ATE353963T1 - In-vitro-selektion and wahlweiser nachweis von polypeptiden unter verwendung von festphasenträgern - Google Patents

In-vitro-selektion and wahlweiser nachweis von polypeptiden unter verwendung von festphasenträgern

Info

Publication number
ATE353963T1
ATE353963T1 AT00946180T AT00946180T ATE353963T1 AT E353963 T1 ATE353963 T1 AT E353963T1 AT 00946180 T AT00946180 T AT 00946180T AT 00946180 T AT00946180 T AT 00946180T AT E353963 T1 ATE353963 T1 AT E353963T1
Authority
AT
Austria
Prior art keywords
library
fusion protein
polypeptides
solid phase
vitro selection
Prior art date
Application number
AT00946180T
Other languages
English (en)
Inventor
Per-Ake Nygren
Mathias Uhlen
Olof Nord
Original Assignee
Affibody Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Affibody Ab filed Critical Affibody Ab
Application granted granted Critical
Publication of ATE353963T1 publication Critical patent/ATE353963T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6811—Selection methods for production or design of target specific oligonucleotides or binding molecules
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
    • C12N15/1034—Isolating an individual clone by screening libraries
    • C12N15/1075—Isolating an individual clone by screening libraries by coupling phenotype to genotype, not provided for in other groups of this subclass

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Physics & Mathematics (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • Biomedical Technology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Analytical Chemistry (AREA)
  • Bioinformatics & Computational Biology (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Immunology (AREA)
  • Plant Pathology (AREA)
  • Peptides Or Proteins (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
AT00946180T 1999-07-20 2000-07-20 In-vitro-selektion and wahlweiser nachweis von polypeptiden unter verwendung von festphasenträgern ATE353963T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GBGB9917027.6A GB9917027D0 (en) 1999-07-20 1999-07-20 In vitro selection and optional identification of polypeptides using solid support carriers

Publications (1)

Publication Number Publication Date
ATE353963T1 true ATE353963T1 (de) 2007-03-15

Family

ID=10857605

Family Applications (1)

Application Number Title Priority Date Filing Date
AT00946180T ATE353963T1 (de) 1999-07-20 2000-07-20 In-vitro-selektion and wahlweiser nachweis von polypeptiden unter verwendung von festphasenträgern

Country Status (13)

Country Link
US (2) US6955877B1 (de)
EP (2) EP1200577B1 (de)
JP (1) JP2003505041A (de)
AT (1) ATE353963T1 (de)
AU (1) AU761985B2 (de)
CA (1) CA2379143A1 (de)
DE (1) DE60033402T2 (de)
DK (1) DK1200577T3 (de)
ES (1) ES2279761T3 (de)
GB (1) GB9917027D0 (de)
NO (1) NO20020276L (de)
WO (1) WO2001005808A2 (de)
ZA (1) ZA200200194B (de)

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EP1737982A4 (de) * 2004-04-14 2009-09-23 Harvard College Nukleinsäureprogrammierbare proteinanordnungen
US8796441B2 (en) * 2005-04-13 2014-08-05 The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services Human sweet and umami taste receptor variants
US8178316B2 (en) 2006-06-29 2012-05-15 President And Fellows Of Harvard College Evaluating proteins
US8906700B2 (en) 2007-11-06 2014-12-09 Ambergen, Inc. Methods and compositions for phototransfer
US8932879B2 (en) * 2007-11-06 2015-01-13 Ambergen, Inc. Methods and compounds for phototransfer
EP2090890A1 (de) 2008-02-15 2009-08-19 Atlas Antibodies AB RBM3 als Marker für die Brustkrebsprognose
WO2010086400A1 (en) 2009-01-30 2010-08-05 Atlas Antibodies Ab Combination treatment of breast cancer
US20110144198A1 (en) 2008-05-16 2011-06-16 Atlas Antibodies Ab Breast cancer prognostics
US9238810B2 (en) 2008-06-05 2016-01-19 Affibody Ab Polypeptide
KR101671537B1 (ko) 2008-08-11 2016-11-01 넥타르 테라퓨틱스 다분지형 중합체 알카노에이트 컨쥬게이트
EP2161577A1 (de) 2008-09-01 2010-03-10 Atlas Antibodies AB ANLN-Protein
EP2172477A1 (de) 2008-10-06 2010-04-07 Atlas Antibodies AB Neue Epitope und Verwendungen davon
EP2241889A1 (de) 2009-04-16 2010-10-20 Atlas Antibodies AB RBM3-Protein bei Kolorektalkrebsprognosen
EP2524928A1 (de) 2011-05-18 2012-11-21 Atlas Antibodies AB RBM3 in Blasenkrebs
US8632984B2 (en) 2009-02-16 2014-01-21 Atlas Antibodies Ab RBM3 as a marker for malignant melanoma prognosis
EP2293070A1 (de) 2009-08-13 2011-03-09 Atlas Antibodies AB Mittel und Verfahren zur Prognose von Eierstockkrebs
EP2259059A1 (de) 2009-05-29 2010-12-08 Atlas Antibodies AB Mittel und Verfahren zur Prognose von Eierstockkrebs
EP2315028A1 (de) 2009-10-26 2011-04-27 Atlas Antibodies AB PODXL-Protein bei Kolorektalkrebs
EP2390665A1 (de) 2010-05-27 2011-11-30 Atlas Antibodies AB Prostatakrebs-Biomarker
US9115204B2 (en) 2010-10-27 2015-08-25 Spiber Technologies Ab Spider silk fusion protein structures for binding to an organic target
WO2012088445A1 (en) 2010-12-22 2012-06-28 Nektar Therapeutics Multi-arm polymeric prodrug conjugates of cabazitaxel-based compounds
WO2012088422A1 (en) 2010-12-22 2012-06-28 Nektar Therapeutics Multi-arm polymeric prodrug conjugates of taxane-based compounds
WO2012110824A1 (en) 2011-02-18 2012-08-23 Astrazeneca Ab Binding agents with specificity for a nucleic acid modification
WO2012166555A1 (en) 2011-05-27 2012-12-06 Nektar Therapeutics Water - soluble polymer - linked binding moiety and drug compounds
EP2544007A1 (de) 2011-07-07 2013-01-09 Atlas Antibodies AB Biomarker für Nierenfunktionsstörung
EP2573566A1 (de) 2011-09-20 2013-03-27 Atlas Antibodies AB RBM3 bei Prostatakrebsprognosen
EP2602622A1 (de) 2011-12-07 2013-06-12 Atlas Antibodies AB Vorhersage der Reaktion auf eine Platinbasierte Therapie
WO2013098676A1 (en) 2011-12-30 2013-07-04 Grifols, S.A. Method for purifying factor viii
WO2013116698A2 (en) * 2012-02-02 2013-08-08 Invenra, Inc. High throughput screen for biologically active polypeptides
CA2872056A1 (en) 2012-05-02 2013-11-07 Spiber Technologies Ab Spider silk fusion protein structures without repetitive fragment for binding to an organic target
JP6302895B2 (ja) 2012-05-02 2018-03-28 スパイバー テクノロジーズ アーベーＳｐｉｂｅｒ Ｔｅｃｈｎｏｌｏｇｉｅｓ Ａｂ 親和性リガンドとして免疫グロブリン断片を組み込んだクモ糸融合タンパク質の構造
EP2746768A1 (de) 2012-12-20 2014-06-25 Atlas Antibodies AB PODXL bei Blasenkrebs
EP2787350A1 (de) 2013-04-05 2014-10-08 Atlas Antibodies AB ASRGL1 bei Gebärmutterschleimhautkrebs
EP3023791A1 (de) 2014-11-21 2016-05-25 Atlas Antibodies AB Vorhersage des Ansprechens auf Behandlung mit Gemcitabin
WO2016168771A2 (en) 2015-04-17 2016-10-20 Alpine Immune Sciences, Inc. Immunomodulatory proteins with tunable affinities

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US5994069A (en) * 1996-01-24 1999-11-30 Third Wave Technologies, Inc. Detection of nucleic acids by multiple sequential invasive cleavages
SE9400088D0 (sv) * 1994-01-14 1994-01-14 Kabi Pharmacia Ab Bacterial receptor structures
US6406848B1 (en) * 1997-05-23 2002-06-18 Lynx Therapeutics, Inc. Planar arrays of microparticle-bound polynucleotides
DK0985032T4 (da) 1997-05-28 2009-08-31 Crescendo Biolog Ltd Ribosom-komplekser som selektionspartikler til in vitro fremvisning og evolution af proteiner
US6368799B1 (en) * 1997-06-13 2002-04-09 Affymetrix, Inc. Method to detect gene polymorphisms and monitor allelic expression employing a probe array
DE69838521T2 (de) 1997-07-07 2008-05-21 Medical Research Council Methode zur Erhöhung der Konzentration von Nucleinsäuremolekülen
DE69841273D1 (de) * 1997-11-17 2009-12-17 Micromet Ag Verfahren zur identifikation von bindestellendomänen, die ihre epitopbindefähigkeit beibehalten
US6265163B1 (en) * 1998-01-09 2001-07-24 Lynx Therapeutics, Inc. Solid phase selection of differentially expressed genes

Also Published As

Publication number Publication date
EP1200577A2 (de) 2002-05-02
JP2003505041A (ja) 2003-02-12
GB9917027D0 (en) 1999-09-22
US20060035265A1 (en) 2006-02-16
NO20020276D0 (no) 2002-01-18
WO2001005808A2 (en) 2001-01-25
ZA200200194B (en) 2003-06-25
AU6005300A (en) 2001-02-05
EP1826270A1 (de) 2007-08-29
DE60033402T2 (de) 2007-11-29
AU761985B2 (en) 2003-06-12
DK1200577T3 (da) 2007-06-11
EP1200577B1 (de) 2007-02-14
US6955877B1 (en) 2005-10-18
DE60033402D1 (de) 2007-03-29
ES2279761T3 (es) 2007-09-01
CA2379143A1 (en) 2001-01-25
WO2001005808A3 (en) 2001-08-02
NO20020276L (no) 2002-03-15

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