ATE42339T1 - Polypeptid- und proteinprodukte und verfahren zu deren herstellung und verwendung. - Google Patents
Polypeptid- und proteinprodukte und verfahren zu deren herstellung und verwendung.Info
- Publication number
- ATE42339T1 ATE42339T1 AT84303517T AT84303517T ATE42339T1 AT E42339 T1 ATE42339 T1 AT E42339T1 AT 84303517 T AT84303517 T AT 84303517T AT 84303517 T AT84303517 T AT 84303517T AT E42339 T1 ATE42339 T1 AT E42339T1
- Authority
- AT
- Austria
- Prior art keywords
- polypeptide
- fusion protein
- calcitonin
- cat
- manufacture
- Prior art date
Links
- 229920001184 polypeptide Polymers 0.000 title abstract 5
- 102000004196 processed proteins & peptides Human genes 0.000 title abstract 5
- 108090000765 processed proteins & peptides Proteins 0.000 title abstract 5
- 238000004519 manufacturing process Methods 0.000 title abstract 2
- 238000000034 method Methods 0.000 title abstract 2
- 108090000623 proteins and genes Proteins 0.000 title abstract 2
- 102000004169 proteins and genes Human genes 0.000 title abstract 2
- 108020001507 fusion proteins Proteins 0.000 abstract 4
- 102000037865 fusion proteins Human genes 0.000 abstract 4
- 108010035563 Chloramphenicol O-acetyltransferase Proteins 0.000 abstract 3
- 108090000746 Chymosin Proteins 0.000 abstract 2
- 230000000890 antigenic effect Effects 0.000 abstract 2
- 102000055006 Calcitonin Human genes 0.000 abstract 1
- 108060001064 Calcitonin Proteins 0.000 abstract 1
- 239000000055 Corticotropin-Releasing Hormone Substances 0.000 abstract 1
- 108090000790 Enzymes Proteins 0.000 abstract 1
- 102000004190 Enzymes Human genes 0.000 abstract 1
- 241000710198 Foot-and-mouth disease virus Species 0.000 abstract 1
- 239000004471 Glycine Substances 0.000 abstract 1
- 102000004877 Insulin Human genes 0.000 abstract 1
- 108090001061 Insulin Proteins 0.000 abstract 1
- 238000001042 affinity chromatography Methods 0.000 abstract 1
- BBBFJLBPOGFECG-VJVYQDLKSA-N calcitonin Chemical compound N([C@H](C(=O)N[C@@H](CC(C)C)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC=1NC=NC=1)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC=1C=CC(O)=CC=1)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H]([C@@H](C)O)C(=O)NCC(=O)N[C@@H](CO)C(=O)NCC(=O)N[C@@H]([C@@H](C)O)C(=O)N1[C@@H](CCC1)C(N)=O)C(C)C)C(=O)[C@@H]1CSSC[C@H](N)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N[C@@H]([C@@H](C)O)C(=O)N1 BBBFJLBPOGFECG-VJVYQDLKSA-N 0.000 abstract 1
- 229960004015 calcitonin Drugs 0.000 abstract 1
- 229940080701 chymosin Drugs 0.000 abstract 1
- 238000003776 cleavage reaction Methods 0.000 abstract 1
- IDLFZVILOHSSID-OVLDLUHVSA-N corticotropin Chemical compound C([C@@H](C(=O)N[C@@H](CO)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC=1NC=NC=1)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](C(C)C)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC=1C=CC(O)=CC=1)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CC(N)=O)C(=O)NCC(=O)N[C@@H](C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CO)C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC=1C=CC=CC=1)C(O)=O)NC(=O)[C@@H](N)CO)C1=CC=C(O)C=C1 IDLFZVILOHSSID-OVLDLUHVSA-N 0.000 abstract 1
- 229960000258 corticotropin Drugs 0.000 abstract 1
- 229940088598 enzyme Drugs 0.000 abstract 1
- 239000000122 growth hormone Substances 0.000 abstract 1
- 229940088597 hormone Drugs 0.000 abstract 1
- 239000005556 hormone Substances 0.000 abstract 1
- 230000002163 immunogen Effects 0.000 abstract 1
- 239000004026 insulin derivative Substances 0.000 abstract 1
- GNOLWGAJQVLBSM-UHFFFAOYSA-N n,n,5,7-tetramethyl-1,2,3,4-tetrahydronaphthalen-1-amine Chemical compound C1=C(C)C=C2C(N(C)C)CCCC2=C1C GNOLWGAJQVLBSM-UHFFFAOYSA-N 0.000 abstract 1
- 108010064037 prorennin Proteins 0.000 abstract 1
- 230000007017 scission Effects 0.000 abstract 1
- 239000000126 substance Substances 0.000 abstract 1
- 239000000758 substrate Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/10—Transferases (2.)
- C12N9/1025—Acyltransferases (2.3)
- C12N9/1029—Acyltransferases (2.3) transferring groups other than amino-acyl groups (2.3.1)
- C12N9/1033—Chloramphenicol O-acetyltransferase (2.3.1.28)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/585—Calcitonins
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/665—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans derived from pro-opiomelanocortin, pro-enkephalin or pro-dynorphin
- C07K14/695—Corticotropin [ACTH]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/40—Fusion polypeptide containing a tag for immunodetection, or an epitope for immunisation
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/50—Fusion polypeptide containing protease site
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/61—Fusion polypeptide containing an enzyme fusion for detection (lacZ, luciferase)
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/70—Fusion polypeptide containing domain for protein-protein interaction
- C07K2319/74—Fusion polypeptide containing domain for protein-protein interaction containing a fusion for binding to a cell surface receptor
- C07K2319/75—Fusion polypeptide containing domain for protein-protein interaction containing a fusion for binding to a cell surface receptor containing a fusion for activation of a cell surface receptor, e.g. thrombopoeitin, NPY and other peptide hormones
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Genetics & Genomics (AREA)
- Zoology (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Microbiology (AREA)
- Gastroenterology & Hepatology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Toxicology (AREA)
- Engineering & Computer Science (AREA)
- Biophysics (AREA)
- Wood Science & Technology (AREA)
- General Engineering & Computer Science (AREA)
- Epidemiology (AREA)
- Biomedical Technology (AREA)
- Endocrinology (AREA)
- Immunology (AREA)
- Mycology (AREA)
- Pharmacology & Pharmacy (AREA)
- Biotechnology (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Peptides Or Proteins (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB838314362A GB8314362D0 (en) | 1983-05-24 | 1983-05-24 | Polypeptide and protein products |
| EP84303517A EP0131363B1 (de) | 1983-05-24 | 1984-05-24 | Polypeptid- und Proteinprodukte und Verfahren zu deren Herstellung und Verwendung |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE42339T1 true ATE42339T1 (de) | 1989-05-15 |
Family
ID=10543274
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT84303517T ATE42339T1 (de) | 1983-05-24 | 1984-05-24 | Polypeptid- und proteinprodukte und verfahren zu deren herstellung und verwendung. |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US5093241A (de) |
| EP (1) | EP0131363B1 (de) |
| JP (1) | JPH0638755B2 (de) |
| AT (1) | ATE42339T1 (de) |
| CA (1) | CA1306207C (de) |
| DE (1) | DE3477810D1 (de) |
| GB (1) | GB8314362D0 (de) |
| WO (1) | WO1984004756A1 (de) |
Families Citing this family (34)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB8412517D0 (en) * | 1984-05-16 | 1984-06-20 | Nagai K | Recombinant fusion proteins |
| US4751180A (en) * | 1985-03-28 | 1988-06-14 | Chiron Corporation | Expression using fused genes providing for protein product |
| ATE63757T1 (de) * | 1985-03-28 | 1991-06-15 | Chiron Corp | Expression durch verwendung von fusionsgenen fuer proteinproduktion. |
| US5342921A (en) * | 1985-03-28 | 1994-08-30 | Chiron Corporation | Superoxide dismutase fusion polypeptides for expression of mammalian proteins |
| EP0440311A1 (de) | 1985-06-20 | 1991-08-07 | Fujisawa Pharmaceutical Co., Ltd. | Herstellungsverfahren für menschliches alpha-Atrio-natriuretisches Polypeptid |
| EP0241546A4 (de) * | 1985-10-11 | 1988-11-02 | Genetics Inst | Verfahren zur herstellung heterologer proteine. |
| DE3781420T2 (de) * | 1986-01-31 | 1993-02-25 | Sagami Chem Res | Hybrides plasminogenaktivatoraehnliches polypeptid. |
| SE8601940D0 (sv) * | 1986-04-25 | 1986-04-25 | Kabigen Ab | Preparation of fused proteins, antibodies and processes therefor |
| US4859609A (en) * | 1986-04-30 | 1989-08-22 | Genentech, Inc. | Novel receptors for efficient determination of ligands and their antagonists or agonists |
| US5013653A (en) | 1987-03-20 | 1991-05-07 | Creative Biomolecules, Inc. | Product and process for introduction of a hinge region into a fusion protein to facilitate cleavage |
| US5215896A (en) * | 1987-03-20 | 1993-06-01 | Creative Biomolecules, Inc. | Leader sequences for the production of recombinant proteins |
| FR2615528B1 (fr) * | 1987-05-18 | 1991-05-24 | Pasteur Institut | Procede de production d'un polypeptide ayant des proprietes choisies determinees, dans un organisme-hote transforme par un adn recombinant contenant des sequences nucleiques codant pour ce polypeptide et pour une proteine affine d'ose |
| DE3731875A1 (de) * | 1987-09-18 | 1989-03-30 | Schering Ag | Gentechnische herstellung von neukombinierten plasmiden fuer die produktion von humanem adrenocorticotropen horman (acth) und davon abgeleiteten derivaten durch enzymatische spaltung primaer synthetisierter fusionsproteine |
| JP2653820B2 (ja) * | 1988-03-14 | 1997-09-17 | 壽之 松尾 | アミド化酵素及びその製造方法 |
| JPH04501204A (ja) * | 1988-08-11 | 1992-03-05 | サイオス ノバ インコーポレイテッド | 異種タンパク発現を安定させる方法およびそれに使用するベクター |
| AU629237B2 (en) * | 1988-08-30 | 1992-10-01 | Applied Research Systems Ars Holding N.V. | Recombinant fusion proteins for altering hormone secretion |
| JP2852431B2 (ja) * | 1988-12-07 | 1999-02-03 | 財団法人阪大微生物病研究会 | レトロウイルスのプロテアーゼ、逆転写酵素及びエンドヌクレアーゼ、並びにこれ等の酵素の製法 |
| WO1990012877A1 (en) * | 1989-04-19 | 1990-11-01 | Cetus Corporation | Multifunctional m-csf proteins and genes encoding therefor |
| JP2546544B2 (ja) * | 1989-10-27 | 1996-10-23 | アーチ ディベラップメント コーポレイション | 免疫強化を促進するための方法と組成物 |
| AU649640B2 (en) * | 1990-05-28 | 1994-06-02 | Research Foundation For Microbial Diseases Of Osaka University, The | A method of preparing a plasmid, the plasmid and expression products thereof |
| US5595887A (en) * | 1990-07-16 | 1997-01-21 | Bionebraska, Inc. | Purification directed cloning of peptides using carbonic anhydrase as the affinity binding segment |
| EP0645454A3 (de) * | 1993-06-22 | 1997-01-15 | Vladimir Glebovich Lunin | Chimäres Somatostatin enthaltendes Protein und kodierende DNA, Immunogen-Zusammensetzungen und Verfahren zur Erhöhung des Produktions von Farmtieren. |
| AU4415796A (en) * | 1994-12-07 | 1996-06-26 | Bionebraska, Inc. | Production of c-terminal amidated peptides from recombinant protein constructs |
| US5962270A (en) * | 1996-02-06 | 1999-10-05 | Bionebraska, Inc. | Recombinant preparation of calcitonin fragments and use thereof in the preparation of calcitonin and related analogs |
| JP4741076B2 (ja) * | 1998-07-10 | 2011-08-03 | サイオス インコーポレイテッド | ８より上または５未満のｐＩを有するペプチドを産生するための方法 |
| AU773428B2 (en) | 1998-10-13 | 2004-05-27 | Peptide Biosciences, Inc. | Stabilized bioactive peptides and methods of identification, synthesis and use |
| US20030190740A1 (en) | 1998-10-13 | 2003-10-09 | The University Of Georgia Research Foundation, Inc | Stabilized bioactive peptides and methods of identification, synthesis, and use |
| US6461834B1 (en) | 1998-11-06 | 2002-10-08 | Bionebraska, Inc. | Clostripain catalyzed amidation of peptides |
| DE60017211T2 (de) | 1999-02-17 | 2005-06-02 | Pfizer Products Inc., Groton | Fusionsproteine mit Trägern welche eine doppelte Immunantwort induzieren |
| EP1572720A4 (de) * | 2002-05-24 | 2008-12-24 | Nps Allelix Corp | Verfahren zur enzymatischen herstellung von glp-2-(1-33)- und glp-2-(1-34)-peptiden |
| CL2007002615A1 (es) * | 2006-09-08 | 2008-04-18 | Wyeth Corp | Metodos para aislar o purificar un producto que comprende poner el producto enlazado en contacto con al menos una solucion de lavado que comprende arginina y luego eluir el producto; y dicho producto. |
| AU2008246442B2 (en) | 2007-05-04 | 2014-07-03 | Technophage, Investigacao E Desenvolvimento Em Biotecnologia, Sa | Engineered rabbit antibody variable domains and uses thereof |
| US8673972B2 (en) | 2012-08-03 | 2014-03-18 | Foundation Medicine, Inc. | Human papilloma virus as predictor of cancer prognosis |
| WO2014169274A2 (en) | 2013-04-12 | 2014-10-16 | Yale University | Modified proteins and methods of use thereof |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4411994A (en) * | 1978-06-08 | 1983-10-25 | The President And Fellows Of Harvard College | Protein synthesis |
| CA1200773A (en) * | 1980-02-29 | 1986-02-18 | William J. Rutter | Expression linkers |
| JPS58501121A (ja) * | 1981-07-15 | 1983-07-14 | セルテク リミテツド | ヒト カルシトニン前駆体ポリ蛋白質構造遺伝子 |
-
1983
- 1983-05-24 GB GB838314362A patent/GB8314362D0/en active Pending
-
1984
- 1984-05-24 CA CA000455032A patent/CA1306207C/en not_active Expired - Lifetime
- 1984-05-24 EP EP84303517A patent/EP0131363B1/de not_active Expired
- 1984-05-24 JP JP50233884A patent/JPH0638755B2/ja not_active Expired - Lifetime
- 1984-05-24 WO PCT/GB1984/000179 patent/WO1984004756A1/en unknown
- 1984-05-24 AT AT84303517T patent/ATE42339T1/de not_active IP Right Cessation
- 1984-05-24 DE DE8484303517T patent/DE3477810D1/de not_active Expired
-
1988
- 1988-09-23 US US07/250,962 patent/US5093241A/en not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| EP0131363A1 (de) | 1985-01-16 |
| US5093241A (en) | 1992-03-03 |
| JPS60501391A (ja) | 1985-08-29 |
| CA1306207C (en) | 1992-08-11 |
| GB8314362D0 (en) | 1983-06-29 |
| DE3477810D1 (en) | 1989-05-24 |
| JPH0638755B2 (ja) | 1994-05-25 |
| EP0131363B1 (de) | 1989-04-19 |
| WO1984004756A1 (en) | 1984-12-06 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| UEP | Publication of translation of european patent specification | ||
| REN | Ceased due to non-payment of the annual fee |