ATE407140T1 - Verfahren zur herstellung von cyclosporin- derivaten - Google Patents
Verfahren zur herstellung von cyclosporin- derivatenInfo
- Publication number
- ATE407140T1 ATE407140T1 AT99957167T AT99957167T ATE407140T1 AT E407140 T1 ATE407140 T1 AT E407140T1 AT 99957167 T AT99957167 T AT 99957167T AT 99957167 T AT99957167 T AT 99957167T AT E407140 T1 ATE407140 T1 AT E407140T1
- Authority
- AT
- Austria
- Prior art keywords
- cyclosporin
- preparing
- optionally
- cyclosporine derivatives
- derivatives
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/64—Cyclic peptides containing only normal peptide links
- C07K7/645—Cyclosporins; Related peptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
- A61P33/06—Antimalarials
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A61P33/10—Anthelmintics
- A61P33/12—Schistosomicides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR9807846A FR2780061B1 (fr) | 1998-06-22 | 1998-06-22 | Nouveau procede de preparation de derives de cyclosporine |
Publications (1)
Publication Number | Publication Date |
---|---|
ATE407140T1 true ATE407140T1 (de) | 2008-09-15 |
Family
ID=9527672
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AT99957167T ATE407140T1 (de) | 1998-06-22 | 1999-06-21 | Verfahren zur herstellung von cyclosporin- derivaten |
Country Status (8)
Country | Link |
---|---|
US (3) | US7226905B2 (de) |
EP (1) | EP1098903B1 (de) |
JP (1) | JP4224213B2 (de) |
AT (1) | ATE407140T1 (de) |
AU (1) | AU4270099A (de) |
DE (1) | DE69939470D1 (de) |
FR (1) | FR2780061B1 (de) |
WO (1) | WO1999067280A1 (de) |
Families Citing this family (23)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
IL143604A0 (en) | 1998-12-30 | 2002-04-21 | Dexcel Ltd | Dispersable concentrate for the delivery of cyclosporin |
US7732404B2 (en) | 1999-12-30 | 2010-06-08 | Dexcel Ltd | Pro-nanodispersion for the delivery of cyclosporin |
KR100465012B1 (ko) * | 2001-05-11 | 2005-01-13 | 주식회사 엘지생활건강 | 모발 성장 효과를 갖는 사이클로스포린 3 위치 유도체를유효성분으로 하는 모발 성장 촉진제 |
IL150600A (en) * | 2001-07-19 | 2005-09-25 | Akzo Nobel Nv | Process for the preparation of compounds containing one or more amide bonds using an excess of an activated carboxylic component and scavenging the residual activated carboxylic component |
TWI247012B (en) * | 2001-07-19 | 2006-01-11 | Akzo Nobel Nv | Process for rapid solution synthesis of peptides |
KR20040039622A (ko) * | 2002-11-04 | 2004-05-12 | 주식회사 엘지생활건강 | 모발 성장 효과를 갖는 사이클로스포린 3 위치 유도체를유효성분으로 하는 모발 성장 촉진제 |
US6987090B2 (en) * | 2002-05-09 | 2006-01-17 | Lg Household & Health Care Ltd. | Use of 3-position cyclosporin derivatives for hair growth |
KR20070009674A (ko) * | 2004-04-08 | 2007-01-18 | 노파르티스 아게 | 대뇌 허혈 및 뇌와 척수 상해에서의 nim811 |
RU2399628C2 (ru) * | 2004-10-01 | 2010-09-20 | Скайнексис, Инк. | Производные циклоспорина, замещенные 3-эфиром и 3-тиоэфиром, для лечения и профилактики инфекционного гепатита с |
US7196161B2 (en) | 2004-10-01 | 2007-03-27 | Scynexis Inc. | 3-ether and 3-thioether substituted cyclosporin derivatives for the treatment and prevention of hepatitis C infection |
EP1933859A2 (de) | 2005-09-30 | 2008-06-25 | Scynexis, Inc. | Verfahren und pharmazeutische zusammensetzungen zur behandlung und prävention von hepatitis-c-infektionen |
WO2007041631A1 (en) | 2005-09-30 | 2007-04-12 | Scynexis, Inc. | ARYIiALKYL AND HETEROARYLALKYL DERIVATIVES OF CYCLOSPORINE A FOR THE TREATMENT AND PREVENTION OF VIRAL INFECTION |
CN101511357B (zh) | 2006-05-19 | 2011-11-02 | 西尼克斯公司 | 环孢菌素类化合物及其组合物在制备治疗和预防眼部疾病的药物中的应用 |
EP2027761A1 (de) * | 2006-06-02 | 2009-02-25 | Claude Annie Perrichon | Verwaltung von aktieven elektronen |
WO2008069917A2 (en) | 2006-11-20 | 2008-06-12 | Scynexis, Inc. | Novel cyclic peptides |
WO2010002428A2 (en) * | 2008-06-06 | 2010-01-07 | Scynexis, Inc. | Novel macrocyclic peptides |
CN102307892A (zh) | 2008-12-31 | 2012-01-04 | 西尼克斯公司 | 环孢菌素a的衍生物 |
JP2012528163A (ja) * | 2009-05-27 | 2012-11-12 | アラーガン、インコーポレイテッド | 炎症性疾患および状態を処置するためのシクロスポリン誘導体 |
CN102834409A (zh) | 2009-12-30 | 2012-12-19 | 西尼克斯公司 | 环孢菌素类似物 |
MX353720B (es) | 2010-12-15 | 2018-01-25 | Contravir Pharmaceuticals Inc | Moleculas analogas de ciclosporina modificadas en el aminoacido 1 y 3. |
JP2015532277A (ja) | 2012-09-29 | 2015-11-09 | ノバルティス アーゲー | 環状ペプチドおよび医薬としてのその使用 |
US10227877B2 (en) | 2016-08-18 | 2019-03-12 | General Electric Company | Cooling circuit for a multi-wall blade |
WO2020037530A1 (en) * | 2018-08-22 | 2020-02-27 | Waterstone Pharmaceuticals (Wuhan) Co., Ltd. | Crystalline form of compound and uses thereof in medicine |
Family Cites Families (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0194972B1 (de) | 1985-03-11 | 1992-07-29 | Sandoz Ag | Cyclosporine |
JPH0267244A (ja) * | 1988-09-01 | 1990-03-07 | Wako Pure Chem Ind Ltd | β−ヒドロキシ脂肪酸の製法 |
US4937355A (en) | 1989-01-17 | 1990-06-26 | E. R. Squibb & Sons, Inc. | Process for preparing (trans)-4-substituted-dl-proline derivatives |
EP0484281B2 (de) * | 1990-11-02 | 2000-11-22 | Novartis AG | Zyklosporine |
JPH0793927B2 (ja) * | 1990-11-02 | 1995-10-11 | 富士通株式会社 | 超音波カラードプラ診断装置 |
US5559256A (en) * | 1992-07-20 | 1996-09-24 | E. R. Squibb & Sons, Inc. | Aminediol protease inhibitors |
FR2757521B1 (fr) * | 1996-12-24 | 1999-01-29 | Rhone Poulenc Rorer Sa | Nouveaux derives de cyclosporine, leur preparation et les compositions pharmaceutiques qui les contiennent |
FR2772768B1 (fr) * | 1997-12-19 | 2000-01-14 | Rhone Poulenc Rorer Sa | Nouveau procede de preparation de derives de cyclosporine |
-
1998
- 1998-06-22 FR FR9807846A patent/FR2780061B1/fr not_active Expired - Fee Related
-
1999
- 1999-06-21 AU AU42700/99A patent/AU4270099A/en not_active Abandoned
- 1999-06-21 WO PCT/FR1999/001480 patent/WO1999067280A1/fr active IP Right Grant
- 1999-06-21 AT AT99957167T patent/ATE407140T1/de not_active IP Right Cessation
- 1999-06-21 DE DE69939470T patent/DE69939470D1/de not_active Expired - Lifetime
- 1999-06-21 JP JP2000555931A patent/JP4224213B2/ja not_active Expired - Fee Related
- 1999-06-21 EP EP99957167A patent/EP1098903B1/de not_active Expired - Lifetime
-
2000
- 2000-12-22 US US09/742,008 patent/US7226905B2/en not_active Expired - Fee Related
-
2007
- 2007-05-09 US US11/797,992 patent/US7678766B2/en not_active Expired - Fee Related
-
2010
- 2010-01-12 US US12/685,965 patent/US20100173838A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
EP1098903A1 (de) | 2001-05-16 |
US7226905B2 (en) | 2007-06-05 |
JP2002518519A (ja) | 2002-06-25 |
US20010025025A1 (en) | 2001-09-27 |
US20100173838A1 (en) | 2010-07-08 |
JP4224213B2 (ja) | 2009-02-12 |
DE69939470D1 (de) | 2008-10-16 |
US7678766B2 (en) | 2010-03-16 |
US20070213260A1 (en) | 2007-09-13 |
EP1098903B1 (de) | 2008-09-03 |
AU4270099A (en) | 2000-01-10 |
FR2780061A1 (fr) | 1999-12-24 |
WO1999067280A1 (fr) | 1999-12-29 |
FR2780061B1 (fr) | 2001-09-07 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |