ATE403653T1 - Pyridin-substituierte furanderivate als raf- kinase inhibitoren - Google Patents

Pyridin-substituierte furanderivate als raf- kinase inhibitoren

Info

Publication number
ATE403653T1
ATE403653T1 AT02777001T AT02777001T ATE403653T1 AT E403653 T1 ATE403653 T1 AT E403653T1 AT 02777001 T AT02777001 T AT 02777001T AT 02777001 T AT02777001 T AT 02777001T AT E403653 T1 ATE403653 T1 AT E403653T1
Authority
AT
Austria
Prior art keywords
sub
sup
kinase inhibitors
raf
pyridine
Prior art date
Application number
AT02777001T
Other languages
English (en)
Inventor
Andrew Kenneth Takle
David Matthew Wilson
David Kenneth Dean
Original Assignee
Smithkline Beecham Plc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB0121485A external-priority patent/GB0121485D0/en
Priority claimed from GB0121493A external-priority patent/GB0121493D0/en
Application filed by Smithkline Beecham Plc filed Critical Smithkline Beecham Plc
Application granted granted Critical
Publication of ATE403653T1 publication Critical patent/ATE403653T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
AT02777001T 2001-09-05 2002-09-05 Pyridin-substituierte furanderivate als raf- kinase inhibitoren ATE403653T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB0121485A GB0121485D0 (en) 2001-09-05 2001-09-05 Compounds
GB0121493A GB0121493D0 (en) 2001-09-05 2001-09-05 Compounds

Publications (1)

Publication Number Publication Date
ATE403653T1 true ATE403653T1 (de) 2008-08-15

Family

ID=26246514

Family Applications (1)

Application Number Title Priority Date Filing Date
AT02777001T ATE403653T1 (de) 2001-09-05 2002-09-05 Pyridin-substituierte furanderivate als raf- kinase inhibitoren

Country Status (6)

Country Link
US (1) US7375105B2 (de)
EP (1) EP1423383B1 (de)
AT (1) ATE403653T1 (de)
DE (1) DE60228098D1 (de)
ES (1) ES2309207T3 (de)
WO (1) WO2003022838A1 (de)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE60037597T2 (de) * 1999-11-22 2008-12-11 Smithkline Beecham P.L.C., Brentford Imidazol- Derivate
DE60103136T2 (de) * 2000-03-06 2004-10-28 Smithkline Beecham Plc, Brentford Imidazolderivate als Raf-Kinase Inhibitoren
GB0112348D0 (en) * 2001-05-19 2001-07-11 Smithkline Beecham Plc Compounds
JP2005504793A (ja) * 2001-09-05 2005-02-17 スミスクライン　ビーチャム　パブリック　リミテッド　カンパニー Ｒａｆキナーゼ阻害剤としてのヘテロサイクルカルボキサミド誘導体
US7827944B2 (en) * 2006-06-30 2010-11-09 Gm Global Technology Operations, Inc. System for controlling the response time of a hydraulic system
EP2162445B1 (de) 2007-06-05 2013-11-27 Takeda Pharmaceutical Company Limited Heterobicyclische verbindungen als kinasehemmer
BRPI0814423B1 (pt) 2007-07-17 2022-04-19 Plexxikon, Inc Compostos que modulam quinase e composição farmacêutica compreendendo os mesmos
JP5270553B2 (ja) 2007-08-23 2013-08-21 武田薬品工業株式会社 複素環化合物およびその用途
WO2009028629A1 (ja) 2007-08-29 2009-03-05 Takeda Pharmaceutical Company Limited 複素環化合物およびその用途
JP5581219B2 (ja) 2008-01-25 2014-08-27 ミレニアム ファーマシューティカルズ， インコーポレイテッド チオフェンおよびホスファチジルイノシトール３−キナーゼ（ｐｉ３ｋ）阻害薬としてのその使用
JP5579619B2 (ja) 2008-12-01 2014-08-27 武田薬品工業株式会社 複素環化合物およびその用途
JO3101B1 (ar) 2008-12-02 2017-09-20 Takeda Pharmaceuticals Co مشتقات بنزوثيازول كعوامل مضادة للسرطان
WO2010090716A1 (en) 2009-01-30 2010-08-12 Millennium Pharmaceuticals, Inc. Heteroaryls and their use as pi3k inhibitors
US8796314B2 (en) 2009-01-30 2014-08-05 Millennium Pharmaceuticals, Inc. Heteroaryls and uses thereof
US9090601B2 (en) 2009-01-30 2015-07-28 Millennium Pharmaceuticals, Inc. Thiazole derivatives
EP2603216A4 (de) * 2010-08-11 2013-12-18 Millennium Pharm Inc Heteroaryle und verwendungen davon
US8796271B2 (en) 2010-08-11 2014-08-05 Millennium Pharmaceuticals, Inc. Heteroaryls and uses thereof
US9062038B2 (en) 2010-08-11 2015-06-23 Millennium Pharmaceuticals, Inc. Heteroaryls and uses thereof
EA201390539A1 (ru) 2010-10-13 2013-09-30 Милленниум Фармасьютикалз, Инк. Гетероарилы и их применение
AU2014240950B2 (en) 2013-03-29 2018-11-01 Avoscience, Llc Lipidic furan, pyrrole, and thiophene compounds for treatment of cancer, neurological disorders, and fibrotic disorders
US20170312246A1 (en) 2016-04-27 2017-11-02 Avoscience, Llc Lipidic furan, pyrrole, and thiophene compounds for use in the treatment of atrophic vaginitis
GB201706806D0 (en) 2017-04-28 2017-06-14 Sentinel Oncology Ltd Pharmaceutical compounds

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4735958A (en) * 1986-12-22 1988-04-05 Warner-Lambert Company Trans-6-[2-[2-(substituted-phenyl)-3- (or 4-) heteroaryl-5-substituted-1H-pyrrol-1-yl]-ethyl]tetrahydro-4-hydroxy-2H-pyran-2-one inhibitors of cholesterol biosynthesis
US5792778A (en) * 1995-08-10 1998-08-11 Merck & Co., Inc. 2-substituted aryl pyrroles, compositions containing such compounds and methods of use
US5776954A (en) * 1996-10-30 1998-07-07 Merck & Co., Inc. Substituted pyridyl pyrroles, compositions containing such compounds and methods of use
PT1056725E (pt) 1997-12-22 2006-09-29 Bayer Pharmaceuticals Corp Inibicao da raf-quinase usando ureias heterociclicas substituidas com arilo e heteroarilo
AU1596101A (en) * 1999-11-12 2001-06-06 Merck & Co., Inc. Aliphatic amine substituted piperidyl diaryl pyrrole derivatives as antiprotozoal agents
ATE318600T1 (de) * 1999-11-12 2006-03-15 Merck & Co Inc Diaryl piperidyl-pyrrol-derivate als antiprotozoenmittel
DE60037597T2 (de) 1999-11-22 2008-12-11 Smithkline Beecham P.L.C., Brentford Imidazol- Derivate
JP2002037784A (ja) * 2000-05-17 2002-02-06 Nikken Chem Co Ltd 新規チオフェンアミド化合物

Also Published As

Publication number Publication date
WO2003022838A1 (en) 2003-03-20
DE60228098D1 (de) 2008-09-18
EP1423383B1 (de) 2008-08-06
WO2003022838A8 (en) 2004-03-25
US7375105B2 (en) 2008-05-20
US20040248896A1 (en) 2004-12-09
ES2309207T3 (es) 2008-12-16
EP1423383A1 (de) 2004-06-02

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Legal Events

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RER Ceased as to paragraph 5 lit. 3 law introducing patent treaties