ATE364080T1 - Erbb4 rezeptor-spezifisches neuregulin, verwandte liganden und deren verwendungen - Google Patents
Erbb4 rezeptor-spezifisches neuregulin, verwandte liganden und deren verwendungenInfo
- Publication number
- ATE364080T1 ATE364080T1 AT98931677T AT98931677T ATE364080T1 AT E364080 T1 ATE364080 T1 AT E364080T1 AT 98931677 T AT98931677 T AT 98931677T AT 98931677 T AT98931677 T AT 98931677T AT E364080 T1 ATE364080 T1 AT E364080T1
- Authority
- AT
- Austria
- Prior art keywords
- domain
- neuregulin
- nrg3
- nucleotide sequences
- related ligands
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/475—Growth factors; Growth regulators
- C07K14/4756—Neuregulins, i.e. p185erbB2 ligands, glial growth factor, heregulin, ARIA, neu differentiation factor
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
- A61P21/04—Drugs for disorders of the muscular or neuromuscular system for myasthenia gravis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/16—Otologicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Toxicology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Gastroenterology & Hepatology (AREA)
- Psychology (AREA)
- Zoology (AREA)
- Psychiatry (AREA)
- Heart & Thoracic Surgery (AREA)
- Hematology (AREA)
- Diabetes (AREA)
- Cardiology (AREA)
- Hospice & Palliative Care (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Pain & Pain Management (AREA)
- Obesity (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Dermatology (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US5201997P | 1997-07-09 | 1997-07-09 | |
US08/899,437 US6121415A (en) | 1997-07-09 | 1997-07-24 | ErbB4 receptor-specific neuregolin related ligands and uses therefor |
Publications (1)
Publication Number | Publication Date |
---|---|
ATE364080T1 true ATE364080T1 (de) | 2007-06-15 |
Family
ID=26730070
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AT98931677T ATE364080T1 (de) | 1997-07-09 | 1998-06-30 | Erbb4 rezeptor-spezifisches neuregulin, verwandte liganden und deren verwendungen |
Country Status (11)
Country | Link |
---|---|
US (6) | US6121415A (de) |
EP (1) | EP1009826B1 (de) |
JP (2) | JP4481485B2 (de) |
AT (1) | ATE364080T1 (de) |
AU (1) | AU738465B2 (de) |
CA (1) | CA2296807C (de) |
DE (1) | DE69837884T2 (de) |
ES (1) | ES2288764T3 (de) |
IL (2) | IL133699A0 (de) |
NZ (1) | NZ501915A (de) |
WO (1) | WO1999002681A1 (de) |
Families Citing this family (32)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7049409B2 (en) * | 1997-06-17 | 2006-05-23 | Human Genome Sciences, Inc. | Heregulin-like factor antibodies |
US6727077B1 (en) | 1997-06-17 | 2004-04-27 | Human Genome Sciences, Inc. | Heregulin-like factor |
EP1001981A4 (de) * | 1997-06-17 | 2000-09-27 | Human Genome Sciences Inc | Heregulin-ähnlicher faktor |
ZA986077B (en) * | 1997-07-09 | 2000-01-10 | Genentech Inc | ErbB4 receptor-specific neuregulin related ligands and uses therefor. |
US6121415A (en) * | 1997-07-09 | 2000-09-19 | Genentech, Inc. | ErbB4 receptor-specific neuregolin related ligands and uses therefor |
EP1146893A1 (de) * | 1998-12-11 | 2001-10-24 | Tejvir S. Khurana | Von neuriten abstammende wachstumsfaktoren zur behandlung von muskeldystrophy |
AUPP785098A0 (en) * | 1998-12-21 | 1999-01-21 | Victor Chang Cardiac Research Institute, The | Treatment of heart disease |
US6635249B1 (en) * | 1999-04-23 | 2003-10-21 | Cenes Pharmaceuticals, Inc. | Methods for treating congestive heart failure |
WO2001014415A2 (en) * | 1999-08-20 | 2001-03-01 | Chiron Corporation | Egfh2 genes and gene products |
US6825333B1 (en) | 1999-08-20 | 2004-11-30 | Chiron Corporation | EGFH2 genes and gene products |
US20020119148A1 (en) | 2000-09-01 | 2002-08-29 | Gerritsen Mary E. | ErbB4 antagonists |
US6335190B1 (en) * | 2000-10-20 | 2002-01-01 | New England Biolabs, Inc. | Method for cloning and producing the BsmI restriction endonuclease in E. coli |
US6413758B1 (en) * | 2000-10-20 | 2002-07-02 | New England Biolabs, Inc. | Method for cloning and expression of Bpml restriction endonuclease in E. coli |
JP2005527490A (ja) * | 2002-01-18 | 2005-09-15 | イノヴィオ アーエス | 筋肉内投与のための二重特異性抗体dna構築物 |
WO2003099320A1 (en) | 2002-05-24 | 2003-12-04 | Zensun (Shanghai) Sci-Tech.Ltd | Neuregulin based methods and compositions for treating viral myocarditis and dilated cardiomyopathy |
US20040223966A1 (en) * | 2002-10-25 | 2004-11-11 | Wolfman Neil M. | ActRIIB fusion polypeptides and uses therefor |
BRPI0406724A (pt) * | 2003-01-13 | 2005-12-20 | Macrogenics Inc | Proteìna de fusão dimérica, métodos de tratar, prevenir ou melhorar um ou mais sintomas de um distúrbio autoimune e um ou mais sintomas de púrpura trombocitopênica idiopática, composição farmacêutica, ácido nucleico, vetor, célula hospedeira, método de produzir recombinantemente o polipeptìdeo, polipeptìdeo isolado, fragmento de qualquer um dos polipeptìdeos, e, molécula de ácido nucleico isolada |
GB0413005D0 (en) * | 2004-06-11 | 2004-07-14 | Coletica | Ligand |
CA2658326C (en) * | 2005-09-02 | 2013-04-23 | Morehouse School Of Medicine | Neuregulins for prevention and treatment of damage from acute assault on vascular and neuronal tissue |
US20070213264A1 (en) | 2005-12-02 | 2007-09-13 | Mingdong Zhou | Neuregulin variants and methods of screening and using thereof |
RU2457854C2 (ru) * | 2005-12-30 | 2012-08-10 | Цзэньсунь (Шанхай) Сайенс Энд Текнолоджи Лимитед | Длительное высвобождение нейрегулина для улучшения сердечной функции |
US20100292209A1 (en) * | 2007-03-30 | 2010-11-18 | Massachusetts Institute Of Technology | Methods for identifying compounds that modulate neurotrophic factor signaling |
US20090291893A1 (en) * | 2008-05-23 | 2009-11-26 | Morehouse School Of Medicine | Compositions for the prevention and treatment of neuroinjury and methods of use thereof |
CA2744512C (en) | 2008-11-25 | 2018-05-15 | Genentech, Inc. | Isoform specific anti-her4 antibodies |
EP2399129B1 (de) | 2009-02-20 | 2015-11-25 | Michael P. Lisanti | Verfahren zur diagnose bzw. prognose eines neoplasmas einschliesslich der bestimmung des expressionsgrads eines proteins in stromazellen neben dem neoplasma |
EP2536748B1 (de) | 2010-02-18 | 2014-08-20 | Genentech, Inc. | Neuregulin-antagonisten und ihre verwendung zur behandlung von krebs |
US20130058871A1 (en) * | 2011-07-28 | 2013-03-07 | Howard Hughes Medical Institute | Method and system for mapping synaptic connectivity using light microscopy |
WO2013053076A1 (en) | 2011-10-10 | 2013-04-18 | Zensun (Shanghai)Science & Technology Limited | Compositions and methods for treating heart failure |
WO2014051567A1 (en) * | 2012-09-26 | 2014-04-03 | Morehouse School Of Medicine | Chimeric neuregulins and method of making and use thereof |
US10377984B2 (en) | 2013-11-27 | 2019-08-13 | Kaneka Corporation | Cell culture medium and culture method using the same |
WO2019005871A1 (en) * | 2017-06-26 | 2019-01-03 | City Of Hope | METHODS FOR CULTURE OF CELLS OF THE ISLANDS OF LANGERHANS |
RU2682175C1 (ru) * | 2018-07-04 | 2019-03-15 | Федеральное государственное бюджетное образовательное учреждение высшего образования "Пермский государственный медицинский университет имени академика Е.А. Вагнера" Министерства здравоохранения Российской Федерации | Способ дифференциальной диагностики посттравматической и идиопатической эпилепсии |
Family Cites Families (14)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4892538A (en) * | 1987-11-17 | 1990-01-09 | Brown University Research Foundation | In vivo delivery of neurotransmitters by implanted, encapsulated cells |
US5011472A (en) * | 1988-09-06 | 1991-04-30 | Brown University Research Foundation | Implantable delivery system for biological factors |
US5225538A (en) * | 1989-02-23 | 1993-07-06 | Genentech, Inc. | Lymphocyte homing receptor/immunoglobulin fusion proteins |
DK0585368T3 (da) * | 1991-04-25 | 1998-03-16 | Univ Brown Res Found | Implanterbart biokompatibelt immunisolatorisk vehikel til afgivelse af udvalgte terapeutiske produkter |
US6087323A (en) * | 1992-04-03 | 2000-07-11 | Cambridge Neuroscience, Inc. | Use of neuregulins as modulators of cellular communication |
AU4528493A (en) * | 1992-06-04 | 1994-01-04 | Regents Of The University Of California, The | In vivo gene therapy with intron-free sequence of interest |
DK0802800T3 (da) * | 1993-08-12 | 2002-10-07 | Neurotech Sa | Biokompatible immunoisolatoriske kapsler indeholdende genetisk ændrede celler for levering af biologisk aktive molekyler |
US5770567A (en) * | 1994-11-14 | 1998-06-23 | Genentech, Inc. | Sensory and motor neuron derived factor (SMDF) |
JPH11505124A (ja) * | 1995-05-16 | 1999-05-18 | ブリストル−マイヤーズ・スクイブ・カンパニー | 組換えヒレグリンおよび受容体活性化後のその生物学的機能 |
US5912326A (en) * | 1995-09-08 | 1999-06-15 | President And Fellows Of Harvard College | Cerebellum-derived growth factors |
US6727077B1 (en) * | 1997-06-17 | 2004-04-27 | Human Genome Sciences, Inc. | Heregulin-like factor |
US7049409B2 (en) * | 1997-06-17 | 2006-05-23 | Human Genome Sciences, Inc. | Heregulin-like factor antibodies |
EP1001981A4 (de) | 1997-06-17 | 2000-09-27 | Human Genome Sciences Inc | Heregulin-ähnlicher faktor |
US6121415A (en) * | 1997-07-09 | 2000-09-19 | Genentech, Inc. | ErbB4 receptor-specific neuregolin related ligands and uses therefor |
-
1997
- 1997-07-24 US US08/899,437 patent/US6121415A/en not_active Expired - Lifetime
-
1998
- 1998-06-30 CA CA2296807A patent/CA2296807C/en not_active Expired - Lifetime
- 1998-06-30 ES ES98931677T patent/ES2288764T3/es not_active Expired - Lifetime
- 1998-06-30 JP JP2000502177A patent/JP4481485B2/ja not_active Expired - Lifetime
- 1998-06-30 NZ NZ501915A patent/NZ501915A/xx not_active IP Right Cessation
- 1998-06-30 AT AT98931677T patent/ATE364080T1/de active
- 1998-06-30 DE DE69837884T patent/DE69837884T2/de not_active Expired - Lifetime
- 1998-06-30 IL IL13369998A patent/IL133699A0/xx active IP Right Grant
- 1998-06-30 WO PCT/US1998/013411 patent/WO1999002681A1/en active IP Right Grant
- 1998-06-30 AU AU81734/98A patent/AU738465B2/en not_active Expired
- 1998-06-30 EP EP98931677A patent/EP1009826B1/de not_active Expired - Lifetime
- 1998-07-30 US US09/126,121 patent/US6252051B1/en not_active Expired - Lifetime
-
1999
- 1999-12-23 IL IL133699A patent/IL133699A/en not_active IP Right Cessation
-
2002
- 2002-04-29 US US10/136,573 patent/US20020161200A1/en not_active Abandoned
- 2002-08-09 US US10/215,862 patent/US20030036166A1/en not_active Abandoned
-
2005
- 2005-01-14 US US11/035,787 patent/US20050136467A1/en not_active Abandoned
-
2006
- 2006-06-15 US US11/454,635 patent/US7846453B2/en not_active Expired - Fee Related
-
2008
- 2008-09-25 JP JP2008246657A patent/JP2009077716A/ja not_active Withdrawn
Also Published As
Publication number | Publication date |
---|---|
ES2288764T3 (es) | 2008-01-16 |
EP1009826B1 (de) | 2007-06-06 |
DE69837884D1 (de) | 2007-07-19 |
IL133699A (en) | 2007-03-08 |
US20070048822A1 (en) | 2007-03-01 |
US20020161200A1 (en) | 2002-10-31 |
US6121415A (en) | 2000-09-19 |
JP2009077716A (ja) | 2009-04-16 |
WO1999002681A1 (en) | 1999-01-21 |
CA2296807A1 (en) | 1999-01-21 |
NZ501915A (en) | 2002-08-28 |
AU738465B2 (en) | 2001-09-20 |
DE69837884T2 (de) | 2008-02-07 |
JP2003517260A (ja) | 2003-05-27 |
US20030036166A1 (en) | 2003-02-20 |
US6252051B1 (en) | 2001-06-26 |
CA2296807C (en) | 2011-08-23 |
IL133699A0 (en) | 2001-04-30 |
US7846453B2 (en) | 2010-12-07 |
AU8173498A (en) | 1999-02-08 |
US20050136467A1 (en) | 2005-06-23 |
EP1009826A1 (de) | 2000-06-21 |
JP4481485B2 (ja) | 2010-06-16 |
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