ATE344028T1 - Antimykotische wirkung von dikationischen molekülen - Google Patents

Antimykotische wirkung von dikationischen molekülen

Info

Publication number
ATE344028T1
ATE344028T1 AT99969025T AT99969025T ATE344028T1 AT E344028 T1 ATE344028 T1 AT E344028T1 AT 99969025 T AT99969025 T AT 99969025T AT 99969025 T AT99969025 T AT 99969025T AT E344028 T1 ATE344028 T1 AT E344028T1
Authority
AT
Austria
Prior art keywords
fungal effect
fungal infections
dicationic molecules
dicationic
molecules
Prior art date
Application number
AT99969025T
Other languages
German (de)
English (en)
Inventor
Richard R Tidwell
David W Boykin
John R Perfect
Original Assignee
Univ North Carolina
Univ Georgia State
Univ Duke
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ North Carolina, Univ Georgia State, Univ Duke filed Critical Univ North Carolina
Application granted granted Critical
Publication of ATE344028T1 publication Critical patent/ATE344028T1/de

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A61K31/4184—1,3-Diazoles condensed with carbocyclic rings, e.g. benzimidazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/34—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
    • A61K31/341—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide not condensed with another ring, e.g. ranitidine, furosemide, bufetolol, muscarine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10—Antimycotics

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Peptides Or Proteins (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Furan Compounds (AREA)
AT99969025T 1998-09-17 1999-09-15 Antimykotische wirkung von dikationischen molekülen ATE344028T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US10092898P 1998-09-17 1998-09-17

Publications (1)

Publication Number Publication Date
ATE344028T1 true ATE344028T1 (de) 2006-11-15

Family

ID=22282251

Family Applications (1)

Application Number Title Priority Date Filing Date
AT99969025T ATE344028T1 (de) 1998-09-17 1999-09-15 Antimykotische wirkung von dikationischen molekülen

Country Status (9)

Country Link
US (1) US6326395B1 (https=)
EP (1) EP1143959B1 (https=)
JP (1) JP2002524503A (https=)
AT (1) ATE344028T1 (https=)
AU (2) AU770656B2 (https=)
CA (1) CA2344445A1 (https=)
DE (1) DE69933890T2 (https=)
ES (1) ES2275362T3 (https=)
WO (1) WO2000015212A2 (https=)

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BR0016565A (pt) * 1999-12-20 2002-09-17 Univ North Carolina Compostos diamidina como ligantes de pequeno sulco de dna
US6569853B1 (en) * 2000-11-06 2003-05-27 Combinatorx, Incorporated Combinations of chlorpromazine and pentamidine for the treatment of neoplastic disorders
IL160208A0 (en) * 2001-08-31 2004-07-25 Neurochem Int Ltd Amidine derivatives for treating amyloidosis
US6951880B2 (en) 2002-05-16 2005-10-04 Genelabs Technologies, Inc. Aryl and heteroaryl compounds as antibacterial and antifungal agents
AU2003295952A1 (en) * 2002-11-27 2004-06-23 Georgia State University Research Foundation, Inc. Process for synthesis bis-aryl diamidoxime compounds
US20050054708A1 (en) * 2003-07-28 2005-03-10 Nichols Matthew James Combinations of drugs for the treatment of neoplasms
AR047938A1 (es) * 2003-08-25 2006-03-15 Combinatorx Inc Formulaciones, conjugados y combinaciones de farmacos para el tratamiento de neoplasmas
US20050158320A1 (en) * 2003-11-12 2005-07-21 Nichols M. J. Combinations for the treatment of proliferative diseases
US20050100508A1 (en) * 2003-11-12 2005-05-12 Nichols M. J. Methods for identifying drug combinations for the treatment of proliferative diseases
EP1689732A4 (en) * 2003-12-05 2008-10-22 Univ North Carolina Cationically substituted benzoufurans as antimicrobial agents
US7262223B2 (en) * 2004-01-23 2007-08-28 Neurochem (International) Limited Amidine derivatives for treating amyloidosis
WO2005086754A2 (en) * 2004-03-08 2005-09-22 Georgia State University Research Foundation, Inc. Dicationic compounds for activity against trichomonas vaginalis
US7994225B2 (en) * 2004-03-17 2011-08-09 Rempex Pharmaceuticals, Inc. Bacterial efflux pump inhibitors for the treatment of ophthalmic and otic infections
EP1732527A2 (en) * 2004-03-17 2006-12-20 Mpex Pharmaceuticals, Inc. Use and administration of bacterial efflux pump inhibitors
EP1742936A2 (en) * 2004-04-13 2007-01-17 Icagen, Inc. Polycyclic pyridines as potassium ion channel modulators
DE102004031656A1 (de) * 2004-06-30 2006-01-19 Merck Patent Gmbh Tetrahydrochinoline
GB0619325D0 (en) * 2006-09-30 2006-11-08 Univ Strathclyde New compounds
DE102007013856A1 (de) 2007-03-20 2008-09-25 Merck Patent Gmbh Substituierte Tetrahydropyrrolochinoline
DE102007013854A1 (de) 2007-03-20 2008-09-25 Merck Patent Gmbh Tetrahydrochinoline
DE102007013855A1 (de) 2007-03-20 2008-09-25 Merck Patent Gmbh Substituierte Tetrahydrochinoline
EP2194981B1 (en) * 2007-10-05 2011-11-23 Université de Mons-Hainaut Bisbenzimidazoles as antimalarial agents
WO2009084544A1 (ja) * 2007-12-27 2009-07-09 Idemitsu Kosan Co., Ltd. 含窒素複素環誘導体及びそれを用いた有機エレクトロルミネッセンス素子
WO2009135125A2 (en) * 2008-05-01 2009-11-05 Bayer Schering Pharma Ag Catheter balloon drug adherence techniques and methods
EP2810951B1 (en) 2008-06-04 2017-03-15 Synergy Pharmaceuticals Inc. Agonists of guanylate cyclase useful for the treatment of gastrointestinal disorders, inflammation, cancer and other disorders
US11141752B2 (en) 2012-12-27 2021-10-12 Kateeva, Inc. Techniques for arrayed printing of a permanent layer with improved speed and accuracy

Family Cites Families (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2122208A1 (en) * 1971-05-05 1972-11-23 Farbwerke Hoechst AG, vormals Meister Lucius & Brüning, 6000 Frankfurt Diamidino-benzimidazole derivs - with fungistatic activity
JPS51110531A (en) * 1975-03-26 1976-09-30 Eisai Co Ltd Amijinokagobutsuno seizoho
JPS5922697B2 (ja) 1976-01-13 1984-05-28 エーザイ株式会社 ビス−（メタ−アミジノフエノキシ）−化合物
DE2833135A1 (de) * 1978-07-28 1980-02-07 Henkel Kgaa Verwendung von substituierten oligocarbamidinen als mikrobistatika sowie diese enthaltende antimikrobielle mittel
US4324794A (en) 1980-08-26 1982-04-13 Research Triangle Institute Inhibition of respiratory syncytial virus-induced cell fusion by amidino compounds
US4397863A (en) 1980-08-26 1983-08-09 Research Triangle Institute Inhibition of respiratory syncytial virus-induced cell fusion by amidino compounds
US4619942A (en) 1982-04-08 1986-10-28 University Of North Carolina Inhibition of Respiratory Syncytial virus-induced cell fusion by amidino compounds
US4940723A (en) 1988-10-20 1990-07-10 University Of North Carolina, Chapel Hill Use of bis-(5-amidino-2-benzimidazolyl) methane (BABIM) to treat arthritis
US4933347A (en) 1988-10-25 1990-06-12 University Of North Carolina At Chapel Hill Diamidines and bis(imidazolines) for the treatment of and prophylaxis against pneumocystis carinii pneumonia
US5202320A (en) 1989-04-06 1993-04-13 Tidwell Richard R Method for treating leishmaniasis
US4963589A (en) 1988-10-25 1990-10-16 The University Of North Carolina At Chapel Hill Methods for treating Giardia lamblia
US5206236A (en) 1989-04-06 1993-04-27 Tidwell Richard R Method for the treatment of malaria
US5428051A (en) 1992-10-13 1995-06-27 University Of North Carolina Methods of combating pneumocystis carinii pneumonia and compounds useful therefor
US5723288A (en) 1994-05-06 1998-03-03 The University Of North Carolina At Chapel Hill Method of fluorescent detection of nucleic acids and cytoskeleton elements using bis-dicationic aryl furans, and kits useful therefor
US5602172A (en) * 1994-05-06 1997-02-11 The University Of North Carolina At Chapel Hill Methods of inhibiting Pneumocystis carinii pneumonia, Giardia lamblia, and Cryptosporidium and compounds useful therefor
US5521189A (en) 1994-05-06 1996-05-28 The University Of Nc At Ch Methods of treating pneumocystis carinii pneumonia
US5667975A (en) 1994-05-06 1997-09-16 The University Of North Carolina Method of fluorescent detection of nucleic acids and cytoskeleton elements using bis-dicationic aryl furans
US5668166A (en) 1995-06-07 1997-09-16 Georgia State University Research Foundation, Inc. Methods of inhibiting pneumocystis carinii pneumonia and compounds useful therefor
US5643935A (en) * 1995-06-07 1997-07-01 The University Of North Carolina At Chapel Hill Method of combatting infectious diseases using dicationic bis-benzimidazoles
US5723495A (en) 1995-11-16 1998-03-03 The University Of North Carolina At Chapel Hill Benzamidoxime prodrugs as antipneumocystic agents

Also Published As

Publication number Publication date
WO2000015212A3 (en) 2001-08-16
AU6045099A (en) 2000-04-03
AU770656B2 (en) 2004-02-26
EP1143959A2 (en) 2001-10-17
JP2002524503A (ja) 2002-08-06
EP1143959B1 (en) 2006-11-02
CA2344445A1 (en) 2000-03-23
US6326395B1 (en) 2001-12-04
ES2275362T3 (es) 2007-06-01
DE69933890D1 (de) 2006-12-14
WO2000015212A2 (en) 2000-03-23
DE69933890T2 (de) 2007-03-15
AU2004202311A1 (en) 2004-06-24

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Legal Events

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RER Ceased as to paragraph 5 lit. 3 law introducing patent treaties