ATE435029T1 - Optimierte expression von hpv 45 l1 in hefe - Google Patents

Optimierte expression von hpv 45 l1 in hefe

Info

Publication number
ATE435029T1
ATE435029T1 AT04788982T AT04788982T ATE435029T1 AT E435029 T1 ATE435029 T1 AT E435029T1 AT 04788982 T AT04788982 T AT 04788982T AT 04788982 T AT04788982 T AT 04788982T AT E435029 T1 ATE435029 T1 AT E435029T1
Authority
AT
Austria
Prior art keywords
hpv
yeast
optimized expression
optimized
expression
Prior art date
Application number
AT04788982T
Other languages
German (de)
English (en)
Inventor
Janine Bryan
Michelle Brownlow
Loren Schultz
Kathrin Jansen
Original Assignee
Merck & Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck & Co Inc filed Critical Merck & Co Inc
Application granted granted Critical
Publication of ATE435029T1 publication Critical patent/ATE435029T1/de

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/005Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
    • C07K14/01DNA viruses
    • C07K14/025Papovaviridae, e.g. papillomavirus, polyomavirus, SV40, BK virus, JC virus
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/005Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00Drugs for genital or sexual disorders; Contraceptives
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12Antivirals
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12Antivirals
    • A61P31/20Antivirals for DNA viruses
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/02Immunomodulators
    • A61P37/04Immunostimulants
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/11DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N7/00Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/51Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/525Virus
    • A61K2039/5258Virus-like particles
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2710/00MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
    • C12N2710/00011Details
    • C12N2710/20011Papillomaviridae
    • C12N2710/20022New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2710/00MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
    • C12N2710/00011Details
    • C12N2710/20011Papillomaviridae
    • C12N2710/20023Virus like particles [VLP]
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2710/00MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
    • C12N2710/00011Details
    • C12N2710/20011Papillomaviridae
    • C12N2710/20034Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Virology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Biophysics (AREA)
  • Biomedical Technology (AREA)
  • Immunology (AREA)
  • Biotechnology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Microbiology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Reproductive Health (AREA)
  • Endocrinology (AREA)
  • Physics & Mathematics (AREA)
  • Plant Pathology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
AT04788982T 2003-09-29 2004-09-24 Optimierte expression von hpv 45 l1 in hefe ATE435029T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US50681203P 2003-09-29 2003-09-29
PCT/US2004/031326 WO2005032586A1 (en) 2003-09-29 2004-09-24 Optimized expression of hpv 45 l1 in yeast

Publications (1)

Publication Number Publication Date
ATE435029T1 true ATE435029T1 (de) 2009-07-15

Family

ID=34421558

Family Applications (1)

Application Number Title Priority Date Filing Date
AT04788982T ATE435029T1 (de) 2003-09-29 2004-09-24 Optimierte expression von hpv 45 l1 in hefe

Country Status (33)

Country Link
US (2) US7250170B2 (show.php)
EP (1) EP1673106B1 (show.php)
JP (4) JP5451960B2 (show.php)
KR (1) KR101165278B1 (show.php)
CN (1) CN1859923B (show.php)
AR (2) AR045804A1 (show.php)
AT (1) ATE435029T1 (show.php)
AU (1) AU2004277934B2 (show.php)
BE (1) BE2015C072I2 (show.php)
BR (1) BRPI0414845B8 (show.php)
CA (1) CA2539168C (show.php)
CY (2) CY1110525T1 (show.php)
DE (1) DE602004021828D1 (show.php)
DK (1) DK1673106T3 (show.php)
ES (1) ES2327530T3 (show.php)
FR (1) FR15C0083I2 (show.php)
HU (1) HUS1500063I1 (show.php)
IL (1) IL174458A (show.php)
IS (1) IS2694B (show.php)
LT (2) LTC1673106I2 (show.php)
LU (1) LU92902I2 (show.php)
MX (1) MXPA06003457A (show.php)
MY (1) MY140664A (show.php)
NL (1) NL300776I1 (show.php)
NO (3) NO339932B1 (show.php)
NZ (1) NZ545834A (show.php)
PL (1) PL1673106T3 (show.php)
PT (1) PT1673106E (show.php)
RU (1) RU2360001C2 (show.php)
SI (1) SI1673106T1 (show.php)
TW (1) TWI350853B (show.php)
WO (1) WO2005032586A1 (show.php)
ZA (1) ZA200601961B (show.php)

Families Citing this family (31)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0206360D0 (en) 2002-03-18 2002-05-01 Glaxosmithkline Biolog Sa Viral antigens
US7858098B2 (en) * 2002-12-20 2010-12-28 Glaxosmithkline Biologicals, S.A. Vaccine
MY139500A (en) 2003-11-12 2009-10-30 Merck Sharp & Dohme Optimized expression of hpv 58 l1 in yeast
JP4833962B2 (ja) * 2004-03-24 2011-12-07 メルク・シャープ・エンド・ドーム・コーポレイション 酵母におけるhpv52l1の最適化された発現
US7758866B2 (en) 2004-06-16 2010-07-20 Glaxosmithkline Biologicals, S.A. Vaccine against HPV16 and HPV18 and at least another HPV type selected from HPV 31, 45 or 52
AU2006236905B2 (en) 2005-04-15 2010-06-03 The Government Of The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Methods and compositions for producing an enhanced immune response to a human papillomavirus immunogen
SG159525A1 (en) * 2005-04-26 2010-03-30 Glaxosmithkline Biolog Sa Vaccine
WO2008026869A1 (en) * 2006-08-28 2008-03-06 Sungkyunkwan University Foundation For Corporate Collaboration A dna vaccine for treating or preventing cervical cancer comprising a gene encoding hpv protein
WO2008112125A1 (en) * 2007-03-09 2008-09-18 Merck & Co., Inc. Papillomavirus vaccine compositions
RU2494106C2 (ru) * 2007-11-23 2013-09-27 Шанхай Зеран Биотекнолоджи Ко., Лтд. Гены, кодирующие главный капсидный белок l1 вируса папилломы человека, и их применение
PL2444103T3 (pl) 2009-06-19 2018-05-30 Eyegene Inc. Szczepionka przeciwko rakowi szyjki macicy
AU2011258501B2 (en) 2010-05-25 2016-07-07 Qiagen Gaithersburg, Inc. Fast results hybrid capture assay and associated strategically-truncated probes
AU2012270418B2 (en) 2011-06-15 2015-08-13 Posvax Co., Ltd Method for enhancing the production yield of human papillomavirus L1 protein
EP2723371B1 (en) 2011-06-24 2019-10-23 Merck Sharp & Dohme Corp. Hpv vaccine formulations comprising aluminum adjuvant and methods of producing same
CN103215302B (zh) * 2012-01-21 2019-01-15 北京安百胜生物科技有限公司 用汉逊酵母表达系统产生hpv18 l1蛋白的方法
CN103361280B (zh) * 2012-03-28 2018-07-24 北京安百胜生物科技有限公司 用汉逊酵母表达系统产生hpv11 l1蛋白的方法
CN110423774A (zh) * 2013-04-26 2019-11-08 北京安百胜生物科技有限公司 用汉逊酵母表达系统产生hpv58 l1蛋白的方法
CN104120089B (zh) * 2013-04-26 2019-09-24 北京安百胜生物科技有限公司 用汉逊酵母表达系统产生hpv52 l1蛋白的方法
CN110295190A (zh) * 2013-05-17 2019-10-01 北京安百胜生物科技有限公司 用汉逊酵母表达系统产生hpv45 l1蛋白的方法
CN112280793B (zh) * 2013-09-29 2022-06-24 上海泽润生物科技有限公司 人乳头瘤病毒基因,及载体,菌株,表达方法
CA2927434C (en) 2013-10-16 2022-07-19 Merck Sharp & Dohme Corp. Method of obtaining thermostable dried vaccine formulations
AR101840A1 (es) * 2014-09-11 2017-01-18 Cadila Healthcare Ltd Antígenos del virus del papiloma humano superiores con propiedades inmunológicas superiores, y vacuna que los contiene
CN106282278B (zh) * 2015-06-29 2021-06-08 广东东阳光药业有限公司 一种人乳头瘤病毒l1蛋白的发酵方法
CN106701798B (zh) * 2015-08-12 2021-09-17 北京康乐卫士生物技术股份有限公司 45型重组人乳头瘤病毒病毒样颗粒及其制备方法
CN109750050B (zh) * 2017-11-07 2023-08-18 上海泽润生物科技有限公司 重组人乳头瘤病毒45亚型蛋白表达
JOP20220187A1 (ar) 2020-02-14 2023-01-30 Merck Sharp And Dohme Llc لقاح فيروس الورم الحليمي البشري (hpv)
CN112680462B (zh) * 2020-12-29 2022-02-22 上海博唯生物科技有限公司 一种人乳头瘤病毒35型/hpv35型l1/l2及其制备与应用
CN113073105B (zh) * 2021-03-23 2023-06-13 重庆博唯佰泰生物制药有限公司 一种表达hpv 56l1的多核苷酸序列及其表达载体、宿主细胞和应用
US20230048144A1 (en) 2021-08-06 2023-02-16 Merck Sharp & Dohme Llc Hpv vaccine
CN118019547A (zh) 2021-08-19 2024-05-10 默沙东有限责任公司 热稳定脂质纳米粒子及其使用方法
US20240408188A1 (en) 2023-06-09 2024-12-12 Merck Sharp & Dohme Llc Nanoemulsion adjuvant compositions for human papillomavirus vaccines

Family Cites Families (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SK147696A3 (en) * 1994-05-16 1997-08-06 Merck & Co Inc Isolated and purified protein of papillomavirus, a capside, a viral particle, pharmaceutical composition comprising its, a method of making them and their use
AR004464A1 (es) 1994-11-14 1998-12-16 Merck Sharp & Dohme Un metodo para producir una proteina de capside de papilomavirus
IL117459A (en) * 1995-03-22 2005-11-20 Merck & Co Inc Dna encoding human papillomavirus type 18
IL117591A0 (en) * 1995-03-30 1996-07-23 Merck & Co Inc Synthetic DNA encoding human papillomavirus type 11 L1 protein
SK106699A3 (en) 1997-02-07 2000-06-12 Merck & Co Inc Synthetic polynucleotide, immunogenic composition and pharmaceutical composition containing the same and its use
EP1015612B1 (en) * 1997-05-27 2005-01-26 Hanil Synthetic Fiber Co., Ltd. Process for preparing recombinant proteins using highly efficient expression vector from saccharomyces cerevisiae
EP1002091B1 (en) 1997-07-09 2012-02-29 Coridon Pty Limited Nucleic acid sequence and method for selectively expressing a protein in a target cell or tissue
ATE344052T1 (de) * 1998-08-14 2006-11-15 Merck & Co Inc Protein-verabreichungssystem, das dem menschlichen papillomavirus ähnliche partikel benützt.
SI1105466T1 (sl) * 1998-08-14 2006-08-31 Merck & Co Inc Postopek za ciscenje virusu podobnih delcev humanega papilomskega virusa
US6991795B1 (en) * 1998-08-14 2006-01-31 Merck & Co., Inc. Protein delivery system using human papillomavirus virus-like particles
AU763853B2 (en) * 1998-12-23 2003-07-31 Merck & Co., Inc. Neutralizing assay using human papillomavirus virus-like particles
ATE284898T1 (de) 1999-08-25 2005-01-15 Merck & Co Inc Synthetische papillomavirus gene, welche für expression in menschlichen zellen optimiert sind
US6436402B1 (en) * 1999-10-15 2002-08-20 Merck & Co., Inc. Process for making human papillomavirus virus-like particles with improved properties
US7026443B1 (en) * 1999-12-10 2006-04-11 Epimmune Inc. Inducing cellular immune responses to human Papillomavirus using peptide and nucleic acid compositions
HK1056195B (en) 2000-07-21 2007-06-22 Glaxo Group Limited Codon-optimized papilloma virus sequences
AU2003213060A1 (en) * 2002-02-14 2003-09-04 Novavax, Inc. Optimization of gene sequences of chimeric virus-like particles for expression in insect cells
GB0206360D0 (en) 2002-03-18 2002-05-01 Glaxosmithkline Biolog Sa Viral antigens
CA2519112C (en) 2003-03-24 2012-09-11 Merck & Co., Inc. Optimized expression of hpv 31 l1 in yeast

Also Published As

Publication number Publication date
FR15C0083I2 (fr) 2016-11-25
NO2022051I1 (no) 2022-11-30
AU2004277934A1 (en) 2005-04-14
BRPI0414845B8 (pt) 2021-06-15
KR20070029628A (ko) 2007-03-14
CA2539168A1 (en) 2005-04-14
NL300776I2 (show.php) 2015-12-29
ZA200601961B (en) 2007-05-30
NZ545834A (en) 2009-02-28
US7250170B2 (en) 2007-07-31
AR077396A2 (es) 2011-08-24
WO2005032586A1 (en) 2005-04-14
ES2327530T3 (es) 2009-10-30
NO20061876L (no) 2006-04-28
JP5451960B2 (ja) 2014-03-26
PL1673106T3 (pl) 2009-12-31
DE602004021828D1 (de) 2009-08-13
JP2011152137A (ja) 2011-08-11
BE2015C072I2 (show.php) 2023-12-14
BRPI0414845B1 (pt) 2020-10-13
KR101165278B1 (ko) 2012-07-23
MY140664A (en) 2010-01-15
FR15C0083I1 (fr) 2016-08-01
AR045804A1 (es) 2005-11-16
EP1673106B1 (en) 2009-07-01
AU2004277934B2 (en) 2009-09-17
TW200521233A (en) 2005-07-01
CY2015050I1 (el) 2016-06-22
NO2017012I1 (no) 2017-04-05
CN1859923B (zh) 2012-09-05
IS2694B (is) 2010-11-15
TWI350853B (en) 2011-10-21
IL174458A0 (en) 2006-08-01
DK1673106T3 (da) 2009-11-09
BRPI0414845A (pt) 2006-11-21
IL174458A (en) 2014-06-30
CY2015050I2 (el) 2016-06-22
SI1673106T1 (sl) 2009-12-31
US20060240040A1 (en) 2006-10-26
IS8362A (is) 2006-03-20
LTC1673106I2 (lt) 2017-05-10
PT1673106E (pt) 2009-09-22
US20080138361A1 (en) 2008-06-12
CN1859923A (zh) 2006-11-08
HUS1500063I1 (hu) 2016-02-29
CA2539168C (en) 2011-05-31
RU2006114701A (ru) 2007-11-10
LTPA2015049I1 (lt) 2016-01-11
CY1110525T1 (el) 2015-04-29
LU92902I2 (fr) 2016-03-08
NO339932B1 (no) 2017-02-20
JP2014221052A (ja) 2014-11-27
EP1673106A1 (en) 2006-06-28
JP2007507207A (ja) 2007-03-29
MXPA06003457A (es) 2006-06-05
RU2360001C2 (ru) 2009-06-27
JP2016136947A (ja) 2016-08-04
NL300776I1 (show.php) 2015-12-29
US7482015B2 (en) 2009-01-27

Similar Documents

Publication Publication Date Title
ATE435029T1 (de) Optimierte expression von hpv 45 l1 in hefe
ATE452977T1 (de) Optimierte expression von hpv-58-l1 in hefe
LTC1730175I2 (lt) Optimizuota HPV 52 L1 raiška mielėse
GB2406169B (en) Methods and compositions relating to labeled rna molecules that reduce gene expression
DE60318819D1 (de) Hitzestabile mutanten von stärkebiosyntheseenzymen
FR2841929B1 (fr) Cadre dormant metallique
FI20035048A0 (fi) Suoramarkkinointikirjekuori sekä sen aihio
ES1053280Y (es) Disposicion publicitaria aplicable en bebidas y combinados
TH98452S (th) แผ่นปูฝนัง

Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification

Ref document number: 1673106

Country of ref document: EP

EEFA Change of the company name