ATE444080T1 - Polymere vorstufenwirkstoffe von amino-und hydroxyl-enthaltenden bioaktiven agentien - Google Patents

Polymere vorstufenwirkstoffe von amino-und hydroxyl-enthaltenden bioaktiven agentien

Info

Publication number
ATE444080T1
ATE444080T1 AT98963173T AT98963173T ATE444080T1 AT E444080 T1 ATE444080 T1 AT E444080T1 AT 98963173 T AT98963173 T AT 98963173T AT 98963173 T AT98963173 T AT 98963173T AT E444080 T1 ATE444080 T1 AT E444080T1
Authority
AT
Austria
Prior art keywords
substituted
alkyls
cycloalkyls
aryls
heteroalkyls
Prior art date
Application number
AT98963173T
Other languages
English (en)
Inventor
Richard Greenwald
Annapurna Pendri
Yun Choe
Samuel Zalipsky
Original Assignee
Enzon Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Enzon Inc filed Critical Enzon Inc
Priority claimed from PCT/US1998/026565 external-priority patent/WO1999030727A1/en
Application granted granted Critical
Publication of ATE444080T1 publication Critical patent/ATE444080T1/de

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
    • A61K47/59—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
    • A61K47/60—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes the organic macromolecular compound being a polyoxyalkylene oligomer, polymer or dendrimer, e.g. PEG, PPG, PEO or polyglycerol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Polyamides (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
AT98963173T 1997-12-17 1998-12-14 Polymere vorstufenwirkstoffe von amino-und hydroxyl-enthaltenden bioaktiven agentien ATE444080T1 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US99243597A 1997-12-17 1997-12-17
US09/183,557 US6180095B1 (en) 1997-12-17 1998-10-30 Polymeric prodrugs of amino- and hydroxyl-containing bioactive agents
PCT/US1998/026565 WO1999030727A1 (en) 1997-12-17 1998-12-14 Polymeric prodrugs of amino- and hydroxyl-containing bioactive agents

Publications (1)

Publication Number Publication Date
ATE444080T1 true ATE444080T1 (de) 2009-10-15

Family

ID=25538340

Family Applications (1)

Application Number Title Priority Date Filing Date
AT98963173T ATE444080T1 (de) 1997-12-17 1998-12-14 Polymere vorstufenwirkstoffe von amino-und hydroxyl-enthaltenden bioaktiven agentien

Country Status (4)

Country Link
US (1) US6180095B1 (de)
EP (1) EP1897561A1 (de)
AT (1) ATE444080T1 (de)
DE (1) DE69841206D1 (de)

Families Citing this family (97)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR100361933B1 (ko) * 1993-09-08 2003-02-14 라 졸라 파마슈티칼 컴파니 화학적으로정의된비중합성결합가플랫폼분자및그것의콘주게이트
AU1825299A (en) * 1997-12-17 1999-07-05 Enzon, Inc. Polymeric prodrugs of amino- and hydroxyl-containing bioactive agents
LT2599503T (lt) 1998-10-16 2017-06-26 Biogen Ma Inc. Interferono beta-1a polimero konjugatai ir jų panaudojimas
CN100480266C (zh) * 1998-10-16 2009-04-22 拜奥根Idec马萨诸塞公司 干扰素-β融合蛋白及用途
US6458953B1 (en) * 1998-12-09 2002-10-01 La Jolla Pharmaceutical Company Valency platform molecules comprising carbamate linkages
AU769425B2 (en) * 1999-04-23 2004-01-29 Alza Corporation Conjugate having a cleavable linkage for use in a liposome
US7303760B2 (en) * 1999-04-23 2007-12-04 Alza Corporation Method for treating multi-drug resistant tumors
US7238368B2 (en) * 1999-04-23 2007-07-03 Alza Corporation Releasable linkage and compositions containing same
US6713454B1 (en) * 1999-09-13 2004-03-30 Nobex Corporation Prodrugs of etoposide and etoposide analogs
AU2002218769A1 (en) * 2000-07-12 2002-01-21 Gryphon Therapeutics, Inc. Chemokine receptor modulators, production and use
KR20030046411A (ko) * 2000-09-08 2003-06-12 그리폰 테라퓨틱스, 인코포레이티드 '위'-천연 화학적 라이게이션
US7118737B2 (en) 2000-09-08 2006-10-10 Amylin Pharmaceuticals, Inc. Polymer-modified synthetic proteins
JP2004530736A (ja) * 2001-02-20 2004-10-07 エンゾン ファーマシューティカルズ，インコーポレーテッド 末端分枝高分子リンカーおよびそれを含む高分子複合体
DE60233315D1 (de) 2001-03-23 2009-09-24 Enzon Inc Prodrugs von krebsmitteln mit substituierten aromatischen säuren
US20040077835A1 (en) * 2001-07-12 2004-04-22 Robin Offord Chemokine receptor modulators, production and use
CN101700401B (zh) 2002-01-18 2013-08-14 比奥根艾迪克Ma公司 具有用于共轭生物活性化合物的部分的聚亚烷基二醇
JP2005537266A (ja) * 2002-07-12 2005-12-08 バイオマリン ファーマシューティカル インコーポレイテッド 加水分解性活性物質であるバイオポリマーコンジュゲートを作製するためのイソシアネートリンカーの使用
US8129330B2 (en) 2002-09-30 2012-03-06 Mountain View Pharmaceuticals, Inc. Polymer conjugates with decreased antigenicity, methods of preparation and uses thereof
US20040062748A1 (en) * 2002-09-30 2004-04-01 Mountain View Pharmaceuticals, Inc. Polymer conjugates with decreased antigenicity, methods of preparation and uses thereof
WO2004043396A2 (en) * 2002-11-09 2004-05-27 Nobex Corporation Modified carbamate-containing prodrugs and methods of synthesizing same
WO2004044223A2 (en) * 2002-11-12 2004-05-27 Enzon Pharmaceuticals, Inc. Prodrugs of vancomycin with hydrolysis resistant polymer linkers
AU2003303595A1 (en) 2002-12-30 2004-07-29 Gryphon Therapeutics, Inc. Water-soluble thioester and selenoester compounds and methods for making and using the same
EP1597299A2 (de) * 2003-02-19 2005-11-23 Pharmacia Corporation Mit oxalatestern aktivierte carbonatester von polyethylenglykol
US7332164B2 (en) * 2003-03-21 2008-02-19 Enzon Pharmaceuticals, Inc. Heterobifunctional polymeric bioconjugates
NZ542687A (en) * 2003-04-13 2010-02-26 Enzon Pharmaceuticals Inc Polymeric oligonucleotide prodrugs
WO2005039489A2 (en) * 2003-09-24 2005-05-06 Polymerix Corporation Compositions and methods for the inhibition of bone growth and resorption
CA2551495A1 (en) * 2004-01-07 2005-07-28 Ambit Biosciences Corporation Conjugated small molecules
US7612153B2 (en) * 2004-10-25 2009-11-03 Intezyne Technologies, Inc. Heterobifunctional poly(ethylene glycol) and uses thereof
EP2314320A2 (de) 2005-04-05 2011-04-27 Istituto di Richerche di Biologia Molecolare P. Angeletti S.p.A. Verfahren zur Abschirmung von funktionalen Stellen oder Epitopen von Proteinen
TWI381850B (zh) * 2005-12-30 2013-01-11 Pharmaessentia Corp 藥物與聚合物之共軛物
GB0604187D0 (en) * 2006-03-02 2006-04-12 Fusion Antibodies Ltd Peptide and uses thereof
EP2010477A4 (de) 2006-04-27 2012-05-30 Intezyne Technologies Inc Poly (ethylenglykol) mit chemisch ungleichen endgruppen
US20080096819A1 (en) * 2006-05-02 2008-04-24 Allozyne, Inc. Amino acid substituted molecules
WO2007130453A2 (en) * 2006-05-02 2007-11-15 Allozyne, Inc. Non-natural amino acid substituted polypeptides
CA2652256A1 (en) * 2006-06-09 2007-12-21 Enzon Pharmaceuticals, Inc. Indenoisoquinoline-releasable polymer conjugates
GB0611405D0 (en) 2006-06-09 2006-07-19 Univ Belfast FKBP-L: A novel inhibitor of angiogenesis
AU2007275535B2 (en) * 2006-06-30 2012-08-16 Servier IP UK Limited Recombinant host for producing L-asparaginase II
CA2662520A1 (en) * 2006-09-15 2008-03-20 Enzon Pharmaceuticals, Inc. Polymeric conjugates containing positively-charged moieties
US7985783B2 (en) 2006-09-21 2011-07-26 The Regents Of The University Of California Aldehyde tags, uses thereof in site-specific protein modification
US20100279408A1 (en) * 2006-11-27 2010-11-04 Enzon Pharmaceuticals, Inc. Polymeric short interfering rna conjugates
CA2671209A1 (en) * 2006-12-29 2008-07-10 Enzon Pharmaceuticals, Inc. Use of adenosine deaminase for treating pulmonary disease
NZ580980A (en) * 2007-04-20 2012-04-27 Sigma Tau Rare Diseases S A Enzymatic anticancer therapy
US8071741B2 (en) * 2007-04-20 2011-12-06 Defiante Farmaceutica, S.A. Stable recombinant adenosine deaminase
US20090016985A1 (en) * 2007-07-11 2009-01-15 Enzon Pharmaceuticals, Inc. Polymeric drug delivery system containing a multi-substituted aromatic moiety
CA2693645A1 (en) * 2007-07-11 2009-01-15 Enzon Pharmaceuticals, Inc. Polymeric drug delivery systems containing an aromatic allylic acid
CA2707840A1 (en) * 2007-08-20 2009-02-26 Allozyne, Inc. Amino acid substituted molecules
EP3309151A1 (de) 2009-06-25 2018-04-18 Alkermes Pharma Ireland Limited Heterocyclische verbindungen zur behandlung von neurologischen und psychologischen erkrankungen
WO2010151711A1 (en) 2009-06-25 2010-12-29 Alkermes, Inc. Prodrugs of nh-acidic compounds
US20110166156A1 (en) * 2010-01-07 2011-07-07 Alkermes, Inc. Prodrugs for the Treatment of Schizophrenia and Bipolar Disease
WO2011084851A1 (en) * 2010-01-07 2011-07-14 Alkermes, Inc. Asenapine produrugs
CA2798172C (en) * 2010-01-07 2017-11-21 Alkermes Pharma Ireland Limited Quaternary ammonium salt prodrugs
US20110166128A1 (en) * 2010-01-07 2011-07-07 Alkermes, Inc. Diaryldiazepine Prodrugs for the Treatment of Neurological and Psychological Disorders
AU2010339691B2 (en) 2010-01-07 2015-04-02 Alkermes Pharma Ireland Limited Prodrugs of heteraromatic compounds
AU2011270701B2 (en) 2010-06-24 2015-05-14 Alkermes Pharma Ireland Limited Prodrugs of NH-acidic compounds: ester, carbonate, carbamate and phosphonate derivatives
KR102472497B1 (ko) 2010-11-12 2022-11-29 넥타르 테라퓨틱스 Ｉｌ-2 부분 및 중합체의 접합체
CA2821411C (en) 2010-12-13 2020-02-25 Marek Kwiatkowski Functionalized polymers
EP2658579A4 (de) * 2010-12-29 2015-07-22 Arrowhead Res Corp Konjugate zur in-vivo-abgabe von polynukleotiden mit enzymempfindlichen bindungen
HRP20240285T1 (hr) 2011-03-18 2024-05-24 Alkermes Pharma Ireland Limited Farmaceutski pripravci koji sadrže sorbitan estere
DE102011118029A1 (de) 2011-06-20 2012-12-20 Universität Leipzig Modifizierte antibiotische Peptide mit variabler systemischer Freisetzung
HUE029855T2 (en) 2011-07-05 2017-04-28 Bioasis Technologies Inc p97 antibody conjugates
ES2715562T3 (es) 2011-12-15 2019-06-04 Alkermes Pharma Ireland Ltd Profármacos de compuestos de amina secundaria
US9999670B2 (en) 2012-03-19 2018-06-19 Alkermes Pharma Ireland Limited Pharmaceutical compositions comprising benzyl alcohol
NZ630643A (en) 2012-03-19 2017-08-25 Alkermes Pharma Ireland Ltd Pharmaceutical compositions comprising fatty acid esters
US9993556B2 (en) 2012-03-19 2018-06-12 Alkermes Pharma Ireland Limited Pharmaceutical compositions comprising fatty glycerol esters
EP3628332A1 (de) 2012-06-12 2020-04-01 QuiaPEG Pharmaceuticals AB Konjugate biologisch aktiver moleküle an funktionalisierte polymere
CA2880162C (en) 2012-07-31 2023-04-04 Bioasis Technologies, Inc. Dephosphorylated lysosomal storage disease proteins and methods of use thereof
WO2014080285A2 (en) 2012-09-19 2014-05-30 Alkermes Pharma Ireland Limited Pharmaceutical compositions having improved storage stability
CA2890906A1 (en) 2012-11-16 2014-05-22 The Regents Of The University Of California Pictet-spengler ligation for protein chemical modification
US9310374B2 (en) 2012-11-16 2016-04-12 Redwood Bioscience, Inc. Hydrazinyl-indole compounds and methods for producing a conjugate
WO2014160438A1 (en) 2013-03-13 2014-10-02 Bioasis Technologies Inc. Fragments of p97 and uses thereof
AU2014312190A1 (en) 2013-08-28 2016-02-18 Bioasis Technologies Inc. CNS-targeted conjugates of antibodies
WO2015081282A1 (en) 2013-11-27 2015-06-04 Redwood Bioscience, Inc. Hydrazinyl-pyrrolo compounds and methods for producing a conjugate
AU2015222879B2 (en) 2014-02-26 2019-12-05 The Board Of Regents Of The University Of Texas System Nitrobenzaldehyde proton release for manipulation of cellular acidosis
BR112016021535A8 (pt) 2014-03-20 2021-07-20 Alkermes Pharma Ireland Ltd kit compreendendo formulações de aripiprazol tendo velocidades de injeção aumentadas útil para o tratamento de uma desordem do sistema nervoso central e uso
PL3207130T3 (pl) 2014-10-14 2020-02-28 Halozyme, Inc. Kompozycje deaminazy adenozyny 2 (ada2), jej warianty i sposoby ich zastosowania
AU2017299374B2 (en) 2016-06-01 2021-05-27 Servier IP UK Limited Formulations of polyalkylene oxide-asparaginase and methods of making and using the same
KR20220150408A (ko) 2016-11-14 2022-11-10 항저우 디에이씨 바이오테크 씨오, 엘티디 결합 링커, 그러한 결합 링커를 함유하는 세포 결합 분자-약물 결합체, 링커를 갖는 그러한 결합체의 제조 및 사용
CN108727208B (zh) * 2017-03-07 2020-06-30 天津键凯科技有限公司 一种连接子化合物、聚乙二醇-连接子结合物及其衍生物和聚乙二醇-连接子-药物结合物
CA3051173A1 (en) 2017-03-10 2018-09-13 Quiapeg Pharmaceuticals Ab Releasable conjugates
JP7022328B2 (ja) 2017-03-30 2022-02-18 日油株式会社 自壊性アセタールリンカーを有する親水性ポリマー誘導体及びそれを用いた複合体
JP7338873B2 (ja) 2017-07-19 2023-09-05 ユニケリス・リミテッド 強皮症関連血管障害を治療または改善するための組成物および方法
WO2019040491A1 (en) 2017-08-22 2019-02-28 Dynavax Technologies Corporation MODIFIED ALKYL CHAIN IMIDAZOQUINOLINE TLR7 / 8 AGONIST COMPOUNDS AND USES THEREOF
CN114668852A (zh) * 2017-09-30 2022-06-28 天津键凯科技有限公司 一种聚乙二醇-多肽和蛋白类药物的结合物
CN109589415B (zh) * 2017-09-30 2022-02-18 天津键凯科技有限公司 一种聚乙二醇-多肽和蛋白类药物的结合物
US10722591B2 (en) 2017-11-14 2020-07-28 Dynavax Technologies Corporation Cleavable conjugates of TLR7/8 agonist compounds, methods for preparation, and uses thereof
EP3732254A4 (de) 2017-12-26 2021-12-22 Becton, Dickinson and Company Tiefe uv-erregbare wassersolvatisierte polymerfarbstoffe
AU2019230014A1 (en) 2018-03-05 2020-09-17 Alkermes Pharma Ireland Limited Aripiprazole dosing strategy
WO2019191482A1 (en) 2018-03-30 2019-10-03 Becton, Dickinson And Company Water-soluble polymeric dyes having pendant chromophores
EP3813867A1 (de) 2018-07-22 2021-05-05 Bioasis Technologies Inc. Behandlung von lymphatischen metastasen
EP3849660A1 (de) 2018-09-12 2021-07-21 QuiaPEG Pharmaceuticals AB Lösbare glp-1-konjugate
EP3909612A1 (de) 2020-05-12 2021-11-17 Life Science Inkubator Betriebs GmbH & Co. KG Zusammensetzung von nanopartikeln
US20210355468A1 (en) 2020-05-18 2021-11-18 Bioasis Technologies, Inc. Compositions and methods for treating lewy body dementia
US20210393787A1 (en) 2020-06-17 2021-12-23 Bioasis Technologies, Inc. Compositions and methods for treating frontotemporal dementia
CA3128035A1 (en) 2020-08-13 2022-02-13 Bioasis Technologies, Inc. Combination therapies for delivery across the blood brain barrier
EP4155349A1 (de) 2021-09-24 2023-03-29 Becton, Dickinson and Company Wasserlösliche gelbe grünabsorbierende farbstoffe
WO2024007016A2 (en) 2022-07-01 2024-01-04 Beckman Coulter, Inc. Novel fluorescent dyes and polymers from dihydrophenanthrene derivatives
WO2024044327A1 (en) 2022-08-26 2024-02-29 Beckman Coulter, Inc. Dhnt monomers and polymer dyes with modified photophysical properties

Family Cites Families (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4179337A (en) 1973-07-20 1979-12-18 Davis Frank F Non-immunogenic polypeptides
JP2958019B2 (ja) 1988-05-06 1999-10-06 住友製薬株式会社 ポリエチレングリコール誘導体、修飾ペプチドおよびその製造方法
US5122614A (en) 1989-04-19 1992-06-16 Enzon, Inc. Active carbonates of polyalkylene oxides for modification of polypeptides
FR2676058B1 (fr) 1991-04-30 1994-02-25 Hoechst Lab Prodrogues glycosylees, leur procede de preparation et leur utilisation dans le traitement des cancers.
US5614549A (en) * 1992-08-21 1997-03-25 Enzon, Inc. High molecular weight polymer-based prodrugs
US5382657A (en) * 1992-08-26 1995-01-17 Hoffmann-La Roche Inc. Peg-interferon conjugates
JP3026133B2 (ja) * 1992-11-05 2000-03-27 コニカ株式会社 ハロゲン化銀写真感光材料
US5349001A (en) 1993-01-19 1994-09-20 Enzon, Inc. Cyclic imide thione activated polyalkylene oxides
US5321095A (en) 1993-02-02 1994-06-14 Enzon, Inc. Azlactone activated polyalkylene oxides
DE69425356T2 (de) * 1993-09-22 2002-04-18 Hoechst Ag Pro-Prodrugs, ihre Herstellung und Anwendung
US5840900A (en) * 1993-10-20 1998-11-24 Enzon, Inc. High molecular weight polymer-based prodrugs
US5643575A (en) 1993-10-27 1997-07-01 Enzon, Inc. Non-antigenic branched polymer conjugates
US5605976A (en) 1995-05-15 1997-02-25 Enzon, Inc. Method of preparing polyalkylene oxide carboxylic acids
US5672584A (en) 1995-04-25 1997-09-30 The University Of Kansas Cyclic prodrugs of peptides and peptide nucleic acids having improved metabolic stability and cell membrane permeability
PT751144E (pt) 1995-06-27 2004-12-31 Pharmachemie Bv Novos pro-farmacos antraciclinicos, metodo para preparacao e tambem a sua utilizacao em quimioterapia selectiva
CA2264227A1 (en) 1996-09-27 1998-04-02 Raymond A. Firestone Hydrolyzable prodrugs for delivery of anticancer drugs to metastatic cells
US5965119A (en) * 1997-12-30 1999-10-12 Enzon, Inc. Trialkyl-lock-facilitated polymeric prodrugs of amino-containing bioactive agents

Also Published As

Publication number Publication date
DE69841206D1 (de) 2009-11-12
US6180095B1 (en) 2001-01-30
EP1897561A1 (de) 2008-03-12

Similar Documents

Publication Publication Date Title
ATE444080T1 (de) Polymere vorstufenwirkstoffe von amino-und hydroxyl-enthaltenden bioaktiven agentien
AU2021299A (en) Trialkyl-lock-facilitated polymeric prodrugs of amino-containing bioactive agents
DK0581452T3 (da) Vaskemiddelsammensætninger med polysuccinimid
ATE102966T1 (de) Blockcopolyester mit verzweigten hydrophilen endgruppen, verwendbar als schmutzentfernungsmittel in waschmittelzusammensetzungen.
CA2312975A1 (en) Polymeric prodrugs of amino- and hydroxyl-containing bioactive agents
NO20020725L (no) Celleadhesjonsinhibitorer
DE69739853D1 (de) Synthetische rapamycinderivate als multimerisierende wirkstoffe für chimere proteine mit von immunophilin abgeleiteten domänen
AR016010A1 (es) UN COMPUESTO DERIVADO DE ACIDO SULFONHIDROXAMICO AROMATICO INHIBIDOR DE METALOPROTEASAS, COMPUESTO INTERMEDIARIO, PROCESO PARA FORMARLO, COMPOSICION FARMACEUTICA Y USO PARA EL TRATAMIENTO DE UN ANIMAL HUESPED MAMíFERO.
DE10075007I2 (de) 1,4,7,10-Tetraazacyclododecan-butyltriole Verfahren zu ihrer Herstellung und diese enthaltende pharmazeutische Mittel
CY1105811T1 (el) Ενωσεις ενισχυτη ταξολης
MX9305489A (es) 3-(dihidrobenzofuran-5-il)benzofuran-2-onas, estabilizadores.
DE69500597T2 (de) N-pyridyl Carboxamidderivate, Verfahren zu ihrer Herstellung und diese enthaltende pharmazeutischen Zusammensetzungen
DK0934080T3 (da) 1,3-Bis-(N-lactamyl)propaner og deres farmaceutiske og kosmetiske anvendelse
ES2056146T3 (es) Monopersulfatos de acidos amino-(poli)percarboxilicos.
DE60233315D1 (de) Prodrugs von krebsmitteln mit substituierten aromatischen säuren
PT1027348E (pt) 2-(2'-hidroxifenil)-benzotriazois utilizados como agentes estabilizadores da luz ultravioleta
DE59704097D1 (de) Multifunktionelle Vinylcyclopropan-Derivate
DE69605838T2 (de) Pigmentkompositionen von 3,6-di(4-biphenylyl)-1,4-diketopyrrolo(3,4)-pyrrol
ATE395382T1 (de) Härtbare polymerverbindung
DE60112009D1 (de) Verfahren zur Herstellung von 3-Arylbenzofuran-2-onen
FI963055A (fi) Kondensaatio- ja additiopolymeereja, jotka sisältävät N,N'-sillan sisältäviä bis(tetrametyylipiperidinyylioksi)-ryhmiä
IT1291320B1 (it) Procedimento per la preparazione di composti aromatici contenenti un sistema eterociclico
DE69837628D1 (de) Aminderivate, verfahren zu ihrer herstellung und ihre verwendung als antimykotische mittel
ATE154345T1 (de) Indol-sulfonamide als antitumormittel
DE50213160D1 (de) Verfahren zur Herstellung von Pyrrolen

Legal Events

Date Code Title Description
RER Ceased as to paragraph 5 lit. 3 law introducing patent treaties