ATE443507T1 - Neue 2-amino-9-((2- hydroxymethyl)cyclopropylidenmethyl)-purine als antivirale mittel - Google Patents

Neue 2-amino-9-((2- hydroxymethyl)cyclopropylidenmethyl)-purine als antivirale mittel

Info

Publication number
ATE443507T1
ATE443507T1 AT03764294T AT03764294T ATE443507T1 AT E443507 T1 ATE443507 T1 AT E443507T1 AT 03764294 T AT03764294 T AT 03764294T AT 03764294 T AT03764294 T AT 03764294T AT E443507 T1 ATE443507 T1 AT E443507T1
Authority
AT
Austria
Prior art keywords
amino
cycloalkyl
group
cyclopropylidenmethyl
purines
Prior art date
Application number
AT03764294T
Other languages
German (de)
English (en)
Inventor
Jiri Zemlicka
John Drach
Xinchao Chen
Original Assignee
Univ Wayne State
Univ Michigan
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Wayne State, Univ Michigan filed Critical Univ Wayne State
Application granted granted Critical
Publication of ATE443507T1 publication Critical patent/ATE443507T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/20—Antivirals for DNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/20—Antivirals for DNA viruses
    • A61P31/22—Antivirals for DNA viruses for herpes viruses
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6561—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings
    • C07F9/65616—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings containing the ring system having three or more than three double bonds between ring members or between ring members and non-ring members, e.g. purine or analogs

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Virology (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Communicable Diseases (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • AIDS & HIV (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
AT03764294T 2002-03-15 2003-03-13 Neue 2-amino-9-((2- hydroxymethyl)cyclopropylidenmethyl)-purine als antivirale mittel ATE443507T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US36449502P 2002-03-15 2002-03-15
PCT/US2003/007909 WO2004006867A2 (en) 2002-03-15 2003-03-13 2-amino-9-[(2-hydroxymethyl) cyclopropylidenemethyl] purine antiviral agents

Publications (1)

Publication Number Publication Date
ATE443507T1 true ATE443507T1 (de) 2009-10-15

Family

ID=30115469

Family Applications (1)

Application Number Title Priority Date Filing Date
AT03764294T ATE443507T1 (de) 2002-03-15 2003-03-13 Neue 2-amino-9-((2- hydroxymethyl)cyclopropylidenmethyl)-purine als antivirale mittel

Country Status (8)

Country Link
US (2) US7183268B2 (enExample)
EP (1) EP1490015B1 (enExample)
JP (2) JP5420135B2 (enExample)
AT (1) ATE443507T1 (enExample)
AU (1) AU2003276824B8 (enExample)
CA (1) CA2479037C (enExample)
DE (1) DE60329375D1 (enExample)
WO (1) WO2004006867A2 (enExample)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MY141789A (en) * 2001-01-19 2010-06-30 Lg Chem Investment Ltd Novel acyclic nucleoside phosphonate derivatives, salts thereof and process for the preparation of the same.
DK1490368T3 (da) * 2002-03-15 2011-10-03 Univ Wayne State 2,2-bis(hydroxymethyl)cyclopropylidenmethyl-puriner og pyrimidiner som antivirale midler
JP3991223B2 (ja) * 2003-02-13 2007-10-17 信越化学工業株式会社 新規スルホニルジアゾメタン化合物、光酸発生剤、並びにそれを用いたレジスト材料及びパターン形成方法
EP1620437B1 (en) 2003-04-29 2009-06-17 Pfizer Limited 5,7-diaminopyrazolo¬4,3-d pyrimidines useful in the traetment of hypertension
US7572799B2 (en) 2003-11-24 2009-08-11 Pfizer Inc Pyrazolo[4,3-d]pyrimidines as Phosphodiesterase Inhibitors
EP1696898B1 (en) * 2003-12-02 2015-11-18 The Ohio State University Research Foundation Zn 2+ -chelating motif-tethered short-chain fatty acids as a novel class of histone deacetylase inhibitors
ATE417849T1 (de) 2004-04-07 2009-01-15 Pfizer Pyrazoloä4,3-düpyrimidine
WO2009048751A1 (en) 2007-10-09 2009-04-16 Dow Agrosciences Llc Insecticidal pyrimidinyl aryl hydrazones
EP2195302B1 (en) 2007-10-09 2015-02-18 Dow AgroSciences LLC Insecticidal substituted azinyl derivatives
US8067588B2 (en) 2007-10-09 2011-11-29 Dow Agrosciences Llc Insecticidal (1,3,5)-triazinyl phenyl hydrazones
IL293475B2 (en) * 2016-08-29 2024-10-01 Hoffmann La Roche 7-substituted sulfonimidoylpurinone compounds for the treatment and prophylaxis of virus infection

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8815265D0 (en) * 1988-06-27 1988-08-03 Wellcome Found Therapeutic nucleosides
PT95516A (pt) * 1989-10-06 1991-08-14 Wellcome Found Processo para a preparacao de derivados de 2',3'-didesoxi nucleosidos 6-substituidos
US6352991B1 (en) * 1997-01-08 2002-03-05 Wayne State University 2-hydroxymethylcyclopropylidenemethylpurines and -pyrimidines as antiviral agents
WO1998030563A1 (en) * 1997-01-08 1998-07-16 The Regents Of The University Of Michigan 2-hydroxymethylcyclopropyli- denemethylpurines and -pyrimidines as antiviral agents
DK1490368T3 (da) * 2002-03-15 2011-10-03 Univ Wayne State 2,2-bis(hydroxymethyl)cyclopropylidenmethyl-puriner og pyrimidiner som antivirale midler

Also Published As

Publication number Publication date
US7183268B2 (en) 2007-02-27
EP1490015B1 (en) 2009-09-23
CA2479037A1 (en) 2004-01-22
AU2003276824A1 (en) 2004-02-02
EP1490015A4 (en) 2005-12-28
DE60329375D1 (en) 2009-11-05
AU2003276824A2 (en) 2004-02-02
US20070225302A1 (en) 2007-09-27
WO2004006867A2 (en) 2004-01-22
AU2003276824B2 (en) 2009-01-08
US9174990B2 (en) 2015-11-03
WO2004006867A3 (en) 2004-10-21
CA2479037C (en) 2010-11-09
EP1490015A2 (en) 2004-12-29
JP5420135B2 (ja) 2014-02-19
JP2005524720A (ja) 2005-08-18
JP2012180361A (ja) 2012-09-20
AU2003276824B8 (en) 2009-01-22
US20050124582A1 (en) 2005-06-09

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