ATE433947T1 - Herstellung von ultrareinem bismut-213 zur verwendung in der therapeutischen nuklearmedizin - Google Patents

Herstellung von ultrareinem bismut-213 zur verwendung in der therapeutischen nuklearmedizin

Info

Publication number
ATE433947T1
ATE433947T1 AT02749614T AT02749614T ATE433947T1 AT E433947 T1 ATE433947 T1 AT E433947T1 AT 02749614 T AT02749614 T AT 02749614T AT 02749614 T AT02749614 T AT 02749614T AT E433947 T1 ATE433947 T1 AT E433947T1
Authority
AT
Austria
Prior art keywords
bismuth
solution
actinium
production
stripped
Prior art date
Application number
AT02749614T
Other languages
English (en)
Inventor
Andrew Bond
E Horwitz
Original Assignee
Pg Res Foundation Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pg Res Foundation Inc filed Critical Pg Res Foundation Inc
Application granted granted Critical
Publication of ATE433947T1 publication Critical patent/ATE433947T1/de

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Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/88—Integrated analysis systems specially adapted therefor, not covered by a single one of the groups G01N30/04 - G01N30/86
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J39/00—Cation exchange; Use of material as cation exchangers; Treatment of material for improving the cation exchange properties
    • B01J39/04—Processes using organic exchangers
    • G—PHYSICS
    • G21—NUCLEAR PHYSICS; NUCLEAR ENGINEERING
    • G21G—CONVERSION OF CHEMICAL ELEMENTS; RADIOACTIVE SOURCES
    • G21G4/00—Radioactive sources
    • G21G4/04—Radioactive sources other than neutron sources
    • G21G4/06—Radioactive sources other than neutron sources characterised by constructional features
    • G21G4/08—Radioactive sources other than neutron sources characterised by constructional features specially adapted for medical application
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
    • B01D15/08—Selective adsorption, e.g. chromatography
    • B01D15/26—Selective adsorption, e.g. chromatography characterised by the separation mechanism
    • B01D15/265—Adsorption chromatography
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
    • B01D15/08—Selective adsorption, e.g. chromatography
    • B01D15/26—Selective adsorption, e.g. chromatography characterised by the separation mechanism
    • B01D15/36—Selective adsorption, e.g. chromatography characterised by the separation mechanism involving ionic interaction
    • B01D15/361—Ion-exchange
    • B01D15/362—Cation-exchange
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/04—Preparation or injection of sample to be analysed
    • G01N30/06—Preparation
    • G01N30/08—Preparation using an enricher
    • G01N2030/085—Preparation using an enricher using absorbing precolumn
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/62—Detectors specially adapted therefor
    • G01N2030/77—Detectors specially adapted therefor detecting radioactive properties
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/88—Integrated analysis systems specially adapted therefor, not covered by a single one of the groups G01N30/04 - G01N30/86
    • G01N2030/8804—Integrated analysis systems specially adapted therefor, not covered by a single one of the groups G01N30/04 - G01N30/86 automated systems
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/88—Integrated analysis systems specially adapted therefor, not covered by a single one of the groups G01N30/04 - G01N30/86
    • G01N2030/8809—Integrated analysis systems specially adapted therefor, not covered by a single one of the groups G01N30/04 - G01N30/86 analysis specially adapted for the sample
    • G01N2030/8868—Integrated analysis systems specially adapted therefor, not covered by a single one of the groups G01N30/04 - G01N30/86 analysis specially adapted for the sample elemental analysis, e.g. isotope dilution analysis
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/26—Conditioning of the fluid carrier; Flow patterns
    • G01N30/38—Flow patterns
    • G01N30/46—Flow patterns using more than one column
    • G01N30/468—Flow patterns using more than one column involving switching between different column configurations
    • G—PHYSICS
    • G21—NUCLEAR PHYSICS; NUCLEAR ENGINEERING
    • G21G—CONVERSION OF CHEMICAL ELEMENTS; RADIOACTIVE SOURCES
    • G21G1/00—Arrangements for converting chemical elements by electromagnetic radiation, corpuscular radiation or particle bombardment, e.g. producing radioactive isotopes
    • G21G1/0005—Isotope delivery systems
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S423/00—Chemistry of inorganic compounds
    • Y10S423/07—Isotope separation

Landscapes

  • Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Physics & Mathematics (AREA)
  • Immunology (AREA)
  • Organic Chemistry (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pathology (AREA)
  • Analytical Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • General Engineering & Computer Science (AREA)
  • High Energy & Nuclear Physics (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
AT02749614T 2001-06-22 2002-06-20 Herstellung von ultrareinem bismut-213 zur verwendung in der therapeutischen nuklearmedizin ATE433947T1 (de)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US30014101P 2001-06-22 2001-06-22
US37232702P 2002-04-12 2002-04-12
US10/159,003 US6852296B2 (en) 2001-06-22 2002-05-31 Production of ultrapure bismuth-213 for use in therapeutic nuclear medicine
PCT/US2002/019487 WO2003000593A1 (en) 2001-06-22 2002-06-20 Production of ultrapure bismuth-213 for use in therapeutic nuclear medicine

Publications (1)

Publication Number Publication Date
ATE433947T1 true ATE433947T1 (de) 2009-07-15

Family

ID=27388257

Family Applications (1)

Application Number Title Priority Date Filing Date
AT02749614T ATE433947T1 (de) 2001-06-22 2002-06-20 Herstellung von ultrareinem bismut-213 zur verwendung in der therapeutischen nuklearmedizin

Country Status (10)

Country Link
US (1) US6852296B2 (de)
EP (1) EP1404616B1 (de)
JP (1) JP3993853B2 (de)
CN (1) CN1258480C (de)
AT (1) ATE433947T1 (de)
AU (1) AU2002320114B8 (de)
CA (1) CA2451676C (de)
DE (1) DE60232658D1 (de)
EA (1) EA005735B1 (de)
WO (1) WO2003000593A1 (de)

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US6974563B2 (en) * 2002-06-18 2005-12-13 Lynntech, Inc. Ion exchange materials for the separation of 90Y from 90SR
AU2003228206A1 (en) * 2002-06-21 2004-01-06 Lynntech, Inc. Ion exchange materials for use in a bi-213 generator
EP1479399A1 (de) * 2003-05-22 2004-11-24 European Atomic Energy Community (Euratom) Verfahren zum Beladen eines Radioelementerzeugers mit einem Mutternuklid
US7914766B1 (en) * 2004-06-03 2011-03-29 Ut-Battelle Llc Inorganic resins for clinical use of 213Bi generators
US10526299B2 (en) 2004-12-22 2020-01-07 Chemtor, Lp Fiber conduit reactor with a heat exchange medium inlet and a heat exchange medium outlet
US9168469B2 (en) 2004-12-22 2015-10-27 Chemtor, Lp Method and system for production of a chemical commodity using a fiber conduit reactor
US20070009409A1 (en) * 2005-07-11 2007-01-11 Hariprasad Gali 212Bi or 213Bi Generator from supported parent isotope
CN102971800B (zh) * 2009-12-07 2016-06-08 医疗物理有限公司 多发生器核素洗脱方法及管理装置
US9468866B2 (en) 2012-09-18 2016-10-18 Chemtor, Lp Use of a fiber conduit contactor for metal and/or metalloid extraction
JP5614821B1 (ja) * 2013-09-24 2014-10-29 株式会社京都ニュートロニクス ウラン２３３製造方法、トリウム核燃料製造方法、医療用ラジオアイソトープ製造方法、及び、医療用ラジオアイソトープ製造用ターゲットプレート製造方法
KR101512248B1 (ko) * 2013-12-24 2015-04-16 한국원자력연구원 방사성 요오드 기체를 포집하는 다공성 포집재 및 이의 제조 방법
JP2017521645A (ja) * 2014-05-15 2017-08-03 メイヨ フォンデーシヨン フォー メディカル エジュケーション アンド リサーチ 放射性金属のサイクロトロン生成用の溶液ターゲット
JP6464475B2 (ja) * 2015-03-02 2019-02-06 清水建設株式会社 放射性ストロンチウムの分析方法
RU2657673C1 (ru) * 2017-08-09 2018-06-14 Артем Сергеевич Даминов Способ получения висмута нитрата основного
WO2019183724A1 (en) 2018-03-26 2019-10-03 Triumf, A Joint Venture Of The Governors Of The University Of Alberta, The University Of British Columbia, The Governors Of The University Of Calgary, Carleton University, University Of Guelph, Mcmaster University, University Of Manitoba, Universite De Montreal, Queen's University, University Of Reg Systems, apparatus and methods for separating actinium, radium, and thorium
FR3086186B1 (fr) * 2018-09-26 2022-01-28 Orano Med Procede de production de plomb-212 a partir d'une solution aqueuse comprenant du thorium-228 et ses descendants
FR3088769B1 (fr) * 2018-11-15 2020-12-25 Orano Med Procede de preparation d'au moins un generateur a haute teneur en radium-228
FR3088768B1 (fr) * 2018-11-15 2020-11-20 Orano Med Procede de transfert d'un radioisotope entre deux phases stationnaires contenues dans deux colonnes de chromatographie
US20230182038A1 (en) * 2020-04-01 2023-06-15 The Texas A&M University System Astatine purification method

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US851401A (en) * 1906-09-17 1907-04-23 Henry G Cady Wagon-jack.
US4574072A (en) * 1983-07-26 1986-03-04 The United States Of America As Represented By The United States Department Of Energy Method for extracting lanthanides and actinides from acid solutions by modification of purex solvent
US4548790A (en) * 1983-07-26 1985-10-22 The United States Of America As Represented By The United States Department Of Energy Method for extracting lanthanides and actinides from acid solutions
US4835107A (en) * 1986-10-21 1989-05-30 Arch Development Corp. Method for the concentration and separation of actinides from biological and environmental samples
DE69007430T2 (de) * 1989-06-19 1994-07-07 Akzo Nobel Nv Radioimmuntherapie unter alphapartikelausstrahlung.
US5281631A (en) * 1991-12-20 1994-01-25 Arch Development Corp. Phosphonic acid based ion exchange resins
CA2100709C (en) * 1992-07-27 2004-03-16 Maurits W. Geerlings Method and means for site directed therapy
US5618851A (en) * 1995-02-06 1997-04-08 Arch Development Corp. Grafted methylenediphosphonate ion exchange resins
US5651883A (en) 1995-06-06 1997-07-29 Argonne National Laboratory/University Of Chicago Development Corp. Method for the chromatographic separation of cations from aqueous samples
WO1998008481A2 (en) * 1996-08-26 1998-03-05 Arch Development Corporation PROCESS AND APPARATUS FOR THE PRODUCTION OF Bi-212 AND A USE THEREOF
EP0834581A1 (de) * 1996-09-30 1998-04-08 Basf Aktiengesellschaft Verwendung von kohlenwasserstofflöslichen Aminomethylenphosphonsäure-Derivaten zur solventextraktiven Abtrennung von Metallionen aus wässrigen Lösungen
US5749042A (en) * 1997-01-28 1998-05-05 Battelle Memorial Institute Bismuth generator method
US5854968A (en) * 1997-06-09 1998-12-29 Arch Development Corporation Process and apparatus for the production of BI-213 cations
US6153154A (en) * 1998-05-27 2000-11-28 Battelle Memorial Institute Method for sequential injection of liquid samples for radioisotope separations
US6232353B1 (en) * 1998-07-02 2001-05-15 Arch Development Corporation Bifunctional phenyl monophosphonic/sulfonic acid ion exchange resin and process for using the same

Also Published As

Publication number Publication date
EA005735B1 (ru) 2005-06-30
JP2004534225A (ja) 2004-11-11
US6852296B2 (en) 2005-02-08
EP1404616A4 (de) 2006-09-13
AU2002320114B8 (en) 2005-09-01
CN1258480C (zh) 2006-06-07
DE60232658D1 (de) 2009-07-30
JP3993853B2 (ja) 2007-10-17
CA2451676A1 (en) 2003-01-03
CA2451676C (en) 2009-08-18
EP1404616B1 (de) 2009-06-17
CN1547555A (zh) 2004-11-17
US20030012715A1 (en) 2003-01-16
EP1404616A1 (de) 2004-04-07
EA200400071A1 (ru) 2004-06-24
AU2002320114B2 (en) 2005-08-18
WO2003000593A1 (en) 2003-01-03

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