ATE431361T1 - Verwendung vom transportergen oatp-c zur screening von testsubstanzen - Google Patents

Verwendung vom transportergen oatp-c zur screening von testsubstanzen

Info

Publication number
ATE431361T1
ATE431361T1 AT04077191T AT04077191T ATE431361T1 AT E431361 T1 ATE431361 T1 AT E431361T1 AT 04077191 T AT04077191 T AT 04077191T AT 04077191 T AT04077191 T AT 04077191T AT E431361 T1 ATE431361 T1 AT E431361T1
Authority
AT
Austria
Prior art keywords
oatp
transporter genes
test substances
screening test
transporter
Prior art date
Application number
AT04077191T
Other languages
English (en)
Inventor
Jun-Ichi Nezu
Asuka Ose
Akira Tsuji
Original Assignee
Chugai Pharmaceutical Co Ltd
Akira Tsuji
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Chugai Pharmaceutical Co Ltd, Akira Tsuji filed Critical Chugai Pharmaceutical Co Ltd
Application granted granted Critical
Publication of ATE431361T1 publication Critical patent/ATE431361T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Toxicology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Cell Biology (AREA)
  • Immunology (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Breeding Of Plants And Reproduction By Means Of Culturing (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Pretreatment Of Seeds And Plants (AREA)
AT04077191T 1999-09-21 2000-09-20 Verwendung vom transportergen oatp-c zur screening von testsubstanzen ATE431361T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP26783599 1999-09-21

Publications (1)

Publication Number Publication Date
ATE431361T1 true ATE431361T1 (de) 2009-05-15

Family

ID=17450292

Family Applications (1)

Application Number Title Priority Date Filing Date
AT04077191T ATE431361T1 (de) 1999-09-21 2000-09-20 Verwendung vom transportergen oatp-c zur screening von testsubstanzen

Country Status (7)

Country Link
US (3) US7045316B2 (de)
EP (4) EP1486510B1 (de)
JP (2) JP4838961B2 (de)
AT (1) ATE431361T1 (de)
AU (1) AU7317400A (de)
DE (1) DE60042220D1 (de)
WO (1) WO2001021792A1 (de)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1486510B1 (de) 1999-09-21 2009-05-13 Chugai Seiyaku Kabushiki Kaisha Verwendung vom transportergen oatp-c zur screening von testsubstanzen
EP1395680A2 (de) * 2001-05-18 2004-03-10 AstraZeneca AB Methode zum nachweis eines polymorphismus im humanen oatpb gen
US20040171010A1 (en) * 2001-05-24 2004-09-02 Rachael Moore Methods
US20080319795A1 (en) * 2002-11-21 2008-12-25 Cdex, Inc. System and methods for detection and identification of chemical substances
US7723019B2 (en) * 2003-05-20 2010-05-25 University Of Kentucky Research Foundation Organic cation transporter preferentially expressed in hematopoietic cells and leukemias and uses thereof
US20070148703A1 (en) * 2003-06-20 2007-06-28 Genomembrane, Inc. Method of screening remedy for breast cancer
US8110350B2 (en) * 2005-11-17 2012-02-07 Karolinska Institutet Innovations Ab Human Bocavirus and methods of diagnosis and treatment
US7435771B2 (en) 2005-11-23 2008-10-14 Arch Chemicals, Inc. Stable antifouling paint composition containing metal salt of pyrithione and cuprous oxide
EP2684963B1 (de) * 2011-03-10 2016-02-03 Eisai R&D Management Co., Ltd. Verfahren zum screening einer verbindung zur verstärkung oder hemmung einer oatp1b1-transportaktivität und verfahren zur bestimmung des expressionslevels von oatp1b1
PL3736329T3 (pl) 2012-09-11 2022-07-18 Corning Incorporated Zużywalne krioprezerwowane komórki wykazujące przejściową nadekspresję genu(-ów) kodującego(-ych) białko(-a) transportera leku i/lub enzym(y) metabolizujący(-e) lek

Family Cites Families (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1592954A (en) * 1976-12-16 1981-07-15 Int Inst Of Differentiation Cell line
EP0239102A3 (de) 1986-03-28 1989-07-12 Tsuji, Kimiyoshi Verfahren zur Herstellung eines Human-Human-Hybridoms
EP0814159B1 (de) 1990-08-29 2005-07-27 GenPharm International, Inc. Transgene Mäuse fähig zur Produktion heterologer Antikörper
WO1993002227A1 (en) 1991-07-15 1993-02-04 Eco-Tec Limited Process and apparatus for treating fluoride containing acid solutions
EP0746609A4 (de) 1991-12-17 1997-12-17 Genpharm Int Heterologe antikörper produzierende transgene nicht-humane tiere
CA2140638C (en) 1992-07-24 2010-05-04 Raju Kucherlapati Generation of xenogeneic antibodies
AU6819494A (en) 1993-04-26 1994-11-21 Genpharm International, Inc. Transgenic non-human animals capable of producing heterologous antibodies
EP0815220A4 (de) * 1995-03-01 2000-10-11 Human Genome Sciences Inc Menschlicher amintransporter
CA2219361C (en) 1995-04-27 2012-02-28 Abgenix, Inc. Human antibodies derived from immunized xenomice
AU2466895A (en) 1995-04-28 1996-11-18 Abgenix, Inc. Human antibodies derived from immunized xenomice
WO1998042738A1 (en) 1997-03-21 1998-10-01 Human Genome Sciences, Inc. 87 human secreted proteins
CA2305690A1 (en) * 1997-10-09 1999-04-22 Human Genome Sciences, Inc. 53 human secreted proteins
CA2332573A1 (en) * 1998-07-06 2000-01-13 Elizabeth Esther Mary Bates Mammalian genes; dendritic cell prostaglandin-like transponder (dc-pgt), hdtea84, hsljd37r and rankl, hcc5 chemokine, deubiquitinating 11 and 12 (dub11, dub12), md-1, md2 and cyclin e2, related reagents and methods
AU5340699A (en) * 1998-08-07 2000-02-28 Axys Pharmaceuticals, Inc. Human anion transporter genes atnov
JP2000116384A (ja) * 1998-08-12 2000-04-25 Kazusa Dna Kenkyusho 新規遺伝子及びそれにコ―ドされる蛋白質ｐｇｔｈ
WO2000009557A1 (fr) * 1998-08-12 2000-02-24 Kazusa Dna Research Institute Foundation Nouveau gene et nouvelle proteine pgth codee par ce gene
JP2003521227A (ja) * 1998-11-04 2003-07-15 インサイト・ファーマスーティカルズ・インコーポレイテッド 膜輸送タンパク質
CA2350415A1 (en) * 1998-11-18 2000-05-25 Incyte Pharmaceuticals, Inc. Inflammation-associated genes
AU3395900A (en) * 1999-03-12 2000-10-04 Human Genome Sciences, Inc. Human lung cancer associated gene sequences and polypeptides
EP1177287A2 (de) * 1999-04-09 2002-02-06 Chiron Corporation Sekretierte menschliche proteine
US6692934B1 (en) * 1999-05-20 2004-02-17 Bristol-Myers Squibb Co. Organic anion transport proteins
JP4071442B2 (ja) * 1999-05-20 2008-04-02 ブリストル−マイヤーズ スクイブ カンパニー 新規有機陰イオン輸送タンパク質
JP2001046083A (ja) * 1999-06-03 2001-02-20 Sankyo Co Ltd 肝臓に発現している新規トランスポーター遺伝子
AU6497700A (en) * 1999-07-30 2001-02-19 Millennium Pharmaceuticals, Inc. Novel transporter-like genes and uses therefor
EP1486510B1 (de) * 1999-09-21 2009-05-13 Chugai Seiyaku Kabushiki Kaisha Verwendung vom transportergen oatp-c zur screening von testsubstanzen
WO2001074897A2 (en) * 2000-04-03 2001-10-11 Curagen Corporation Protein amf-1 to amf-10 and nucleic acids encoding the same
US20020090622A1 (en) * 2000-08-23 2002-07-11 Monisola Adeokun Chemical compounds
DE10043748B4 (de) 2000-09-05 2004-01-15 W. C. Heraeus Gmbh & Co. Kg Zylinderförmiges Sputtertarget, Verfahren zu seiner Herstellung und Verwendung

Also Published As

Publication number Publication date
JP4838961B2 (ja) 2011-12-14
AU7317400A (en) 2001-04-24
EP1223217A1 (de) 2002-07-17
JP2011015694A (ja) 2011-01-27
US7045316B2 (en) 2006-05-16
EP1223217A4 (de) 2003-06-25
DE60042220D1 (de) 2009-06-25
WO2001021792A1 (fr) 2001-03-29
EP2316848A1 (de) 2011-05-04
US20030022199A1 (en) 2003-01-30
US8748128B2 (en) 2014-06-10
EP1486510A1 (de) 2004-12-15
US20060121523A1 (en) 2006-06-08
EP1486510B1 (de) 2009-05-13
US20100196960A1 (en) 2010-08-05
EP2030985A1 (de) 2009-03-04
JP5395767B2 (ja) 2014-01-22

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