ATE365045T1 - Vermehrung des weich- sowie des knochengewebes anhand von aus muskeln stammenden vorläuferzellen,sowie damit verbundene zusammensetzungen und behandlungsformen - Google Patents

Vermehrung des weich- sowie des knochengewebes anhand von aus muskeln stammenden vorläuferzellen,sowie damit verbundene zusammensetzungen und behandlungsformen

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Publication number
ATE365045T1
ATE365045T1 AT01924998T AT01924998T ATE365045T1 AT E365045 T1 ATE365045 T1 AT E365045T1 AT 01924998 T AT01924998 T AT 01924998T AT 01924998 T AT01924998 T AT 01924998T AT E365045 T1 ATE365045 T1 AT E365045T1
Authority
AT
Austria
Prior art keywords
mdcs
muscle
treatment
soft
production
Prior art date
Application number
AT01924998T
Other languages
German (de)
English (en)
Inventor
Michael B Chancellor
Johnny Huard
Christopher C Capelli
Zhuqing Qu
Original Assignee
Univ Pittsburgh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=24195003&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ATE365045(T1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority claimed from US09/549,937 external-priority patent/US7115417B1/en
Application filed by Univ Pittsburgh filed Critical Univ Pittsburgh
Application granted granted Critical
Publication of ATE365045T1 publication Critical patent/ATE365045T1/de

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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/34Muscles; Smooth muscle cells; Heart; Cardiac stem cells; Myoblasts; Myocytes; Cardiomyocytes
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/0019Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/02Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/18Drugs for disorders of the alimentary tract or the digestive system for pancreatic disorders, e.g. pancreatic enzymes
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00Drugs for disorders of the urinary system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00Drugs for disorders of the urinary system
    • A61P13/02Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00Drugs for disorders of the urinary system
    • A61P13/10Drugs for disorders of the urinary system of the bladder
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00Drugs for disorders of the urinary system
    • A61P13/12Drugs for disorders of the urinary system of the kidneys
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00Drugs for genital or sexual disorders; Contraceptives
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00Drugs for dermatological disorders
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00Drugs for dermatological disorders
    • A61P17/02Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00Drugs for disorders of the muscular or neuromuscular system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
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    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12N5/00Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06Animal cells or tissues; Human cells or tissues
    • C12N5/0602Vertebrate cells
    • C12N5/0652Cells of skeletal and connective tissues; Mesenchyme
    • C12N5/0658Skeletal muscle cells, e.g. myocytes, myotubes, myoblasts
    • CCHEMISTRY; METALLURGY
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    • C12N5/00Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06Animal cells or tissues; Human cells or tissues
    • C12N5/0602Vertebrate cells
    • C12N5/0652Cells of skeletal and connective tissues; Mesenchyme
    • C12N5/0658Skeletal muscle cells, e.g. myocytes, myotubes, myoblasts
    • C12N5/0659Satellite cells
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • CCHEMISTRY; METALLURGY
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    • C12N2500/00Specific components of cell culture medium
    • C12N2500/70Undefined extracts
    • C12N2500/80Undefined extracts from animals
    • C12N2500/84Undefined extracts from animals from mammals
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    • C12N2510/00Genetically modified cells
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    • C12N2510/00Genetically modified cells
    • C12N2510/02Cells for production
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    • C12N2533/00Supports or coatings for cell culture, characterised by material
    • C12N2533/50Proteins
    • C12N2533/54Collagen; Gelatin

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • Zoology (AREA)
  • Biotechnology (AREA)
  • Cell Biology (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • Rheumatology (AREA)
  • Developmental Biology & Embryology (AREA)
  • Urology & Nephrology (AREA)
  • Epidemiology (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Cardiology (AREA)
  • Dermatology (AREA)
  • Virology (AREA)
  • Immunology (AREA)
  • Vascular Medicine (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Endocrinology (AREA)
  • Pulmonology (AREA)
  • Reproductive Health (AREA)
AT01924998T 2000-04-14 2001-04-12 Vermehrung des weich- sowie des knochengewebes anhand von aus muskeln stammenden vorläuferzellen,sowie damit verbundene zusammensetzungen und behandlungsformen ATE365045T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US09/549,937 US7115417B1 (en) 1998-05-01 2000-04-14 Soft tissue and bone augmentation and bulking utilizing muscle-derived progenito compositions, and treatments thereof

Publications (1)

Publication Number Publication Date
ATE365045T1 true ATE365045T1 (de) 2007-07-15

Family

ID=24195003

Family Applications (1)

Application Number Title Priority Date Filing Date
AT01924998T ATE365045T1 (de) 2000-04-14 2001-04-12 Vermehrung des weich- sowie des knochengewebes anhand von aus muskeln stammenden vorläuferzellen,sowie damit verbundene zusammensetzungen und behandlungsformen

Country Status (13)

Country Link
US (3) US9499791B2 (https=)
EP (1) EP1272204B1 (https=)
JP (2) JP5684963B2 (https=)
AT (1) ATE365045T1 (https=)
AU (2) AU5159901A (https=)
CA (1) CA2406393C (https=)
CY (1) CY1108090T1 (https=)
DE (1) DE60129007T2 (https=)
DK (1) DK1272204T3 (https=)
ES (1) ES2288946T3 (https=)
HK (1) HK1052645B (https=)
PT (1) PT1272204E (https=)
WO (1) WO2001078754A2 (https=)

Families Citing this family (41)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6485723B1 (en) 1995-02-10 2002-11-26 Purdue Research Foundation Enhanced submucosal tissue graft constructs
US7115417B1 (en) 1998-05-01 2006-10-03 Chancellor Michael B Soft tissue and bone augmentation and bulking utilizing muscle-derived progenito compositions, and treatments thereof
US6866842B1 (en) 1998-05-01 2005-03-15 University Of Pittsburgh Muscle-derived cells (MDCs) for treating muscle-or bone-related injury or dysfunction
HK1052645B (en) 2000-04-14 2008-03-20 Universtiy Of Pittsburgh Soft tissue and bone augmentation and bulking utilizing muscle-derived progenitor cells, compositions and treatments thereof
US20020155096A1 (en) 2001-02-23 2002-10-24 Chancellor Michael B. Rapid preparation of stem cell matrices for use in tissue and organ treatment and repair
US20030082153A1 (en) * 2001-10-22 2003-05-01 The Government Of The United States Of America Stem cells that transform to beating cardiomyocytes
CN1665527A (zh) 2002-05-02 2005-09-07 普渡研究基金会 血管化增强的移植构造物
WO2003092381A1 (en) 2002-05-02 2003-11-13 Purdue Research Foundation Vascularization enhanced graft constructs
US9492267B2 (en) 2002-05-02 2016-11-15 Cook Biotech Incorporated Cell-seeded extracellular matrix grafts
EP1503652A4 (en) 2002-05-02 2006-02-08 Purdue Research Foundation HYBRID GRAFTS WITH IMPROVED VASCULARIZATION
JP4764626B2 (ja) * 2002-05-06 2011-09-07 ベクトン・ディキンソン・アンド・カンパニー 薬剤の薬物動力学を制御する方法およびデバイス
WO2004017972A1 (en) * 2002-08-23 2004-03-04 Law Peter K Biologic skin repair and enhancement
CN103230415B (zh) * 2003-04-25 2016-05-04 匹兹堡大学联邦制高等教育 用于促进和增强神经修复和再生的肌肉来源的细胞(mdc)
WO2005065079A2 (en) 2003-11-10 2005-07-21 Angiotech International Ag Medical implants and fibrosis-inducing agents
WO2005070328A1 (en) 2004-01-09 2005-08-04 Regeneration Technologies, Inc. Muscle-based grafts/implants
US7001430B2 (en) 2004-01-09 2006-02-21 Regeneration Technologies, Inc. Matrix composition for human grafts/implants
WO2005070439A1 (en) 2004-01-09 2005-08-04 Regeneration Technologies Inc. Implant comprising a human muscle tissue matrix
CA2607975A1 (en) * 2005-05-30 2006-12-07 Commonwealth Scientific And Industrial Research Organisation Preparation and use of basement membrane particles
US20070065415A1 (en) * 2005-09-16 2007-03-22 Kleinsek Donald A Compositions and methods for the augmentation and repair of defects in tissue
US7815923B2 (en) 2005-12-29 2010-10-19 Cook Biotech Incorporated Implantable graft material
AU2007325698B2 (en) * 2006-11-28 2014-03-20 University Of Pittsburgh Muscle derived cells for the treatment of cardiac pathologies and methods of making and using the same
US9121009B2 (en) 2006-12-18 2015-09-01 University of Pittsburgh—Of the Commonweath System of Higher Education Muscle derived cells for the treatment of gastro-esophageal pathologies and methods of making and using the same
US20100158875A1 (en) 2006-12-18 2010-06-24 University Of Pittsburgh - Of The Commonwealth System Of Higher Education Muscle derived cells for the treatment of gastro-esophageal pathologies and methods of making and using the same
JP5425641B2 (ja) 2007-01-11 2014-02-26 ユニバーシティー オブ ピッツバーグ − オブ ザ コモンウェルス システム オブ ハイヤー エデュケーション 尿路病状の処置のための筋由来細胞ならびにその作製および使用の方法
CA2722758C (en) * 2007-05-29 2017-04-25 Thomas Payne Bone augmentation utilizing muscle-derived progenitor compositions, and treatments thereof
JP5687059B2 (ja) * 2007-10-04 2015-03-18 ユニバーシティー オブ ピッツバーグ − オブ ザ コモンウェルス システム オブ ハイヤー エデュケーション 筋肉誘導前駆体組成物を利用した骨格筋の強化およびその処置
AU2009282619B2 (en) 2008-08-18 2015-08-20 University Of Pittsburgh - Of The Commonwealth System Of Higher Education Bone augmentation utilizing muscle-derived progenitor compositions in biocompatible matrix, and treatments thereof
US20130123647A1 (en) 2011-05-03 2013-05-16 The Research Foundation Of State University Of New York Methods Useful in Optimizing the Treatment of Neuropathies and Targeting Tissues with Cosmetic Botulinum Injections
US9878071B2 (en) 2013-10-16 2018-01-30 Purdue Research Foundation Collagen compositions and methods of use
EP3185922B1 (en) 2014-08-27 2025-04-02 Purdue Research Foundation Collagen-based therapeutic delivery systems
US11919941B2 (en) 2015-04-21 2024-03-05 Purdue Research Foundation Cell-collagen-silica composites and methods of making and using the same
CA3052266A1 (en) 2017-01-31 2018-08-09 Geniphys, Llc Methods and compositions for matrix preparation
US11739291B2 (en) 2017-04-25 2023-08-29 Purdue Research Foundation 3-dimensional (3D) tissue-engineered muscle for tissue restoration
IL309687A (en) 2017-12-14 2024-02-01 Innovacell Biotechnologie Ag Methods for obtaining cells extracted from muscle
IL286509B1 (en) 2019-03-22 2026-04-01 Innovacell Gmbh Methods for obtaining induced smooth muscle cells
EP3778875A1 (en) * 2019-08-14 2021-02-17 MaxiVax SA Immortalized myoblast cell lines and uses thereof
EP4096635A4 (en) 2020-01-27 2024-02-21 GeniPhys, Inc. BIOLOGICAL FILLER FOR TISSUE RESTORATION AND REGENERATION
IL319288A (en) 2022-09-02 2025-04-01 Universit?T Z?Rich Injection device
EP4622706A1 (en) 2022-11-21 2025-10-01 Ecole Polytechnique Fédérale de Lausanne (EPFL) System for control of spasticity
CN120283042A (zh) 2022-12-01 2025-07-08 苏黎世大学 肌肉前体细胞(mpc)大规模培养物的制备方法及其用途
JP2025041170A (ja) * 2023-09-13 2025-03-26 昌毅 本田 肛門狭窄化治療法

Family Cites Families (78)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4424208A (en) 1982-01-11 1984-01-03 Collagen Corporation Collagen implant material and method for augmenting soft tissue
US4851521A (en) 1985-07-08 1989-07-25 Fidia, S.P.A. Esters of hyaluronic acid
US5863531A (en) * 1986-04-18 1999-01-26 Advanced Tissue Sciences, Inc. In vitro preparation of tubular tissue structures by stromal cell culture on a three-dimensional framework
US5902741A (en) * 1986-04-18 1999-05-11 Advanced Tissue Sciences, Inc. Three-dimensional cartilage cultures
US5510254A (en) * 1986-04-18 1996-04-23 Advanced Tissue Sciences, Inc. Three dimensional cell and tissue culture system
US5266480A (en) * 1986-04-18 1993-11-30 Advanced Tissue Sciences, Inc. Three-dimensional skin culture system
US5053050A (en) * 1988-04-29 1991-10-01 Samuel Itay Compositions for repair of cartilage and bone
US5130141A (en) * 1988-05-24 1992-07-14 Law Peter K Compositions for and methods of treating muscle degeneration and weakness
US5082670A (en) * 1988-12-15 1992-01-21 The Regents Of The University Of California Method of grafting genetically modified cells to treat defects, disease or damage or the central nervous system
US5045601A (en) * 1989-06-13 1991-09-03 Biointerface Technologies, Inc. Pressure-sensitive adhesive compositions suitable for medical uses
US5538722A (en) 1989-06-13 1996-07-23 Stanford University Isolation, growth, differentiation and genetic engineering of human muscle cells
JP3040815B2 (ja) 1989-11-24 2000-05-15 モナッシュ・ユニバーシティ 随伴細胞に及ぼす白血病抑制因子の増殖作用
US5206028A (en) * 1991-02-11 1993-04-27 Li Shu Tung Dense collagen membrane matrices for medical uses
US6497872B1 (en) * 1991-07-08 2002-12-24 Neurospheres Holdings Ltd. Neural transplantation using proliferated multipotent neural stem cells and their progeny
AU3941293A (en) * 1992-04-06 1993-11-08 Uroplasty, Inc. Treatment of reflux disorder by microparticles injection
WO1994007999A1 (en) 1992-09-28 1994-04-14 Brown University Research Foundation Chitosan matrices for encapsulated cells
US5633001A (en) 1993-03-19 1997-05-27 Medinvent Composition and a method for tissue augmentation
US5709854A (en) 1993-04-30 1998-01-20 Massachusetts Institute Of Technology Tissue formation by injecting a cell-polymeric solution that gels in vivo
US6001654A (en) * 1994-01-28 1999-12-14 California Institute Of Technology Methods for differentiating neural stem cells to neurons or smooth muscle cells using TGT-β super family growth factors
US5656478A (en) * 1994-02-25 1997-08-12 The Regents Of The University Of California Smooth muscle tissue formation in vivo using cultured smooth muscle cells combined with an extracellular matrix
US6174333B1 (en) * 1994-06-06 2001-01-16 Osiris Therapeutics, Inc. Biomatrix for soft tissue regeneration using mesenchymal stem cells
US5516532A (en) * 1994-08-05 1996-05-14 Children's Medical Center Corporation Injectable non-immunogenic cartilage and bone preparation
US5594032A (en) * 1994-11-10 1997-01-14 Gonzalez-Cadavid; Nestor F. Amelioration of human erectile dysfunction by treatment with iNOS, inducers of iNOS or iNOS cDNA
SG99279A1 (en) 1994-12-13 2003-10-27 Peter K Law Myoblast therapy for cosmetic treatment
US7141072B2 (en) * 1998-10-05 2006-11-28 Ed. Geistlich Soehne Ag Fuer Chemische Industrie Method for promoting regeneration of surface cartilage in a damaged joint using multi-layer covering
US5833978A (en) * 1995-03-16 1998-11-10 Universite Laval Method of in vitro preconditioning healthy donor's myoblasts before transplantation thereof in compatible patients suffering of recessive myopathies like muscular dystrophy, for improving transplantation success
US5733337A (en) * 1995-04-07 1998-03-31 Organogenesis, Inc. Tissue repair fabric
US6121042A (en) * 1995-04-27 2000-09-19 Advanced Tissue Sciences, Inc. Apparatus and method for simulating in vivo conditions while seeding and culturing three-dimensional tissue constructs
US5855610A (en) * 1995-05-19 1999-01-05 Children's Medical Center Corporation Engineering of strong, pliable tissues
DE69637669D1 (de) * 1995-06-06 2008-10-16 Osiris Therapeutics Inc Myogene differenzierung menschlicher mesenchymaler stammzellen
US5591444A (en) 1995-07-28 1997-01-07 Isolagen Technologies, Inc. Use of autologous dermal fibroblasts for the repair of skin and soft tissue defects
US5869041A (en) * 1996-01-12 1999-02-09 The Miriam Hospital Delivery of bioactive compounds to an organism
US6200606B1 (en) * 1996-01-16 2001-03-13 Depuy Orthopaedics, Inc. Isolation of precursor cells from hematopoietic and nonhematopoietic tissues and their use in vivo bone and cartilage regeneration
US5858351A (en) * 1996-01-18 1999-01-12 Avigen, Inc. Methods for delivering DNA to muscle cells using recombinant adeno-associated virus vectors
US5876447A (en) 1996-02-14 1999-03-02 Implantech Associates Silicone implant for facial plastic surgery
US5842477A (en) * 1996-02-21 1998-12-01 Advanced Tissue Sciences, Inc. Method for repairing cartilage
US6299905B1 (en) * 1996-04-16 2001-10-09 Depuy Orthopaedics, Inc. Bioerodable polymeric adhesives for tissue repair
US5895745A (en) * 1996-09-25 1999-04-20 W.R. Grace & Co.-Conn. Method of thawing cryopreserved cells
US6150338A (en) 1997-02-13 2000-11-21 Albert Einstein College Of Medicine Of Yeshiva University Gene therapy for alleviating erectile dysfunction
US6337184B1 (en) * 1997-04-01 2002-01-08 Jeffrey B. Miller Molecular marker for muscle stem cells
US6110459A (en) 1997-05-28 2000-08-29 Mickle; Donald A. G. Transplants for myocardial scars and methods and cellular preparations
US6099832A (en) * 1997-05-28 2000-08-08 Genzyme Corporation Transplants for myocardial scars
US20020068048A1 (en) * 1997-09-05 2002-06-06 Patrick A. Dreyfus Method for the treatment or diagnosis of human pathologies with disseminated or difficult to access cells or tissues
US6171340B1 (en) * 1998-02-27 2001-01-09 Mcdowell Charles L. Method and device for regenerating cartilage in articulating joints
EP1059943B1 (en) * 1998-03-06 2004-12-01 Biosepra Medical Inc. Implantable particles for tissue bulking and the treatment of gastroesophageal reflux disease, urinary incontinence, and skin wrinkles
AU749675B2 (en) * 1998-03-13 2002-07-04 Mesoblast International Sarl Uses for human non-autologous mesenchymal stem cells
US6328960B1 (en) 1998-03-18 2001-12-11 Osiris Therapeutics, Inc. Mesenchymal stem cells for prevention and treatment of immune responses in transplantation
DK1604674T3 (da) 1998-05-01 2009-03-23 Univ Pittsburgh Anvendelse af myoblaster til fremstilling af et medikament til behandling af stressinkontinens
US6866842B1 (en) * 1998-05-01 2005-03-15 University Of Pittsburgh Muscle-derived cells (MDCs) for treating muscle-or bone-related injury or dysfunction
US7115417B1 (en) * 1998-05-01 2006-10-03 Chancellor Michael B Soft tissue and bone augmentation and bulking utilizing muscle-derived progenito compositions, and treatments thereof
AU3697899A (en) 1998-05-05 1999-11-23 Institut Fur Diagnostikforschung Gmbh An Der Freien Universitat Berlin Diagnostic agent for mr diagnosis
JP4341050B2 (ja) * 1998-06-05 2009-10-07 オルガノジェネシス インク. 生体工学により作成した血管移植片補綴
US6190893B1 (en) 1998-09-18 2001-02-20 Massachusetts Institute Of Technology Electroactive materials for stimulation of biological activity of bone marrow stromal cells
AU1626500A (en) 1998-11-16 2000-06-05 Osiris Therapeutics, Inc. Alginate layer system for chondrogenic differentiation of human mesenchymal stemcells
JP2000287683A (ja) 1999-04-08 2000-10-17 Frontier:Kk ニューロン生存活性を有する筋由来成分およびrna
US6328762B1 (en) * 1999-04-27 2001-12-11 Sulzer Biologics, Inc. Prosthetic grafts
US6306424B1 (en) * 1999-06-30 2001-10-23 Ethicon, Inc. Foam composite for the repair or regeneration of tissue
AU763021B2 (en) * 1999-09-14 2003-07-10 Children's Medical Center Corporation Isolation of muscle-derived stem cells and uses therefor
ATE369077T1 (de) * 1999-12-03 2007-08-15 Univ Leeds Wiederherstellung von beschädigtem gewebe
US6368859B1 (en) * 1999-12-29 2002-04-09 Children's Medical Center Corporation Methods and compositions for producing a fascial sling
HK1052645B (en) 2000-04-14 2008-03-20 Universtiy Of Pittsburgh Soft tissue and bone augmentation and bulking utilizing muscle-derived progenitor cells, compositions and treatments thereof
AU2006202380B2 (en) 2000-04-14 2007-06-21 University Of Pittsburgh Soft tissue and bone augmentation and bulking utilizing muscle-derived progenitor cells, compositions and treatments thereof
EP1276465B1 (en) * 2000-04-20 2014-03-12 Jagotec AG Improved water-insoluble drug particle process
FR2810045B1 (fr) * 2000-06-07 2004-09-03 Assist Publ Hopitaux De Paris Procede d'obtention de population cellulaires caracterisees d'origine musculaire et utilisations
CA2430554A1 (en) * 2000-12-01 2002-07-25 Nephros Therapeutics, Inc. Intravascular blood conditioning device and use thereof
US20020155096A1 (en) * 2001-02-23 2002-10-24 Chancellor Michael B. Rapid preparation of stem cell matrices for use in tissue and organ treatment and repair
CA2338124C (en) 2001-02-26 2010-08-03 Valerie Dumont Dicianna Self-tanning composition in sheeted substrate
US20030031651A1 (en) 2001-04-13 2003-02-13 Lee Ike W. Methods and reagents for cell transplantation
AU2003266282A1 (en) 2002-07-30 2004-02-23 Tigenix N.V. Compositions comprising muscle progenitor cells and uses thereof
CN103230415B (zh) 2003-04-25 2016-05-04 匹兹堡大学联邦制高等教育 用于促进和增强神经修复和再生的肌肉来源的细胞(mdc)
PL1789534T3 (pl) * 2004-08-16 2015-03-31 Cellresearch Corp Pte Ltd Wyodrębnienie komórek macierzystych/progenitorowych z błony owodniowej pępowiny
US20090221644A1 (en) * 2005-06-30 2009-09-03 Stuart Edward Bradley Gpcr Agonists
AU2007325698B2 (en) * 2006-11-28 2014-03-20 University Of Pittsburgh Muscle derived cells for the treatment of cardiac pathologies and methods of making and using the same
US9121009B2 (en) * 2006-12-18 2015-09-01 University of Pittsburgh—Of the Commonweath System of Higher Education Muscle derived cells for the treatment of gastro-esophageal pathologies and methods of making and using the same
JP5425641B2 (ja) 2007-01-11 2014-02-26 ユニバーシティー オブ ピッツバーグ − オブ ザ コモンウェルス システム オブ ハイヤー エデュケーション 尿路病状の処置のための筋由来細胞ならびにその作製および使用の方法
TW200902007A (en) 2007-05-25 2009-01-16 Astrazeneca Ab Spirocyclopropyl piperidine derivatives
CA2722758C (en) 2007-05-29 2017-04-25 Thomas Payne Bone augmentation utilizing muscle-derived progenitor compositions, and treatments thereof
AU2009282619B2 (en) 2008-08-18 2015-08-20 University Of Pittsburgh - Of The Commonwealth System Of Higher Education Bone augmentation utilizing muscle-derived progenitor compositions in biocompatible matrix, and treatments thereof

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WO2001078754A3 (en) 2002-04-25
US20170209495A1 (en) 2017-07-27
ES2288946T3 (es) 2008-02-01
WO2001078754A2 (en) 2001-10-25
EP1272204B1 (en) 2007-06-20
US9499791B2 (en) 2016-11-22
DK1272204T3 (da) 2007-09-10
US20210145892A1 (en) 2021-05-20
CA2406393C (en) 2012-10-02
JP2003531125A (ja) 2003-10-21
HK1052645B (en) 2008-03-20
PT1272204E (pt) 2007-10-02
DE60129007D1 (de) 2007-08-02
HK1052645A1 (en) 2003-09-26
CY1108090T1 (el) 2014-02-12
AU2001251599B2 (en) 2006-03-02
EP1272204A2 (en) 2003-01-08
JP5684963B2 (ja) 2015-03-18
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US20090098094A1 (en) 2009-04-16
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