ATE428778T1 - Verfahren zum screening auf agonistische antikörper - Google Patents
Verfahren zum screening auf agonistische antikörperInfo
- Publication number
- ATE428778T1 ATE428778T1 AT03719213T AT03719213T ATE428778T1 AT E428778 T1 ATE428778 T1 AT E428778T1 AT 03719213 T AT03719213 T AT 03719213T AT 03719213 T AT03719213 T AT 03719213T AT E428778 T1 ATE428778 T1 AT E428778T1
- Authority
- AT
- Austria
- Prior art keywords
- agonistic antibodies
- screening
- dependent
- antibodies
- effective screening
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C40—COMBINATORIAL TECHNOLOGY
- C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
- C40B30/00—Methods of screening libraries
- C40B30/04—Methods of screening libraries by measuring the ability to specifically bind a target molecule, e.g. antibody-antigen binding, receptor-ligand binding
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
- G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2002127260 | 2002-04-26 | ||
PCT/JP2003/005372 WO2003091424A1 (fr) | 2002-04-26 | 2003-04-25 | Procede de criblage d'un anticorps agoniste |
Publications (1)
Publication Number | Publication Date |
---|---|
ATE428778T1 true ATE428778T1 (de) | 2009-05-15 |
Family
ID=29267644
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AT03719213T ATE428778T1 (de) | 2002-04-26 | 2003-04-25 | Verfahren zum screening auf agonistische antikörper |
Country Status (7)
Country | Link |
---|---|
US (1) | US7732149B2 (de) |
EP (1) | EP1505148B1 (de) |
JP (1) | JP4518941B2 (de) |
AT (1) | ATE428778T1 (de) |
AU (1) | AU2003235833A1 (de) |
DE (1) | DE60327199D1 (de) |
WO (1) | WO2003091424A1 (de) |
Families Citing this family (37)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
KR100874280B1 (ko) * | 1999-10-20 | 2008-12-18 | 제넨테크, 인크. | T 헬퍼 세포 매개 질환의 치료를 위한 t 세포 분화의조절 |
US7393532B1 (en) * | 2000-10-18 | 2008-07-01 | Genentech, Inc. | Modulation of T cell differentiation for the treatment of T helper cell mediated diseases |
US7754208B2 (en) | 2001-01-17 | 2010-07-13 | Trubion Pharmaceuticals, Inc. | Binding domain-immunoglobulin fusion proteins |
DE60233248D1 (de) * | 2001-11-15 | 2009-09-17 | Childrens Medical Center | Verfahren zur isolierung, expansion und differenzierung fötaler stammzellen aus chorionzotte, fruchtwasser und plazenta und therapeutische verwendungen davon |
AU2003235833A1 (en) | 2002-04-26 | 2003-11-10 | Chugai Seiyaku Kabushiki Kaisha | Method of screening agonistic antibody |
WO2005035753A1 (ja) | 2003-10-10 | 2005-04-21 | Chugai Seiyaku Kabushiki Kaisha | 機能蛋白質を代替する二重特異性抗体 |
AU2003271186A1 (en) * | 2003-10-14 | 2005-04-27 | Chugai Seiyaku Kabushiki Kaisha | Double specific antibodies substituting for functional protein |
EP3115057B1 (de) | 2004-10-21 | 2019-09-04 | ONO Pharmaceutical Co., Ltd. | Verwendung eines immunsuppressiven rezeptors |
KR20070095949A (ko) * | 2004-12-16 | 2007-10-01 | 제넨테크, 인크. | 자가면역 장애의 치료 방법 |
US10011858B2 (en) | 2005-03-31 | 2018-07-03 | Chugai Seiyaku Kabushiki Kaisha | Methods for producing polypeptides by regulating polypeptide association |
DK2824183T3 (da) * | 2005-04-08 | 2020-09-28 | Chugai Pharmaceutical Co Ltd | Fremgangsmåde til fremstilling af bispecifikke antistoffer |
DK1912675T3 (en) | 2005-07-25 | 2014-03-24 | Emergent Product Dev Seattle | B-cell reduction using specific and cd37-cd20-specific binding molecules |
DK3056568T3 (da) | 2006-03-31 | 2021-11-01 | Chugai Pharmaceutical Co Ltd | Fremgangsmåder til kontrollering af antistoffers blodfarmakokinetik |
ES2654040T3 (es) | 2006-03-31 | 2018-02-12 | Chugai Seiyaku Kabushiki Kaisha | Método de modificación de anticuerpos para la purificación de anticuerpos biespecíficos |
JP2009539413A (ja) | 2006-06-12 | 2009-11-19 | トゥルビオン・ファーマシューティカルズ・インコーポレーテッド | エフェクター機能を有する単鎖多価結合タンパク質 |
CN106519025B (zh) | 2007-09-26 | 2021-04-23 | 中外制药株式会社 | 利用cdr的氨基酸取代来改变抗体等电点的方法 |
ES2368700T3 (es) | 2008-04-11 | 2011-11-21 | Emergent Product Development Seattle, Llc | Agente inmunoterapéutico para cd37 y combinación con un agente quimioterapéutico bifuncional del mismo. |
US9796788B2 (en) | 2010-02-08 | 2017-10-24 | Regeneron Pharmaceuticals, Inc. | Mice expressing a limited immunoglobulin light chain repertoire |
US20130045492A1 (en) | 2010-02-08 | 2013-02-21 | Regeneron Pharmaceuticals, Inc. | Methods For Making Fully Human Bispecific Antibodies Using A Common Light Chain |
EP3095871B1 (de) | 2010-02-08 | 2019-04-10 | Regeneron Pharmaceuticals, Inc. | Maus mit gemeinen leichten ketten |
TR201802772T4 (tr) | 2010-11-17 | 2018-03-21 | Chugai Pharmaceutical Co Ltd | Kan pıhtılaşma faktörü VIII in işlevi için alternatif işleve sahip multi-spesifik antijen bağlayıcı molekül. |
MY172718A (en) | 2011-08-05 | 2019-12-11 | Regeneron Pharma | Humanized universal light chain mice |
JP6267689B2 (ja) | 2012-05-10 | 2018-01-24 | バイオアトラ、エルエルシー | 多重特異性モノクローナル抗体 |
BR112016006197B1 (pt) | 2013-09-27 | 2023-04-11 | Chugai Seiyaku Kabushiki Kaisha | Método para produzir um anticorpo biespecífico de polipeptídeos |
SG11201607203XA (en) | 2014-03-21 | 2016-09-29 | Regeneron Pharma | Non-human animals that make single domain binding proteins |
MA40764A (fr) | 2014-09-26 | 2017-08-01 | Chugai Pharmaceutical Co Ltd | Agent thérapeutique induisant une cytotoxicité |
TWI700300B (zh) | 2014-09-26 | 2020-08-01 | 日商中外製藥股份有限公司 | 中和具有第viii凝血因子(fviii)機能替代活性的物質之抗體 |
TWI701435B (zh) | 2014-09-26 | 2020-08-11 | 日商中外製藥股份有限公司 | 測定fviii的反應性之方法 |
CA2979702A1 (en) | 2015-03-19 | 2016-09-22 | Regeneron Pharmaceuticals, Inc. | Non-human animals that select for light chain variable regions that bind antigen |
EP3279216A4 (de) | 2015-04-01 | 2019-06-19 | Chugai Seiyaku Kabushiki Kaisha | Verfahren zur herstellung von polypeptid-hetero-oligomer |
EP3352760A4 (de) | 2015-09-21 | 2019-03-06 | Aptevo Research and Development LLC | Cd3-bindende polypeptide |
WO2017115773A1 (ja) | 2015-12-28 | 2017-07-06 | 中外製薬株式会社 | Fc領域含有ポリペプチドの精製を効率化するための方法 |
CA3035327A1 (en) | 2016-09-06 | 2018-03-15 | Chugai Seiyaku Kabushiki Kaisha | Methods of using a bispecific antibody that recognizes coagulation factor ix and/or activated coagulation factor ix and coagulation factor x and/or activated coagulation factor x |
EP3612210A4 (de) | 2017-04-19 | 2021-01-27 | Board Of Regents, The University Of Texas System | Manipulierte antigenrezeptoren exprimierende immunzellen |
EP3630156A4 (de) * | 2017-05-25 | 2021-03-31 | The Broad Institute, Inc. | Lymphozyten-antigen-cd5-like (cd5l)-monomer, homodimer und interleukin 12b (p40)-heterodimer-agonisten und anwendungsverfahren dafür |
MX2020002710A (es) | 2017-09-29 | 2020-07-20 | Chugai Pharmaceutical Co Ltd | Molecula de union al antigeno multiespecifica que tiene actividad de sustitucion de la funcion de cofactor del factor viii de coagulacion de sangre (fviii) y formulacion farmaceutica que contiene tal molecula como ingrediente activo. |
JPWO2020196926A1 (de) | 2019-03-28 | 2020-10-01 |
Family Cites Families (14)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3773919A (en) | 1969-10-23 | 1973-11-20 | Du Pont | Polylactide-drug mixtures |
IE52535B1 (en) | 1981-02-16 | 1987-12-09 | Ici Plc | Continuous release pharmaceutical compositions |
HUT35524A (en) | 1983-08-02 | 1985-07-29 | Hoechst Ag | Process for preparing pharmaceutical compositions containing regulatory /regulative/ peptides providing for the retarded release of the active substance |
JP2928287B2 (ja) | 1988-09-29 | 1999-08-03 | 協和醗酵工業株式会社 | 新規ポリペプチド |
DE3920358A1 (de) | 1989-06-22 | 1991-01-17 | Behringwerke Ag | Bispezifische und oligospezifische, mono- und oligovalente antikoerperkonstrukte, ihre herstellung und verwendung |
JP3881689B2 (ja) | 1992-03-11 | 2007-02-14 | パウダージェクト ヴァクシンズ,インコーポレイテッド | 免疫不全ウイルス用の遺伝子ワクチン |
DE69830901T2 (de) | 1997-05-02 | 2006-05-24 | Genentech Inc., San Francisco | ein verfahren zur herstellung multispezifischer antikörper die heteromultimere und gemeinsame komponenten besitzen |
US6342220B1 (en) | 1997-08-25 | 2002-01-29 | Genentech, Inc. | Agonist antibodies |
RU2221809C2 (ru) | 1997-10-03 | 2004-01-20 | Тугаи Сейяку Кабусики Кайся | Способ получения природного гуманизированного антитела |
AU2333999A (en) | 1998-01-23 | 1999-08-09 | Prolifaron, Inc. | Methods and compositions for the identification of growth factor mimetics, growth factors and inhibitors |
GB2344886B (en) * | 1999-03-10 | 2000-11-01 | Medical Res Council | Selection of intracellular immunoglobulins |
AU2001246934A1 (en) | 2000-04-17 | 2001-10-30 | Chugai Seiyaku Kabushiki Kaisha | Agonist antibodies |
AU2002210917B2 (en) | 2000-10-20 | 2006-05-18 | Chugai Seiyaku Kabushiki Kaisha | Degraded TPO agonist antibody |
AU2003235833A1 (en) | 2002-04-26 | 2003-11-10 | Chugai Seiyaku Kabushiki Kaisha | Method of screening agonistic antibody |
-
2003
- 2003-04-25 AU AU2003235833A patent/AU2003235833A1/en not_active Abandoned
- 2003-04-25 EP EP03719213A patent/EP1505148B1/de not_active Expired - Lifetime
- 2003-04-25 AT AT03719213T patent/ATE428778T1/de not_active IP Right Cessation
- 2003-04-25 US US10/511,993 patent/US7732149B2/en active Active
- 2003-04-25 WO PCT/JP2003/005372 patent/WO2003091424A1/ja active Application Filing
- 2003-04-25 DE DE60327199T patent/DE60327199D1/de not_active Expired - Lifetime
- 2003-04-25 JP JP2004501976A patent/JP4518941B2/ja not_active Expired - Lifetime
Also Published As
Publication number | Publication date |
---|---|
WO2003091424A1 (fr) | 2003-11-06 |
US20050164307A1 (en) | 2005-07-28 |
DE60327199D1 (de) | 2009-05-28 |
JP4518941B2 (ja) | 2010-08-04 |
JPWO2003091424A1 (ja) | 2005-09-02 |
EP1505148B1 (de) | 2009-04-15 |
US7732149B2 (en) | 2010-06-08 |
AU2003235833A1 (en) | 2003-11-10 |
EP1505148A1 (de) | 2005-02-09 |
EP1505148A4 (de) | 2006-07-26 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |