ATE405154T1 - Verfahren zur erschaffung transgener nicht- menschlicher tiere - Google Patents
Verfahren zur erschaffung transgener nicht- menschlicher tiereInfo
- Publication number
- ATE405154T1 ATE405154T1 AT98910494T AT98910494T ATE405154T1 AT E405154 T1 ATE405154 T1 AT E405154T1 AT 98910494 T AT98910494 T AT 98910494T AT 98910494 T AT98910494 T AT 98910494T AT E405154 T1 ATE405154 T1 AT E405154T1
- Authority
- AT
- Austria
- Prior art keywords
- present
- transgenic non
- animals
- human animals
- creation
- Prior art date
Links
- 241001465754 Metazoa Species 0.000 title abstract 3
- 238000000034 method Methods 0.000 title abstract 3
- 230000009261 transgenic effect Effects 0.000 title abstract 3
- 210000000287 oocyte Anatomy 0.000 abstract 2
- 108700019146 Transgenes Proteins 0.000 abstract 1
- 235000013601 eggs Nutrition 0.000 abstract 1
- 230000004720 fertilization Effects 0.000 abstract 1
- 208000015181 infectious disease Diseases 0.000 abstract 1
- 230000002458 infectious effect Effects 0.000 abstract 1
- 230000035800 maturation Effects 0.000 abstract 1
- 238000000520 microinjection Methods 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 150000007523 nucleic acids Chemical group 0.000 abstract 1
- 210000004681 ovum Anatomy 0.000 abstract 1
- 241001430294 unidentified retrovirus Species 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K67/00—Rearing or breeding animals, not otherwise provided for; New or modified breeds of animals
- A01K67/027—New or modified breeds of vertebrates
- A01K67/0275—Genetically modified vertebrates, e.g. transgenic
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
- C12N15/8509—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells for producing genetically modified animals, e.g. transgenic
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
- C12N15/86—Viral vectors
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2217/00—Genetically modified animals
- A01K2217/05—Animals comprising random inserted nucleic acids (transgenic)
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2227/00—Animals characterised by species
- A01K2227/10—Mammal
- A01K2227/101—Bovine
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2267/00—Animals characterised by purpose
- A01K2267/01—Animal expressing industrially exogenous proteins
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2267/00—Animals characterised by purpose
- A01K2267/02—Animal zootechnically ameliorated
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2730/00—Reverse transcribing DNA viruses
- C12N2730/00011—Details
- C12N2730/10011—Hepadnaviridae
- C12N2730/10111—Orthohepadnavirus, e.g. hepatitis B virus
- C12N2730/10122—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2740/00—Reverse transcribing RNA viruses
- C12N2740/00011—Details
- C12N2740/10011—Retroviridae
- C12N2740/13011—Gammaretrovirus, e.g. murine leukeamia virus
- C12N2740/13041—Use of virus, viral particle or viral elements as a vector
- C12N2740/13043—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2740/00—Reverse transcribing RNA viruses
- C12N2740/00011—Details
- C12N2740/10011—Retroviridae
- C12N2740/13011—Gammaretrovirus, e.g. murine leukeamia virus
- C12N2740/13051—Methods of production or purification of viral material
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Engineering & Computer Science (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Biotechnology (AREA)
- Zoology (AREA)
- Biomedical Technology (AREA)
- General Engineering & Computer Science (AREA)
- Wood Science & Technology (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biophysics (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Microbiology (AREA)
- Plant Pathology (AREA)
- Physics & Mathematics (AREA)
- Veterinary Medicine (AREA)
- Virology (AREA)
- Environmental Sciences (AREA)
- Medicinal Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Animal Behavior & Ethology (AREA)
- Animal Husbandry (AREA)
- Biodiversity & Conservation Biology (AREA)
- Gastroenterology & Hepatology (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US08/821,984 US6080912A (en) | 1997-03-20 | 1997-03-20 | Methods for creating transgenic animals |
Publications (1)
Publication Number | Publication Date |
---|---|
ATE405154T1 true ATE405154T1 (de) | 2008-09-15 |
Family
ID=25234786
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AT98910494T ATE405154T1 (de) | 1997-03-20 | 1998-03-18 | Verfahren zur erschaffung transgener nicht- menschlicher tiere |
Country Status (8)
Country | Link |
---|---|
US (5) | US6080912A (de) |
EP (1) | EP0909313B1 (de) |
AT (1) | ATE405154T1 (de) |
AU (1) | AU6472398A (de) |
CA (1) | CA2254866C (de) |
DE (1) | DE69839905D1 (de) |
NZ (1) | NZ332854A (de) |
WO (1) | WO1998041615A1 (de) |
Families Citing this family (91)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20040076613A1 (en) * | 2000-11-03 | 2004-04-22 | Nicholas Mazarakis | Vector system |
US6818209B1 (en) * | 1998-05-22 | 2004-11-16 | Oxford Biomedica (Uk) Limited | Retroviral delivery system |
US20070213290A1 (en) * | 1996-10-17 | 2007-09-13 | Kingsman Alan J | Neurite regeneration |
US6080912A (en) * | 1997-03-20 | 2000-06-27 | Wisconsin Alumni Research Foundation | Methods for creating transgenic animals |
EP1130960A4 (de) * | 1998-11-19 | 2003-07-30 | Wisconsin Alumni Res Found | Transgene tiere |
AU2103601A (en) * | 1999-12-17 | 2001-06-25 | Oregon Health And Science University | Methods for producing transgenic animals |
AU2001271614B2 (en) | 2000-07-03 | 2007-05-31 | Catalent Pharma Solutions, Llc | Host cells containing multiple integrating vectors |
CA2413156C (en) * | 2000-07-03 | 2009-08-18 | Gala Design, Inc. | Expression vectors |
US20040235173A1 (en) * | 2000-07-03 | 2004-11-25 | Gala Design, Inc. | Production of host cells containing multiple integrating vectors by serial transduction |
US20030224415A1 (en) * | 2001-06-29 | 2003-12-04 | Gala Design, Inc. | Selection free growth of host cells containing multiple integrating vectors |
IL154751A0 (en) | 2000-08-03 | 2003-10-31 | Humanized antibodies, recombination vectors, transgenic vectors and methods for the preparation of humanized antibodies from transgenic animals | |
US20080194022A1 (en) * | 2000-08-03 | 2008-08-14 | Clarke Michael F | Isolation and use of solid tumor stem cells |
US8044259B2 (en) | 2000-08-03 | 2011-10-25 | The Regents Of The University Of Michigan | Determining the capability of a test compound to affect solid tumor stem cells |
US6984522B2 (en) * | 2000-08-03 | 2006-01-10 | Regents Of The University Of Michigan | Isolation and use of solid tumor stem cells |
AU2001284843A1 (en) * | 2000-08-14 | 2002-02-25 | Iogenetics, Llc | Fatty liver disease resistant bovines |
US6677500B2 (en) * | 2000-08-15 | 2004-01-13 | Board Of Trustees Of The University Of Illinois | Ungulates expressing exogenous IGF-I in their milk |
US7060442B2 (en) * | 2000-10-30 | 2006-06-13 | Regents Of The University Of Michigan | Modulators on Nod2 signaling |
EP2138583A1 (de) | 2000-12-22 | 2009-12-30 | Institut National De La Recherche Agronomique | Positionsunabhängige und gewebespezifische Expression eines Transgens in der Milch eines Transgen-Tieres |
US6849449B2 (en) * | 2001-03-01 | 2005-02-01 | Regents Of The University Of Michigan | Orphanin FQ receptor nucleic acids |
JP3966819B2 (ja) * | 2001-05-24 | 2007-08-29 | キム,スーギョン | 毛嚢に存在する新規の第2ケラチノサイト成長因子類似体 |
US7229774B2 (en) | 2001-08-02 | 2007-06-12 | Regents Of The University Of Michigan | Expression profile of prostate cancer |
US7176278B2 (en) | 2001-08-30 | 2007-02-13 | Biorexis Technology, Inc. | Modified transferrin fusion proteins |
AU2002336517B2 (en) * | 2001-09-13 | 2008-09-11 | California Institute Of Technology | Method for producing transgenic animals |
US20030167500A1 (en) * | 2001-12-21 | 2003-09-04 | Ram Ramabhadran | Methods and compositions for generating a genetically modified animal using lentiviral vectors |
WO2003057916A2 (en) | 2002-01-09 | 2003-07-17 | Riken | Cancer profiles |
US7255986B2 (en) * | 2002-01-31 | 2007-08-14 | The Board Of Trustees Operating Michigan State University | Compositions for the diagnosis and treatment of epizootic catarrhal enteritis in ferrets |
US20040038304A1 (en) * | 2002-03-28 | 2004-02-26 | Gala Design, Inc. | Antibody libraries |
US7384738B2 (en) * | 2002-03-28 | 2008-06-10 | Bremel Robert D | Retrovirus-based genomic screening |
AU2003253651C1 (en) * | 2002-06-14 | 2010-06-03 | Gen-Probe Incorporated | Compositions and methods for detecting hepatitis B virus |
US20040235011A1 (en) * | 2002-06-26 | 2004-11-25 | Cooper Richard K. | Production of multimeric proteins |
US20040172667A1 (en) * | 2002-06-26 | 2004-09-02 | Cooper Richard K. | Administration of transposon-based vectors to reproductive organs |
US7527966B2 (en) * | 2002-06-26 | 2009-05-05 | Transgenrx, Inc. | Gene regulation in transgenic animals using a transposon-based vector |
USRE47770E1 (en) | 2002-07-18 | 2019-12-17 | Merus N.V. | Recombinant production of mixtures of antibodies |
SI1523496T1 (sl) * | 2002-07-18 | 2011-11-30 | Merus B V | Rekombinantno proizvajanje zmesi protiteles |
US7371922B2 (en) * | 2002-07-31 | 2008-05-13 | The Board Of Trustees Of The University Of Illinois | Nuclear transfer with porcine embryonic stem cells |
US6863731B2 (en) * | 2002-10-18 | 2005-03-08 | Controls Corporation Of America | System for deposition of inert barrier coating to increase corrosion resistance |
WO2004042363A2 (en) * | 2002-11-04 | 2004-05-21 | Dana-Farber Cancer Institute, Inc. | In vivo imaging of e2f-regulated bioluminescent proteins |
WO2004061125A2 (en) | 2002-12-31 | 2004-07-22 | Mmi Genomics, Inc. | Compositions, methods and systems for inferring bovine traits |
US7173010B2 (en) * | 2003-05-19 | 2007-02-06 | Regents Of The University Of Michigan | Orphanin FQ receptor |
AU2004242614B2 (en) | 2003-05-30 | 2011-09-22 | Merus N.V. | Fab library for the preparation of anti vegf and anti rabies virus fabs |
CA2531197A1 (en) * | 2003-05-30 | 2005-01-06 | The Board Of Trustees Of The University Of Illinois | Gene expression profiles that identify genetically elite ungulate mammals |
US20100069614A1 (en) | 2008-06-27 | 2010-03-18 | Merus B.V. | Antibody producing non-human mammals |
US20060019256A1 (en) | 2003-06-09 | 2006-01-26 | The Regents Of The University Of Michigan | Compositions and methods for treating and diagnosing cancer |
BRPI0415468A (pt) * | 2003-10-24 | 2007-03-27 | Mmi Genomics Inc | métodos e sistemas para inferir caracterìsticas para controlar criação não de gado |
WO2005062881A2 (en) | 2003-12-24 | 2005-07-14 | Transgenrx, Inc. | Gene therapy using transposon-based vectors |
US20050221429A1 (en) * | 2004-01-16 | 2005-10-06 | Cardinal Health Pts, Llc | Host cells containing multiple integrating vectors comprising an amplifiable marker |
EP1737971B1 (de) | 2004-01-20 | 2017-08-16 | Merus N.V. | Gemische bindender proteine |
US7432057B2 (en) * | 2004-01-30 | 2008-10-07 | Michigan State University | Genetic test for PSE-susceptible turkeys |
US7223562B2 (en) * | 2004-03-31 | 2007-05-29 | New York University | Compositions for controlling hair growth |
US7858323B2 (en) | 2004-06-09 | 2010-12-28 | The Regents Of The University Of Michigan | Phage microarray profiling of the humoral response to disease |
US7939257B2 (en) * | 2005-05-12 | 2011-05-10 | Third Wave Technologies, Inc. | Polymorphic GHSR nucleic acids and uses thereof |
EP1907858A4 (de) * | 2005-06-13 | 2009-04-08 | Univ Michigan | Zusammensetzungen und verfahren zur behandlung und diagnose von krebs |
EP2612870A1 (de) | 2005-09-12 | 2013-07-10 | The Regents of the University of Michigan | Häufige Genfusionen bei Prostatakrebs |
US9957569B2 (en) * | 2005-09-12 | 2018-05-01 | The Regents Of The University Of Michigan | Recurrent gene fusions in prostate cancer |
TW200732347A (en) | 2005-10-06 | 2007-09-01 | Trophogen Inc | VEGF analogs and methods of use |
US7794951B2 (en) * | 2005-10-18 | 2010-09-14 | University Of Massachusetts Medical School | SREBP2gc transcription factors and uses thereof |
US7723112B2 (en) | 2005-10-31 | 2010-05-25 | The Regents Of The University Of Michigan | Compositions and methods for treating and diagnosing cancer |
US7723477B2 (en) * | 2005-10-31 | 2010-05-25 | Oncomed Pharmaceuticals, Inc. | Compositions and methods for inhibiting Wnt-dependent solid tumor cell growth |
WO2007053577A2 (en) | 2005-10-31 | 2007-05-10 | Oncomed Pharmaceuticals, Inc. | Compositions and methods for diagnosing and treating cancer |
CA2661848C (en) | 2006-09-01 | 2015-02-03 | Therapeutic Human Polyclonals, Inc. | Enhanced expression of human or humanized immunoglobulin in non-human transgenic animals |
WO2008045952A2 (en) * | 2006-10-10 | 2008-04-17 | The Regents Of The University Of Michigan | Photoreceptor precursor cells |
WO2008067422A2 (en) * | 2006-11-28 | 2008-06-05 | Zgi, Inc. | Replication of undifferentiated diploid cells in a weightless environment, uses thereof and a facility for such replication |
WO2008092002A2 (en) | 2007-01-24 | 2008-07-31 | The Regents Of The University Of Michigan | Compositions and methods for treating and diagnosing pancreatic cancer |
PL3009148T3 (pl) | 2007-07-02 | 2019-03-29 | Oncomed Pharmaceuticals, Inc. | Kompozycje oraz sposoby leczenia i diagnozowania nowotworu |
WO2009009431A2 (en) | 2007-07-06 | 2009-01-15 | The Regents Of The University Of Michigan | Mipol1-etv1 gene rearrangements |
CA2814246A1 (en) | 2007-07-06 | 2009-01-15 | The Regents Of The University Of Michigan | Solute carrier family 45 member 3 (slc45a3) and erg family gene fusions in prostate cancer |
EP2179292B1 (de) | 2007-08-16 | 2012-11-28 | The Regents of the University of Michigan | Metabolomische profilierung von prostatakrebs |
KR101588474B1 (ko) * | 2008-01-29 | 2016-01-25 | 각고호우징 게이오기주크 | 영장류 동물의 초기 배아에의 외래 유전자 도입법 및 상기 도입법을 포함하는 트랜스제닉 영장류 동물을 작출하는 방법 |
US9150880B2 (en) * | 2008-09-25 | 2015-10-06 | Proteovec Holding, L.L.C. | Vectors for production of antibodies |
US20100081789A1 (en) * | 2008-09-25 | 2010-04-01 | Cooper Richard K | Novel Vectors for Production of Interferon |
WO2010036978A2 (en) * | 2008-09-25 | 2010-04-01 | Transgenrx, Inc. | Novel vectors for production of growth hormone |
RU2579897C2 (ru) | 2008-09-26 | 2016-04-10 | Онкомед Фармасьютикалс, Инк. | Агенты, связывающие рецептор "frizzled", и их применение |
JP2012514475A (ja) | 2009-01-09 | 2012-06-28 | ザ リージェンツ オブ ザ ユニバーシティ オブ ミシガン | 癌における再現性の遺伝子融合物 |
EP2417263B1 (de) * | 2009-04-09 | 2015-09-23 | ProteoVec Holding L.L.C. | Herstellung von proteinen unter verwendung von vektoren auf transposonbasis |
US9938582B2 (en) * | 2009-09-17 | 2018-04-10 | The Regents Of The University Of Michigan | Recurrent gene fusions in prostate cancer |
TWI535445B (zh) | 2010-01-12 | 2016-06-01 | 安可美德藥物股份有限公司 | Wnt拮抗劑及治療和篩選方法 |
EP2548025A4 (de) | 2010-03-17 | 2013-09-25 | Univ Michigan | Verwendung von phagenepitopen zur profilierung einer immunreaktion |
KR20130043102A (ko) | 2010-04-01 | 2013-04-29 | 온코메드 파마슈티칼스, 인크. | 프리즐드-결합 작용제 및 그의 용도 |
CN102399263B (zh) * | 2010-09-14 | 2016-03-09 | 吉林农业大学 | 鲤春病毒血症抗原表位 |
US8945556B2 (en) | 2010-11-19 | 2015-02-03 | The Regents Of The University Of Michigan | RAF gene fusions |
WO2012122512A1 (en) | 2011-03-10 | 2012-09-13 | Hco Antibody, Inc. | Recombinant production of mixtures of single chain antibodies |
EA035344B1 (ru) | 2012-04-20 | 2020-05-29 | Мерюс Н.В. | Способ получения двух антител из одной клетки-хозяина |
US10457713B2 (en) | 2012-07-30 | 2019-10-29 | Trophogen, Inc. | Glycoprotein hormone long-acting superagonists |
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AU2013334790A1 (en) | 2012-10-23 | 2015-04-30 | Oncomed Pharmaceuticals, Inc. | Methods of treating neuroendocrine tumors using Wnt pathway-binding agents |
CN105073195A (zh) | 2013-02-04 | 2015-11-18 | 昂科梅德制药有限公司 | 使用Wnt途径抑制剂进行治疗的方法及对该治疗的监测 |
US9168300B2 (en) | 2013-03-14 | 2015-10-27 | Oncomed Pharmaceuticals, Inc. | MET-binding agents and uses thereof |
WO2014197586A1 (en) | 2013-06-04 | 2014-12-11 | Virginia Commonwealth University | Mda-9/syntenin promoter to image and treat metastatic cancer cells |
WO2014209553A1 (en) | 2013-06-04 | 2014-12-31 | Virginia Commonwealth University | Use of a truncated ccn1 promoter for cancer diagnostics, therapeutics and theranostics |
AR098314A1 (es) | 2013-11-05 | 2016-05-26 | Trophogen Inc | Superagonistas de acción prolongada de hormonas glicoproteicas |
CN112342238A (zh) * | 2020-10-21 | 2021-02-09 | 复旦大学 | Trip13基因突变引发卵子成熟障碍的卵子功能恢复制剂及其使用方法 |
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US5550034A (en) * | 1992-12-04 | 1996-08-27 | Arch Development Corp. | Apolipoprotein B mRNA editing protein compositions and methods |
WO1994018834A1 (en) * | 1993-02-16 | 1994-09-01 | Virginia Tech Intellectual Properties, Inc. | Polyelectrolyte dna conjugation and genetic transformation of an animal |
EP1149898A2 (de) * | 1993-12-23 | 2001-10-31 | Infigen, Inc. | Embryonale Stammzellen von Huftieren als Kerndonatoren und Kerntransfertechniken zur Herstellung chimärer und transgener Tiere |
US6080912A (en) * | 1997-03-20 | 2000-06-27 | Wisconsin Alumni Research Foundation | Methods for creating transgenic animals |
-
1997
- 1997-03-20 US US08/821,984 patent/US6080912A/en not_active Expired - Lifetime
-
1998
- 1998-03-18 AT AT98910494T patent/ATE405154T1/de not_active IP Right Cessation
- 1998-03-18 DE DE69839905T patent/DE69839905D1/de not_active Expired - Lifetime
- 1998-03-18 WO PCT/US1998/005376 patent/WO1998041615A1/en active Application Filing
- 1998-03-18 AU AU64723/98A patent/AU6472398A/en not_active Abandoned
- 1998-03-18 EP EP98910494A patent/EP0909313B1/de not_active Expired - Lifetime
- 1998-03-18 NZ NZ332854A patent/NZ332854A/xx not_active IP Right Cessation
- 1998-03-18 CA CA2254866A patent/CA2254866C/en not_active Expired - Lifetime
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1999
- 1999-06-10 US US09/329,749 patent/US6291740B1/en not_active Expired - Fee Related
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2000
- 2000-02-11 US US09/502,264 patent/US6548740B1/en not_active Expired - Lifetime
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2001
- 2001-05-04 US US09/849,566 patent/US20020104109A1/en not_active Abandoned
- 2001-07-18 US US09/907,859 patent/US7138562B2/en not_active Expired - Fee Related
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NZ332854A (en) | 2000-07-28 |
US6080912A (en) | 2000-06-27 |
US6291740B1 (en) | 2001-09-18 |
US20020129393A1 (en) | 2002-09-12 |
US20020104109A1 (en) | 2002-08-01 |
AU6472398A (en) | 1998-10-12 |
CA2254866A1 (en) | 1998-09-24 |
CA2254866C (en) | 2010-05-11 |
US7138562B2 (en) | 2006-11-21 |
US6548740B1 (en) | 2003-04-15 |
EP0909313A4 (de) | 2001-09-26 |
EP0909313B1 (de) | 2008-08-20 |
EP0909313A1 (de) | 1999-04-21 |
DE69839905D1 (de) | 2008-10-02 |
WO1998041615A1 (en) | 1998-09-24 |
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