ATE374207T1 - Verfahren zur herstellung von lipid ii - Google Patents
Verfahren zur herstellung von lipid iiInfo
- Publication number
- ATE374207T1 ATE374207T1 AT02723498T AT02723498T ATE374207T1 AT E374207 T1 ATE374207 T1 AT E374207T1 AT 02723498 T AT02723498 T AT 02723498T AT 02723498 T AT02723498 T AT 02723498T AT E374207 T1 ATE374207 T1 AT E374207T1
- Authority
- AT
- Austria
- Prior art keywords
- cell wall
- bacterial cell
- wall biosynthesis
- producing lipid
- lipid
- Prior art date
Links
- ULXTYUPMJXVUHQ-UHFFFAOYSA-N lipid ii Chemical compound OC(=O)C(C)NC(=O)C(C)NC(=O)C(CCCCN)NC(=O)CCC(C(O)=O)NC(=O)C(C)NC(=O)C(C)OC1C(NC(C)=O)C(OP(O)(=O)OP(O)(=O)OCC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)C)OC(CO)C1OC1C(NC(C)=O)C(O)C(O)C(CO)O1 ULXTYUPMJXVUHQ-UHFFFAOYSA-N 0.000 title 1
- 238000004519 manufacturing process Methods 0.000 title 1
- 230000001580 bacterial effect Effects 0.000 abstract 2
- 230000015572 biosynthetic process Effects 0.000 abstract 2
- 210000002421 cell wall Anatomy 0.000 abstract 2
- 108010062010 N-Acetylmuramoyl-L-alanine Amidase Proteins 0.000 abstract 1
- -1 analogs thereof Chemical compound 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- ULXTYUPMJXVUHQ-OVTFQNCVSA-N lipid II Chemical compound OC(=O)[C@@H](C)NC(=O)[C@@H](C)NC(=O)[C@H](CCCCN)NC(=O)CC[C@H](C(O)=O)NC(=O)[C@H](C)NC(=O)[C@@H](C)O[C@@H]1[C@@H](NC(C)=O)[C@@H](OP(O)(=O)OP(O)(=O)OC\C=C(\C)CC\C=C(\C)CC\C=C(\C)CC\C=C(\C)CC\C=C(\C)CC\C=C(\C)CC\C=C(\C)CC\C=C(\C)CC\C=C(/C)CC\C=C(/C)CCC=C(C)C)O[C@H](CO)[C@H]1O[C@H]1[C@H](NC(C)=O)[C@@H](O)[C@H](O)[C@@H](CO)O1 ULXTYUPMJXVUHQ-OVTFQNCVSA-N 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 239000000758 substrate Substances 0.000 abstract 1
- 238000003786 synthesis reaction Methods 0.000 abstract 1
- 229940124597 therapeutic agent Drugs 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H11/00—Compounds containing saccharide radicals esterified by inorganic acids; Metal salts thereof
- C07H11/04—Phosphates; Phosphites; Polyphosphates
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K9/00—Peptides having up to 20 amino acids, containing saccharide radicals and having a fully defined sequence; Derivatives thereof
- C07K9/001—Peptides having up to 20 amino acids, containing saccharide radicals and having a fully defined sequence; Derivatives thereof the peptide sequence having less than 12 amino acids and not being part of a ring structure
- C07K9/005—Peptides having up to 20 amino acids, containing saccharide radicals and having a fully defined sequence; Derivatives thereof the peptide sequence having less than 12 amino acids and not being part of a ring structure containing within the molecule the substructure with m, n > 0 and m+n > 0, A, B, D, E being heteroatoms; X being a bond or a chain, e.g. muramylpeptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Molecular Biology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Biochemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Biotechnology (AREA)
- Engineering & Computer Science (AREA)
- Crystallography & Structural Chemistry (AREA)
- Biophysics (AREA)
- Medicinal Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Peptides Or Proteins (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US09/833,647 US7169919B2 (en) | 2000-04-18 | 2001-04-18 | Process for preparing lipid II |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE374207T1 true ATE374207T1 (de) | 2007-10-15 |
Family
ID=25264939
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT02723498T ATE374207T1 (de) | 2001-04-18 | 2002-04-18 | Verfahren zur herstellung von lipid ii |
Country Status (6)
| Country | Link |
|---|---|
| EP (1) | EP1417223B8 (de) |
| JP (1) | JP2005529838A (de) |
| AT (1) | ATE374207T1 (de) |
| DE (1) | DE60222672T2 (de) |
| ES (1) | ES2292750T3 (de) |
| WO (1) | WO2002085929A1 (de) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1275731A1 (de) * | 2001-07-09 | 2003-01-15 | Universiteit Utrecht Holding B.V. | Verfahren zur Herstellung von Lipid II und Verwendung des so hergestellten Lipid II |
| JP2007505905A (ja) * | 2003-09-17 | 2007-03-15 | イーライ リリー アンド カンパニー | 疾患における免疫学的介入のための合成多糖抗原 |
| CN113214335A (zh) * | 2020-01-21 | 2021-08-06 | 上海医药工业研究院 | Lipid X中间体及其制备方法 |
| WO2025089217A1 (ja) * | 2023-10-23 | 2025-05-01 | 株式会社ヤクルト本社 | γ－Ｄ－グルタミル－Ｌ－リシルエンドペプチダーゼの活性を評価するための基質として用いられる化合物 |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BR0109968A (pt) * | 2000-04-18 | 2003-05-27 | Lilly Co Eli | Processo para a preparação de lipìdeo ii |
-
2002
- 2002-04-18 WO PCT/US2002/008266 patent/WO2002085929A1/en not_active Ceased
- 2002-04-18 EP EP02723498A patent/EP1417223B8/de not_active Expired - Lifetime
- 2002-04-18 ES ES02723498T patent/ES2292750T3/es not_active Expired - Lifetime
- 2002-04-18 DE DE60222672T patent/DE60222672T2/de not_active Expired - Fee Related
- 2002-04-18 AT AT02723498T patent/ATE374207T1/de not_active IP Right Cessation
- 2002-04-18 JP JP2002583455A patent/JP2005529838A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| EP1417223B1 (de) | 2007-09-26 |
| EP1417223B8 (de) | 2008-02-13 |
| DE60222672D1 (de) | 2007-11-08 |
| WO2002085929A1 (en) | 2002-10-31 |
| ES2292750T3 (es) | 2008-03-16 |
| EP1417223A1 (de) | 2004-05-12 |
| JP2005529838A (ja) | 2005-10-06 |
| DE60222672T2 (de) | 2008-07-24 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |