DE60140934D1 - Polymorphismen des humanen cyp2b6 gens und deren verwendung in diagnostischen und therapeutischen anwendungen - Google Patents
Polymorphismen des humanen cyp2b6 gens und deren verwendung in diagnostischen und therapeutischen anwendungenInfo
- Publication number
- DE60140934D1 DE60140934D1 DE60140934T DE60140934T DE60140934D1 DE 60140934 D1 DE60140934 D1 DE 60140934D1 DE 60140934 T DE60140934 T DE 60140934T DE 60140934 T DE60140934 T DE 60140934T DE 60140934 D1 DE60140934 D1 DE 60140934D1
- Authority
- DE
- Germany
- Prior art keywords
- cyp2b6
- well
- polynucleotides
- diagnosing
- vectors
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 101000957383 Homo sapiens Cytochrome P450 2B6 Proteins 0.000 title 1
- 102000054765 polymorphisms of proteins Human genes 0.000 title 1
- 230000001225 therapeutic effect Effects 0.000 title 1
- 108010020070 Cytochrome P-450 CYP2B6 Proteins 0.000 abstract 4
- 102000040430 polynucleotide Human genes 0.000 abstract 4
- 108091033319 polynucleotide Proteins 0.000 abstract 4
- 239000002157 polynucleotide Substances 0.000 abstract 4
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 3
- 238000000034 method Methods 0.000 abstract 3
- 239000013598 vector Substances 0.000 abstract 3
- 101150069992 CYP2B6 gene Proteins 0.000 abstract 2
- 102000009666 Cytochrome P-450 CYP2B6 Human genes 0.000 abstract 2
- 208000035475 disorder Diseases 0.000 abstract 2
- 239000003814 drug Substances 0.000 abstract 2
- 229940079593 drug Drugs 0.000 abstract 2
- 239000003112 inhibitor Substances 0.000 abstract 2
- 230000002159 abnormal effect Effects 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 230000007257 malfunction Effects 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 108090000623 proteins and genes Proteins 0.000 abstract 1
- 102000004169 proteins and genes Human genes 0.000 abstract 1
- 238000001228 spectrum Methods 0.000 abstract 1
- 239000000758 substrate Substances 0.000 abstract 1
- 238000002560 therapeutic procedure Methods 0.000 abstract 1
- 230000009261 transgenic effect Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/0004—Oxidoreductases (1.)
- C12N9/0012—Oxidoreductases (1.) acting on nitrogen containing compounds as donors (1.4, 1.5, 1.6, 1.7)
- C12N9/0036—Oxidoreductases (1.) acting on nitrogen containing compounds as donors (1.4, 1.5, 1.6, 1.7) acting on NADH or NADPH (1.6)
- C12N9/0038—Oxidoreductases (1.) acting on nitrogen containing compounds as donors (1.4, 1.5, 1.6, 1.7) acting on NADH or NADPH (1.6) with a heme protein as acceptor (1.6.2)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
- C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/573—Immunoassay; Biospecific binding assay; Materials therefor for enzymes or isoenzymes
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2217/00—Genetically modified animals
- A01K2217/05—Animals comprising random inserted nucleic acids (transgenic)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/156—Polymorphic or mutational markers
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/158—Expression markers
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/172—Haplotypes
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- Genetics & Genomics (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biotechnology (AREA)
- Microbiology (AREA)
- Biochemistry (AREA)
- Analytical Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Immunology (AREA)
- General Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Medicinal Chemistry (AREA)
- Physics & Mathematics (AREA)
- Pathology (AREA)
- Hematology (AREA)
- Biophysics (AREA)
- Urology & Nephrology (AREA)
- Cell Biology (AREA)
- Food Science & Technology (AREA)
- General Physics & Mathematics (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP00102701 | 2000-02-09 | ||
| PCT/EP2001/001456 WO2001059152A2 (en) | 2000-02-09 | 2001-02-09 | Polymorphisms in the human cyp2b6 gene and their use in diagnostic and therapeutic applications |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DE60140934D1 true DE60140934D1 (de) | 2010-02-11 |
Family
ID=8167810
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE60140934T Expired - Lifetime DE60140934D1 (de) | 2000-02-09 | 2001-02-09 | Polymorphismen des humanen cyp2b6 gens und deren verwendung in diagnostischen und therapeutischen anwendungen |
Country Status (9)
| Country | Link |
|---|---|
| US (2) | US20040224313A1 (de) |
| EP (1) | EP1272663B1 (de) |
| AT (1) | ATE453725T1 (de) |
| AU (1) | AU3925701A (de) |
| DE (1) | DE60140934D1 (de) |
| DK (1) | DK1272663T3 (de) |
| ES (1) | ES2338523T3 (de) |
| PT (1) | PT1272663E (de) |
| WO (1) | WO2001059152A2 (de) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2660156T3 (es) * | 2011-05-05 | 2018-03-21 | Institut National De La Santé Et De La Recherche Médicale (Inserm) | Proteínas 2B6 mutantes de citocromo P450 y usos de las mismas |
| CN115976190B (zh) * | 2022-11-15 | 2024-08-27 | 苏州吉赛基因测序科技有限公司 | 剖宫产患者术后镇痛用药相关基因分型检测的产品及用途 |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9103314D0 (en) * | 1991-02-16 | 1991-04-03 | Imp Cancer Res Tech | Assay systems |
| US6620593B1 (en) * | 1993-07-20 | 2003-09-16 | Sumitomo Chemical Company, Limited | Method for safety evaluation of chemical compound using recombinant yeast expressing human cytochrome P450 |
| US5688773A (en) * | 1994-08-17 | 1997-11-18 | The General Hospital Corporation | Method of selectively destroying neoplastic cells |
| US6207648B1 (en) * | 1997-07-24 | 2001-03-27 | Trustees Of Boston University | Methods of using cytochrome P450 reductase for the enhancement of P450-based anti-cancer gene therapy |
| EP1068338A2 (de) * | 1998-03-06 | 2001-01-17 | Oxford Biomedica (UK) Limited | Verbesserte 'prodrug'-aktivierung. |
-
2001
- 2001-02-09 EP EP01913809A patent/EP1272663B1/de not_active Expired - Lifetime
- 2001-02-09 WO PCT/EP2001/001456 patent/WO2001059152A2/en active Application Filing
- 2001-02-09 DE DE60140934T patent/DE60140934D1/de not_active Expired - Lifetime
- 2001-02-09 DK DK01913809.8T patent/DK1272663T3/da active
- 2001-02-09 AU AU39257/01A patent/AU3925701A/en not_active Abandoned
- 2001-02-09 ES ES01913809T patent/ES2338523T3/es not_active Expired - Lifetime
- 2001-02-09 AT AT01913809T patent/ATE453725T1/de active
- 2001-02-09 US US09/958,635 patent/US20040224313A1/en not_active Abandoned
- 2001-02-09 PT PT01913809T patent/PT1272663E/pt unknown
-
2009
- 2009-03-16 US US12/404,772 patent/US20090311696A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| ATE453725T1 (de) | 2010-01-15 |
| WO2001059152A9 (en) | 2002-08-08 |
| AU3925701A (en) | 2001-08-20 |
| EP1272663A2 (de) | 2003-01-08 |
| US20090311696A1 (en) | 2009-12-17 |
| PT1272663E (pt) | 2010-03-01 |
| WO2001059152A2 (en) | 2001-08-16 |
| WO2001059152A3 (en) | 2002-10-31 |
| EP1272663B1 (de) | 2009-12-30 |
| ES2338523T3 (es) | 2010-05-10 |
| US20040224313A1 (en) | 2004-11-11 |
| DK1272663T3 (da) | 2010-04-26 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| 8327 | Change in the person/name/address of the patent owner |
Owner name: PGXHEALTH, LLC, NEWTON, MASS., US |
|
| 8364 | No opposition during term of opposition |