ATE360066T1 - Aus einer menschlichen glial zelllinie- abgeleiteter promotor eines neurotrophischen faktors, diesen enthaltende vektoren und methoden zum screenen von verbindungen damit - Google Patents

Aus einer menschlichen glial zelllinie- abgeleiteter promotor eines neurotrophischen faktors, diesen enthaltende vektoren und methoden zum screenen von verbindungen damit

Info

Publication number
ATE360066T1
ATE360066T1 AT98942603T AT98942603T ATE360066T1 AT E360066 T1 ATE360066 T1 AT E360066T1 AT 98942603 T AT98942603 T AT 98942603T AT 98942603 T AT98942603 T AT 98942603T AT E360066 T1 ATE360066 T1 AT E360066T1
Authority
AT
Austria
Prior art keywords
cell line
neurotrophic factor
derived neurotrophic
methods
glial cell
Prior art date
Application number
AT98942603T
Other languages
English (en)
Inventor
Preston Albert Baecker
Randolph Mellus Johnson
Walter Hom Lee
Adrian Neil Verity
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Application granted granted Critical
Publication of ATE360066T1 publication Critical patent/ATE360066T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/475—Growth factors; Growth regulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2830/00—Vector systems having a special element relevant for transcription
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2830/00—Vector systems having a special element relevant for transcription
    • C12N2830/80—Vector systems having a special element relevant for transcription from vertebrates
    • C12N2830/85—Vector systems having a special element relevant for transcription from vertebrates mammalian
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2840/00—Vectors comprising a special translation-regulating system
    • C12N2840/44—Vectors comprising a special translation-regulating system being a specific part of the splice mechanism, e.g. donor, acceptor

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Zoology (AREA)
  • General Health & Medical Sciences (AREA)
  • General Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Neurosurgery (AREA)
  • Medicinal Chemistry (AREA)
  • Neurology (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Molecular Biology (AREA)
  • Hospice & Palliative Care (AREA)
  • General Chemical & Material Sciences (AREA)
  • Microbiology (AREA)
  • Plant Pathology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Physics & Mathematics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Psychiatry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Toxicology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
AT98942603T 1997-08-05 1998-07-23 Aus einer menschlichen glial zelllinie- abgeleiteter promotor eines neurotrophischen faktors, diesen enthaltende vektoren und methoden zum screenen von verbindungen damit ATE360066T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US5481297P 1997-08-05 1997-08-05
US8175198P 1998-04-14 1998-04-14

Publications (1)

Publication Number Publication Date
ATE360066T1 true ATE360066T1 (de) 2007-05-15

Family

ID=26733548

Family Applications (1)

Application Number Title Priority Date Filing Date
AT98942603T ATE360066T1 (de) 1997-08-05 1998-07-23 Aus einer menschlichen glial zelllinie- abgeleiteter promotor eines neurotrophischen faktors, diesen enthaltende vektoren und methoden zum screenen von verbindungen damit

Country Status (7)

Country Link
EP (1) EP1002071B1 (de)
JP (1) JP3761152B2 (de)
AT (1) ATE360066T1 (de)
AU (1) AU737944B2 (de)
CA (1) CA2299586C (de)
DE (1) DE69837600T2 (de)
WO (1) WO1999007843A1 (de)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19816186A1 (de) * 1998-04-14 1999-10-21 Univ Muenchen L Maximilians GDNF-kodierende DNA, Teile davon und GDNF-Varianten
US20110003701A1 (en) * 2008-02-27 2011-01-06 454 Life Sciences Corporation System and method for improved processing of nucleic acids for production of sequencable libraries
WO2014152511A1 (en) 2013-03-15 2014-09-25 The Jackson Laboratory Methods for promoting wound healing and hair growth

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2119463C (en) * 1991-09-20 2003-09-16 Leu-Fen H. Lin Glial cell line-derived neutrophic factor
AU6975198A (en) * 1997-04-15 1998-11-11 University Of Medicine And Dentistry Of New Jersey Cdna for human gdnf and promoter therefor which allows regulated and constitutive expression

Also Published As

Publication number Publication date
JP2001512679A (ja) 2001-08-28
JP3761152B2 (ja) 2006-03-29
DE69837600D1 (de) 2007-05-31
DE69837600T2 (de) 2007-12-27
AU737944B2 (en) 2001-09-06
AU9067998A (en) 1999-03-01
WO1999007843A1 (en) 1999-02-18
EP1002071A1 (de) 2000-05-24
CA2299586A1 (en) 1999-02-18
CA2299586C (en) 2007-09-18
EP1002071B1 (de) 2007-04-18

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