ATE435013T1 - Histon deazetylase enzym-hemmende hydroxamsäurederivate als neue entzündungshemmer zur hemmung der zytokinsynthese - Google Patents
Histon deazetylase enzym-hemmende hydroxamsäurederivate als neue entzündungshemmer zur hemmung der zytokinsyntheseInfo
- Publication number
- ATE435013T1 ATE435013T1 AT02764796T AT02764796T ATE435013T1 AT E435013 T1 ATE435013 T1 AT E435013T1 AT 02764796 T AT02764796 T AT 02764796T AT 02764796 T AT02764796 T AT 02764796T AT E435013 T1 ATE435013 T1 AT E435013T1
- Authority
- AT
- Austria
- Prior art keywords
- inhibiting
- enzyme
- histone
- deazetylase
- hydroxamic acid
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
- A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
- A61K31/166—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the carbon of a carboxamide group directly attached to the aromatic ring, e.g. procainamide, procarbazine, metoclopramide, labetalol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
- A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
- A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
- A61K31/167—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the nitrogen of a carboxamide group directly attached to the aromatic ring, e.g. lidocaine, paracetamol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Epidemiology (AREA)
- Pain & Pain Management (AREA)
- Pulmonology (AREA)
- Neurosurgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Urology & Nephrology (AREA)
- Rheumatology (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Virology (AREA)
- Vascular Medicine (AREA)
- Communicable Diseases (AREA)
- Dermatology (AREA)
- Immunology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Oncology (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
IT2001MI001733A ITMI20011733A1 (it) | 2001-08-07 | 2001-08-07 | Derivati dell'acido idrossamico inibitori degli enzimi istone deacetilasi, quali nuovi farmaci antiinfiammatori inibenti la sintesi di citoc |
PCT/EP2002/008379 WO2003013493A1 (en) | 2001-08-07 | 2002-07-26 | Histone deacetylase enzyme-inhibiting derivatives of hydroxamic acid as new cytokine synthesis-inhibiting anti-inflammatory drugs |
Publications (1)
Publication Number | Publication Date |
---|---|
ATE435013T1 true ATE435013T1 (de) | 2009-07-15 |
Family
ID=11448251
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AT02764796T ATE435013T1 (de) | 2001-08-07 | 2002-07-26 | Histon deazetylase enzym-hemmende hydroxamsäurederivate als neue entzündungshemmer zur hemmung der zytokinsynthese |
Country Status (23)
Country | Link |
---|---|
US (1) | US20040157930A1 (de) |
EP (1) | EP1414428B1 (de) |
JP (1) | JP2005506320A (de) |
KR (1) | KR20040035724A (de) |
CN (1) | CN1538838A (de) |
AT (1) | ATE435013T1 (de) |
BR (1) | BR0212014A (de) |
CA (1) | CA2456533A1 (de) |
CY (1) | CY1109391T1 (de) |
DE (1) | DE60232797D1 (de) |
DK (1) | DK1414428T3 (de) |
ES (1) | ES2328468T3 (de) |
HU (1) | HUP0401167A2 (de) |
IL (1) | IL160075A0 (de) |
IS (1) | IS7124A (de) |
IT (1) | ITMI20011733A1 (de) |
MX (1) | MXPA04001190A (de) |
NO (1) | NO20040513L (de) |
PL (1) | PL365391A1 (de) |
PT (1) | PT1414428E (de) |
RU (1) | RU2004106605A (de) |
SI (1) | SI1414428T1 (de) |
WO (1) | WO2003013493A1 (de) |
Families Citing this family (34)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7842727B2 (en) | 2001-03-27 | 2010-11-30 | Errant Gene Therapeutics, Llc | Histone deacetylase inhibitors |
US8026280B2 (en) | 2001-03-27 | 2011-09-27 | Errant Gene Therapeutics, Llc | Histone deacetylase inhibitors |
US7312247B2 (en) | 2001-03-27 | 2007-12-25 | Errant Gene Therapeutics, Llc | Histone deacetylase inhibitors |
US7314953B2 (en) | 2001-03-27 | 2008-01-01 | Errant Gene Therapeutics, Llc | Treatment of lung cells with histone deacetylase inhibitors |
AU2003219803B8 (en) * | 2002-02-15 | 2005-08-25 | Sloan-Kettering Institute For Cancer Research | Method of treating TRX mediated diseases |
AU2003211362A1 (en) * | 2002-02-21 | 2003-09-09 | Osaka Industrial Promotion Organization | N-hydroxycarboxamide derivative |
US7456219B2 (en) | 2002-03-04 | 2008-11-25 | Merck Hdac Research, Llc | Polymorphs of suberoylanilide hydroxamic acid |
EP1487426B1 (de) | 2002-03-04 | 2012-08-22 | Sloan-kettering Institute For Cancer Research | Verfahren zur einleitung einer terminalen differenzierung |
EP1511477A4 (de) | 2002-05-22 | 2008-04-09 | Errant Gene Therapeutics Llc | Histondeacetylase-hemmer auf basis von alpha-ketoepoxid-verbindungen |
ITMI20030025A1 (it) | 2003-01-10 | 2004-07-11 | Italfarmaco Spa | Derivati dell'acido idrossammico ad attivita' antinfiammatoria. |
ITMI20030064A1 (it) | 2003-01-17 | 2004-07-18 | Italfarmaco Spa | Uso dei derivati dell'acido idrossamico per la preparazione |
WO2004092115A2 (en) | 2003-04-07 | 2004-10-28 | Axys Pharmaceuticals Inc. | Hydroxamates as therapeutic agents |
EP1491188A1 (de) * | 2003-06-25 | 2004-12-29 | G2M Cancer Drugs AG | Topische Verwendung von Valproinsäure zur Behandlung von Hauterkrankungen |
DK1663194T3 (da) * | 2003-08-26 | 2010-07-19 | Merck Hdac Res Llc | Anvendelse af SAHA til behandling af mesotheliom |
CA2552279C (en) * | 2003-12-02 | 2014-07-15 | The Ohio State University Research Foundation | Zn2+-chelating motif-tethered short -chain fatty acids as a novel class of histone deacetylase inhibitors |
US7368476B2 (en) * | 2004-04-07 | 2008-05-06 | Pharmacyclics, Inc. | Hydroxamates as therapeutic agents |
JP2008505969A (ja) * | 2004-07-12 | 2008-02-28 | メルク エンド カムパニー インコーポレーテッド | ヒストン脱アセチル化酵素の阻害剤 |
GB2417682A (en) * | 2004-08-18 | 2006-03-08 | Univ East Anglia | Histone deacetylse inhibitor for treating connective tissue disorders |
CN101263121A (zh) | 2005-07-14 | 2008-09-10 | 塔克达圣地亚哥公司 | 组蛋白脱乙酰基酶抑制剂 |
WO2007109178A2 (en) | 2006-03-16 | 2007-09-27 | Pharmacyclics, Inc. | Indole derivatives as inhibitors of histone deacetylase |
WO2008061160A1 (en) * | 2006-11-14 | 2008-05-22 | Pharmacyclics, Inc. | Uses of selective inhibitors of hdac8 for treatment of inflammatory conditions |
US7820711B2 (en) * | 2006-11-14 | 2010-10-26 | Pharmacyclics Inc. | Uses of selective inhibitors of HDAC8 for treatment of T-cell proliferative disorders |
DK2099442T3 (en) * | 2006-12-26 | 2015-02-16 | Pharmacyclics Inc | Method of using histone deacetylase inhibitors and monitoring biomarkers in combination therapy |
NZ579048A (en) | 2007-01-30 | 2012-05-25 | Pharmacyclics Inc | Methods for determining cancer resistance to histone deacetylase inhibitors |
US9827212B2 (en) * | 2009-03-18 | 2017-11-28 | The Trustees Of The University Of Pennsylvania | Compositions and methods for treating asthma and other lung diseases |
US8603521B2 (en) | 2009-04-17 | 2013-12-10 | Pharmacyclics, Inc. | Formulations of histone deacetylase inhibitor and uses thereof |
CA2770158A1 (en) * | 2009-08-14 | 2011-02-17 | Cellzome Ag | Methods for the identification and characterization of hdac interacting compounds |
WO2012018499A2 (en) * | 2010-08-05 | 2012-02-09 | Acetylon Pharmaceuticals | Specific regulation of cytokine levels by hdac6 inhibitors |
CN110063951A (zh) * | 2011-03-09 | 2019-07-30 | 赛伦诺科学有限公司 | 利用组蛋白脱乙酰酶抑制物改善受损的内源纤维蛋白溶解作用的化合物和方法 |
US9492423B2 (en) | 2011-09-13 | 2016-11-15 | Pharmacyclics Llc | Formulations of histone deacetylase inhibitor in combination with bendamustine and uses thereof |
CN104093403A (zh) * | 2012-02-03 | 2014-10-08 | 意大发马克股份公司 | 用于治疗肌肉萎缩症的二乙基-[6-(4-羟基氨基甲酰基-苯基-氨基甲酰氧基-甲基)-萘-2-基-甲基]-氯化铵 |
CN102793693A (zh) * | 2012-09-07 | 2012-11-28 | 天津医科大学 | 伏立诺他在制备治疗自身免疫及炎症性疾病药物方面的应用 |
GB201417828D0 (en) | 2014-10-08 | 2014-11-19 | Cereno Scient Ab | New methods and compositions |
CN109414423A (zh) | 2016-04-08 | 2019-03-01 | 赛伦诺科技有限公司 | 包含丙戊酸的延迟释放药物制剂和其用途 |
Family Cites Families (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5700811A (en) | 1991-10-04 | 1997-12-23 | Sloan-Kettering Institute For Cancer Research | Potent inducers of terminal differentiation and method of use thereof |
US5318964A (en) * | 1992-06-11 | 1994-06-07 | Hoffmann-La Roche Inc. | Hydroxamic derivatives and pharmaceutical compositions |
DE69624536T2 (de) * | 1995-08-08 | 2003-06-05 | Ono Pharmaceutical Co | Hydroxamsäurederivate verwendbar zur Hemmung von Gelatinase |
US6777217B1 (en) * | 1996-03-26 | 2004-08-17 | President And Fellows Of Harvard College | Histone deacetylases, and uses related thereto |
IT1283637B1 (it) * | 1996-05-14 | 1998-04-23 | Italfarmaco Spa | Composti ad attivita' antinfiammatoria ed immunosoppressiva |
AU2002243231A1 (en) * | 2000-11-21 | 2002-07-24 | Wake Forest University | Method of treating autoimmune diseases |
-
2001
- 2001-08-07 IT IT2001MI001733A patent/ITMI20011733A1/it unknown
-
2002
- 2002-07-26 DE DE60232797T patent/DE60232797D1/de not_active Expired - Lifetime
- 2002-07-26 CN CNA028154363A patent/CN1538838A/zh active Pending
- 2002-07-26 SI SI200230840T patent/SI1414428T1/sl unknown
- 2002-07-26 HU HU0401167A patent/HUP0401167A2/hu unknown
- 2002-07-26 RU RU2004106605/15A patent/RU2004106605A/ru not_active Application Discontinuation
- 2002-07-26 PL PL02365391A patent/PL365391A1/xx not_active Application Discontinuation
- 2002-07-26 WO PCT/EP2002/008379 patent/WO2003013493A1/en active Application Filing
- 2002-07-26 ES ES02764796T patent/ES2328468T3/es not_active Expired - Lifetime
- 2002-07-26 PT PT02764796T patent/PT1414428E/pt unknown
- 2002-07-26 KR KR10-2004-7001946A patent/KR20040035724A/ko not_active Application Discontinuation
- 2002-07-26 DK DK02764796T patent/DK1414428T3/da active
- 2002-07-26 JP JP2003518503A patent/JP2005506320A/ja active Pending
- 2002-07-26 BR BR0212014-3A patent/BR0212014A/pt not_active IP Right Cessation
- 2002-07-26 EP EP02764796A patent/EP1414428B1/de not_active Expired - Lifetime
- 2002-07-26 CA CA002456533A patent/CA2456533A1/en not_active Abandoned
- 2002-07-26 US US10/486,152 patent/US20040157930A1/en not_active Abandoned
- 2002-07-26 MX MXPA04001190A patent/MXPA04001190A/es unknown
- 2002-07-26 IL IL16007502A patent/IL160075A0/xx unknown
- 2002-07-26 AT AT02764796T patent/ATE435013T1/de active
-
2004
- 2004-01-26 IS IS7124A patent/IS7124A/is unknown
- 2004-01-29 NO NO20040513A patent/NO20040513L/no unknown
-
2009
- 2009-09-21 CY CY20091100978T patent/CY1109391T1/el unknown
Also Published As
Publication number | Publication date |
---|---|
ES2328468T3 (es) | 2009-11-13 |
PL365391A1 (en) | 2005-01-10 |
EP1414428A1 (de) | 2004-05-06 |
PT1414428E (pt) | 2009-08-25 |
ITMI20011733A1 (it) | 2003-02-07 |
US20040157930A1 (en) | 2004-08-12 |
RU2004106605A (ru) | 2005-05-10 |
JP2005506320A (ja) | 2005-03-03 |
DE60232797D1 (de) | 2009-08-13 |
HUP0401167A2 (hu) | 2004-11-29 |
CY1109391T1 (el) | 2014-07-02 |
BR0212014A (pt) | 2004-08-03 |
IL160075A0 (en) | 2004-06-20 |
MXPA04001190A (es) | 2005-02-17 |
SI1414428T1 (sl) | 2009-10-31 |
DK1414428T3 (da) | 2009-08-31 |
KR20040035724A (ko) | 2004-04-29 |
CA2456533A1 (en) | 2003-02-20 |
WO2003013493A8 (en) | 2004-02-26 |
NO20040513L (no) | 2004-03-24 |
CN1538838A (zh) | 2004-10-20 |
ITMI20011733A0 (it) | 2001-08-07 |
IS7124A (is) | 2004-01-26 |
EP1414428B1 (de) | 2009-07-01 |
WO2003013493A1 (en) | 2003-02-20 |
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