ATE364704T1 - Mutanten von op-1 - Google Patents
Mutanten von op-1Info
- Publication number
- ATE364704T1 ATE364704T1 AT99954771T AT99954771T ATE364704T1 AT E364704 T1 ATE364704 T1 AT E364704T1 AT 99954771 T AT99954771 T AT 99954771T AT 99954771 T AT99954771 T AT 99954771T AT E364704 T1 ATE364704 T1 AT E364704T1
- Authority
- AT
- Austria
- Prior art keywords
- proteins
- finger
- domain
- sub
- tgf
- Prior art date
Links
- 102000004887 Transforming Growth Factor beta Human genes 0.000 abstract 3
- 108090001012 Transforming Growth Factor beta Proteins 0.000 abstract 3
- ZRKFYGHZFMAOKI-QMGMOQQFSA-N tgfbeta Chemical compound C([C@H](NC(=O)[C@H](C(C)C)NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@H](C)NC(=O)[C@H](CO)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](N)CCSC)C(C)C)[C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H](C)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(C)C)C(=O)N1[C@@H](CCC1)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(O)=O)C1=CC=C(O)C=C1 ZRKFYGHZFMAOKI-QMGMOQQFSA-N 0.000 abstract 3
- 102000035118 modified proteins Human genes 0.000 abstract 2
- 108091005573 modified proteins Proteins 0.000 abstract 2
- 102000004169 proteins and genes Human genes 0.000 abstract 2
- 108090000623 proteins and genes Proteins 0.000 abstract 2
- 150000001413 amino acids Chemical class 0.000 abstract 1
- 230000000921 morphogenic effect Effects 0.000 abstract 1
- 238000006467 substitution reaction Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/62—DNA sequences coding for fusion proteins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/70—Fusion polypeptide containing domain for protein-protein interaction
- C07K2319/74—Fusion polypeptide containing domain for protein-protein interaction containing a fusion for binding to a cell surface receptor
- C07K2319/75—Fusion polypeptide containing domain for protein-protein interaction containing a fusion for binding to a cell surface receptor containing a fusion for activation of a cell surface receptor, e.g. thrombopoeitin, NPY and other peptide hormones
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Genetics & Genomics (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Zoology (AREA)
- Biomedical Technology (AREA)
- Molecular Biology (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biotechnology (AREA)
- Biochemistry (AREA)
- Wood Science & Technology (AREA)
- General Engineering & Computer Science (AREA)
- Biophysics (AREA)
- Medicinal Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Toxicology (AREA)
- Microbiology (AREA)
- Plant Pathology (AREA)
- Gastroenterology & Hepatology (AREA)
- Physics & Mathematics (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US10341898P | 1998-10-07 | 1998-10-07 | |
| US09/374,958 US6677432B1 (en) | 1998-10-07 | 1999-08-16 | Mutations of the C-terminal portion of TGF-β superfamily proteins |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE364704T1 true ATE364704T1 (de) | 2007-07-15 |
Family
ID=26800441
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT99954771T ATE364704T1 (de) | 1998-10-07 | 1999-10-07 | Mutanten von op-1 |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US6677432B1 (de) |
| EP (1) | EP1117804B1 (de) |
| JP (3) | JP3971107B2 (de) |
| AT (1) | ATE364704T1 (de) |
| AU (1) | AU772930B2 (de) |
| CA (1) | CA2344974C (de) |
| DE (1) | DE69936312T2 (de) |
| WO (1) | WO2000020607A2 (de) |
Families Citing this family (37)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6919308B2 (en) * | 1988-04-08 | 2005-07-19 | Stryker Corporation | Osteogenic devices |
| DE68929453T2 (de) * | 1988-04-08 | 2003-11-20 | Stryker Corp., Kalamazoo | Osteogene Vorrichtungen |
| US6586388B2 (en) * | 1988-04-08 | 2003-07-01 | Stryker Corporation | Method of using recombinant osteogenic protein to repair bone or cartilage defects |
| US20030185792A1 (en) * | 1996-01-22 | 2003-10-02 | Curis, Inc. | Morphogen analogs of bone morphogenic proteins |
| WO1997026277A2 (en) * | 1996-01-22 | 1997-07-24 | Creative Biomolecules, Inc. | Morphogen analogs and methods for producing them |
| US6294662B1 (en) | 1996-08-27 | 2001-09-25 | University Of South Florida | Nucleic acids encoding an endometrial bleeding associated factor (ebaf) |
| US7211644B1 (en) * | 1996-08-27 | 2007-05-01 | University Of South Florida | Diagnostic markers of human female infertility |
| US8106001B2 (en) * | 1996-08-27 | 2012-01-31 | University Of South Florida | Diagnostic markers of human female infertility |
| US6683156B1 (en) | 1996-08-27 | 2004-01-27 | University Of South Florida | Method for diagnosing selected adenocarcinomas |
| WO2000020449A2 (en) * | 1998-10-07 | 2000-04-13 | Stryker Corporation | MODIFIED TGF-β SUPERFAMILY PROTEINS |
| DE10026713A1 (de) * | 2000-05-30 | 2001-12-06 | Walter Sebald | Mutein einer Kette eines Proteins aus der Superfamilie des Wachstumsfaktors TGF-beta |
| JP4685294B2 (ja) * | 2001-09-18 | 2011-05-18 | 株式会社カネカ | 新規ペプチド、生産方法、新規吸着体、吸着器および吸着方法 |
| ES2397327T3 (es) * | 2002-06-17 | 2013-03-06 | Thrasos, Inc. | Compuestos asociados a un dominio único de TDF y análogos de los mismos |
| AU2003283155A1 (en) | 2002-11-14 | 2004-06-03 | Adherex Technologies Inc. | Compounds and methods for modulating functions of classical cadherins |
| AU2005230854A1 (en) * | 2004-03-31 | 2005-10-20 | Xencor, Inc | BMP-7 variants with improved properties |
| US7795389B2 (en) | 2004-09-28 | 2010-09-14 | The Board Of Regents Of The University Of Texas System | Antagonizing TGF-beta activity with various ectodomains TGF-beta receptors used in combination or as fusion proteins |
| EP1698691A1 (de) * | 2005-03-04 | 2006-09-06 | Biopharm Gesellschaft zur biotechnologischen Entwicklung von Pharmaka mbH | Mutanten von Wachstumsfaktoren mit verbesserter biologischer Eigenschaft |
| US7807627B2 (en) * | 2005-05-27 | 2010-10-05 | Bbs-Bioactive Bone Substitutes Oy | Bone morphogenetic protein 4 and osteogenic devices and pharmaceutical products containing thereof |
| US7659250B2 (en) * | 2005-12-22 | 2010-02-09 | Centocor, Inc. | BMP-7 variant compositions, methods and uses |
| GB0604966D0 (en) | 2006-03-11 | 2006-04-19 | Renovo Ltd | Medicaments and proteins |
| GB0604938D0 (en) * | 2006-03-11 | 2006-04-19 | Renovo Ltd | Proteins, nucleic acids and medicaments |
| GB0604964D0 (en) | 2006-03-11 | 2006-04-19 | Renovo Ltd | Protein folding |
| EP2056852A4 (de) * | 2006-07-27 | 2010-01-13 | Centocor Ortho Biotech Inc | Bmp-7-varianten-zusammensetzungen, verfahren und verwendungen |
| ES2447516T3 (es) | 2006-12-21 | 2014-03-12 | Stryker Corporation | Formulaciones de liberación sostenida que comprenden cristales BMP-7 |
| US20100204123A1 (en) | 2009-02-12 | 2010-08-12 | Mary Elizabeth Pecquet Goad | Peripheral Administration of Proteins Including TGF-beta Superfamily Members for Treatment of Systemic Disorders and Disease |
| CA2752160A1 (en) | 2009-02-12 | 2010-08-19 | Stryker Corporation | Compositions and methods for minimally-invasive systemic delivery of proteins including tgf-.beta. superfamily members |
| EP2401293B1 (de) | 2009-02-24 | 2016-02-10 | The Salk Institute For Biological Studies | Designer-liganden der tgf-beta-superfamilie |
| US20120148539A1 (en) | 2009-03-24 | 2012-06-14 | Moulay Hicham Alaoui-Ismaili | Methods and Compositions for Tissue Engineering |
| US20110224138A1 (en) | 2009-09-09 | 2011-09-15 | Julie Krop | Methods for treating pain induced by injuries and diseases of an articular joint |
| AU2010295509A1 (en) | 2009-09-17 | 2012-04-19 | Stryker Corporation | Buffers for controlling the pH of bone morphogenetic proteins |
| EP2516456A1 (de) | 2009-12-22 | 2012-10-31 | Stryker Corporation | Bmp-7-varianten mit reduzierter immunogenität |
| CU24181B1 (es) * | 2012-11-09 | 2016-04-25 | Ct De Inmunología Molecular | POLIPÉPTIDOS DERIVADOS DEL TGFß |
| EP3240563B1 (de) | 2014-12-29 | 2020-12-09 | Bioventus LLC | Systeme und verfahren zur verbesserten freisetzung von osteoinduktiven moleküle zur knochenreparatur |
| US11578110B2 (en) | 2015-08-25 | 2023-02-14 | Histide Ag | Compounds for inducing tissue formation and uses thereof |
| CN109311957A (zh) * | 2015-08-25 | 2019-02-05 | 伊斯迪德股份公司 | 诱导组织形成的化合物及其应用 |
| CN109415425A (zh) | 2016-05-31 | 2019-03-01 | 财团法人牧岩生命科学研究所 | TGF-β超家族的AB6家族设计配体 |
| EP3878856A4 (de) * | 2018-11-05 | 2022-07-13 | Ajinomoto Co., Inc. | Verfahren zur herstellung eines rückgefalteten proteins unter verwendung eines strömungsmikroreaktors und proteinrückfaltungsvorrichtung |
Family Cites Families (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5250302A (en) | 1988-04-08 | 1993-10-05 | Stryker Corporation | Osteogenic devices |
| US5266683A (en) | 1988-04-08 | 1993-11-30 | Stryker Corporation | Osteogenic proteins |
| US5011691A (en) | 1988-08-15 | 1991-04-30 | Stryker Corporation | Osteogenic devices |
| JP2845346B2 (ja) | 1989-10-17 | 1999-01-13 | ストライカー・コーポレーション | 骨形成具 |
| JPH05501500A (ja) | 1989-10-18 | 1993-03-25 | クリエイティブ・バイオマリキュールズ・インコーポレーテッド | ＴＧＦ―βの生合成構築物 |
| GB8927546D0 (en) | 1989-12-06 | 1990-02-07 | Ciba Geigy | Process for the production of biologically active tgf-beta |
| US5071655A (en) * | 1990-01-12 | 1991-12-10 | Baylink David J | Pharmaceutical combination for treatment of bone-wasting diseases |
| AU660019B2 (en) | 1991-03-11 | 1995-06-08 | Stryker Corporation | Protein-induced morphogenesis |
| DE4131545C2 (de) | 1991-09-21 | 1995-02-02 | Krupp Industrietech | Federbein für hydraulischen Radantrieb |
| EP1439190A1 (de) | 1993-01-12 | 2004-07-21 | The Johns Hopkins University School Of Medicine | Growth differentiation factor-5 |
| JPH09503903A (ja) | 1993-07-09 | 1997-04-22 | ザ ジョーンズ ホプキンス ユニバーシティー スクール オブ メディシン | 増殖分化因子−６ |
| DK0733109T3 (da) | 1993-12-07 | 2006-07-03 | Genetics Inst Llc | BMP-12, BMP-13 og seneinducerende præparater dermed |
| US5399677A (en) | 1993-12-07 | 1995-03-21 | Genetics Institute, Inc. | Mutants of bone morphogenetic proteins |
| FR2720069A1 (fr) | 1994-05-19 | 1995-11-24 | Inst Nat Sante Rech Med | Dérivés de facteurs de croissance et d'hormones de la superfamille des TGFB, procédé pour leur obtention et leurs applications biologiques. |
| US5674292A (en) | 1995-06-07 | 1997-10-07 | Stryker Corporation | Terminally sterilized osteogenic devices and preparation thereof |
-
1999
- 1999-08-16 US US09/374,958 patent/US6677432B1/en not_active Expired - Lifetime
- 1999-10-07 AT AT99954771T patent/ATE364704T1/de not_active IP Right Cessation
- 1999-10-07 WO PCT/US1999/023371 patent/WO2000020607A2/en active IP Right Grant
- 1999-10-07 EP EP99954771A patent/EP1117804B1/de not_active Expired - Lifetime
- 1999-10-07 CA CA2344974A patent/CA2344974C/en not_active Expired - Fee Related
- 1999-10-07 JP JP2000574702A patent/JP3971107B2/ja not_active Expired - Fee Related
- 1999-10-07 DE DE69936312T patent/DE69936312T2/de not_active Expired - Lifetime
- 1999-10-07 AU AU11038/00A patent/AU772930B2/en not_active Ceased
-
2005
- 2005-06-17 JP JP2005178654A patent/JP4294010B2/ja not_active Expired - Fee Related
-
2008
- 2008-05-20 JP JP2008132454A patent/JP5149070B2/ja not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| AU772930B2 (en) | 2004-05-13 |
| WO2000020607A9 (en) | 2001-03-29 |
| DE69936312D1 (de) | 2007-07-26 |
| WO2000020607A3 (en) | 2000-07-06 |
| DE69936312T2 (de) | 2008-02-14 |
| AU1103800A (en) | 2000-04-26 |
| CA2344974C (en) | 2011-03-29 |
| JP4294010B2 (ja) | 2009-07-08 |
| EP1117804A2 (de) | 2001-07-25 |
| JP2002526115A (ja) | 2002-08-20 |
| WO2000020607A2 (en) | 2000-04-13 |
| CA2344974A1 (en) | 2000-04-13 |
| EP1117804B1 (de) | 2007-06-13 |
| JP2005290016A (ja) | 2005-10-20 |
| JP5149070B2 (ja) | 2013-02-20 |
| JP2008237223A (ja) | 2008-10-09 |
| JP3971107B2 (ja) | 2007-09-05 |
| US6677432B1 (en) | 2004-01-13 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |