ATE442592T1 - Detektion und/oder beobachtung von synuclein- assoziierten krankheiten - Google Patents

Detektion und/oder beobachtung von synuclein- assoziierten krankheiten

Info

Publication number
ATE442592T1
ATE442592T1 AT03709934T AT03709934T ATE442592T1 AT E442592 T1 ATE442592 T1 AT E442592T1 AT 03709934 T AT03709934 T AT 03709934T AT 03709934 T AT03709934 T AT 03709934T AT E442592 T1 ATE442592 T1 AT E442592T1
Authority
AT
Austria
Prior art keywords
synuclein
monitoring
detection
patient
associated diseases
Prior art date
Application number
AT03709934T
Other languages
English (en)
Inventor
David Allsop
Omar M A El-Agnaf
Sultan A Salem
Original Assignee
Lancaster University Business
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=9931023&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ATE442592(T1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Lancaster University Business filed Critical Lancaster University Business
Application granted granted Critical
Publication of ATE442592T1 publication Critical patent/ATE442592T1/de

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • G01N33/57484—Immunoassay; Biospecific binding assay; Materials therefor for cancer involving compounds serving as markers for tumor, cancer, neoplasia, e.g. cellular determinants, receptors, heat shock/stress proteins, A-protein, oligosaccharides, metabolites
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6893—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere
    • G01N33/6896—Neurological disorders, e.g. Alzheimer's disease
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/52—Predicting or monitoring the response to treatment, e.g. for selection of therapy based on assay results in personalised medicine; Prognosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Biomedical Technology (AREA)
  • Chemical & Material Sciences (AREA)
  • Urology & Nephrology (AREA)
  • Molecular Biology (AREA)
  • Hematology (AREA)
  • Cell Biology (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Pathology (AREA)
  • General Physics & Mathematics (AREA)
  • General Health & Medical Sciences (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Microbiology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Hospice & Palliative Care (AREA)
  • Oncology (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
AT03709934T 2002-02-14 2003-02-14 Detektion und/oder beobachtung von synuclein- assoziierten krankheiten ATE442592T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB0203446.0A GB0203446D0 (en) 2002-02-14 2002-02-14 Detection and/or monitoring of synuclein-related diseases
PCT/GB2003/000677 WO2003069332A2 (en) 2002-02-14 2003-02-14 Detection and/or monitoring of synuclein-related diseases

Publications (1)

Publication Number Publication Date
ATE442592T1 true ATE442592T1 (de) 2009-09-15

Family

ID=9931023

Family Applications (1)

Application Number Title Priority Date Filing Date
AT03709934T ATE442592T1 (de) 2002-02-14 2003-02-14 Detektion und/oder beobachtung von synuclein- assoziierten krankheiten

Country Status (9)

Country Link
US (1) US20050176078A1 (de)
EP (1) EP1476758B2 (de)
JP (1) JP2005528588A (de)
AT (1) ATE442592T1 (de)
AU (1) AU2003214364A1 (de)
CA (1) CA2480466C (de)
DE (1) DE60329165D1 (de)
GB (1) GB0203446D0 (de)
WO (1) WO2003069332A2 (de)

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US20040146521A1 (en) * 1999-06-01 2004-07-29 Schenk Dale B. Prevention and treatment of synucleinopathic disease
US8506959B2 (en) * 2002-11-01 2013-08-13 Neotope Biosciences Limited Prevention and treatment of synucleinopathic and amyloidogenic disease
US20080014194A1 (en) * 2003-10-31 2008-01-17 Elan Pharmaceuticals, Inc. Prevention and Treatment of Synucleinopathic and Amyloidogenic Disease
US8697082B2 (en) * 2002-11-01 2014-04-15 Neotope Biosciences Limited Prevention and treatment of synucleinopathic and amyloidogenic disease
US9034337B2 (en) 2003-10-31 2015-05-19 Prothena Biosciences Limited Treatment and delay of outset of synucleinopathic and amyloidogenic disease
TW200509968A (en) * 2002-11-01 2005-03-16 Elan Pharm Inc Prevention and treatment of synucleinopathic disease
US7358331B2 (en) * 2003-05-19 2008-04-15 Elan Pharmaceuticals, Inc. Truncated fragments of alpha-synuclein in Lewy body disease
WO2005047860A2 (en) 2003-11-08 2005-05-26 Elan Pharmaceuticals, Inc. Antibodies to alpha-synuclein
DE10361258A1 (de) 2003-12-24 2005-07-28 Schwarz Pharma Ag Verwendung von substituierten 2-Aminotetralinen zur vorbeugenden Behandlung von Morbus Parkinson
DE102004014841B4 (de) 2004-03-24 2006-07-06 Schwarz Pharma Ag Verwendung von Rotigotin zur Behandlung und Prävention des Parkinson-Plus-Syndroms
ES2310057B1 (es) * 2004-07-19 2009-11-17 Oryzon Genomics, S.A. Metodo de analisis molecular y tratamiento en demencia de cuerpos de lewy.
CN1752104B (zh) * 2004-09-21 2010-05-05 北京市肿瘤防治研究所 突触蛋白γ的单克隆抗体及其应用
CA2657953A1 (en) * 2005-07-19 2007-01-25 University Of Rochester Alpha-synuclein antibodies and methods related thereto
IL199534A (en) 2007-01-05 2013-01-31 Univ Zuerich An isolated human antibody capable of detecting a neoepitope in a disease-related protein, a polynucleotide encoding an antibody, a vector containing the polynucleotide, a host cell containing the polynucleotide or vector, a preparation containing the antibody and related methods and uses.
US8147833B2 (en) * 2007-02-23 2012-04-03 Neotope Biosciences Limited Prevention and treatment of synucleinopathic and amyloidogenic disease
CA2678963C (en) * 2007-02-23 2018-05-01 Elan Pharmaceuticals, Inc. Prevention and treatment of synucleinopathic and amyloidogenic disease
GB0716885D0 (en) 2007-08-30 2007-10-10 United Arab Emirates Universit Diagnostic agent
ES2544569T3 (es) 2008-12-19 2015-09-01 Biogen International Neuroscience Gmbh Autoanticuerpos humanos anti alfa-sinucleina
WO2011033252A1 (en) * 2009-09-16 2011-03-24 United Arab Emirates University Diagnostic agent for parkinson's disease
CN101692092B (zh) * 2009-09-24 2013-04-10 首都医科大学宣武医院 定量检测人血清中自体α-突触核蛋白抗体的方法
US10989718B2 (en) * 2014-09-11 2021-04-27 Amprion, Inc. Detection of misfolded alpha synuclein protein
US20130309690A1 (en) * 2010-11-05 2013-11-21 The Brigham And Women's Hospital, Inc. Tetrameric alpha-synuclein as biomarkers
JP6006908B2 (ja) * 2010-11-05 2016-10-12 ブランダイス ユニバーシティＢｒａｎｄｅｉｓ Ｕｎｉｖｅｒｓｉｔｙ Ｉｃｅ阻害化合物およびその使用
AU2011336895A1 (en) * 2010-11-24 2013-06-06 Elan Pharmaceuticals, Inc. Phagocytic activity as a marker of synucleinopathic disease
DK2723379T3 (en) * 2011-06-23 2018-10-15 Biogen Int Neuroscience Gmbh ANTI-ALPHA SYNUCLEIN BINDING MOLECULES
US20140295465A1 (en) * 2011-11-02 2014-10-02 Biogen Idec International Neuroscience Gmbh USE OF AN ANTI-alpha-SYNUCLEIN ANTIBODY TO DIAGNOSE AN ELEVATED LEVEL OF alpha-SYNUCLEIN IN THE BRAIN
ES2481517B1 (es) * 2013-01-29 2015-06-01 Universidad De Sevilla Método para el diagnóstico de la enfermedad de parkinson en estadios tempranos
ES2953855T3 (es) * 2014-09-11 2023-11-16 Univ Texas Detección de proteínas mal plegadas
EP3961216B1 (de) 2014-11-14 2024-02-14 United Arab Emirates University Dihydromyricetin zur verwendung als bildgebungsmittel
MA41115A (fr) 2014-12-02 2017-10-10 Biogen Int Neuroscience Gmbh Procédé de traitement de la maladie d'alzheimer
CN104711280B (zh) * 2014-12-10 2018-04-13 中国医学科学院医学生物学研究所 表达和纯化同时缺失外显子3和5 的α突触核蛋白选择性剪切体蛋白的方法
CA3062876A1 (en) 2017-05-16 2018-11-22 Amprion, Inc. Detection of misfolded tau protein
CA3067135A1 (en) * 2017-06-19 2018-12-27 Kainos Medicine Inc. Modulators of alpha-synuclein
WO2019040612A1 (en) 2017-08-22 2019-02-28 Biogen Ma Inc. PHARMACEUTICAL COMPOSITIONS CONTAINING ANTI-BETA-AMYLOID ANTIBODIES
JP7173532B2 (ja) * 2018-08-28 2022-11-16 学校法人順天堂 α－シヌクレイノパチーの診断
RU2703430C1 (ru) * 2018-12-13 2019-10-16 Федеральное государственное бюджетное учреждение "Национальный медицинский исследовательский центр глазных болезней имени Гельмгольца" Министерства здравоохранения Российской Федерации (ФГБУ "НМИЦ ГБ им. Гельмгольца" Минздрава России) Способ прогнозирования развития нейродегенеративных заболеваний, в основе патогенеза которых лежит гамма-синуклеинопатия
EP3779448A1 (de) * 2019-08-12 2021-02-17 Baden-Württemberg Stiftung gGmbH Neuartiger diagnostischer marker für die creutzfeldt-jakob-krankheit und morbus-alzheimer
EP4111197A1 (de) * 2020-02-25 2023-01-04 Markus Otto Diagnose einer mit synaptischer degeneration assoziierten erkrankung mittels elisa zur bestimmung einer beta-synuklein-konzentration in csf
US20240003918A1 (en) 2020-11-30 2024-01-04 Enigma Biointelligence, Inc. Non-invasive assessment of alzheimer's disease

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5602042A (en) * 1994-04-14 1997-02-11 Cytyc Corporation Method and apparatus for magnetically separating biological particles from a mixture
WO1999050300A1 (en) * 1998-03-30 1999-10-07 The Trustees Of The University Of Pennsylvania Method of identifying, diagnosing and treating synuclein positive neurodegenerative disorders
BR9911291A (pt) * 1998-07-03 2001-12-04 Innogenetics Nv Diagnóstico diferencial de neurodegeneração
JP2004502781A (ja) * 2000-07-07 2004-01-29 パナシア　ファーマシューティカルズ　インコーポレーテッド 神経組織の損傷を予防するため、およびα−シヌクレイン疾患を処置するための方法
US20020150948A1 (en) * 2000-11-03 2002-10-17 Gerardo Castillo Antibody PTI-HS7 for treatment of alzheimer's disease and other amyloidoses and parkinson's disease

Also Published As

Publication number Publication date
AU2003214364A1 (en) 2003-09-04
EP1476758A2 (de) 2004-11-17
CA2480466C (en) 2010-12-21
US20050176078A1 (en) 2005-08-11
JP2005528588A (ja) 2005-09-22
EP1476758B2 (de) 2015-02-11
WO2003069332A2 (en) 2003-08-21
DE60329165D1 (de) 2009-10-22
EP1476758B1 (de) 2009-09-09
CA2480466A1 (en) 2003-08-21
GB0203446D0 (en) 2002-04-03
WO2003069332A3 (en) 2004-01-08

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