ATE41309T1 - Hepatitis-b-vakzin und verfahren zur herstellung. - Google Patents
Hepatitis-b-vakzin und verfahren zur herstellung.Info
- Publication number
- ATE41309T1 ATE41309T1 AT84107773T AT84107773T ATE41309T1 AT E41309 T1 ATE41309 T1 AT E41309T1 AT 84107773 T AT84107773 T AT 84107773T AT 84107773 T AT84107773 T AT 84107773T AT E41309 T1 ATE41309 T1 AT E41309T1
- Authority
- AT
- Austria
- Prior art keywords
- hepatitis
- vaccine
- inactivated
- stabilizer
- manufacture
- Prior art date
Links
- SPSXSWRZQFPVTJ-ZQQKUFEYSA-N hepatitis b vaccine Chemical compound C([C@H](NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](CO)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC=1C2=CC=CC=C2NC=1)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](N)CCSC)C(=O)N[C@@H](CC1N=CN=C1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(O)=O)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](C(C)C)C(=O)OC(=O)CNC(=O)CNC(=O)[C@H](C)NC(=O)[C@H]1N(CCC1)C(=O)[C@H](CC=1C=CC=CC=1)NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@@H](N)CCCNC(N)=N)C1=CC=CC=C1 SPSXSWRZQFPVTJ-ZQQKUFEYSA-N 0.000 title abstract 2
- 229940124736 hepatitis-B vaccine Drugs 0.000 title abstract 2
- 238000004519 manufacturing process Methods 0.000 title 1
- 238000000034 method Methods 0.000 title 1
- 239000000427 antigen Substances 0.000 abstract 3
- 102000036639 antigens Human genes 0.000 abstract 3
- 108091007433 antigens Proteins 0.000 abstract 3
- 241000700721 Hepatitis B virus Species 0.000 abstract 2
- XAGFODPZIPBFFR-UHFFFAOYSA-N aluminium Chemical compound [Al] XAGFODPZIPBFFR-UHFFFAOYSA-N 0.000 abstract 2
- 229910052782 aluminium Inorganic materials 0.000 abstract 2
- 239000004411 aluminium Substances 0.000 abstract 2
- 239000003381 stabilizer Substances 0.000 abstract 2
- 208000002672 hepatitis B Diseases 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 238000011321 prophylaxis Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/12—Viral antigens
- A61K39/29—Hepatitis virus
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2730/00—Reverse transcribing DNA viruses
- C12N2730/00011—Details
- C12N2730/10011—Hepadnaviridae
- C12N2730/10111—Orthohepadnavirus, e.g. hepatitis B virus
- C12N2730/10122—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Virology (AREA)
- General Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- Biophysics (AREA)
- Mycology (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Gastroenterology & Hepatology (AREA)
- Communicable Diseases (AREA)
- Immunology (AREA)
- Microbiology (AREA)
- Genetics & Genomics (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP58122945A JPS6013718A (ja) | 1983-07-05 | 1983-07-05 | B型肝炎ワクチン |
EP84107773A EP0130619B1 (de) | 1983-07-05 | 1984-07-04 | Hepatitis-B-Vakzin und Verfahren zur Herstellung |
Publications (1)
Publication Number | Publication Date |
---|---|
ATE41309T1 true ATE41309T1 (de) | 1989-04-15 |
Family
ID=14848502
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AT84107773T ATE41309T1 (de) | 1983-07-05 | 1984-07-04 | Hepatitis-b-vakzin und verfahren zur herstellung. |
Country Status (7)
Country | Link |
---|---|
EP (1) | EP0130619B1 (de) |
JP (1) | JPS6013718A (de) |
KR (1) | KR910005888B1 (de) |
AT (1) | ATE41309T1 (de) |
AU (1) | AU572162B2 (de) |
CA (1) | CA1237076A (de) |
DE (1) | DE3477139D1 (de) |
Families Citing this family (24)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS60193925A (ja) * | 1984-03-13 | 1985-10-02 | Chemo Sero Therapeut Res Inst | 凍結乾燥製剤化ワクチン |
EP0294071A3 (de) * | 1987-06-03 | 1990-08-01 | Merck & Co. Inc. | Impfstoffe gegen Hepatitis B hergestellt mit vorherhergestellten Aluminiumhydroxydengelen und Verfahren zu deren Herstellung |
ES2118963T3 (es) * | 1992-05-23 | 1998-10-01 | Smithkline Beecham Biolog | Vacunas combinadas, que contienen antigeno de superficie de la hepatitis b y otros antigenos. |
AU4932493A (en) * | 1992-09-25 | 1994-04-26 | Dynagen, Inc. | An immunobooster for delayed release of immunogen |
US6290967B1 (en) * | 1996-12-20 | 2001-09-18 | Merck & Co., Inc. | Stabilizers for lyophilized vaccines |
US6051238A (en) * | 1996-12-20 | 2000-04-18 | Merck & Co., Inc. | Stabilizers for lyophilized mumps vaccines |
IL153241A0 (en) * | 2000-06-08 | 2003-07-06 | Powderject Vaccines Inc | Powder compositions |
UA79735C2 (uk) | 2000-08-10 | 2007-07-25 | Глаксосмітклайн Байолоджікалз С.А. | Очищення антигенів вірусу гепатиту b (hbv) для використання у вакцинах |
AU2002302814A1 (en) | 2001-06-08 | 2002-12-23 | Powderject Vaccines, Inc. | Spray freeze-dried compositions |
KR20030025480A (ko) * | 2001-09-21 | 2003-03-29 | 보령제약 주식회사 | 약독화 수두 생바이러스 백신용 무단백질 안정화제 |
US20060228369A1 (en) * | 2005-04-11 | 2006-10-12 | Program For Appropriate Technology In Health | Stabilization and preservation of temperature-sensitive vaccines |
AU2006299310A1 (en) | 2005-10-04 | 2007-04-12 | Alk-Abello A/S | Solid vaccine formulation |
EP2086581B1 (de) | 2006-11-07 | 2014-08-13 | Sanofi Pasteur Biologics, LLC | Impfstoffstabilisierung mittels lyophilisierung |
TW201043267A (en) * | 2009-03-19 | 2010-12-16 | Intervet Int Bv | In situ constituting a vaccine for administration to a predetermined herd of animals |
JP6023696B2 (ja) * | 2010-03-31 | 2016-11-09 | スタビリテック リミテッド | ミョウバンアジュバントおよびミョウバンアジュバント化ワクチンの保存方法 |
HUE026885T2 (en) | 2010-03-31 | 2016-08-29 | Stabilitech Ltd | Stabilize virus fragments |
BR112012025047A2 (pt) | 2010-03-31 | 2016-06-21 | Stabilitech Ltd | formulações líquidas estabilizadas |
RU2610174C2 (ru) | 2011-06-24 | 2017-02-08 | Мерк Шарп И Доум Корп. | Вакцинные составы против вируса папилломы человека (hpv), содержащие алюминиевый адъювант, и способы их получения |
WO2013012022A1 (ja) | 2011-07-19 | 2013-01-24 | 中外製薬株式会社 | アルギニンアミドまたはその類似化合物を含む安定なタンパク質含有製剤 |
GB201117233D0 (en) | 2011-10-05 | 2011-11-16 | Stabilitech Ltd | Stabilisation of polypeptides |
JP5931449B2 (ja) * | 2012-01-11 | 2016-06-08 | 日東電工株式会社 | 医薬組成物及びその製造方法 |
GB201406569D0 (en) | 2014-04-11 | 2014-05-28 | Stabilitech Ltd | Vaccine compositions |
JP6606600B2 (ja) | 2016-04-15 | 2019-11-13 | 富士フイルム株式会社 | マイクロニードルアレイ |
GB2562241B (en) | 2017-05-08 | 2022-04-06 | Stabilitech Biopharma Ltd | Vaccine compositions |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US2879202A (en) * | 1954-11-05 | 1959-03-24 | American Cyanamid Co | Stabilization of live viral vaccines by hexahydric alcohols |
DE1617457A1 (de) * | 1966-12-16 | 1972-04-20 | Erba Carlo Spa | Verfahren zur Stabilisierung von Zubereitungen interferierender Virusprodukte |
DE1617350C3 (de) * | 1967-06-22 | 1979-09-06 | Behringwerke Ag, 3550 Marburg | Verfahren zur Inaktivierung von biologischem Material |
US3636191A (en) * | 1969-10-08 | 1972-01-18 | Cancer Res Inst | Vaccine against viral hepatitis and process |
JPS5523253B2 (de) * | 1973-12-28 | 1980-06-21 |
-
1983
- 1983-07-05 JP JP58122945A patent/JPS6013718A/ja active Granted
-
1984
- 1984-06-28 AU AU29993/84A patent/AU572162B2/en not_active Ceased
- 1984-07-02 KR KR1019840003814A patent/KR910005888B1/ko not_active IP Right Cessation
- 1984-07-04 AT AT84107773T patent/ATE41309T1/de not_active IP Right Cessation
- 1984-07-04 EP EP84107773A patent/EP0130619B1/de not_active Expired
- 1984-07-04 DE DE8484107773T patent/DE3477139D1/de not_active Expired
- 1984-07-05 CA CA000458226A patent/CA1237076A/en not_active Expired
Also Published As
Publication number | Publication date |
---|---|
CA1237076A (en) | 1988-05-24 |
JPH0437806B2 (de) | 1992-06-22 |
JPS6013718A (ja) | 1985-01-24 |
KR910005888B1 (ko) | 1991-08-06 |
EP0130619A2 (de) | 1985-01-09 |
KR850002277A (ko) | 1985-05-10 |
EP0130619A3 (en) | 1985-04-10 |
EP0130619B1 (de) | 1989-03-15 |
DE3477139D1 (en) | 1989-04-20 |
AU572162B2 (en) | 1988-05-05 |
AU2999384A (en) | 1985-01-10 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
ATE41309T1 (de) | Hepatitis-b-vakzin und verfahren zur herstellung. | |
ATE74012T1 (de) | Lyophilisierte hepatitis-b-vakzine. | |
EP0339667A3 (en) | Hepatitis a,b,-combined adjuvanted vaccine | |
PT88178A (pt) | Metodo para a purificacao de virus da hepatite a | |
ATE42679T1 (de) | Verfahren zur isolierung und reinigung des hepatitis-b-oberflaechen-antigens. | |
BRPI0113155B8 (pt) | métodos para produção de uma vacina para hepatite b e de um antígeno de superfície para hepatite b | |
DE3775321D1 (de) | Verfahren zur kultur des virus der rhinotracheitis des truthahnes und daraus hergestelltes vakzin. | |
ATE49707T1 (de) | Rabies-vakzine und verfahren zur herstellung. | |
HUP9801223A2 (hu) | Eljárás specifikus antigénekre adott antitest válasz fokozására interleukin-10-zel | |
HUT65367A (en) | Method for the preparation of chicken anaemia agent vaccine | |
DE69030099D1 (de) | Verfahren zur herstellung von impfstoffen oder toxoiden | |
AU2403188A (en) | Infectious bovine rhinotracheitis virus mutants, vaccines containing same, methods for the production of same and methods for the use of same | |
ATA292889A (de) | Verfahren zur herstellung von fsme-virus-antigen | |
NZ228232A (en) | Live combined vaccine comprising at least one live infectious bronchitis virus and at least one other virus infectious to poultry | |
DE3787121D1 (de) | Verfahren zur Herstellung und Verwendung von Katzenleukämievirus-Antigenen. | |
AT385203B (de) | Verfahren zur herstellung einer fruehsommermeningoenzephalitis-virus (fsme-virus)-vakzine | |
PT82983B (pt) | Processo para a preparacao de vacinas contra bronquite infecciosa de pintos de um dia | |
DE3781049D1 (de) | Verfahren zur herstellung von hepatitis-b-virus-innenkoerperantigen (hbcag) in hefe. | |
ATE111954T1 (de) | Verfahren zur transformation von menschlichen b- lymphocyten. | |
TH2141EX (th) | วัคซีนสำหรับตับอักเสบชนิด b | |
AU457758B2 (en) | Infectious bovine rhinotracheitis virus vaccine and method of preparing and using thesame | |
CA960586A (en) | Infectious bovine rhinotracheitis virus vaccine and method of preparing and using the same | |
ATE38152T1 (de) | Verfahren zur reinigung des hepatitis-b-virusoberfl|chenantigens. | |
AU3626071A (en) | Infectious bovine rhinotracheitis virus vaccine and method of preparing and using thesame | |
TH3859EX (th) | เฮพาไททีส บี วัคซีนแห้งโดยการแช่แข็งภายใต้การลด ความดัน (กรรมวิธี) |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
UEP | Publication of translation of european patent specification | ||
REN | Ceased due to non-payment of the annual fee |