ATE437639T1 - 4-(1-(sulfonyl)-1h-indol-2-yl)-4-(hydroxy)- cyclohexa-2,5-dienone verbindungen und ihre analoge als therapeutische wirkstoffe - Google Patents

4-(1-(sulfonyl)-1h-indol-2-yl)-4-(hydroxy)- cyclohexa-2,5-dienone verbindungen und ihre analoge als therapeutische wirkstoffe

Info

Publication number
ATE437639T1
ATE437639T1 AT02788211T AT02788211T ATE437639T1 AT E437639 T1 ATE437639 T1 AT E437639T1 AT 02788211 T AT02788211 T AT 02788211T AT 02788211 T AT02788211 T AT 02788211T AT E437639 T1 ATE437639 T1 AT E437639T1
Authority
AT
Austria
Prior art keywords
sup
compounds
independently
indol
sulfonyl
Prior art date
Application number
AT02788211T
Other languages
English (en)
Inventor
Malcolm F G Stevens
Andrew D Westwell
Tracey D Poole
Geoffrey Wells
Jane M Berry
Original Assignee
Cancer Rec Tech Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Cancer Rec Tech Ltd filed Critical Cancer Rec Tech Ltd
Application granted granted Critical
Publication of ATE437639T1 publication Critical patent/ATE437639T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/12—Radicals substituted by oxygen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A61K31/404—Indoles, e.g. pindolol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
AT02788211T 2002-12-20 2002-12-20 4-(1-(sulfonyl)-1h-indol-2-yl)-4-(hydroxy)- cyclohexa-2,5-dienone verbindungen und ihre analoge als therapeutische wirkstoffe ATE437639T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/GB2002/005842 WO2004056361A1 (en) 2002-12-20 2002-12-20 4-(1-(sulfonyl)-1h-indol-2-yl)-4-(hydroxy)-cyclohexa-2,5-dienone compounds and analogs thereof as therapeutic agents

Publications (1)

Publication Number Publication Date
ATE437639T1 true ATE437639T1 (de) 2009-08-15

Family

ID=32670966

Family Applications (1)

Application Number Title Priority Date Filing Date
AT02788211T ATE437639T1 (de) 2002-12-20 2002-12-20 4-(1-(sulfonyl)-1h-indol-2-yl)-4-(hydroxy)- cyclohexa-2,5-dienone verbindungen und ihre analoge als therapeutische wirkstoffe

Country Status (12)

Country Link
US (1) US7307099B2 (de)
EP (1) EP1572197B1 (de)
JP (1) JP4465281B2 (de)
CN (1) CN100363347C (de)
AT (1) ATE437639T1 (de)
AU (1) AU2002353193B2 (de)
BR (1) BR0215986A (de)
CA (1) CA2508275A1 (de)
DE (1) DE60233175D1 (de)
ES (1) ES2330205T3 (de)
MX (1) MXPA05006650A (de)
WO (1) WO2004056361A1 (de)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101675032B (zh) * 2007-05-03 2012-10-31 苏文生命科学有限公司 氨基烷氧基芳基磺酰胺化合物及其作为5-ht6配体的用途
GB0905127D0 (en) 2009-03-25 2009-05-06 Pharminox Ltd Novel prodrugs
CN102051406A (zh) * 2009-11-03 2011-05-11 凯熙医药(武汉)有限公司 一种用于预报人体发生异常增殖或肿瘤发生风险的检测方法
WO2023133507A1 (en) * 2022-01-07 2023-07-13 University Of Maryland, Baltimore Estradiol prodrugs and methods of use thereof

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4414217A (en) 1981-11-23 1983-11-08 Riker Laboratories, Inc. 3,5-Di(t-butyl)-4-hydroxyphenyl substituted pyridines
US4535165A (en) * 1981-11-23 1985-08-13 Riker Laboratories, Inc. Substituted diazoles and thiazoles
US4357345A (en) * 1981-11-23 1982-11-02 Riker Laboratories, Inc. Substituted furans
FR2665441B1 (fr) 1990-07-31 1992-12-04 Sanofi Sa Derives de la n-sulfonyl indoline, leur preparation, les compositions pharmaceutiques en contenant.
ZA929008B (en) 1991-12-13 1993-05-21 Bristol Myers Squibb Co Piperazinyl- and piperidinyl-cyclohexanols.
CA2091204C (en) * 1992-03-11 1997-04-08 Ronald J. Mattson Antiischemic-piperazinyl and piperidinyl-cyclohexanes
US5391570A (en) * 1993-10-14 1995-02-21 Bristol-Myers Squibb Aminomethyl-benzodioxane and benzopyran serotonergic agents
CA2409006A1 (en) 2000-05-31 2001-12-06 Warner-Lambert Company Biciclic cyclohexylamines and their use as nmda receptor antogonists
GB0116594D0 (en) * 2001-07-06 2001-08-29 Cancer Res Ventures Ltd Therapeutic compounds

Also Published As

Publication number Publication date
AU2002353193B2 (en) 2010-03-25
ES2330205T3 (es) 2009-12-07
MXPA05006650A (es) 2005-09-30
US20060100265A1 (en) 2006-05-11
JP4465281B2 (ja) 2010-05-19
JP2006512351A (ja) 2006-04-13
WO2004056361A1 (en) 2004-07-08
CN100363347C (zh) 2008-01-23
BR0215986A (pt) 2005-11-01
CA2508275A1 (en) 2004-07-08
EP1572197A1 (de) 2005-09-14
EP1572197B1 (de) 2009-07-29
DE60233175D1 (de) 2009-09-10
CN1717233A (zh) 2006-01-04
US7307099B2 (en) 2007-12-11
AU2002353193A1 (en) 2004-07-14

Similar Documents

Publication Publication Date Title
MX2022006475A (es) Compuestos triciclicos sustituidos.
MX2009000871A (es) Novedosos inhibidores de transcriptasa inversa de vih.
MX2010007375A (es) Nuevos derivados de lupano.
MX9301525A (es) Esteriodes substituidos en la posicion 17 y composicion farmaceutica que los contiene.
ATE286501T1 (de) Pyrimidinderivate
MX2010007374A (es) Nuevos derivados de c-21-ceto lupano, preparacion y uso de los mismos.
MX2009013804A (es) Inhibidores novedosos de transcriptasa inversa de vih.
PH12021551256A1 (en) Pantetheine derivatives and uses thereof
ATE327748T1 (de) Alkandiol derivate zur behandlung von knochenkrankheiten
AR049405A1 (es) Compuesto de dicetopiperazina, composicion farmaceutica que lo comprende, uso del compuesto para la fabricacion de un medicamento y procedimiento para la preparacion del mismo
US10759803B2 (en) Asparagine endopeptidase (AEP) inhibitors for managing cancer and compositions related thereto
SG147450A1 (en) Sustained release pharmaceutical compositions comprising aplindore and derivatives thereof
DE60330356D1 (en) Stickstoff-lost-derivaten
AR054707A1 (es) Derivados de octahidropirrolo 3,4-c pirrol, un procedimiento para su preparacion, una composicion farmaceutica y uso del compuesto para la fabricacion de un medicamento
SE0402925D0 (sv) Novel Compounds
MX2022015886A (es) Derivados de amidopirimidona.
FR2850023B1 (fr) Medicaments pour le systeme nerveux
ATE457306T1 (de) 4-aryl substituierte chinole und analoga als therapeutische wirkstoffe
SG145570A1 (en) 4-æ7-halo-2-quino(xa-)linyloxy!phenoxy-propionic acid derivatives as antineoplastic agents
ATE437639T1 (de) 4-(1-(sulfonyl)-1h-indol-2-yl)-4-(hydroxy)- cyclohexa-2,5-dienone verbindungen und ihre analoge als therapeutische wirkstoffe
ATE371644T1 (de) Neues alkaloidderivat und dieses enthaltende pharmazeutische zusammensetzung
ZA202201499B (en) Dual atm and dna-pk inhibitors for use in anti-tumor therapy
CR20230218A (es) Nuevos derivados de indazol acetileno
EE05300B1 (et) Akrloldistamtsiini derivaati sisaldav farmatseutiline kompositsioon, derivaadi kasutamine tuumorivastase ravimi valmistamiseks ning kombineeritud ravimpreparaat
RS20050954A (en) Use of bycyclo/2.2.1/heptane derivatives for the preparation of neuroprotective pharmaceutical compositions

Legal Events

Date Code Title Description
RER Ceased as to paragraph 5 lit. 3 law introducing patent treaties