prime Therapeutics, Inc. | Hair growth methods using fgfr3 extracellular domains |
| HRP20190047T1 (hr) | 2010-05-04 | 2019-02-22 | Five Prime Therapeutics, Inc. | Protutijela koja se vežu na csf1r |
| DK2585098T3 (da) | 2010-06-28 | 2014-11-03 | Five Prime Therapeutics Inc | Ekstracellulære FZD8-domæner og fusionsmolekyler fraekstracellulære FZD8-domæner til anvendelse ved behandling afobesitet og obesitet-relaterede lidelser |
| EP2444495A1 (en) * | 2010-10-20 | 2012-04-25 | Algenics | Secretion of recombinant polypeptides in the extracellular medium of diatoms |
| KR101910779B1 (ko) | 2010-11-15 | 2018-10-22 | 파이브 프라임 테라퓨틱스, 인크. | Ｆｇｆｒ１ 세포밖 도메인 조합치료 |
| US8481038B2 (en) | 2010-11-15 | 2013-07-09 | Five Prime Therapeutics, Inc. | Treatment of cancer with elevated dosages of soluble FGFR1 fusion proteins |
| US8951972B2 (en) | 2010-12-09 | 2015-02-10 | Five Prime Therapeutics, Inc. | FGFR1 extracellular domain combination therapies for lung cancer |
| AU2012205384B2 (en) | 2011-01-14 | 2015-09-10 | Five Prime Therapeutics, Inc. | IL-27 antagonists for treating inflammatory diseases |
| CN107823630A (zh) | 2011-11-14 | 2018-03-23 | 戊瑞治疗有限公司 | 治疗癌症的方法 |
| US9822170B2 (en) | 2012-02-22 | 2017-11-21 | Alethia Biotherapeutics Inc. | Co-use of a clusterin inhibitor with an EGFR inhibitor to treat cancer |
| RU2670743C9 (ru) | 2012-05-11 | 2018-12-19 | Файв Прайм Терапьютикс, Инк. | Способы лечения состояний антителами, которые связывают рецептор колониестимулирующего фактора 1 (csf1r) |
| EP2858679B2 (en) | 2012-06-08 | 2024-06-05 | Translate Bio, Inc. | Pulmonary delivery of mrna to non-lung target cells |
| CN107759690A (zh) | 2012-08-31 | 2018-03-06 | 戊瑞治疗有限公司 | 用结合群落刺激因子1受体(csf1r)的抗体治疗病状的方法 |
| EP4331620A3 (en) | 2012-12-07 | 2024-12-04 | Translate Bio, Inc. | Lipidic nanoparticles for mrna delivery |
| EP2970940B1 (en) | 2013-03-14 | 2018-07-25 | Translate Bio, Inc. | Mrna therapeutic compositions and use to treat diseases and disorders |
| KR102516152B1 (ko) | 2013-08-01 | 2023-03-31 | 파이브 프라임 테라퓨틱스, 인크. | 비푸코실화된 항-ｆｇｆｒ２ｉｉｉｂ 항체 |
| SG11201610672YA (en) | 2014-06-23 | 2017-01-27 | Five Prime Therapeutics Inc | Methods of treating conditions with antibodies that bind colony stimulating factor 1 receptor (csf1r) |
| EP3212670B1 (en) | 2014-10-29 | 2020-12-23 | Five Prime Therapeutics, Inc. | Combination therapy for cancer |
| MX2017008218A (es) | 2014-12-22 | 2017-10-18 | Five Prime Therapeutics Inc | Anticuerpos anti-csf1r para tratar pvns. |
| RS60614B1 (sr) | 2015-03-23 | 2020-08-31 | Jounce Therapeutics Inc | Antitela za icos |
| AU2016249981B2 (en) | 2015-04-13 | 2022-02-17 | Five Prime Therapeutics, Inc. | Combination therapy for cancer |
| AU2016342269A1 (en) | 2015-10-22 | 2018-03-29 | Jounce Therapeutics, Inc. | Gene signatures for determining icos expression |
| ES2981471T3 (es) | 2016-04-25 | 2024-10-09 | Five Prime Therapeutics Inc | NOPE para el tratamiento de la pérdida de masa muscular y la debilidad muscular patológicas |
| HRP20211703T1 (hr) | 2016-11-02 | 2022-02-04 | Jounce Therapeutics, Inc. | Protutijela protiv pd-1 i njihova upotreba |
| CN109906030B (zh) | 2016-11-04 | 2022-03-18 | 安健基因公司 | 用于产生仅重链抗体的经基因修饰的非人动物和方法 |
| TWI685351B (zh) * | 2016-12-29 | 2020-02-21 | 財團法人生物技術開發中心 | 延長蛋白質藥物體內半衰期的激肽原-1衍生胜肽 |
| CN110709420A (zh) | 2017-03-31 | 2020-01-17 | 戊瑞治疗有限公司 | 使用抗gitr抗体的癌症组合疗法 |
| US20200024351A1 (en) | 2017-04-03 | 2020-01-23 | Jounce Therapeutics, Inc. | Compositions and Methods for the Treatment of Cancer |
| AU2018281334A1 (en) | 2017-06-06 | 2019-12-19 | Kindred Biosciences, Inc. | Erythropoietin and analogs for veterinary use |
| EA202091540A1 (ru) | 2017-12-22 | 2021-03-22 | Джаунс Терапьютикс, Инк. | Антитела к lilrb2 |
| CN113056483B (zh) | 2018-07-09 | 2025-08-01 | 戊瑞治疗有限公司 | 结合到ilt4的抗体 |
| US20220112257A1 (en) * | 2019-01-11 | 2022-04-14 | Arbele Limited | Mul tispecific prochemokine therapeutic proteins (park) and method of making and using thereof |
| US20220152098A1 (en) | 2019-03-01 | 2022-05-19 | Achelois Biopharma, Inc. | Methods of modulating cd160 function in the antigen-specific immune cell and uses thereof |
| WO2021178001A1 (en) * | 2020-03-05 | 2021-09-10 | Curie Co. Inc. | Methods for cell free protein expression of mature polypeptides derived from zymogens and proproteins |
| TWI890283B (zh) | 2020-02-14 | 2025-07-11 | 美商基利科學股份有限公司 | 結合ccr8之抗體及融合蛋白及其用途 |
| CN116724051A (zh) | 2020-08-10 | 2023-09-08 | 上海寻百会生物技术有限公司 | 用于通过靶向igsf8来治疗自身免疫性疾病和癌症的组合物和方法 |
| WO2023235699A1 (en) | 2022-05-31 | 2023-12-07 | Jounce Therapeutics, Inc. | Antibodies to lilrb4 and uses thereof |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5712114A (en) * | 1995-06-06 | 1998-01-27 | Basf Aktiengesellschaft | Compositions for expression of proteins in host cells using a preprocollagen signal sequence |
| DK1105508T3 (da) * | 1998-08-17 | 2003-01-06 | Europ Lab Molekularbiolog | Fremgangsmåde til oprensning af biomolekyle- eller proteinkomplekser |
| US20080242603A1 (en) * | 2004-02-20 | 2008-10-02 | Yan Wang | Novel Apo2L and IL-24 Polypeptides, Polynucleotides, and Methods of Their Use |
| EP2479277B1 (en) * | 2004-07-22 | 2015-09-02 | Five Prime Therapeutics, Inc. | Use of MGD-CSF in a method of treatment of Alzheimer's disease. |
-
2006
- 2006-01-27 CA CA002589895A patent/CA2589895A1/en not_active Abandoned
- 2006-01-27 EP EP06719694A patent/EP1841874B1/en not_active Expired - Lifetime
- 2006-01-27 DE DE602006011574T patent/DE602006011574D1/de not_active Expired - Lifetime
- 2006-01-27 WO PCT/US2006/002951 patent/WO2006081430A2/en not_active Ceased
- 2006-01-27 DK DK06719694.9T patent/DK1841874T3/da active
- 2006-01-27 AT AT06719694T patent/ATE454455T1/de not_active IP Right Cessation
- 2006-01-27 AU AU2006207999A patent/AU2006207999A1/en not_active Abandoned
- 2006-01-27 JP JP2007553266A patent/JP2008528033A/ja active Pending
- 2006-01-27 US US11/883,065 patent/US20080286834A1/en not_active Abandoned
-
2009
- 2009-01-19 JP JP2009009381A patent/JP2009131268A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| WO2006081430A2 (en) | 2006-08-03 |
| EP1841874A2 (en) | 2007-10-10 |
| AU2006207999A1 (en) | 2006-08-03 |
| US20080286834A1 (en) | 2008-11-20 |
| JP2009131268A (ja) | 2009-06-18 |
| EP1841874B1 (en) | 2010-01-06 |
| CA2589895A1 (en) | 2006-08-03 |
| WO2006081430A9 (en) | 2006-11-30 |
| JP2008528033A (ja) | 2008-07-31 |
| WO2006081430A3 (en) | 2007-04-05 |
| DK1841874T3 (da) | 2010-05-17 |
| DE602006011574D1 (de) | 2010-02-25 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |