ATE348632T1 - Prion protein peptide und deren verwendung - Google Patents

Prion protein peptide und deren verwendung

Info

Publication number
ATE348632T1
ATE348632T1 AT00941708T AT00941708T ATE348632T1 AT E348632 T1 ATE348632 T1 AT E348632T1 AT 00941708 T AT00941708 T AT 00941708T AT 00941708 T AT00941708 T AT 00941708T AT E348632 T1 ATE348632 T1 AT E348632T1
Authority
AT
Austria
Prior art keywords
prion protein
protein peptides
prp
therapeutic
antibodies specific
Prior art date
Application number
AT00941708T
Other languages
English (en)
Inventor
Neil R Cashman
Eustache Paramithiotis
Jacek Slon-Usakiewicz
Ashkan Haghighat
Marc Pinard
Trebor Lawton
Original Assignee
Caprion Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=22492135&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ATE348632(T1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Caprion Pharmaceuticals Inc filed Critical Caprion Pharmaceuticals Inc
Application granted granted Critical
Publication of ATE348632T1 publication Critical patent/ATE348632T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/10—Tetrapeptides
    • C07K5/1002—Tetrapeptides with the first amino acid being neutral
    • C07K5/1005—Tetrapeptides with the first amino acid being neutral and aliphatic
    • C07K5/1008—Tetrapeptides with the first amino acid being neutral and aliphatic the side chain containing 0 or 1 carbon atoms, i.e. Gly, Ala
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/10—Tetrapeptides
    • C07K5/1002—Tetrapeptides with the first amino acid being neutral
    • C07K5/1005—Tetrapeptides with the first amino acid being neutral and aliphatic
    • C07K5/1013—Tetrapeptides with the first amino acid being neutral and aliphatic the side chain containing O or S as heteroatoms, e.g. Cys, Ser
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/52—Constant or Fc region; Isotype

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Zoology (AREA)
  • Peptides Or Proteins (AREA)
  • Toxicology (AREA)
  • Hospice & Palliative Care (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Psychiatry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Enzymes And Modification Thereof (AREA)
AT00941708T 1999-06-23 2000-06-23 Prion protein peptide und deren verwendung ATE348632T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US14063499P 1999-06-23 1999-06-23

Publications (1)

Publication Number Publication Date
ATE348632T1 true ATE348632T1 (de) 2007-01-15

Family

ID=22492135

Family Applications (1)

Application Number Title Priority Date Filing Date
AT00941708T ATE348632T1 (de) 1999-06-23 2000-06-23 Prion protein peptide und deren verwendung

Country Status (12)

Country Link
EP (1) EP1194164B8 (de)
JP (1) JP2003521477A (de)
CN (1) CN1370078A (de)
AT (1) ATE348632T1 (de)
AU (1) AU783484B2 (de)
CA (1) CA2377648A1 (de)
DE (1) DE60032486T2 (de)
ES (1) ES2278617T3 (de)
HK (1) HK1048955A1 (de)
MX (1) MXPA01013186A (de)
NZ (1) NZ516240A (de)
WO (1) WO2000078344A1 (de)

Families Citing this family (37)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7041807B1 (en) 1999-06-23 2006-05-09 Caprion Pharmaceuticals, Inc. Antibodies to a YYX epitope of a mammalian prion protein
EP1294759A1 (de) * 2000-06-26 2003-03-26 Universität Zürich Prionen-bindungsaktivtiät in serum und plasma bestimmt als plasminogen und fibrinogen
US7303907B2 (en) 2001-01-08 2007-12-04 Health Protection Agency Degradation and detection of TSE infectivity
GB2376071A (en) * 2001-05-31 2002-12-04 Mini Agriculture & Fisheries Method for typing a TSE strain
GB2379737A (en) * 2001-09-05 2003-03-19 Univ Geneve Diagnostic method for spongiform encephalopathy disease
WO2003040685A2 (en) * 2001-11-09 2003-05-15 King's College London Diagnosis demyelinating or spongiform disease
AU2003205623A1 (en) * 2002-01-18 2003-07-30 Cytos Biotechnology Ag Prion protein carrier-conjugates
EP1572937B1 (de) 2002-04-09 2012-02-08 The Scripps Research Institute Hybrid-polypeptide mit eingefügten sequenzmotiven und ihre verwendungen
EP1382971A1 (de) * 2002-07-17 2004-01-21 Pepscan Systems B.V. Nachweis von Prion Erkrankung
US20040072236A1 (en) * 2002-09-27 2004-04-15 Neil Cashman PrPSc -interacting molecules and uses thereof
EP2211181A1 (de) * 2002-10-30 2010-07-28 Proteome Sciences Plc Methoden um übertragbare Spongiforme Enzephalopathien zu diagnostizieren
GB0227886D0 (en) * 2002-11-29 2003-01-08 Medical Res Council Prion inhibition
MXPA05005920A (es) * 2002-12-03 2006-03-17 American Nat Red Cross Ligandos de proteina prion y metodos de uso.
US20040192887A1 (en) * 2003-03-25 2004-09-30 Ralph Zahn PH-dependent polypeptide aggregation and its use
CN1297663C (zh) * 2003-05-07 2007-01-31 中国科学院微生物研究所 一类重组基因产生的朊蛋白（PrPC）融合变构体及其用途
NZ545385A (en) 2003-08-13 2010-12-24 Novartis Vaccines & Diagnostic Prion-specific peptide reagents
US20070003977A1 (en) 2003-08-20 2007-01-04 Amorfix Life Sciences Ltd Epitope protection assay and method for detecting protein conformations
RU2251699C1 (ru) * 2003-09-25 2005-05-10 Киселев Всеволод Иванович Способ ранней и доклинической диагностики цервикального рака
US7482172B2 (en) 2005-09-19 2009-01-27 Ortho-Clinical Diagnostics, Inc. Peptides for discrimination of prions
AU2005209592B2 (en) 2004-09-30 2012-07-12 Ortho-Clinical Diagnostics, Inc. Peptides for discrimination of prions
DK1931695T3 (da) 2005-09-09 2013-07-01 Novartis Ag Prionspecifikke peptoidreagenser
US7887803B2 (en) 2005-12-02 2011-02-15 Amorfix Life Sciences Methods and compositions to treat misfolded-SOD1 mediated diseases
US7794692B2 (en) 2005-12-02 2010-09-14 Amorfix Life Sciences Ltd. Methods and compositions for detecting amyotrophic lateral sclerosis
CA2642848C (en) 2006-03-03 2016-07-12 Amorfix Life Sciences Ltd. Methods and compositions to treat and detect misfolded-sod1 mediated diseases
US7601506B2 (en) * 2006-07-28 2009-10-13 Idexx Laboratories, Inc. Identification of leucocytes bearing diagnostic markers for transmissible spongiform encephalopathies
US9056918B2 (en) 2008-04-25 2015-06-16 University Of Saskatchewan Prion epitopes and methods of use thereof
EP2128618A1 (de) * 2008-05-30 2009-12-02 Prion Diagnostica S.r.l. Verfahren zur Kontrolle der Präsenz von pathogenen Wirkstoffen in biologischen Flüssigkeiten durch nanostrukturierte Stoffe
US20100233176A1 (en) * 2008-10-06 2010-09-16 Cashman Neil R Methods and systems for predicting misfolded protein epitopes
WO2010111514A1 (en) * 2009-03-25 2010-09-30 Los Alamos National Security, Llc Rapid antemortem detection of infectious agents
AU2010229858A1 (en) 2009-03-25 2011-09-22 Los Alamos National Security, Llc Fiber optical assembly for fluorescence spectrometry
TWI419711B (zh) * 2010-07-27 2013-12-21 Univ Nat Changhua Education Tyrosinase polypeptide inhibitor
CN102492018A (zh) * 2010-07-27 2012-06-13 萧乃文 酪氨酸酶多肽抑制剂
WO2012099884A1 (en) * 2011-01-18 2012-07-26 The United States Of America, As Represented By The Secretary, Department Of Health & Human Services Methods for amplification and detection of prions
CA2877505C (en) * 2012-06-12 2020-09-22 Helix Biopharma Corp. Antibodies and conjugates that target misfolded prion protein
US9809620B2 (en) 2013-04-30 2017-11-07 University Of Saskatchewan Prion disease-specific epitopes and methods of use thereof
CN108409865A (zh) * 2018-01-19 2018-08-17 鄞州出入境检验检疫局综合技术服务中心 特异性双酚a羊多克隆抗体及其应用
EP3966227A1 (de) 2019-05-07 2022-03-16 Voyager Therapeutics, Inc. Zusammensetzungen und verfahren zur vektorisierten vermehrung von proteinzerstörung, -expression und/oder -regulierung

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE177754T1 (de) * 1991-12-03 1999-04-15 Proteus Molecular Design Fragmente von prion proteinen.
AU4376093A (en) * 1992-05-15 1993-12-13 Instituto Nazionale Neurologico C. Besta Soluble prion polypeptides, and methods for detecting and purifying thereof
CA2231409C (en) * 1995-09-14 2003-02-11 The Regents Of The University Of California Antibodies specific for native prpsc
US5750361A (en) * 1995-11-02 1998-05-12 The Regents Of The University Of California Formation and use of prion protein (PRP) complexes
EP0861900A1 (de) * 1997-02-21 1998-09-02 Erziehungsdirektion Of The Canton Zurich Immunologischer Nachweis von Prionen
US5891641A (en) * 1997-02-21 1999-04-06 The Regents Of The University Of California Assay for disease related conformation of a protein
US6165784A (en) * 1997-10-14 2000-12-26 The United States Of America As Represented By The Secretary Of Agriculture Antibodies for the detection of prion protein as an indication of transmissible spongiform encephalopathies

Also Published As

Publication number Publication date
HK1048955A1 (zh) 2003-04-25
JP2003521477A (ja) 2003-07-15
AU5637500A (en) 2001-01-09
EP1194164A4 (de) 2004-09-08
CA2377648A1 (en) 2000-12-28
DE60032486T2 (de) 2007-08-16
EP1194164B1 (de) 2006-12-20
DE60032486D1 (de) 2007-02-01
EP1194164B8 (de) 2007-03-21
WO2000078344A8 (en) 2001-11-15
AU783484B2 (en) 2005-11-03
EP1194164A1 (de) 2002-04-10
ES2278617T3 (es) 2007-08-16
NZ516240A (en) 2005-11-25
CN1370078A (zh) 2002-09-18
MXPA01013186A (es) 2002-08-12
WO2000078344A1 (en) 2000-12-28

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