ATE430134T1 - Chinolinderivate, syntheseverfahren und diese derivate enthaltende medikamente - Google Patents
Chinolinderivate, syntheseverfahren und diese derivate enthaltende medikamenteInfo
- Publication number
- ATE430134T1 ATE430134T1 AT02795314T AT02795314T ATE430134T1 AT E430134 T1 ATE430134 T1 AT E430134T1 AT 02795314 T AT02795314 T AT 02795314T AT 02795314 T AT02795314 T AT 02795314T AT E430134 T1 ATE430134 T1 AT E430134T1
- Authority
- AT
- Austria
- Prior art keywords
- sub
- derivatives
- coor
- cooh
- synthesis processes
- Prior art date
Links
- 239000003814 drug Substances 0.000 title abstract 2
- SMWDFEZZVXVKRB-UHFFFAOYSA-N Quinoline Chemical class N1=CC=CC2=CC=CC=C21 SMWDFEZZVXVKRB-UHFFFAOYSA-N 0.000 title 1
- 229940027991 antiseptic and disinfectant quinoline derivative Drugs 0.000 title 1
- 230000015572 biosynthetic process Effects 0.000 title 1
- 229940079593 drug Drugs 0.000 title 1
- 238000000034 method Methods 0.000 title 1
- 238000003786 synthesis reaction Methods 0.000 title 1
- 125000003118 aryl group Chemical group 0.000 abstract 3
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 abstract 2
- 229910052757 nitrogen Inorganic materials 0.000 abstract 2
- 229910052760 oxygen Inorganic materials 0.000 abstract 2
- -1 -COOR Chemical group 0.000 abstract 1
- 102000012330 Integrases Human genes 0.000 abstract 1
- 108010061833 Integrases Proteins 0.000 abstract 1
- 239000004480 active ingredient Substances 0.000 abstract 1
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- 125000004432 carbon atom Chemical group C* 0.000 abstract 1
- 125000005842 heteroatom Chemical group 0.000 abstract 1
- 230000002401 inhibitory effect Effects 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 125000001424 substituent group Chemical group 0.000 abstract 1
- 238000006467 substitution reaction Methods 0.000 abstract 1
- 229910052717 sulfur Inorganic materials 0.000 abstract 1
- 241001430294 unidentified retrovirus Species 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/48—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Virology (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Molecular Biology (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Tropical Medicine & Parasitology (AREA)
- AIDS & HIV (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Quinoline Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR0113209A FR2830863B1 (fr) | 2001-10-12 | 2001-10-12 | Derives de quinoleine, procede de synthese, et medicaments renfermant ces derives |
| PCT/FR2002/003512 WO2003031413A1 (fr) | 2001-10-12 | 2002-10-14 | Derives de quinoleine, procede de synthese, et medicaments renfermant ces derives |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE430134T1 true ATE430134T1 (de) | 2009-05-15 |
Family
ID=8868255
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT02795314T ATE430134T1 (de) | 2001-10-12 | 2002-10-14 | Chinolinderivate, syntheseverfahren und diese derivate enthaltende medikamente |
Country Status (10)
| Country | Link |
|---|---|
| US (2) | US7064133B2 (https=) |
| EP (1) | EP1461319B1 (https=) |
| JP (1) | JP2005508350A (https=) |
| AT (1) | ATE430134T1 (https=) |
| DE (1) | DE60232186D1 (https=) |
| DK (1) | DK1461319T3 (https=) |
| ES (1) | ES2326115T3 (https=) |
| FR (1) | FR2830863B1 (https=) |
| IL (2) | IL161320A0 (https=) |
| WO (1) | WO2003031413A1 (https=) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2830863B1 (fr) * | 2001-10-12 | 2004-01-30 | Bioalliance Pharma | Derives de quinoleine, procede de synthese, et medicaments renfermant ces derives |
| FR2839646B1 (fr) * | 2002-05-17 | 2008-04-11 | Bioalliance Pharma | Utilisation de derives de quinoleine a effet anti-integrase et ses applications |
| US7132432B2 (en) * | 2003-06-05 | 2006-11-07 | Bristol-Myers Squibb Company | Hydantoin derivatives as inhibitors of tumor necrosis factor-alpha converting enzyme (TACE) |
| TW200510425A (en) | 2003-08-13 | 2005-03-16 | Japan Tobacco Inc | Nitrogen-containing fused ring compound and use thereof as HIV integrase inhibitor |
| US20070185007A1 (en) | 2003-09-19 | 2007-08-09 | Haolun Jin | Aza-quinolinol phosphonate integrase inhibitor compounds |
| US20080280849A1 (en) * | 2005-06-01 | 2008-11-13 | Herve Leh | Synergic Combinations Comprising a Quinoline Compound and Other Hiv Infection Therapeutic Agents |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2761687B1 (fr) * | 1997-04-08 | 2000-09-15 | Centre Nat Rech Scient | Derives de quinoleines, possedant notamment des proprietes antivirales, leurs preparations et leurs applications biologiques |
| FR2830863B1 (fr) * | 2001-10-12 | 2004-01-30 | Bioalliance Pharma | Derives de quinoleine, procede de synthese, et medicaments renfermant ces derives |
-
2001
- 2001-10-12 FR FR0113209A patent/FR2830863B1/fr not_active Expired - Fee Related
-
2002
- 2002-10-14 IL IL16132002A patent/IL161320A0/xx unknown
- 2002-10-14 WO PCT/FR2002/003512 patent/WO2003031413A1/fr not_active Ceased
- 2002-10-14 DK DK02795314T patent/DK1461319T3/da active
- 2002-10-14 ES ES02795314T patent/ES2326115T3/es not_active Expired - Lifetime
- 2002-10-14 AT AT02795314T patent/ATE430134T1/de not_active IP Right Cessation
- 2002-10-14 JP JP2003534397A patent/JP2005508350A/ja active Pending
- 2002-10-14 EP EP02795314A patent/EP1461319B1/fr not_active Expired - Lifetime
- 2002-10-14 US US10/492,088 patent/US7064133B2/en not_active Expired - Fee Related
- 2002-10-14 DE DE60232186T patent/DE60232186D1/de not_active Expired - Lifetime
-
2004
- 2004-04-07 IL IL161320A patent/IL161320A/en not_active IP Right Cessation
-
2006
- 2006-03-01 US US11/364,329 patent/US20060148849A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| WO2003031413A1 (fr) | 2003-04-17 |
| FR2830863A1 (fr) | 2003-04-18 |
| FR2830863B1 (fr) | 2004-01-30 |
| US20060148849A1 (en) | 2006-07-06 |
| EP1461319B1 (fr) | 2009-04-29 |
| DK1461319T3 (da) | 2009-08-03 |
| EP1461319A1 (fr) | 2004-09-29 |
| ES2326115T3 (es) | 2009-10-01 |
| IL161320A (en) | 2009-09-01 |
| US20040259911A1 (en) | 2004-12-23 |
| DE60232186D1 (de) | 2009-06-10 |
| US7064133B2 (en) | 2006-06-20 |
| IL161320A0 (en) | 2004-09-27 |
| JP2005508350A (ja) | 2005-03-31 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |