KR100361933B1
(ko)
*
|
1993-09-08 |
2003-02-14 |
라 졸라 파마슈티칼 컴파니 |
화학적으로정의된비중합성결합가플랫폼분자및그것의콘주게이트
|
WO1999030727A1
(en)
*
|
1997-12-17 |
1999-06-24 |
Enzon, Inc. |
Polymeric prodrugs of amino- and hydroxyl-containing bioactive agents
|
PL200586B1
(pl)
*
|
1998-10-16 |
2009-01-30 |
Biogen Idec Inc |
Polipeptydy zawierające mutanty interferonu-beta-1a, kodujące je cząsteczki kwasów nukleinowych, komórki gospodarza transformowane tymi cząsteczkami, sposób wytwarzania polipeptydów, zawierające je kompozycje farmaceutyczne i zastosowania polipeptydów
|
EP1656952B1
(de)
|
1998-10-16 |
2013-12-18 |
Biogen Idec MA Inc. |
Polyalkylenglykol-Konjugate von Interferon beta-1A und ihre Verwendungen
|
US6458953B1
(en)
*
|
1998-12-09 |
2002-10-01 |
La Jolla Pharmaceutical Company |
Valency platform molecules comprising carbamate linkages
|
US7303760B2
(en)
*
|
1999-04-23 |
2007-12-04 |
Alza Corporation |
Method for treating multi-drug resistant tumors
|
IL146055A0
(en)
*
|
1999-04-23 |
2002-07-25 |
Alza Corp |
Conjugate having a cleavable linkage for use in a liposome
|
US7238368B2
(en)
*
|
1999-04-23 |
2007-07-03 |
Alza Corporation |
Releasable linkage and compositions containing same
|
US6713454B1
(en)
|
1999-09-13 |
2004-03-30 |
Nobex Corporation |
Prodrugs of etoposide and etoposide analogs
|
IL153789A0
(en)
*
|
2000-07-12 |
2003-07-31 |
Gryphon Therapeutics Inc |
Chemokine receptor modulators, production and use
|
HUP0303854A2
(hu)
*
|
2000-09-08 |
2004-03-01 |
Gryhon Therapeutics, Inc. |
Szintetikus erythropoiesis-stimuláló proteinek
|
US7118737B2
(en)
|
2000-09-08 |
2006-10-10 |
Amylin Pharmaceuticals, Inc. |
Polymer-modified synthetic proteins
|
WO2002066066A1
(en)
*
|
2001-02-20 |
2002-08-29 |
Enzon, Inc. |
Terminally-branched polymeric linkers and polymeric conjugates containing the same
|
CA2440091C
(en)
|
2001-03-23 |
2011-05-03 |
Enzon, Inc. |
Prodrugs of anticancer agents employing substituted aromatic acids
|
US20040077835A1
(en)
*
|
2001-07-12 |
2004-04-22 |
Robin Offord |
Chemokine receptor modulators, production and use
|
EP1476181B1
(de)
*
|
2002-01-18 |
2016-03-23 |
Biogen MA Inc. |
Polyalkylen-polymerverbindungen und ihre verwendung
|
CA2491661A1
(en)
*
|
2002-07-12 |
2004-01-22 |
Biomarin Pharmaceutical Inc. |
The use of isocyanate linkers to make hydrolyzable active agent biopolymer conjugates
|
US20040062748A1
(en)
|
2002-09-30 |
2004-04-01 |
Mountain View Pharmaceuticals, Inc. |
Polymer conjugates with decreased antigenicity, methods of preparation and uses thereof
|
US8129330B2
(en)
|
2002-09-30 |
2012-03-06 |
Mountain View Pharmaceuticals, Inc. |
Polymer conjugates with decreased antigenicity, methods of preparation and uses thereof
|
WO2004043396A2
(en)
*
|
2002-11-09 |
2004-05-27 |
Nobex Corporation |
Modified carbamate-containing prodrugs and methods of synthesizing same
|
US7462687B2
(en)
*
|
2002-11-12 |
2008-12-09 |
Enzon Pharmaceuticals, Inc. |
Prodrugs of vancomycin with hydrolysis resistant polymer linkages
|
WO2004061094A1
(en)
|
2002-12-30 |
2004-07-22 |
Gryphon Therapeutics, Inc. |
Water-soluble thioester and selenoester compounds and methods for making and using the same
|
WO2004074345A2
(en)
*
|
2003-02-19 |
2004-09-02 |
Pharmacia Corporation |
Carbonate esters of polyethylene glycol activated by means of oxalate esters
|
US7332164B2
(en)
*
|
2003-03-21 |
2008-02-19 |
Enzon Pharmaceuticals, Inc. |
Heterobifunctional polymeric bioconjugates
|
RU2394041C2
(ru)
*
|
2003-04-13 |
2010-07-10 |
Энзон Фармасьютикалз, Инк. |
Полимерные олигонуклеотидные пролекарства
|
US20050249697A1
(en)
*
|
2003-09-24 |
2005-11-10 |
Uhrich Kathryn E |
Compositions and methods for the inhibition of bone growth and resorption
|
JP2007521338A
(ja)
*
|
2004-01-07 |
2007-08-02 |
アンビット バイオサイエンシス コーポレーション |
共役化された低分子
|
CA2584510C
(en)
*
|
2004-10-25 |
2013-05-28 |
Intezyne Technologies, Incorporated |
Heterobifunctional poly(ethylene glycol) and uses thereof
|
US20100092505A1
(en)
|
2005-04-05 |
2010-04-15 |
Elisabetta Bianchi |
Method for Shielding Functional Sites or Epitopes on Proteins
|
CN101405024B
(zh)
*
|
2005-12-30 |
2012-01-18 |
药华医药股份有限公司 |
药物-聚合物的结合物
|
GB0604187D0
(en)
*
|
2006-03-02 |
2006-04-12 |
Fusion Antibodies Ltd |
Peptide and uses thereof
|
CA2861601A1
(en)
|
2006-04-27 |
2007-11-08 |
Intezyne Technologies, Inc. |
Poly (ethylene glycol) containing chemically disparate endgroups
|
WO2007130453A2
(en)
|
2006-05-02 |
2007-11-15 |
Allozyne, Inc. |
Non-natural amino acid substituted polypeptides
|
US20080096819A1
(en)
*
|
2006-05-02 |
2008-04-24 |
Allozyne, Inc. |
Amino acid substituted molecules
|
GB0611405D0
(en)
*
|
2006-06-09 |
2006-07-19 |
Univ Belfast |
FKBP-L: A novel inhibitor of angiogenesis
|
EP2035016A2
(de)
*
|
2006-06-09 |
2009-03-18 |
Enzon Pharmaceuticals, Inc. |
Indenoisochinolin-lösliche polymer-konjugate
|
PL2046369T3
(pl)
*
|
2006-06-30 |
2016-01-29 |
Sigma Tau Pharma Ltd |
Rekombinowany gospodarz służący do wytwarzania L-Asparaginazy II
|
EP2076257A4
(de)
*
|
2006-09-15 |
2014-04-16 |
Belrose Pharma Inc |
Polymere konjugate mit positiv geladenen teilen
|
US7985783B2
(en)
|
2006-09-21 |
2011-07-26 |
The Regents Of The University Of California |
Aldehyde tags, uses thereof in site-specific protein modification
|
US20100279408A1
(en)
*
|
2006-11-27 |
2010-11-04 |
Enzon Pharmaceuticals, Inc. |
Polymeric short interfering rna conjugates
|
US20080159964A1
(en)
*
|
2006-12-29 |
2008-07-03 |
Enzon Pharmaceuticals, Inc. |
Use of adenosine deaminase for treating pulmonary disease
|
DK2147116T3
(en)
|
2007-04-20 |
2016-05-30 |
Sigma Tau Rare Disease Ltd |
STABLE RECOMBINANT adenosine deaminase
|
SI2147122T1
(sl)
*
|
2007-04-20 |
2015-01-30 |
Sigma-Tau Pharma Limited |
Encimatska terapija proti raku
|
EP2176404A4
(de)
*
|
2007-07-11 |
2014-11-19 |
Belrose Pharma Inc |
Polymere arzneistoffzuführsysteme mit einer aromatischen allylsäure
|
CA2693616A1
(en)
*
|
2007-07-11 |
2009-01-15 |
Enzon Pharmaceuticals, Inc. |
Polymeric drug delivery system containing a multi-substituted aromatic moiety
|
CA2707840A1
(en)
|
2007-08-20 |
2009-02-26 |
Allozyne, Inc. |
Amino acid substituted molecules
|
CA2937222C
(en)
|
2009-06-25 |
2019-06-04 |
Alkermes Pharma Ireland Limited |
Prodrugs of nh-acidic compounds
|
DK2445502T4
(da)
|
2009-06-25 |
2022-11-28 |
Alkermes Pharma Ireland Ltd |
Heterocycliske forbindelser til behandling af neurologiske og psykologiske lidelser
|
WO2011084849A1
(en)
*
|
2010-01-07 |
2011-07-14 |
Alkermes, Inc. |
Diaryldiazepine prodrugs for the treatment of neurological and psychological disorders
|
JP6076740B2
(ja)
*
|
2010-01-07 |
2017-02-08 |
アルカーメス ファーマ アイルランド リミテッド |
第四級アンモニウム塩プロドラッグ
|
US9107911B2
(en)
|
2010-01-07 |
2015-08-18 |
Alkermes Pharma Ireland Limited |
Prodrugs of heteraromatic compounds
|
WO2011084851A1
(en)
*
|
2010-01-07 |
2011-07-14 |
Alkermes, Inc. |
Asenapine produrugs
|
US20110166156A1
(en)
*
|
2010-01-07 |
2011-07-07 |
Alkermes, Inc. |
Prodrugs for the Treatment of Schizophrenia and Bipolar Disease
|
AU2011270701B2
(en)
|
2010-06-24 |
2015-05-14 |
Alkermes Pharma Ireland Limited |
Prodrugs of NH-acidic compounds: ester, carbonate, carbamate and phosphonate derivatives
|
HUE054318T2
(hu)
*
|
2010-11-12 |
2021-08-30 |
Nektar Therapeutics |
IL-2 molekularész konjugátumai és polimer
|
EP2651448B1
(de)
|
2010-12-13 |
2018-11-28 |
QuiaPEG Pharmaceuticals AB |
Wasserlösliche, nicht-peptidische, nicht-nukleotidischen phosphoramidatfunktionalisierte polymere
|
AU2011352204B2
(en)
*
|
2010-12-29 |
2015-05-21 |
Arrowhead Pharmaceuticals, Inc. |
In vivo polynucleotide delivery conjugates having enzyme sensitive linkages
|
HUE065359T2
(hu)
|
2011-03-18 |
2024-05-28 |
Alkermes Pharma Ireland Ltd |
Szorbitán-észtereket tartalmazó gyógyászati készítmények
|
DE102011118029A1
(de)
|
2011-06-20 |
2012-12-20 |
Universität Leipzig |
Modifizierte antibiotische Peptide mit variabler systemischer Freisetzung
|
CN103747807B
(zh)
|
2011-07-05 |
2016-12-07 |
比奥阿赛斯技术有限公司 |
P97‑抗体缀合物和使用方法
|
JP5952912B2
(ja)
|
2011-12-15 |
2016-07-13 |
アルカーメス ファーマ アイルランド リミテッド |
二級アミン化合物のプロドラッグ
|
CA2867123C
(en)
|
2012-03-19 |
2021-02-16 |
Alkermes Pharma Ireland Limited |
Pharmaceutical compositions comprising water-insoluble antipsychotic agents and glycerol esters
|
WO2013142205A1
(en)
|
2012-03-19 |
2013-09-26 |
Alkermes Pharma Ireland Limited |
Pharmaceutical compositions comprising benzyl alcohol
|
CA2867121C
(en)
|
2012-03-19 |
2021-05-25 |
Alkermes Pharma Ireland Limited |
Pharmaceutical compositions comprising fatty acid esters
|
WO2013186632A2
(en)
|
2012-06-12 |
2013-12-19 |
Quiapeg Ab |
Conjugates of biologically active molecules to functionalized polymers
|
EP2880156B1
(de)
|
2012-07-31 |
2017-08-23 |
biOasis Technologies Inc |
Dephosphorylierte proteine lysosomaler speicherkrankheiten und verwendung davon
|
US9193685B2
(en)
|
2012-09-19 |
2015-11-24 |
Alkermes Pharma Ireland Limited |
Pharmaceutical compositions having improved storage stability
|
US9310374B2
(en)
|
2012-11-16 |
2016-04-12 |
Redwood Bioscience, Inc. |
Hydrazinyl-indole compounds and methods for producing a conjugate
|
JP2016505528A
(ja)
|
2012-11-16 |
2016-02-25 |
ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア |
タンパク質の化学修飾のためのピクテ−スペングラーライゲーション
|
WO2014160438A1
(en)
|
2013-03-13 |
2014-10-02 |
Bioasis Technologies Inc. |
Fragments of p97 and uses thereof
|
EP3038657A2
(de)
|
2013-08-28 |
2016-07-06 |
Bioasis Technologies Inc. |
Cns-gerichtete konjugate mit modifizierten fc-regionen und verfahren zur verwendung davon
|
JP6745218B2
(ja)
|
2013-11-27 |
2020-08-26 |
レッドウッド バイオサイエンス, インコーポレイテッド |
ヒドラジニル−ピロロ化合物及び複合体を生成するための方法
|
WO2015130997A1
(en)
|
2014-02-26 |
2015-09-03 |
Gdovin Matthew |
Nitrobenzaldehyde proton release for manipulation of cellular acidosis
|
CN110368360A
(zh)
|
2014-03-20 |
2019-10-25 |
奥克梅斯制药爱尔兰有限公司 |
具有增加的注射速度的阿立哌唑制剂
|
JP6625627B2
(ja)
|
2014-10-14 |
2019-12-25 |
ハロザイム インコーポレイテッド |
アデノシンデアミナーゼ−2(ada2)、その変異体の組成物およびそれを使用する方法
|
EP3463308B1
(de)
|
2016-06-01 |
2021-12-01 |
Servier IP UK Limited |
Formulierungen von polyalkylen-oxid-asparaginase und verfahren zur herstellung und verwendung davon
|
US20210308277A1
(en)
|
2016-11-14 |
2021-10-07 |
Hangzhou Dac Biotech Co., Ltd. |
Conjugation linkers, cell binding molecule-drug conjugates containing the linkers, methods of making and uses such conjugates with the linkers
|
CN108727208B
(zh)
*
|
2017-03-07 |
2020-06-30 |
天津键凯科技有限公司 |
一种连接子化合物、聚乙二醇-连接子结合物及其衍生物和聚乙二醇-连接子-药物结合物
|
AU2018231832A1
(en)
|
2017-03-10 |
2019-08-08 |
Quiapeg Pharmaceuticals Ab |
Releasable conjugates
|
US11319408B2
(en)
|
2017-03-30 |
2022-05-03 |
Nof Corporation |
Hydrophilic polymer derivative having self-immolative acetal linker and conjugate using same
|
EP3655021B1
(de)
|
2017-07-19 |
2023-03-22 |
Unikeris Limited |
Adenosine deaminase zur verbesserung und behandlung von skleroderma-assoziierte vaskulopathie
|
US10618896B2
(en)
|
2017-08-22 |
2020-04-14 |
Dynavax Technologies Corporation |
Alkyl chain modified imidazoquinoline TLR7/8 agonist compounds and uses thereof
|
CN114668852A
(zh)
*
|
2017-09-30 |
2022-06-28 |
天津键凯科技有限公司 |
一种聚乙二醇-多肽和蛋白类药物的结合物
|
CN109589415B
(zh)
|
2017-09-30 |
2022-02-18 |
天津键凯科技有限公司 |
一种聚乙二醇-多肽和蛋白类药物的结合物
|
EP3710059A1
(de)
|
2017-11-14 |
2020-09-23 |
Dynavax Technologies Corporation |
Spaltbare konjugate von tlr7/8-agonist-verbindungen, verfahren zur herstellung und verwendungen davon
|
US11492493B2
(en)
|
2017-12-26 |
2022-11-08 |
Becton, Dickinson And Company |
Deep ultraviolet-excitable water-solvated polymeric dyes
|
CN112423754A
(zh)
|
2018-03-05 |
2021-02-26 |
奥克梅斯制药爱尔兰有限公司 |
阿立哌唑的给药策略
|
JP2021519841A
(ja)
|
2018-03-30 |
2021-08-12 |
ベクトン・ディキンソン・アンド・カンパニーBecton, Dickinson And Company |
ペンダントクロモフォアを有する水溶性ポリマー色素
|
CA3107332A1
(en)
|
2018-07-22 |
2020-01-30 |
Bioasis Technologies Inc. |
Treatment of lymphatic metastases
|
EP3849660A1
(de)
|
2018-09-12 |
2021-07-21 |
QuiaPEG Pharmaceuticals AB |
Lösbare glp-1-konjugate
|
EP3909612A1
(de)
|
2020-05-12 |
2021-11-17 |
Life Science Inkubator Betriebs GmbH & Co. KG |
Zusammensetzung von nanopartikeln
|
US20210355468A1
(en)
|
2020-05-18 |
2021-11-18 |
Bioasis Technologies, Inc. |
Compositions and methods for treating lewy body dementia
|
US20210393787A1
(en)
|
2020-06-17 |
2021-12-23 |
Bioasis Technologies, Inc. |
Compositions and methods for treating frontotemporal dementia
|
CA3128035A1
(en)
|
2020-08-13 |
2022-02-13 |
Bioasis Technologies, Inc. |
Combination therapies for delivery across the blood brain barrier
|
EP4155349A1
(de)
|
2021-09-24 |
2023-03-29 |
Becton, Dickinson and Company |
Wasserlösliche gelbe grünabsorbierende farbstoffe
|
WO2024007016A2
(en)
|
2022-07-01 |
2024-01-04 |
Beckman Coulter, Inc. |
Novel fluorescent dyes and polymers from dihydrophenanthrene derivatives
|
WO2024044327A1
(en)
|
2022-08-26 |
2024-02-29 |
Beckman Coulter, Inc. |
Dhnt monomers and polymer dyes with modified photophysical properties
|