ATE406947T1 - Modul und verfahren zur einführung einer probe in eine chromatographische kolonne - Google Patents

Modul und verfahren zur einführung einer probe in eine chromatographische kolonne

Info

Publication number
ATE406947T1
ATE406947T1 AT99934054T AT99934054T ATE406947T1 AT E406947 T1 ATE406947 T1 AT E406947T1 AT 99934054 T AT99934054 T AT 99934054T AT 99934054 T AT99934054 T AT 99934054T AT E406947 T1 ATE406947 T1 AT E406947T1
Authority
AT
Austria
Prior art keywords
sample
module
introducing
chromatographic column
chromatography
Prior art date
Application number
AT99934054T
Other languages
German (de)
English (en)
Inventor
Ivan Hargro
Jeffrey Horsman
Peter Rahn
Peter Vandavelaar
Original Assignee
Biotage Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=22476620&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ATE406947(T1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Biotage Ab filed Critical Biotage Ab
Application granted granted Critical
Publication of ATE406947T1 publication Critical patent/ATE406947T1/de

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/60—Construction of the column
    • G01N30/6004—Construction of the column end pieces
    • G01N30/6026—Fluid seals
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
    • B01D15/08—Selective adsorption, e.g. chromatography
    • B01D15/10—Selective adsorption, e.g. chromatography characterised by constructional or operational features
    • B01D15/14—Selective adsorption, e.g. chromatography characterised by constructional or operational features relating to the introduction of the feed to the apparatus
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/60—Construction of the column
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/60—Construction of the column
    • G01N30/6004—Construction of the column end pieces
    • G01N30/6017—Fluid distributors
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/60—Construction of the column
    • G01N30/6091—Cartridges
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/04—Preparation or injection of sample to be analysed
    • G01N30/06—Preparation
    • G01N30/08—Preparation using an enricher
    • G01N2030/085—Preparation using an enricher using absorbing precolumn
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/04—Preparation or injection of sample to be analysed
    • G01N30/16—Injection
    • G01N2030/167—Injection on-column injection
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/50—Conditioning of the sorbent material or stationary liquid
    • G01N30/52—Physical parameters
    • G01N2030/522—Physical parameters pressure
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/60—Construction of the column
    • G01N30/6004—Construction of the column end pieces
    • G01N30/6021—Adjustable pistons
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/60—Construction of the column
    • G01N30/6052—Construction of the column body
    • G01N30/6069—Construction of the column body with compartments or bed substructure

Landscapes

  • Chemical & Material Sciences (AREA)
  • Analytical Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Physics & Mathematics (AREA)
  • General Physics & Mathematics (AREA)
  • Immunology (AREA)
  • Pathology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Treatment Of Liquids With Adsorbents In General (AREA)
  • Sampling And Sample Adjustment (AREA)
AT99934054T 1998-08-20 1999-07-14 Modul und verfahren zur einführung einer probe in eine chromatographische kolonne ATE406947T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US09/137,278 US6139733A (en) 1998-08-20 1998-08-20 Module and method for introducing a sample into a chromatography column

Publications (1)

Publication Number Publication Date
ATE406947T1 true ATE406947T1 (de) 2008-09-15

Family

ID=22476620

Family Applications (1)

Application Number Title Priority Date Filing Date
AT99934054T ATE406947T1 (de) 1998-08-20 1999-07-14 Modul und verfahren zur einführung einer probe in eine chromatographische kolonne

Country Status (8)

Country Link
US (3) US6139733A (enExample)
EP (1) EP1113849B1 (enExample)
JP (1) JP4328898B2 (enExample)
AT (1) ATE406947T1 (enExample)
AU (1) AU4997399A (enExample)
DE (1) DE69939479D1 (enExample)
ES (1) ES2313788T3 (enExample)
WO (1) WO2000010676A1 (enExample)

Families Citing this family (42)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6436284B1 (en) * 1997-11-12 2002-08-20 Biotage, Inc. Chromatography apparatus
US20030217973A1 (en) * 1998-08-20 2003-11-27 Horsman Jeffrey A. Method for introducing a sample into a chromatography column
US6679989B2 (en) * 2001-06-01 2004-01-20 Agilent Technologies, Inc. Integral, thru-bore, direct coupled high pressure liquid chromatography guard column
US6880576B2 (en) 2001-06-07 2005-04-19 Nanostream, Inc. Microfluidic devices for methods development
US20020187557A1 (en) * 2001-06-07 2002-12-12 Hobbs Steven E. Systems and methods for introducing samples into microfluidic devices
US7261812B1 (en) 2002-02-13 2007-08-28 Nanostream, Inc. Multi-column separation devices and methods
AU2003213071A1 (en) * 2002-02-13 2003-09-04 Nanostream, Inc. Microfluidic separation column devices and fabrication methods
US6649051B1 (en) 2002-05-01 2003-11-18 Biotage, Inc. Processing of chemicals in flow-through device with porous media
US20030205456A1 (en) * 2002-05-01 2003-11-06 Jamalabadi Shahnaz Ghassemi Processing of chemicals in flow-through device with porous media
KR100505361B1 (ko) * 2002-06-03 2005-08-03 정원조 소결 무기 분말 프릿이 장착된 금속 튜빙/프릿 및 이를이용하여 제작하는 크로마토그래피 컬럼
US20040142488A1 (en) * 2002-07-15 2004-07-22 Gierde Douglas T. Method and device for extracting an analyte
EP1521637B1 (en) * 2002-07-15 2011-10-19 Phynexus, Inc. Extraction column device
US6783673B2 (en) * 2002-08-23 2004-08-31 Biotage, Inc. Composite chromatography column
JP4909513B2 (ja) 2002-09-10 2012-04-04 ウオーターズ・テクノロジーズ・コーポレイシヨン クロマトグラフカラムおよび吸収剤密度を制御するための方法
US6936167B2 (en) * 2002-10-31 2005-08-30 Nanostream, Inc. System and method for performing multiple parallel chromatographic separations
AU2003298894A1 (en) * 2002-11-26 2004-06-18 Prime Separations, Incorporated Chromatographic separation processes and apparatus
WO2004058379A1 (en) * 2002-12-17 2004-07-15 Biotage,Inc. Processing of chemicals in flow-through device porous media
JP4791352B2 (ja) * 2003-02-07 2011-10-12 ウオーターズ・テクノロジーズ・コーポレイシヨン クロマトグラフィーナノカラム用ポリマー固体支持体
DE112004000244T5 (de) * 2003-02-10 2006-02-09 Waters Investments Ltd., New Castle Siloxan-immobilisierte partikuläre stationäre Phasen für chromatographische Auftrennungen und Extraktionen
WO2005007264A2 (en) * 2003-07-14 2005-01-27 Waters Investments Limited Separation device with integral guard column
US7943393B2 (en) * 2003-07-14 2011-05-17 Phynexus, Inc. Method and device for extracting an analyte
US20050011821A1 (en) * 2003-07-17 2005-01-20 Sigma-Aldrich Co. High throughput flash purification stand and cartridge
US20050011835A1 (en) * 2003-07-17 2005-01-20 Sigma-Aldrich Co. High throughput flash purification stand and cartridge
US20050211617A1 (en) * 2003-07-17 2005-09-29 Sigma-Aldrich Co. High throughput flash purification stand and cartridge
US20050032238A1 (en) * 2003-08-07 2005-02-10 Nanostream, Inc. Vented microfluidic separation devices and methods
US7028536B2 (en) * 2004-06-29 2006-04-18 Nanostream, Inc. Sealing interface for microfluidic device
US7404893B2 (en) * 2003-10-17 2008-07-29 Varian, Inc. Chromatography cartridge and method for manufacturing a chromatography cartridge
US7351332B2 (en) * 2003-10-17 2008-04-01 Varian, Inc. Chromatography cartridge and method for manufacturing a chromatography cartridge
US7686959B2 (en) 2004-05-05 2010-03-30 Biotage Ab Control system and method for flash separation
US20050247625A1 (en) * 2004-05-05 2005-11-10 Jianbo Liu Determining conditions for chromatography
US7138061B2 (en) * 2004-05-10 2006-11-21 Scientific Plastic Products, Inc. Flash chromatography cartridge
GB2467031B8 (en) * 2004-08-19 2010-12-22 Waters Investments Ltd Analytical column for use in hplc separations.
US7348526B2 (en) * 2004-08-20 2008-03-25 Cem Corporation Microwave-assisted chromatography preparation
US7674383B2 (en) * 2005-10-25 2010-03-09 Phenomenex, Inc. Method and apparatus for packing chromatography columns
US7670487B2 (en) * 2006-07-21 2010-03-02 Wikfors Edwin E De-pressurization scheme for chromatography columns
CN103630639A (zh) 2007-12-05 2014-03-12 全技术联合公司 用于分析样本和收集样本流份的方法和装置
CN102307665A (zh) 2008-12-04 2012-01-04 全技术联合公司 用于移动等分流体试样的方法和设备
JP2012511725A (ja) 2008-12-10 2012-05-24 オールテック・アソシエイツ・インコーポレーテッド クロマトグラフィーシステムおよびシステム部品
EP2204225A1 (en) * 2008-12-22 2010-07-07 SynChro GmbH Column reactor
US8305582B2 (en) 2009-09-01 2012-11-06 Alltech Associates, Inc. Methods and apparatus for analyzing samples and collecting sample fractions
WO2012074452A1 (en) * 2010-11-30 2012-06-07 Biotage Ab Chromatography column assembly comprising a sealing device
JP5879592B2 (ja) * 2011-12-26 2016-03-08 東京理化器械株式会社 カラム

Family Cites Families (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2008354A1 (de) * 1970-02-23 1971-09-09 Boehnnger Mannheim GmbH, 6800 Mann heim Kombinationssaule
US3266554A (en) * 1963-11-29 1966-08-16 Possis Machine Corp Apparatus for preparing specimens for chromatographic analysis
US3398512A (en) * 1966-04-18 1968-08-27 Continental Oil Co Chromatography apparatus
CH500486A (de) * 1967-10-09 1970-12-15 Ceskoslovenska Akademie Ved Vorrichtung zur Aufrechterhaltung der Konzentrationsgradienten gelöster Stoffe in einem Flüssigkeitsstrom
US3682315A (en) * 1969-10-20 1972-08-08 Wolfgang Haller Cartridge type column for treatment of liquid streams and substrate enclosure therefor
US3692669A (en) * 1970-08-10 1972-09-19 California Inst Of Techn Method and apparatus for micro dry column chromatography
US3902849A (en) * 1971-08-19 1975-09-02 Medi Physics Inc Radioisotope and radiopharmaceutical generators
US4093550A (en) * 1975-06-04 1978-06-06 Riedel-De Haen Aktiengesellschaft Column for high pressure liquid chromatography
US4250035A (en) * 1978-11-13 1981-02-10 Waters Associates, Inc. Radial compression of packed beds
US4565532A (en) 1981-02-18 1986-01-21 Kaama Marine Engineering, Inc. Stern drive
EP0068343B1 (de) * 1981-06-19 1986-10-01 Ceskoslovenska akademie ved Säule für Flüssigchromatographie
US4457846A (en) * 1982-07-08 1984-07-03 Milton Roy Company Liquid chromatography methods and devices
US4483374A (en) * 1982-11-01 1984-11-20 Ethyl Corporation Chromatographic column
DE3436095A1 (de) * 1984-10-02 1986-04-10 Merck Patent Gmbh, 6100 Darmstadt Chromatographiesaeule
US4636316A (en) * 1985-01-11 1987-01-13 Beckman Instruments, Inc. Disposable column cartridge
US4565632A (en) * 1985-01-11 1986-01-21 Beckman Instruments, Inc. Chromatographic cartridge column system
US4719011A (en) * 1985-03-22 1988-01-12 H. T. Chemicals, Inc. High pressure liquid chromatography columns
US4876005A (en) * 1988-02-12 1989-10-24 The Perkin-Elmer Corporation High pressure column assembly for a liquid chromatograph system
US5227059A (en) * 1989-11-08 1993-07-13 Alltech Associates, Inc. Chromatography columns
US5614089A (en) * 1990-07-13 1997-03-25 Isco, Inc. Apparatus and method for supercritical fluid extraction or supercritical fluid chromatography
US5234599A (en) * 1990-10-09 1993-08-10 The Dow Chemical Company On-line multidimensional chromatographic system with large volume injection handling for supercritical fluid chromatography
EP0545843B1 (en) * 1991-12-03 1995-08-16 Tracer Analitica S.L. Fixing arrangement for chromatography columns
US5338448A (en) * 1992-10-16 1994-08-16 Sarasep, Inc. Method of preventing contamination of a chromatography column
WO1995027547A1 (en) * 1994-04-07 1995-10-19 Biotage, Inc. Apparatus for pressurizing a removable chromatography cartridge
US5462660A (en) * 1994-04-22 1995-10-31 The United States Of America As Represented By The Secretary Of Agriculture High performance liquid chromatography injection system for the simultaneous concentration and analysis of trace components

Also Published As

Publication number Publication date
DE69939479D1 (de) 2008-10-16
JP2002523728A (ja) 2002-07-30
AU4997399A (en) 2000-03-14
EP1113849A1 (en) 2001-07-11
WO2000010676A1 (en) 2000-03-02
US6139733A (en) 2000-10-31
ES2313788T3 (es) 2009-03-01
EP1113849B1 (en) 2008-09-03
JP4328898B2 (ja) 2009-09-09
EP1113849A4 (en) 2001-10-17
US6294087B1 (en) 2001-09-25
US6221252B1 (en) 2001-04-24

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