ATE353222T1 - Eine mutante phospholamban moleküle und deren verwendung zur behandlung von herzkrankheiten und herzversagen - Google Patents

Eine mutante phospholamban moleküle und deren verwendung zur behandlung von herzkrankheiten und herzversagen

Info

Publication number
ATE353222T1
ATE353222T1 AT99960187T AT99960187T ATE353222T1 AT E353222 T1 ATE353222 T1 AT E353222T1 AT 99960187 T AT99960187 T AT 99960187T AT 99960187 T AT99960187 T AT 99960187T AT E353222 T1 ATE353222 T1 AT E353222T1
Authority
AT
Austria
Prior art keywords
phospholamban
treatment
mutant
molecule
heart failure
Prior art date
Application number
AT99960187T
Other languages
English (en)
Inventor
Kenneth Chien
Wolfgang Dillman
Susanne Minamisawa
Huaping He
Masahiko Hoshijima
Markus Meyer
Christopher Scott
Yibin Wang
Gregg J Silverman
Original Assignee
Univ California
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ California filed Critical Univ California
Application granted granted Critical
Publication of ATE353222T1 publication Critical patent/ATE353222T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/1703—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • A61K38/1709—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A01K2217/05—Animals comprising random inserted nucleic acids (transgenic)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2799/00—Uses of viruses
    • C12N2799/02—Uses of viruses as vector
    • C12N2799/021—Uses of viruses as vector for the expression of a heterologous nucleic acid
    • C12N2799/022—Uses of viruses as vector for the expression of a heterologous nucleic acid where the vector is derived from an adenovirus

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Zoology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Biophysics (AREA)
  • Immunology (AREA)
  • Hospice & Palliative Care (AREA)
  • Marine Sciences & Fisheries (AREA)
  • Toxicology (AREA)
  • Biochemistry (AREA)
  • Epidemiology (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
AT99960187T 1998-11-02 1999-11-02 Eine mutante phospholamban moleküle und deren verwendung zur behandlung von herzkrankheiten und herzversagen ATE353222T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US10671898P 1998-11-02 1998-11-02
US14588399P 1999-07-27 1999-07-27

Publications (1)

Publication Number Publication Date
ATE353222T1 true ATE353222T1 (de) 2007-02-15

Family

ID=26803944

Family Applications (1)

Application Number Title Priority Date Filing Date
AT99960187T ATE353222T1 (de) 1998-11-02 1999-11-02 Eine mutante phospholamban moleküle und deren verwendung zur behandlung von herzkrankheiten und herzversagen

Country Status (8)

Country Link
EP (1) EP1126866B1 (de)
JP (2) JP2002528512A (de)
CN (1) CN1354671A (de)
AT (1) ATE353222T1 (de)
AU (1) AU1711100A (de)
CA (1) CA2349758A1 (de)
DE (1) DE69935078T2 (de)
WO (1) WO2000025804A2 (de)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7745416B2 (en) * 1995-04-11 2010-06-29 The Regents Of The University Of California Method for in vivo regulation of cardiac muscle contractility
DE10027777A1 (de) * 2000-06-07 2001-12-13 Otogene Ag Transfektionsverfahren
ES2320975T3 (es) 2000-09-11 2009-06-01 The Regents Of The University Of California Mutante plb dominante negativo para su utilizacion en el tratamiento de enfermedades cardiacas.
US20040262226A1 (en) * 2001-08-01 2004-12-30 Atsushi Ikeda Blood purification apparatus for elevating purification efficiency
US20050037420A1 (en) * 2001-09-14 2005-02-17 Mei-Yun Zhang Immunoglobulin having particular framework scaffold and methods of making and using
EP1693451B1 (de) * 2003-11-21 2011-11-09 Daiichi Sankyo Company, Limited Verfahren zur anzucht von myokardzellen
EP2801366A3 (de) * 2004-09-02 2015-04-29 Cognosci, Inc. Verbesserte ApoE-Analoga und Verwendungsverfahren dafür
US20060198825A1 (en) * 2005-03-03 2006-09-07 Kaemmerer William F Reagents, methods and systems to suppress phospholamban expression
GB0518027D0 (en) * 2005-09-05 2005-10-12 Birkeland Innovasjon As Compounds
AU2008247564B2 (en) * 2007-05-02 2014-06-05 Intrexon Corporation PP1 ligands
US8221738B2 (en) 2008-02-19 2012-07-17 Celladon Corporation Method for enhanced uptake of viral vectors in the myocardium
US8609813B2 (en) 2009-06-22 2013-12-17 Health Research Inc. Prodrug anti-cancer therapy
CN103865945A (zh) * 2010-02-10 2014-06-18 中国人民解放军军事医学科学院放射与辐射医学研究所 Tat核心肽段在制备高效、可溶性表达的外源蛋白中的应用
US10208085B2 (en) * 2012-07-05 2019-02-19 Gwangju Institute Of Science And Technology Decoy peptides inhibiting protein phosphatase 1-mediated dephosphorylation of phospholamban
CN104193826B (zh) * 2014-09-17 2018-02-23 山东大学齐鲁医院 一种融合多肽及其在制备抗肿瘤药物中的应用
CN109890400B (zh) * 2016-10-24 2022-12-20 贝特基因公司 包含蛋白磷酸酶1抑制肽的血管疾病治疗用组合物
CN106831956B (zh) * 2017-03-29 2019-11-08 华中科技大学同济医学院附属协和医院 一种抗肿瘤多肽mudp-21及其应用
CN115354043B (zh) * 2022-07-08 2023-12-08 南京大学 一种动物模型

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5652122A (en) * 1989-12-21 1997-07-29 Frankel; Alan Nucleic acids encoding and methods of making tat-derived transport polypeptides
US6884600B1 (en) * 1996-03-30 2005-04-26 Medical Research Council London Protein phosphatase-1 catalytic subunit interactions
FR2753722A1 (fr) * 1996-09-26 1998-03-27 Smithkline Beecham Lab Procede de detection de modulateurs de relaxation cardiaque et modulateurs ainsi obtenus
US5968959A (en) * 1997-12-12 1999-10-19 Orion Corporation Method for the prevention and treatment of stunned myocardium

Also Published As

Publication number Publication date
CN1354671A (zh) 2002-06-19
EP1126866B1 (de) 2007-02-07
DE69935078D1 (de) 2007-03-22
WO2000025804A9 (en) 2001-12-06
CA2349758A1 (en) 2000-05-11
JP2008037870A (ja) 2008-02-21
AU1711100A (en) 2000-05-22
EP1126866A2 (de) 2001-08-29
JP2002528512A (ja) 2002-09-03
WO2000025804A2 (en) 2000-05-11
WO2000025804A3 (en) 2000-10-05
DE69935078T2 (de) 2007-11-15

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