AU2003276824B8 - Novel 2-amino-9-[(2-hydroxymethyl) cyclopropylidenemethyl] purines as antiviral agents - Google Patents

Novel 2-amino-9-[(2-hydroxymethyl) cyclopropylidenemethyl] purines as antiviral agents Download PDF

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Publication number
AU2003276824B8
AU2003276824B8 AU2003276824A AU2003276824A AU2003276824B8 AU 2003276824 B8 AU2003276824 B8 AU 2003276824B8 AU 2003276824 A AU2003276824 A AU 2003276824A AU 2003276824 A AU2003276824 A AU 2003276824A AU 2003276824 B8 AU2003276824 B8 AU 2003276824B8
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AU
Australia
Prior art keywords
group
cycloalkyl
amino
aryl
heterocyclyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
AU2003276824A
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English (en)
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AU2003276824A1 (en
AU2003276824A2 (en
AU2003276824B2 (en
Inventor
Xinchao Chen
John C. Drach
Jiri Zemlicka
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Wayne State University
University of Michigan System
Original Assignee
Wayne State University
University of Michigan System
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Publication date
Application filed by Wayne State University, University of Michigan System filed Critical Wayne State University
Publication of AU2003276824A1 publication Critical patent/AU2003276824A1/en
Publication of AU2003276824A2 publication Critical patent/AU2003276824A2/en
Publication of AU2003276824B2 publication Critical patent/AU2003276824B2/en
Application granted granted Critical
Publication of AU2003276824B8 publication Critical patent/AU2003276824B8/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/20—Antivirals for DNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/20—Antivirals for DNA viruses
    • A61P31/22—Antivirals for DNA viruses for herpes viruses
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6561—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings
    • C07F9/65616—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings containing the ring system having three or more than three double bonds between ring members or between ring members and non-ring members, e.g. purine or analogs

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Virology (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Communicable Diseases (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • AIDS & HIV (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
AU2003276824A 2002-03-15 2003-03-13 Novel 2-amino-9-[(2-hydroxymethyl) cyclopropylidenemethyl] purines as antiviral agents Ceased AU2003276824B8 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US36449502P 2002-03-15 2002-03-15
US60/364,495 2002-03-15
PCT/US2003/007909 WO2004006867A2 (en) 2002-03-15 2003-03-13 2-amino-9-[(2-hydroxymethyl) cyclopropylidenemethyl] purine antiviral agents

Publications (4)

Publication Number Publication Date
AU2003276824A1 AU2003276824A1 (en) 2004-02-02
AU2003276824A2 AU2003276824A2 (en) 2004-02-02
AU2003276824B2 AU2003276824B2 (en) 2009-01-08
AU2003276824B8 true AU2003276824B8 (en) 2009-01-22

Family

ID=30115469

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2003276824A Ceased AU2003276824B8 (en) 2002-03-15 2003-03-13 Novel 2-amino-9-[(2-hydroxymethyl) cyclopropylidenemethyl] purines as antiviral agents

Country Status (8)

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US (2) US7183268B2 (enExample)
EP (1) EP1490015B1 (enExample)
JP (2) JP5420135B2 (enExample)
AT (1) ATE443507T1 (enExample)
AU (1) AU2003276824B8 (enExample)
CA (1) CA2479037C (enExample)
DE (1) DE60329375D1 (enExample)
WO (1) WO2004006867A2 (enExample)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MY141789A (en) * 2001-01-19 2010-06-30 Lg Chem Investment Ltd Novel acyclic nucleoside phosphonate derivatives, salts thereof and process for the preparation of the same.
DK1490368T3 (da) * 2002-03-15 2011-10-03 Univ Wayne State 2,2-bis(hydroxymethyl)cyclopropylidenmethyl-puriner og pyrimidiner som antivirale midler
JP3991223B2 (ja) * 2003-02-13 2007-10-17 信越化学工業株式会社 新規スルホニルジアゾメタン化合物、光酸発生剤、並びにそれを用いたレジスト材料及びパターン形成方法
EP1620437B1 (en) 2003-04-29 2009-06-17 Pfizer Limited 5,7-diaminopyrazolo¬4,3-d pyrimidines useful in the traetment of hypertension
US7572799B2 (en) 2003-11-24 2009-08-11 Pfizer Inc Pyrazolo[4,3-d]pyrimidines as Phosphodiesterase Inhibitors
EP1696898B1 (en) * 2003-12-02 2015-11-18 The Ohio State University Research Foundation Zn 2+ -chelating motif-tethered short-chain fatty acids as a novel class of histone deacetylase inhibitors
ATE417849T1 (de) 2004-04-07 2009-01-15 Pfizer Pyrazoloä4,3-düpyrimidine
WO2009048751A1 (en) 2007-10-09 2009-04-16 Dow Agrosciences Llc Insecticidal pyrimidinyl aryl hydrazones
EP2195302B1 (en) 2007-10-09 2015-02-18 Dow AgroSciences LLC Insecticidal substituted azinyl derivatives
US8067588B2 (en) 2007-10-09 2011-11-29 Dow Agrosciences Llc Insecticidal (1,3,5)-triazinyl phenyl hydrazones
IL293475B2 (en) * 2016-08-29 2024-10-01 Hoffmann La Roche 7-substituted sulfonimidoylpurinone compounds for the treatment and prophylaxis of virus infection

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6352991B1 (en) * 1997-01-08 2002-03-05 Wayne State University 2-hydroxymethylcyclopropylidenemethylpurines and -pyrimidines as antiviral agents

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8815265D0 (en) * 1988-06-27 1988-08-03 Wellcome Found Therapeutic nucleosides
PT95516A (pt) * 1989-10-06 1991-08-14 Wellcome Found Processo para a preparacao de derivados de 2',3'-didesoxi nucleosidos 6-substituidos
WO1998030563A1 (en) * 1997-01-08 1998-07-16 The Regents Of The University Of Michigan 2-hydroxymethylcyclopropyli- denemethylpurines and -pyrimidines as antiviral agents
DK1490368T3 (da) * 2002-03-15 2011-10-03 Univ Wayne State 2,2-bis(hydroxymethyl)cyclopropylidenmethyl-puriner og pyrimidiner som antivirale midler

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6352991B1 (en) * 1997-01-08 2002-03-05 Wayne State University 2-hydroxymethylcyclopropylidenemethylpurines and -pyrimidines as antiviral agents

Also Published As

Publication number Publication date
US7183268B2 (en) 2007-02-27
EP1490015B1 (en) 2009-09-23
ATE443507T1 (de) 2009-10-15
CA2479037A1 (en) 2004-01-22
AU2003276824A1 (en) 2004-02-02
EP1490015A4 (en) 2005-12-28
DE60329375D1 (en) 2009-11-05
AU2003276824A2 (en) 2004-02-02
US20070225302A1 (en) 2007-09-27
WO2004006867A2 (en) 2004-01-22
AU2003276824B2 (en) 2009-01-08
US9174990B2 (en) 2015-11-03
WO2004006867A3 (en) 2004-10-21
CA2479037C (en) 2010-11-09
EP1490015A2 (en) 2004-12-29
JP5420135B2 (ja) 2014-02-19
JP2005524720A (ja) 2005-08-18
JP2012180361A (ja) 2012-09-20
US20050124582A1 (en) 2005-06-09

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Legal Events

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DA3 Amendments made section 104

Free format text: THE NATURE OF THE AMENDMENT IS: ADD CO-INVENTOR CHEN, XINCHAO

DA3 Amendments made section 104

Free format text: THE NATURE OF THE AMENDMENT IS AS SHOWN IN THE STATEMENT(S) FILED 30 OCT 2006

TH Corrigenda

Free format text: IN VOL 23, NO 1, PAGE(S) 6183 UNDER THE HEADING APPLICATIONS ACCEPTED - NAME INDEX UNDER THE NAME THE REGENTS OF THE UNIVERSITY OF MICHIGAN AND WAYNE STATE UNIVERSITY, APPLICATION NO. 2003276824, UNDER INID(54), CORRECT THE INVENTION TITLE TO NOVEL 2-AMINO-9-[(2-HYDROXYMETHYL) CYCLOPROPYLIDENEMETHYL] PURINES AS ANTIVIRAL AGENTS

FGA Letters patent sealed or granted (standard patent)
MK14 Patent ceased section 143(a) (annual fees not paid) or expired