ATE435650T1 - 2,5-disubstituierte phenylmethanonderivative als glycintransporter-1-inhibitoren (glyt-1) zur behandlung von neurologischen und neuropsychiatrischen störungen - Google Patents
2,5-disubstituierte phenylmethanonderivative als glycintransporter-1-inhibitoren (glyt-1) zur behandlung von neurologischen und neuropsychiatrischen störungenInfo
- Publication number
- ATE435650T1 ATE435650T1 AT06700397T AT06700397T ATE435650T1 AT E435650 T1 ATE435650 T1 AT E435650T1 AT 06700397 T AT06700397 T AT 06700397T AT 06700397 T AT06700397 T AT 06700397T AT E435650 T1 ATE435650 T1 AT E435650T1
- Authority
- AT
- Austria
- Prior art keywords
- glyt
- treatment
- inhibitors
- disubstituted
- neurological
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D207/12—Oxygen or sulfur atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/397—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having four-membered rings, e.g. azetidine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D205/00—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom
- C07D205/02—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings
- C07D205/04—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D211/40—Oxygen atoms
- C07D211/44—Oxygen atoms attached in position 4
- C07D211/46—Oxygen atoms attached in position 4 having a hydrogen atom as the second substituent in position 4
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Psychiatry (AREA)
- Epidemiology (AREA)
- Hospice & Palliative Care (AREA)
- Pain & Pain Management (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Hydrogenated Pyridines (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pyrrole Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP05100280 | 2005-01-18 | ||
| PCT/EP2006/000127 WO2006077026A1 (en) | 2005-01-18 | 2006-01-10 | 2, 5-disubstituted phenyl methanone derivatives as glycine transporter 1 (glyt-i) inhibitors for the treatment of neurological and neuropsychiatry disorders |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE435650T1 true ATE435650T1 (de) | 2009-07-15 |
Family
ID=35985447
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT06700397T ATE435650T1 (de) | 2005-01-18 | 2006-01-10 | 2,5-disubstituierte phenylmethanonderivative als glycintransporter-1-inhibitoren (glyt-1) zur behandlung von neurologischen und neuropsychiatrischen störungen |
Country Status (14)
| Country | Link |
|---|---|
| US (1) | US7790763B2 (de) |
| EP (1) | EP1843767B1 (de) |
| JP (1) | JP2008527016A (de) |
| KR (1) | KR100935256B1 (de) |
| CN (1) | CN101141959B (de) |
| AT (1) | ATE435650T1 (de) |
| AU (1) | AU2006207650B2 (de) |
| BR (1) | BRPI0606730A2 (de) |
| CA (1) | CA2601326A1 (de) |
| DE (1) | DE602006007682D1 (de) |
| ES (1) | ES2326833T3 (de) |
| IL (1) | IL184439A (de) |
| MX (1) | MX2007008616A (de) |
| WO (1) | WO2006077026A1 (de) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2653355C (en) * | 2006-06-22 | 2014-04-15 | F. Hoffmann-La Roche Ag | Substituted phenyl methanone derivatives |
| US8586571B2 (en) * | 2007-10-18 | 2013-11-19 | Takeda Pharmaceutical Company Limited | Heterocyclic compound |
| EP3215500A1 (de) * | 2014-11-05 | 2017-09-13 | Dart NeuroScience (Cayman) Ltd. | Substituierte azetidinylverbindungen als glyt1-inhibitoren |
Family Cites Families (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE2423847A1 (de) | 1973-05-28 | 1975-01-02 | Ciba Geigy Ag | Neue sulfamoylbenzoesaeureamide |
| DE2611705A1 (de) | 1976-03-18 | 1977-09-22 | Josef Dipl Chem Dr Rer N Klosa | N-5-(nitrofurfuryliden-)-1-amino- hydantoin enthaltende kristalloesungsmittel |
| IT1176613B (it) | 1984-08-14 | 1987-08-18 | Ravizza Spa | Derivati piperazinici farmacologicamente attivi e processo per la loro preparazione |
| US5393771A (en) | 1993-05-12 | 1995-02-28 | Brisol-Myers Squibb Company | 4-substituted benzopyran and related compounds |
| US6001854A (en) * | 1996-05-31 | 1999-12-14 | Allelix Neuroscience Inc. | Pharmaceutical for treating of neurological and neuropsychiatric disorders |
| CA2255727A1 (en) * | 1996-05-31 | 1997-12-04 | Trophix Pharmaceuticals, Inc. | Pharmaceutical for treating of neurological and neuropsychiatric disorders |
| KR20010032968A (ko) * | 1998-03-06 | 2001-04-25 | 디르크 반테 | 글리신 수송 저해제 |
| CN1291984A (zh) | 1998-03-06 | 2001-04-18 | 詹森药业有限公司 | 甘氨酸传输抑制剂 |
| AU2001254546A1 (en) * | 2000-04-20 | 2001-11-07 | Nps Allelix Corp. | Aminopiperidines |
| DOP2001000189A (es) * | 2000-06-30 | 2002-03-30 | Pfizer Prod Inc | Benzofenonas y sulfonas como inhibidores de la captación de glicina |
| GB0021419D0 (en) | 2000-08-31 | 2000-10-18 | Oxford Glycosciences Uk Ltd | Compounds |
| JP2005502623A (ja) | 2001-07-02 | 2005-01-27 | ノボ ノルディスク アクティーゼルスカブ | 置換ピペラジンおよびジアゼパン |
| WO2003035602A1 (fr) | 2001-10-25 | 2003-05-01 | Sankyo Company, Limited | Modulateurs lipidiques |
| WO2004037800A1 (en) | 2002-10-22 | 2004-05-06 | Glaxo Group Limited | Aryloxyalkylamine derivates as h3 receptor ligands |
| SE0302116D0 (sv) * | 2003-07-21 | 2003-07-21 | Astrazeneca Ab | Novel compounds |
| SI1656361T1 (sl) | 2003-08-11 | 2008-04-30 | Hoffmann La Roche | Piperazin z OR-substituirano fenilno skupino in njuna uporaba kot zaviralca GLYT1 |
| CA2537292C (en) | 2003-09-09 | 2013-04-02 | F. Hoffmann-La Roche Ag | 1- (2-amino-benzol) -piperazine derivatives as glycine uptake inhibitors for the treatment of psychoses |
| JP4563387B2 (ja) | 2003-09-09 | 2010-10-13 | エフ．ホフマン−ラ ロシュ アーゲー | 精神病の処置のためのグリシン取り込み阻害剤としての１−ベンゾイル−ピペラジン誘導体 |
| GB0329362D0 (en) * | 2003-12-18 | 2004-01-21 | Glaxo Group Ltd | Compounds |
| JP2007535538A (ja) * | 2004-04-29 | 2007-12-06 | メルク エンド カムパニー インコーポレーテッド | アゼチジングリシン輸送体インヒビター |
| CA2653355C (en) * | 2006-06-22 | 2014-04-15 | F. Hoffmann-La Roche Ag | Substituted phenyl methanone derivatives |
-
2006
- 2006-01-10 AU AU2006207650A patent/AU2006207650B2/en not_active Ceased
- 2006-01-10 AT AT06700397T patent/ATE435650T1/de active
- 2006-01-10 WO PCT/EP2006/000127 patent/WO2006077026A1/en active Application Filing
- 2006-01-10 KR KR1020077018714A patent/KR100935256B1/ko not_active IP Right Cessation
- 2006-01-10 CN CN2006800085770A patent/CN101141959B/zh not_active Expired - Fee Related
- 2006-01-10 DE DE602006007682T patent/DE602006007682D1/de active Active
- 2006-01-10 EP EP06700397A patent/EP1843767B1/de not_active Not-in-force
- 2006-01-10 CA CA002601326A patent/CA2601326A1/en not_active Abandoned
- 2006-01-10 ES ES06700397T patent/ES2326833T3/es active Active
- 2006-01-10 JP JP2007551582A patent/JP2008527016A/ja active Pending
- 2006-01-10 BR BRPI0606730-1A patent/BRPI0606730A2/pt not_active IP Right Cessation
- 2006-01-10 MX MX2007008616A patent/MX2007008616A/es active IP Right Grant
- 2006-01-17 US US11/332,999 patent/US7790763B2/en not_active Expired - Fee Related
-
2007
- 2007-07-05 IL IL184439A patent/IL184439A/en not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| AU2006207650B2 (en) | 2011-01-27 |
| WO2006077026A1 (en) | 2006-07-27 |
| ES2326833T3 (es) | 2009-10-20 |
| US7790763B2 (en) | 2010-09-07 |
| IL184439A0 (en) | 2007-10-31 |
| EP1843767A1 (de) | 2007-10-17 |
| AU2006207650A1 (en) | 2006-07-27 |
| CN101141959B (zh) | 2010-12-15 |
| EP1843767B1 (de) | 2009-07-08 |
| BRPI0606730A2 (pt) | 2009-07-14 |
| DE602006007682D1 (de) | 2009-08-20 |
| JP2008527016A (ja) | 2008-07-24 |
| CN101141959A (zh) | 2008-03-12 |
| IL184439A (en) | 2011-11-30 |
| US20060160788A1 (en) | 2006-07-20 |
| KR20070094971A (ko) | 2007-09-27 |
| CA2601326A1 (en) | 2006-07-27 |
| MX2007008616A (es) | 2007-09-11 |
| KR100935256B1 (ko) | 2010-01-06 |
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| Date | Code | Title | Description |
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| UEP | Publication of translation of european patent specification |
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