ATE375158T1 - Kalziumkanalblocker mit zwei benzhydril-teilen - Google Patents

Kalziumkanalblocker mit zwei benzhydril-teilen

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Publication number
ATE375158T1
ATE375158T1 AT04726397T AT04726397T ATE375158T1 AT E375158 T1 ATE375158 T1 AT E375158T1 AT 04726397 T AT04726397 T AT 04726397T AT 04726397 T AT04726397 T AT 04726397T AT E375158 T1 ATE375158 T1 AT E375158T1
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AT
Austria
Prior art keywords
sub
sup
calcium channel
phi
alkyl
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Application number
AT04726397T
Other languages
English (en)
Inventor
Francesco Belardetti
Hassan Pajouhesh
Hossein Pajouhesh
Terrance Snutch
Gerald Zamponi
Original Assignee
Neuromed Tech Inc
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Publication of ATE375158T1 publication Critical patent/ATE375158T1/de

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    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4468—Non condensed piperidines, e.g. piperocaine having a nitrogen directly attached in position 4, e.g. clebopride, fentanyl
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    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/451—Non condensed piperidines, e.g. piperocaine having a carbocyclic group directly attached to the heterocyclic ring, e.g. glutethimide, meperidine, loperamide, phencyclidine, piminodine
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    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/454—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. pimozide, domperidone
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    • A61K31/5375—1,4-Oxazines, e.g. morpholine
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    • A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
    • A61K31/5415—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame ortho- or peri-condensed with carbocyclic ring systems, e.g. phenothiazine, chlorpromazine, piroxicam
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    • C07D317/50—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to atoms of the carbocyclic ring
    • C07D317/60—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
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    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings

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AT04726397T 2003-04-08 2004-04-08 Kalziumkanalblocker mit zwei benzhydril-teilen ATE375158T1 (de)

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CA2521875A1 (en) 2004-10-21
EP1610792A1 (de) 2006-01-04
US7064128B2 (en) 2006-06-20
DE602004009426D1 (de) 2007-11-22
US20040192703A1 (en) 2004-09-30
ES2295850T3 (es) 2008-04-16
JP2006522741A (ja) 2006-10-05
US6949554B2 (en) 2005-09-27
EP1610792B1 (de) 2007-10-10
DE602004009426T2 (de) 2008-10-23
US20040034035A1 (en) 2004-02-19
US6951862B2 (en) 2005-10-04

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