ATE421503T1 - N-substituierten, 6,8-dialkoxy-1,2,3,4-tetrahydro-1h-isochinolin derivate als kaliumkanal- modulatoren - Google Patents
N-substituierten, 6,8-dialkoxy-1,2,3,4-tetrahydro-1h-isochinolin derivate als kaliumkanal- modulatorenInfo
- Publication number
- ATE421503T1 ATE421503T1 AT04740010T AT04740010T ATE421503T1 AT E421503 T1 ATE421503 T1 AT E421503T1 AT 04740010 T AT04740010 T AT 04740010T AT 04740010 T AT04740010 T AT 04740010T AT E421503 T1 ATE421503 T1 AT E421503T1
- Authority
- AT
- Austria
- Prior art keywords
- cycloalkyl
- aryl
- alkyl
- hydroxyalkyl
- heteroaryl
- Prior art date
Links
- 102000004257 Potassium Channel Human genes 0.000 title 1
- 108020001213 potassium channel Proteins 0.000 title 1
- 125000003342 alkenyl group Chemical group 0.000 abstract 4
- 125000000217 alkyl group Chemical group 0.000 abstract 4
- 125000000304 alkynyl group Chemical group 0.000 abstract 4
- 125000003118 aryl group Chemical group 0.000 abstract 4
- 125000000753 cycloalkyl group Chemical group 0.000 abstract 4
- 125000004438 haloalkoxy group Chemical group 0.000 abstract 4
- 125000001188 haloalkyl group Chemical group 0.000 abstract 4
- 125000001072 heteroaryl group Chemical group 0.000 abstract 4
- 125000002768 hydroxyalkyl group Chemical group 0.000 abstract 4
- 229910052736 halogen Inorganic materials 0.000 abstract 3
- 150000002367 halogens Chemical class 0.000 abstract 3
- 125000003545 alkoxy group Chemical group 0.000 abstract 2
- 150000003973 alkyl amines Chemical class 0.000 abstract 2
- 125000004414 alkyl thio group Chemical group 0.000 abstract 2
- 125000004103 aminoalkyl group Chemical group 0.000 abstract 2
- 125000006528 (C2-C6) alkyl group Chemical group 0.000 abstract 1
- 125000002915 carbonyl group Chemical group [*:2]C([*:1])=O 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- -1 hydroxyalkyl-amine Chemical group 0.000 abstract 1
- 229940002612 prodrug Drugs 0.000 abstract 1
- 239000000651 prodrug Substances 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 125000001424 substituent group Chemical group 0.000 abstract 1
- 125000000472 sulfonyl group Chemical group *S(*)(=O)=O 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
- C07D217/02—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines
- C07D217/06—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines with the ring nitrogen atom acylated by carboxylic or carbonic acids, or with sulfur or nitrogen analogues thereof, e.g. carbamates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Pulmonology (AREA)
- Immunology (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Urology & Nephrology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP03013842A EP1489071A1 (de) | 2003-06-18 | 2003-06-18 | N-Substituierten, 3,4-Dihydro-1H-Isochinolin Derivate als Kaliumkanal-Modulatoren |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE421503T1 true ATE421503T1 (de) | 2009-02-15 |
Family
ID=33395821
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT04740010T ATE421503T1 (de) | 2003-06-18 | 2004-06-17 | N-substituierten, 6,8-dialkoxy-1,2,3,4-tetrahydro-1h-isochinolin derivate als kaliumkanal- modulatoren |
Country Status (5)
| Country | Link |
|---|---|
| EP (2) | EP1489071A1 (de) |
| AT (1) | ATE421503T1 (de) |
| CA (1) | CA2524700A1 (de) |
| DE (1) | DE602004019228D1 (de) |
| WO (1) | WO2004113302A1 (de) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20050165004A1 (en) * | 2004-01-22 | 2005-07-28 | Staffan Skogvall | Bronchorelaxing compounds |
| KR100915472B1 (ko) * | 2005-01-26 | 2009-09-03 | 에프. 호프만-라 로슈 아게 | 페닐 메탄온 유도체 및 그의 글라이신 트랜스포터 1억제제로서의 용도 |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH05339240A (ja) * | 1992-06-04 | 1993-12-21 | Yamanouchi Pharmaceut Co Ltd | テトラヒドロイソキノリンアミド誘導体 |
| WO1999007672A1 (en) * | 1997-08-05 | 1999-02-18 | Novo Nordisk A/S | Derivatives of 2,5- and 3,5-disubstituted anilines, their preparation and use |
| WO2000034328A1 (en) * | 1998-12-10 | 2000-06-15 | Peng, Yongde | Tpaaoh04: human g protein sara gene |
| EP1113007A1 (de) * | 1999-12-24 | 2001-07-04 | Pfizer Inc. | Tetrahydroisochinolin-Verbindungen zur Verwendung als Östrogen-Agonisten/-Antagonisten |
| DE10128331A1 (de) * | 2001-06-12 | 2002-12-19 | Aventis Pharma Gmbh | Anthranilsäureamide mit Heteroarylsulfonyl-Seitenkette, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament oder Diagnostikum sowie sie enthaltende pharmazeutische Zubereitungen |
-
2003
- 2003-06-18 EP EP03013842A patent/EP1489071A1/de not_active Withdrawn
-
2004
- 2004-06-17 DE DE602004019228T patent/DE602004019228D1/de not_active Expired - Lifetime
- 2004-06-17 EP EP04740010A patent/EP1663983B1/de not_active Expired - Lifetime
- 2004-06-17 WO PCT/EP2004/006552 patent/WO2004113302A1/en not_active Ceased
- 2004-06-17 CA CA002524700A patent/CA2524700A1/en not_active Abandoned
- 2004-06-17 AT AT04740010T patent/ATE421503T1/de not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| EP1489071A1 (de) | 2004-12-22 |
| EP1663983A1 (de) | 2006-06-07 |
| CA2524700A1 (en) | 2004-12-29 |
| DE602004019228D1 (de) | 2009-03-12 |
| EP1663983B1 (de) | 2009-01-21 |
| WO2004113302A1 (en) | 2004-12-29 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |